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Cited by 371

The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.

Prevention of Myocardial Damage in Acute Myocardial Ischemia by Early Treatment with Intravenous Streptokinase

Koren, Gideon, Weiss, Avraham T., Hasin, Yonathan, Appelbaum, David, Welber, Sima, Rozenman, Yoseph, Lotan, Chaim, Mosseri, Morris, Sapoznikov, Dan, Luria, Myron H., Gotsman, Mervyn S.·1985·New England Journal of Medicine
DOI 10.1056/nejm198511283132204
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Abstract

We evaluated the effectiveness of early intravenous administration of 750,000 units of streptokinase in 53 patients with acute myocardial ischemia treated by a mobile-care unit at home (9 patients) or in the hospital (44 patients). Treatment was begun an average (+/- S.D.) of 1.7 +/- 0.8 hours from the onset of pain. Non-Q-wave infarctions developed subsequently in eight patients, whereas all the others had typical Q-wave infarct patterns. In 81 per cent of the patients the infarct-related artery was patent at angiography performed four to nine days after admission. Vessel patency was independent of the time of treatment, but residual left ventricular function was time dependent. Patients treated less than 1.5 hours after the onset of pain had a significantly higher ejection fraction (56 +/- 15 vs. 47 +/- 14 per cent; P less than 0.05) and infarct-related regional ejection fraction (51 +/- 19 vs. 34 +/- 20 per cent; P less than 0.01) and a lower QRS score (5.6 +/- 4.9 vs. 8.6 +/- 5.5; P less than 0.01) than patients receiving treatment between 1.5 and 4 hours after the onset of pain. Patients treated earlier by the mobile-care unit also had better-preserved left ventricular function than patients treated in the hospital. We conclude that thrombolytic therapy with streptokinase is most effective if given within the first 1.5 hours after the onset of symptoms of acute myocardial infarction.

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Crossref · 10.1056/nejm198511283132204

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Metadata

Authors
Koren, G., Weiss, A. T., Hasin, Y., Appelbaum, D., Welber, S., Rozenman, Y., Lotan, C., Mosseri, M., Sapoznikov, D., Luria, M. H., & Gotsman, M. S.
Venue
New England Journal of Medicine
Publisher
Massachusetts Medical Society
Published
1985-11-28
Volume
313
Issue
22
Pages
1384-1389
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
DOI
10.1056/nejm198511283132204
OpenAlex
W2322228296
Cited by
371
References
15
FWCI
35.90
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Prevention of Myocardial Damage in Acute Myocardial Ischemia by Early Treatment with Intravenous Streptokinase. https://app.cochat.ai/papers/10.1056/nejm198511283132204
The paper
Koren, G., Weiss, A. T., Hasin, Y., Appelbaum, D., Welber, S., Rozenman, Y., Lotan, C., Mosseri, M., Sapoznikov, D., Luria, M. H., & Gotsman, M. S. (1985). Prevention of Myocardial Damage in Acute Myocardial Ischemia by Early Treatment with Intravenous Streptokinase. New England Journal of Medicine. https://doi.org/10.1056/nejm198511283132204

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.