The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
The Effect on Serum Cholesterol Levels of Coffee Brewed by Filtering or Boiling
Abstract
Previous reports have indicated that coffee consumption may increase serum cholesterol levels. We studied the effects of coffee prepared by two common brewing methods (filtering and boiling) on serum lipid levels in a 12-week randomized trial involving 107 young adult subjects with normal serum cholesterol levels. After a three-week run-in period during which they all consumed filtered coffee, the participants were randomly assigned to one of three groups receiving four to six cups of boiled coffee a day, four to six cups of filtered coffee a day, or no coffee, for a period of nine weeks. As compared with the change from base line in the filtered-coffee group, the serum total cholesterol level increased after the consumption of boiled coffee by 0.48 mmol per liter (95 percent confidence limits, 0.13 and 0.83), and the low-density lipoprotein cholesterol level increased by 0.39 mmol per liter (95 percent confidence limits, -0.04 and 0.82). There was no significant difference in the change in serum total or low-density lipoprotein cholesterol levels between the filtered-coffee group and the group that drank no coffee. The levels of high-density lipoprotein cholesterol and apolipoproteins were not affected by boiled or filtered coffee. We conclude that drinking filtered coffee does not affect serum lipid levels. The consumption of boiled coffee, however, has an effect on serum cholesterol levels amounting to a mean net increase of 10 percent of the base-line level after nine weeks.
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“It has been shown that drinking boiled coffee increases serum cholesterol, an important risk factor for CVD5.”
From Long-Term Coffee Consumption and Risk of Cardiovascular Disease: A Systematic Review and a Dose–Response Meta-Analysis of Prospective Cohort Studies (2014) · cites this paper as [5]
Citations
Cites
Rapid method for the isolation of lipoproteins from human serum by precipitation with polyanions
Burstein, M., Scholnick, H. R., & Morfin, R. F. (1970) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)42943-8 · Cited by 2,500
Thelle, D. S., Arnesen, E., & Førde, O. H. (1983) · New England Journal of Medicine · doi:10.1056/nejm198306163082405 · Cited by 493
The Measurement of Apolipoprotein A-I and A-II Levels in Men and Women by Immunoassay
Cheung, M. C., & Albers, J. J. (1977) · Journal of Clinical Investigation · doi:10.1172/jci108767 · Cited by 381
Plasma Lipids and Lipoproteins in Vegetarians and Controls
Sacks, F. M., Castelli, W. P., Donner, A., & Kass, E. H. (1975) · New England Journal of Medicine · doi:10.1056/nejm197505292922203 · Cited by 356
Coffee consumption and the incidence of coronary heart disease.
LaCroix, A. Z., Mead, L. A., Liang, K.-Y., Thomas, C. B., & Pearson, T. A. (1986) · New England Journal of Medicine · doi:10.1056/nejm198610163151601 · Cited by 183
Coffee and Cardiovascular Disease
Dawber, T. R., Kannel, W. B., & Gordon, T. (1974) · New England Journal of Medicine · doi:10.1056/nejm197410242911703 · Cited by 183
Weksler, M. E., Kuntz, M. M., Lockshin, M., Kohn, R. M., & Eisenhauer, A. (1974) · The Lancet · doi:10.1016/s0140-6736(74)90600-x · Cited by 174
Coffee and cardiovascular disease.
Yuan, S. (1977) · PubMed · Cited by 172
van Gent, C. M., van der Voort, H. A., Bruyn, A. M. D., & Klein, F. (1977) · Clinica Chimica Acta · doi:10.1016/0009-8981(77)90195-4 · Cited by 131
Independence of serum lipid levels and dietary habits. The Tecumseh study
Nichols, A. B. (1976) · JAMA · doi:10.1001/jama.236.17.1948 · Cited by 127
Research works printed but not linked: 7
- Nichols, 1976, JAMA, 236, 1948, 10.1001/jama.1976.03270180024014 · DOI
- Kovar, 1983, N Engl J Med, 309, 1249
- Shekelle, 1983, N Engl J Med, 309, 1249
- Arab, 1983, N Engl J Med, 309, 1250
- Folsom, 1984, CVD Epidemiol Newsl, 35, 53
- Amesen, 1984, Br Med J, 288, 1960
- Grove, 1979, ClinChem, 25, 560
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Ding, M., Bhupathiraju, S. N., Satija, A., van Dam, R. M., & Hu, F. B. (2014) · Circulation · doi:10.1161/circulationaha.113.005925 · Cited by 565
“It has been shown that drinking boiled coffee increases serum cholesterol, an important risk factor for CVD.(5) Second, in earlier studies, the sample size was typically small, the measurement of baseline characteristics was typically crude, statistical control of confounders such as diet was inadequate, and the avera…”
InfluentialCoffee, CYP1A2 genotype, and risk of myocardial infarction
Cornelis, M. C., El-Sohemy, A., Kabagambe, E. K., & Campos, H. (2006) · JAMA · doi:10.1001/jama.295.10.1135 · Cited by 490
The lipid fraction of the coffee bean
Speer, K., & Kölling-Speer, I. (2006) · Brazilian Journal of Plant Physiology · doi:10.1590/s1677-04202006000100014 · Cited by 382
O’Keefe, J. H., Bhatti, S. K., Patil, H., DiNicolantonio, J. J., Lucan, S. C., & Lavie, C. J. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.06.035 · Cited by 353
Landin‐Wllhelmsen, K., Wllhelmsen, L., Lappast, G., Rosén, T., Lindstedt, G., Lundberg, P., & Bengtsson, B. (1994) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1994.tb02556.x · Cited by 338
Metadata
- Authors
- Bak, A. A. A., & Grobbee, D. E.
- Affiliations
- Erasmus MC (NL)
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1989-11-23
- Volume
- 321
- Issue
- 21
- Pages
- 1432-1437
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2332265208
- Cited by
- 194
- References
- 38
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 5 · 2023: 4 · 2022: 1 · 2021: 2 · 2020: 5 · 2019: 5 · 2018: 6 · 2017: 5 · 2016: 4 · 2015: 4 · 2014: 3 · 2013: 5 · 2012: 1
- FWCI
- 15.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Coffee research and impacts
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Life Sciences › Agricultural and Biological Sciences › Food Science › Coconut Research and Applications
- Keywords
- coffee, brewing technology, filtered coffee, boiled coffee, serum cholesterol, LDL cholesterol, serum lipids, HDL cholesterol, apolipoproteins, dietary fat intake
- MeSH terms
- Adult, Apolipoproteins, Cholesterol, Coffee, Cooking, Female, Filtration, Humans, Cholesterol, HDL, Cholesterol, LDL, Male, Random Allocation
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