The DOI matches its Crossref record.
Permanent Coverage of Large Burn Wounds with Autologous Cultured Human Epithelium
Abstract
WHEN burns are so extensive that skin grafts obtainable from remaining donor sites are insufficient to provide wound coverage, a new source of autograft must be found. Human epidermal cells from a small skin-biopsy sample can be cultured to produce coherent epithelial sheets sufficient to cover the entire body surface.1,2 When this epithelium was applied to wounds on athymic mice it generated a human epidermis.3 Autologous cultured epithelium placed on small burn wounds in adults'1 and children5 adhered and generated a permanent epidermis similar to that resulting from split-thickness skin grafts. We report here that in two children who sustained . . .
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Citations
Cited by
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Regeneration of the entire human epidermis using transgenic stem cells
Hirsch, T., Rothoeft, T., Teig, N., Bauer, J. W., Pellegrini, G., De Rosa, L., Scaglione, D., Reichelt, J., Klausegger, A., Kneisz, D., et al. (2017) · Nature · doi:10.1038/nature24487 · Cited by 693
Tissue Stem Cells: Architects of Their Niches
Fuchs, E., & Blau, H. M. (2020) · Cell Stem Cell · doi:10.1016/j.stem.2020.09.011 · Cited by 332
Cultured epithelial autograft (CEA) in burn treatment: Three decades later
Atiyeh, B. S., & Costagliola, M. (2007) · Burns · doi:10.1016/j.burns.2006.11.002 · Cited by 327
Collagen—emerging collagen based therapies hit the patient
Abou Neel, E. A., Bozec, L., Knowles, J. C., Syed, O., Mudera, V., Day, R., & Hyun, J. K. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.08.010 · Cited by 296
Gene therapy for severe combined immunodeficiency: are we there yet?
Cavazzana-Calvo, M., & Fischer, A. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30953 · Cited by 183
Boyce, S. T., Supp, A. P., Swope, V. B., & Warden, G. D. (2002) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2002.01717.x · Cited by 172
Unger, C., Kramer, N., Walzl, A., Scherzer, M., Hengstschläger, M., & Dolznig, H. (2014) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2014.10.015 · Cited by 158
Epidermal stem cells are resistant to cellular aging
Stern, M. M., & Bickenbach, J. R. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00318.x · Cited by 79
From Grafts to Human Bioengineered Vascularized Skin Substitutes
Oualla-Bachiri, W., Fernández-González, A., Quiñones-Vico, M. I., & Arias-Santiago, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21218197 · Cited by 69
Enzo, E., Secone Seconetti, A., Forcato, M., Tenedini, E., Polito, M. P., Sala, I., Carulli, S., Contin, R., Peano, C., Tagliafico, E., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-22779-9 · Cited by 66
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Warrick, E., Garcia, M., Chagnoleau, C., Chevallier, O., Bergoglio, V., Sartori, D., Mavilio, F., Angulo, J. F., Avril, M.-F., Sarasin, A., et al. (2012) · Molecular Therapy · doi:10.1038/mt.2011.233 · Cited by 58
Collagen in Dermal Wound Repair
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Metadata
- Authors
- Gallico, G. G., O'Connor, N. E., Compton, C. C., Kehinde, O., & Green, H.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1984-08-16
- Volume
- 311
- Issue
- 7
- Pages
- 448-451
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2036189250
- Cited by
- 1,155
- References
- 0
- FWCI
- 19.10
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
