Cited by 293Nitric Oxide and Endothelin EffectsNeutrophil, Myeloperoxidase and Oxidative MechanismsRedox biology and oxidative stress

Modulation of leukocyte–endothelial interactions by reactive metabolites of oxygen and nitrogen: relevance to ischemic heart disease

Grisham, Matthew B., Granger, D.Neil, Lefer, David J.·1998·Free Radical Biology and Medicine

Abstract

Ischemia and reperfusion (I/R) are thought to play an important role in the pathophysiology of ischemic diseases of the heart. It is now well appreciated that leukocyte-endothelial cell interactions are important determinants for I/R-induced microvascular injury and dysfunction. There is a growing body of experimental data to suggest that reactive metabolites of oxygen and nitrogen are important physiological modulators of leukocyte-endothelial cell interactions. A number of investigators have demonstrated that I/R enhances oxidant production within the microcirculation resulting in increases in leukocyte adhesion and transendothelial cell migration. Several other studies have shown that exogenous nitric oxide (NO) donors may attenuate leukocyte and platelet adhesion and/or aggregation in a number of different inflammatory conditions including I/R. The objective of this review is to discuss the physiological chemistry of reactive metabolites of oxygen and nitrogen with special attention given to those interactions that may modulate leukocyte-endothelial cell interactions, provide an overview of the evidence implicating reactive metabolites of oxygen and nitrogen as modulators of leukocyte-endothelial cell interactions in vivo, and discuss how these mechanisms may be involved in the pathophysiology of ischemic heart disease.

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  • Decreased NO levels contribute to endothelial cell dysfunction, atherosclerotic plaque development, arteriosclerosis, vessel restenosis, peripheral vascular disease, and ischemia-reperfusion injury.

    “It is well accepted that decreased NO levels contribute to endothelial cell dysfunction, atherosclerotic plaque development, arteriosclerosis, vessel restenosis, peripheral vascular disease, and ischemia-reperfusion injury [14, 15, 138–140].”

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Authors
Grisham, M. B., Granger, D. N., & Lefer, D. J.
Affiliations
Louisiana State University (US)
Corresponding author
Grisham, Matthew B.
Venue
Free Radical Biology and Medicine
Publisher
Elsevier BV
Published
1998-09
Volume
25
Issue
4-5
Pages
404-433
ISSN
0891-5849 (ISSN-L)
OpenAlex
W2094525668
Cited by
293
References
211
Citations by year
2025: 5 · 2024: 5 · 2023: 4 · 2022: 4 · 2021: 4 · 2020: 11 · 2019: 5 · 2018: 4 · 2017: 4 · 2016: 4 · 2015: 6 · 2014: 7 · 2013: 6 · 2012: 11
FWCI
3.21
Type
journal article
Language
en
Open access
closed
Locations
  • Free Radical Biology and Medicine (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01dk047663-06)
  • National Institute of Diabetes and Digestive and Kidney Diseases (P01 DK-43785, DK-47663, P01DK043785)
Topics
  • Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
  • Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords
reactive oxygen species, reactive nitrogen species, leukocyte-endothelium interaction, ischemia-reperfusion injury, ischemic heart disease, nitric oxide donors, leukocyte adhesion, transendothelial migration, platelet aggregation, microvascular damage, oxidative stress
MeSH terms
Animals, Cell Adhesion, Endothelium, Vascular, Humans, Iron, Leukocytes, Nitric Oxide, Oxidation-Reduction, Myocardial Reperfusion Injury, Myocardial Ischemia, Reactive Oxygen Species

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