The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Monoclonality and Abnormal Parathyroid Hormone Genes in Parathyroid Adenomas
Abstract
Previous work based on the relative tissue content of glucose-6-phosphate dehydrogenase isoenzymes suggested that parathyroid adenomas, like primary hyperplasia, may be multicellular (not clonal) in origin. We have reexamined this issue by using two independent molecular genetic methods. We report tumor-cell-specific restriction-fragment-length alterations involving the parathyroid hormone gene from two human parathyroid adenomas. These abnormal restriction fragments indicate that in each case a clonal proliferation of cells was present and also suggest that DNA alterations involving the parathyroid hormone locus may be important in the tumorigenesis or clonal evolution of some parathyroid adenomas. In addition, we used a restriction-fragment-length polymorphism in an X-linked gene (hypoxanthine phosphoribosyltransferase) to examine the clonality of eight parathyroid adenomas in women. Of these eight adenomas, six had the DNA hybridization pattern of monoclonality, and two had an equivocal pattern. None of five hyperplastic parathyroid glands had a monoclonal pattern. We conclude that some (and perhaps many) single parathyroid adenomas are monoclonal neoplasms. Our observations suggest that there is a fundamental biologic difference between parathyroid adenomas and primary hyperplasia--a difference that could prove useful in distinguishing these entities clinically.
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Cited by
Clonal Origin of Pituitary Adenomas*
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Clonal Origin of Bladder Cancer
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Hormones and Disorders of Mineral Metabolism
Bringhurst, F. R., Demay, M. B., & Kronenberg, H. M. (2011) · Williams Textbook of Endocrinology · doi:10.1016/b978-1-4377-0324-5.00028-6 · Cited by 298
Self-citationClonal analysis of human adrenocortical carcinomas and secreting adenomas
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Metadata
- Authors
- Arnold, A., Staunton, C. E., Kim, H. G., Gaz, R. D., & Kronenberg, H. M.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1988-03-17
- Volume
- 318
- Issue
- 11
- Pages
- 658-662
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2337271927
- Cited by
- 294
- References
- 20
- FWCI
- 16.29
- Type
- journal article
- Language
- en
- Open access
- closed
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- Arnold, A., Staunton, C. E., Kim, H. G., Gaz, R. D., & Kronenberg, H. M. (1988). Monoclonality and Abnormal Parathyroid Hormone Genes in Parathyroid Adenomas. New England Journal of Medicine. https://doi.org/10.1056/nejm198803173181102
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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