Cited by 194Coffee research and impactsAlcohol Consumption and Health EffectsCoconut Research and Applications

The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.

The Effect on Serum Cholesterol Levels of Coffee Brewed by Filtering or Boiling

Bak, Annette A.A., Grobbee, Diederick E.·1989·New England Journal of Medicine

DOI 10.1056/nejm198911233212103

Open this paper in CoChat — free account

Abstract

Previous reports have indicated that coffee consumption may increase serum cholesterol levels. We studied the effects of coffee prepared by two common brewing methods (filtering and boiling) on serum lipid levels in a 12-week randomized trial involving 107 young adult subjects with normal serum cholesterol levels. After a three-week run-in period during which they all consumed filtered coffee, the participants were randomly assigned to one of three groups receiving four to six cups of boiled coffee a day, four to six cups of filtered coffee a day, or no coffee, for a period of nine weeks. As compared with the change from base line in the filtered-coffee group, the serum total cholesterol level increased after the consumption of boiled coffee by 0.48 mmol per liter (95 percent confidence limits, 0.13 and 0.83), and the low-density lipoprotein cholesterol level increased by 0.39 mmol per liter (95 percent confidence limits, -0.04 and 0.82). There was no significant difference in the change in serum total or low-density lipoprotein cholesterol levels between the filtered-coffee group and the group that drank no coffee. The levels of high-density lipoprotein cholesterol and apolipoproteins were not affected by boiled or filtered coffee. We conclude that drinking filtered coffee does not affect serum lipid levels. The consumption of boiled coffee, however, has an effect on serum cholesterol levels amounting to a mean net increase of 10 percent of the base-line level after nine weeks.

Integrity signals

Registry

Crossref · 10.1056/nejm198911233212103

Cites

38 of 38 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Rapid method for the isolation of lipoproteins from human serum by precipitation with polyanions
Burstein, M., Scholnick, H. R., & Morfin, R. F. (1970) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)42943-8 · Cited by 2,500
The Tromsø Heart Study
Thelle, D. S., Arnesen, E., & Førde, O. H. (1983) · New England Journal of Medicine · doi:10.1056/nejm198306163082405 · Cited by 493
The Measurement of Apolipoprotein A-I and A-II Levels in Men and Women by Immunoassay
Cheung, M. C., & Albers, J. J. (1977) · Journal of Clinical Investigation · doi:10.1172/jci108767 · Cited by 381
Plasma Lipids and Lipoproteins in Vegetarians and Controls
Sacks, F. M., Castelli, W. P., Donner, A., & Kass, E. H. (1975) · New England Journal of Medicine · doi:10.1056/nejm197505292922203 · Cited by 356
Coffee consumption and the incidence of coronary heart disease.
LaCroix, A. Z., Mead, L. A., Liang, K.-Y., Thomas, C. B., & Pearson, T. A. (1986) · New England Journal of Medicine · doi:10.1056/nejm198610163151601 · Cited by 183
Coffee and Cardiovascular Disease
Dawber, T. R., Kannel, W. B., & Gordon, T. (1974) · New England Journal of Medicine · doi:10.1056/nejm197410242911703 · Cited by 183
LYMPHOCYTE RESPONSE
Weksler, M. E., Kuntz, M. M., Lockshin, M., Kohn, R. M., & Eisenhauer, A. (1974) · The Lancet · doi:10.1016/s0140-6736(74)90600-x · Cited by 174
Coffee and cardiovascular disease.
Yuan, S. (1977) · PubMed · Cited by 172
Cholesterol determinations. a comparative study of methods with special reference to enzymatic procedures
van Gent, C. M., van der Voort, H. A., Bruyn, A. M. D., & Klein, F. (1977) · Clinica Chimica Acta · doi:10.1016/0009-8981(77)90195-4 · Cited by 131
Independence of serum lipid levels and dietary habits. The Tecumseh study
Nichols, A. B. (1976) · JAMA · doi:10.1001/jama.236.17.1948 · Cited by 127

Show all 38 references

Research works printed but not linked: 7

Nichols, 1976, JAMA, 236, 1948, 10.1001/jama.1976.03270180024014 · DOI
Kovar, 1983, N Engl J Med, 309, 1249
Shekelle, 1983, N Engl J Med, 309, 1249
Arab, 1983, N Engl J Med, 309, 1250
Folsom, 1984, CVD Epidemiol Newsl, 35, 53
Amesen, 1984, Br Med J, 288, 1960
Grove, 1979, ClinChem, 25, 560

Sorted by citations

Long-Term Coffee Consumption and Risk of Cardiovascular Disease: A Systematic Review and a Dose–Response Meta-Analysis of Prospective Cohort Studies
Ding, M., Bhupathiraju, S. N., Satija, A., van Dam, R. M., & Hu, F. B. (2014) · Circulation · doi:10.1161/circulationaha.113.005925 · Cited by 565
“It has been shown that drinking boiled coffee increases serum cholesterol, an important risk factor for CVD.(5) Second, in earlier studies, the sample size was typically small, the measurement of baseline characteristics was typically crude, statistical control of confounders such as diet was inadequate, and the avera…”
Influential
Coffee, CYP1A2 genotype, and risk of myocardial infarction
Cornelis, M. C., El-Sohemy, A., Kabagambe, E. K., & Campos, H. (2006) · JAMA · doi:10.1001/jama.295.10.1135 · Cited by 490
The lipid fraction of the coffee bean
Speer, K., & Kölling-Speer, I. (2006) · Brazilian Journal of Plant Physiology · doi:10.1590/s1677-04202006000100014 · Cited by 382
Effects of Habitual Coffee Consumption on Cardiometabolic Disease, Cardiovascular Health, and All-Cause Mortality
O’Keefe, J. H., Bhatti, S. K., Patil, H., DiNicolantonio, J. J., Lucan, S. C., & Lavie, C. J. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.06.035 · Cited by 353
Serum insulin‐like growth factor I in a random population sample of men and women: relation to age, sex, smoking habits, coffee consumption and physical activity, blood pressure and concentrations of plasma lipids, fibrinogen, parathyroid hormone and osteocalcin
Landin‐Wllhelmsen, K., Wllhelmsen, L., Lappast, G., Rosén, T., Lindstedt, G., Lundberg, P., & Bengtsson, B. (1994) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1994.tb02556.x · Cited by 338
Coffee, caffeine, and cardiovascular disease in men.
Grobbee, D. E., Rimm, E. B., Giovannucci, E., Colditz, G., Stampfer, M., & Willett, W. (1990) · New England Journal of Medicine · doi:10.1056/nejm199010113231504 · Cited by 322
Self-citation
Coffee Consumption and Serum Lipids: A Meta-Analysis of Randomized Controlled Clinical Trials
Jee, S. H., He, J., Appel, L. J., Whelton, P. K., Suh, II, & Klag, M. J. (2001) · American Journal of Epidemiology · doi:10.1093/aje/153.4.353 · Cited by 301
Tea drinking and bone mineral density in older women
Hegarty, V., May, H. M., & Khaw, K. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.4.1003 · Cited by 293
Tea consumption. Relationship to cholesterol, blood pressure, and coronary and total mortality
Stensvold, I., Tverdal, A., Solvoll, K., & FOSS, O. P. (1992) · Preventive Medicine · doi:10.1016/0091-7435(92)90062-m · Cited by 271
THE CHOLESTEROL-RAISING FACTOR FROM COFFEE BEANS
Urgert, R., & Katan, M. B. (1997) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.17.1.305 · Cited by 260
Coffee consumption and human health - beneficial or detrimental? - Mechanisms for effects of coffee consumption on different risk factors for cardiovascular disease and type 2 diabetes mellitus
Ranheim, T., & Halvorsen, B. L. (2005) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200400109 · Cited by 251
In vitro antioxidant activity of coffees brewed using different procedures (Italian, espresso and filter)
Sánchez-González, I., Jiménez‐Escrig, A., & Saura-Calixto, F. D. (2004) · Food Chemistry · doi:10.1016/j.foodchem.2004.03.037 · Cited by 227
Caffeine and cardiovascular health
Turnbull, D., Rodricks, J. V., Mariano, G. F., & Chowdhury, F. (2017) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2017.07.025 · Cited by 216
Coffee Consumption and Coronary Heart Disease in Men and Women: A Prospective Cohort Study
Lopez-Garcia, E., van Dam, R. M., Willett, W. C., Rimm, E. B., Manson, J. E., Stampfer, M. J., Rexrode, K. M., & Hu, F. B. (2006) · Circulation · doi:10.1161/circulationaha.105.598664 · Cited by 215
Analysis of the content of the diterpenes cafestol and kahweol in coffee brews
Gross, G., Jaccaud, E., & Huggett, A. C. (1997) · Food and Chemical Toxicology · doi:10.1016/s0278-6915(96)00123-8 · Cited by 213
The effect of coffee consumption on serum lipids: a meta-analysis of randomized controlled trials
Cai, L., Ma, D., Zhang, Y., Liu, Z., & Wang, P. (2012) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2012.68 · Cited by 205
Identity of the cholesterol-raising factor from boiled coffee and its effects on liver function enzymes.
Wouw, M. P. M. E. W.-V. D., Katan, M., Viani, R., Huggett, A. C., Liardon, R., Liardon, R., Lund‐Larsen, P. G., Thelle, D. S., Ahola, I., & Aro, A. (1994) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)41169-1 · Cited by 200
A meta‐analysis of coffee, myocardial infarction, and coronary death
Greenland, S. (1993) · Epidemiology · doi:10.1097/00001648-199307000-00013 · Cited by 163
The effects of foods on LDL cholesterol levels: A systematic review of the accumulated evidence from systematic reviews and meta-analyses of randomized controlled trials
Schoeneck, M., & Iggman, D. (2021) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2020.12.032 · Cited by 161
Coffee and incidence of diabetes in Swedish women: a prospective 18‐year follow‐up study
Rosengren, A., Dotevall, A., Wilhelmsen, L., Thelle, D. S., & Johansson, S. (2003) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.2003.01260.x · Cited by 157
Coffee consumption, health benefits and side effects: a narrative review and update for dietitians and nutritionists
Barrea, L., Pugliese, G., Frías-Toral, E., Ghoch, M. E., Castellucci, B., Chapela, S. P., Carignano, M. D. L. A., Laudisio, D., Savastano, S., Colao, A., et al. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1963207 · Cited by 170
The effect of drinking coffee and smoking cigarettes on the risk of cirrhosis associated with alcohol consumption
The Provincial Group for the Study of Chronic Liver Disease, Corrao, G., Lepore, A. R., Torchio, P., Valenti, M., GALATOLA, G., D’Amicis, A., Aricò, S., & di Orio, F. (1994) · European Journal of Epidemiology · doi:10.1007/bf01719277 · Cited by 132
Effect of a lipid-rich fraction from boiled coffee on serum cholesterol
Zock, P. L., Katan, M., Merkus, M. P., Dusseldorp, M., & Harryvan, J. L. (1990) · The Lancet · doi:10.1016/0140-6736(90)91302-q · Cited by 127
Lipid content and composition of coffee brews prepared by different methods
Ratnayake, W. M. N., Hollywood, R., O'Grady, E. B., & Stavrić, B. (1993) · Food and Chemical Toxicology · doi:10.1016/0278-6915(93)90076-b · Cited by 126
Wake up and smell the coffee. Caffeine, coffee, and the medical consequences.
Chou, T. M. (1992) · PubMed Central · Cited by 124
Coffee Consumption Enhances High-Density Lipoprotein-Mediated Cholesterol Efflux in Macrophages
Uto‐Kondo, H., Ayaori, M., Ogura, M., Nakaya, K., Ito, M., Suzuki, A., Takiguchi, S., Yakushiji, E., Terao, Y., Ozasa, H., et al. (2010) · Circulation Research · doi:10.1161/circresaha.109.206615 · Cited by 119
Cholesterol-raising factor from boiled coffee does not pass a paper filter.
Dusseldorp, M., Katan, M., van Vliet, T., Demacker, P. N. M., & Stalenhoef, A. F. H. (1991) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.11.3.586 · Cited by 116
Extraction of coffee diterpenes and coffee oil using supercritical carbon dioxide
Araújo, J. M. A., & Sandi, D. (2006) · Food Chemistry · doi:10.1016/j.foodchem.2006.03.008 · Cited by 107
Heterogeneity in Assessing Self-Reports of Caffeine Exposure
Bracken, M. B., Triche, E. W., Grosso, L. M., HELLENBRAND, K. G., Belanger, K. D., & Leaderer, B. P. (2002) · Epidemiology · doi:10.1097/00001648-200203000-00011 · Cited by 107
Effects of caffeine with repeated dosing
Denaro, C. P., Brown, C. R., Jacob, P., & Benowitz, N. L. (1991) · European Journal of Clinical Pharmacology · doi:10.1007/bf00315208 · Cited by 106
Abstention from filtered coffee reduces the concentrations of plasma homocysteine and serum cholesterol—a randomized controlled trial
Christensen, B., Mosdøl, A., Retterstøl, L., Landaas, S., & Thelle, D. S. (2001) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/74.3.302 · Cited by 104
Separate effects of the coffee diterpenes cafestol and kahweol on serum lipids and liver aminotransferases
Rob Urgert, B., Essed, N., van der Weg, G., Kosmeijer‐Schuil, T. G., & Katan, M. (1997) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/65.2.519 · Cited by 100
Comparison of effect of cafetiere and filtered coffee on serum concentrations of liver aminotransferases and lipids: six month randomised controlled trial
Rob Urgert, B., Meyboom, S., Kuilman, M., Rexwinkel, H., Vissers, M. N., Klerk, M., & Katan, M. (1996) · BMJ · doi:10.1136/bmj.313.7069.1362 · Cited by 96
Caffeine and coffee: effects on health and cardiovascular disease
Chou, T. M., & Benowitz, N. L. (1994) · Comparative Biochemistry and Physiology Part C Pharmacology Toxicology and Endocrinology · doi:10.1016/0742-8413(94)00048-f · Cited by 97
Cardiovascular effects of caffeinated beverages
Voskoboinik, A., Koh, Y., & Kistler, P. M. (2018) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2018.09.019 · Cited by 92
How coffee affects metabolic syndrome and its components
Başpınar, B., Eskici, G., & Özçelik, A. Ö. (2017) · Food & Function · doi:10.1039/c7fo00388a · Cited by 90
Caffeine content in coffee as influenced by grinding and brewing techniques
Bell, L. N., Wetzel, C. R., & Grand, A. N. (1996) · Food Research International · doi:10.1016/s0963-9969(97)00002-1 · Cited by 88
Is habitual caffeine use a preventable cardiovascular risk factor?
James, J. E. (1997) · The Lancet · doi:10.1016/s0140-6736(96)04253-5 · Cited by 85
Coffee and tea consumption and the prevalence of coronary heart disease in men and women: results from the Scottish Heart Health Study.
Brown, C. A., Bolton-Smith, C., Woodward, M., & Tunstall‐Pedoe, H. (1993) · Journal of Epidemiology & Community Health · doi:10.1136/jech.47.3.171 · Cited by 80
Effects of cafestol and kahweol from coffee grounds on serum lipids and serum liver enzymes in humans
Rob Urgert, B., Schulz, A., & Katan, M. (1995) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/61.1.149 · Cited by 80
The Cholesterol-Raising Factor from Coffee Beans
Rob Urgert, B., & Katan, M. (1996) · Journal of the Royal Society of Medicine · doi:10.1177/014107689608901107 · Cited by 78
Cafestol, the Cholesterol-Raising Factor in Boiled Coffee, Suppresses Bile Acid Synthesis by Downregulation of Cholesterol 7α-Hydroxylase and Sterol 27-Hydroxylase in Rat Hepatocytes
Post, S. M., de Wit, E. C. M., & Princen, H. M. G. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.11.3064 · Cited by 77
Caffeinated and decaffeinated coffee effects on plasma lipoprotein cholesterol, apolipoproteins, and lipase activity: a controlled, randomized trial
Superko, H. R., Bortz, W. M., Williams, P., Albers, J., & Wood, P. D. (1991) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/54.3.599 · Cited by 69
The hypercholesterolaemic factor in boiled coffee is retained by a paper filter
Ahola, I., Jauhiainen, M., & Aro, A. (1991) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.1991.tb00447.x · Cited by 70
Caffeine decreases exercise-induced myocardial flow reserve
Namdar, M., Koepfli, P., Grathwohl, R., Siegrist, P. T., Klainguti, M., Schepis, T., Delaloye, R., Wyss, C. A., Fleischmann, S. P., Gaemperli, O., et al. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.08.064 · Cited by 60
A Comprehensive Overview of the Risks and Benefits of Coffee Consumption
Pourshahidi, L. K., Navarini, L., Petracco, M., & Strain, J. (2016) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12206 · Cited by 64
Dose-dependent effect on serum cholesterol and apoprotein B concentrations by consumption of boiled, non-filtered coffee
Aro, A., Teirilä, J., & Gref, C.-G. (1990) · Atherosclerosis · doi:10.1016/0021-9150(90)90171-e · Cited by 59
Effect of coffee consumption on dyslipidemia: A meta-analysis of randomized controlled trials
Du, Y., Lv, Y., Zha, W., Hong, X., & Luo, Q. (2020) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2020.08.017 · Cited by 58
Coffee, coronary heart disease and mortality in middle‐aged Swedish men: findings from the Primary Prevention Study
ROSENGREN, A., & WILHELMSEN, L. (1991) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.1991.tb00407.x · Cited by 54
Impact of Coffee Consumption on Cardiovascular Health
Mendoza, M. F., Sulague, R. M., Posas-Mendoza, T., & Lavie, C. J. (2023) · Ochsner Journal · doi:10.31486/toj.22.0073 · Cited by 54
A placebo-controlled parallel study of the effect of two types of coffee oil on serum lipids and transaminases: identification of chemical substances involved in the cholesterol-raising effect of coffee
van Rooij, J., van der Stegen, G. H. D., Schoemaker, R. C., Kroon, C., Burggraaf, J., Hollaar, L., Vroon, T., Smelt, A., & Cohen, A. (1995) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/61.6.1277 · Cited by 51
Cardiovascular Effects of Coffee: Is It a Risk Factor?
Sudano, I., Binggeli, C., Spieker, L. E., Lüscher, T. F., Ruschitzka, F. T., Noll, G., & Corti, R. (2005) · Progress in Cardiovascular Nursing · doi:10.1111/j.0889-7204.2005.02477.x · Cited by 48
Coffee intake and coronary heart disease
Klag, M. J., Mead, L. A., Lacroix, A. Z., Wang, N.-Y., Coresh, J., Liang, K.-Y., Pearson, T. A., & Levine, D. M. (1994) · Annals of Epidemiology · doi:10.1016/1047-2797(94)90001-9 · Cited by 47
DYSPNEA DURING PREGNANCY
Zeldis, S. M. (1992) · Clinics in Chest Medicine · doi:10.1016/s0272-5231(21)01126-6 · Cited by 48
Association of serum lipoproteins and health-related habits with coffee and tea consumption in free-living subjects examined in the Israeli CORDIS study
Green, M. S., & Harari, G. (1992) · Preventive Medicine · doi:10.1016/0091-7435(92)90061-l · Cited by 47
Isolation of coffee diterpenes by means of high-speed countercurrent chromatography
Scharnhop, H., & Winterhalter, P. (2009) · Journal of Food Composition and Analysis · doi:10.1016/j.jfca.2008.10.018 · Cited by 45
Coffee consumption and risk of heart failure in men: An analysis from the Cohort of Swedish Men
Ahmed, H. N., Levitan, E. B., Wolk, A., & Mittleman, M. A. (2009) · American Heart Journal · doi:10.1016/j.ahj.2009.07.006 · Cited by 45
Review of Analytical Methods to Detect Adulteration in Coffee
Wang, X., Lim, L., & Fu, Y. (2020) · Journal of AOAC International · doi:10.1093/jaocint/qsz019 · Cited by 48
Coffee drinking timing and mortality in US adults
Wang, X., Ma, H., Sun, Q., Li, J., Heianza, Y., van Dam, R. M., Hu, F. B., Rimm, E. B., Manson, J. E., & Qi, L. (2025) · European Heart Journal · doi:10.1093/eurheartj/ehae871 · Cited by 50
Coffee and metabolic impairment: An updated review of epidemiological studies
Buscemi, S., Marventano, S., Antoci, M., Cagnetti, A., Castorina, G., Galvano, F., Marranzano, M., & Mistretta, A. (2016) · NFS Journal · doi:10.1016/j.nfs.2016.02.001 · Cited by 44
Coffee: One of the Most Consumed Beverages in the World
Lim, L., Zwicker, M., & Wang, X. (2019) · Elsevier eBooks · doi:10.1016/b978-0-444-64046-8.00462-6 · Cited by 46
Effect of Coffee Lipids (Cafestol and Kahweol) on Regulation of Cholesterol Metabolism in HepG2 Cells
Rustan, A. C., Halvorsen, B. L., Huggett, A. C., Ranheim, T., & Drevon, C. A. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.10.2140 · Cited by 44
Diterpene composition of oils from Arabica and Robusta coffee beans and their effects on serum lipids in man
Mensink, R. P., LEBBINK, W. J., LOBBEZOO, I. E., Wouw, M. P. M. E. W.-V. D., Zock, P. L., & Katan, M. (1995) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.1995.tb00883.x · Cited by 44
An update on research with coffee/caffeine (1989–1990)
Stavrić, B. (1992) · Food and Chemical Toxicology · doi:10.1016/0278-6915(92)90106-u · Cited by 43
Effect of a coffee lipid (cafestol) on cholesterol metabolism in human skin fibroblasts
Halvorsen, B. L., Ranheim, T., Nenseter, M. S., Huggett, A. C., & Drevon, C. A. (1998) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)32576-1 · Cited by 43
Cardiovascular Risk Factors in Commercial Flight Aircrew Officers Compared with Those in the General Population
Ekstrand, K., Boström, P. A., Arborelius, M., Nilsson, J., & Lindell, S. (1996) · Angiology · doi:10.1177/000331979604701109 · Cited by 42
Coffee consumption and cause-specific mortality association with age at death and compression of mortality
Lindsted, K. D., Kuzma, J. W., & Anderson, J. L. (1992) · Journal of Clinical Epidemiology · doi:10.1016/0895-4356(92)90051-n · Cited by 41
Relationship of Coffee Consumption with Serum Lipids and Lipoproteins in Japanese Men
Miyake, Y., Kono, S., Nishiwaki, M., Hamada, H., Nishikawa, H., Koga, H., & Ogawa, S. (1999) · Annals of Epidemiology · doi:10.1016/s1047-2797(98)00051-9 · Cited by 38
Coffee consumption and serum lipids: A randomized, crossover clinical trial
Rosmarin, P. C., Applegate, W. B., & Somes, G. W. (1990) · The American Journal of Medicine · doi:10.1016/0002-9343(90)90488-y · Cited by 38
Boiled coffee and blood pressure. A 14-week controlled trial.
Dusseldorp, M., Smits, P., Lenders, J. W. M., Thien, T. A., & Katan, M. (1991) · Hypertension · doi:10.1161/01.hyp.18.5.607 · Cited by 37
Coffee consumption and health-related quality of life
López‐García, E., Guallar‐Castillón, P., León-Muñoz, L. M., Graciani, A., & Rodríguez‐Artalejo, F. (2013) · Clinical Nutrition · doi:10.1016/j.clnu.2013.04.004 · Cited by 35
Diterpenes from coffee beans decrease serum levels of lipoprotein(a) in humans: results from four randomised controlled trials
Rob Urgert, B., der Wouw, M. W.-V., Hovenier, R., Meyboom, S., Beynen, A. C., & Katan, M. (1997) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1600414 · Cited by 35
Coffee drinking and blood cholesterol—effects of brewing method, food intake and life style
Lindahl, B., Johansson, I., Huhtasaari, F., Hallmans, G., & Asplund, K. (1991) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.1991.tb00448.x · Cited by 32
Coffee consumption and risk of myocardial infarction: a dose-response meta-analysis of observational studies
Mo, L., Xie, W., Pu, X.-Q., & Ouyang, D. (2018) · Oncotarget · doi:10.18632/oncotarget.23947 · Cited by 31
Coffee Consumption and C-Reactive Protein Levels: A Systematic Review and Meta-Analysis
Moua, E. D., Hu, C., Day, N. B., Hord, N. G., & Takata, Y. (2020) · Nutrients · doi:10.3390/nu12051349 · Cited by 32
Diet and lifestyle modification and its relationship to atherosclerosis
Denke, M. A. (1994) · Medical Clinics of North America · doi:10.1016/s0025-7125(16)30183-3 · Cited by 32
Coffee consumption and risk of physical function impairment, frailty and disability in older adults
Machado‐Fragua, M. D., Struijk, E. A., Graciani, A., Guallar‐Castillón, P., Rodríguez‐Artalejo, F., & López‐García, E. (2018) · European Journal of Nutrition · doi:10.1007/s00394-018-1664-7 · Cited by 32
Caffeine, blood pressure, and serum lipids
Bak, A. A. A., & Grobbee, D. E. (1991) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/53.4.971 · Cited by 30
Self-citation
Coffee Consumption, Alcohol Use, and Cigarette Smoking as Determinants of Serum Total and HDL Cholesterol in Two Serbian Cohorts of the Seven Countries Study
Jansen, D. F., Nedeljković, S., Feskens, E. J. M., Ostojić, M., Grujic, M. Z., Bloemberg, B. P. M., & Kromhout, D. (1995) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvb.15v11.1793 · Cited by 29
The impact of changes in coffee consumption on serum cholesterol
Wei, M., Macera, C. A., Hornung, C. A., & Blair, S. N. (1995) · Journal of Clinical Epidemiology · doi:10.1016/0895-4356(95)00023-w · Cited by 30
Italian Style Brewed Coffee: Effect on Serum Cholesterol in Young Men
D’Amicis, A., Scaccini, C., Tomassi, G., ANACLERIO, M., Stornelli, R., & BERNINI, A. (1996) · International Journal of Epidemiology · doi:10.1093/ije/25.3.513 · Cited by 29
Relationship between lifestyle and serum lipid and lipoprotein levels in middle-aged Japanese men
Nakanishi, N., Nakamura, K., Ichikawa, S., Suzuki, K., & Tatara, K. (1999) · European Journal of Epidemiology · doi:10.1023/a:1007527111946 · Cited by 25
Lipid Analysis ofCoffea ArabicaLinn. Beans and Their Possible Hypercholesterolemic Effects
Al-Kanhal, M. A. (1997) · International Journal of Food Sciences and Nutrition · doi:10.3109/09637489709006973 · Cited by 24
Acute Coffee Ingestion Does Not Affect LDL Cholesterol Level
Cheung, R. J., Gupta, E. K., & Ito, M. K. (2005) · Annals of Pharmacotherapy · doi:10.1345/aph.1g005 · Cited by 24
Boiled or Filtered Coffee?
Rodrigues, I. M., & Klein, L. C. (2006) · Toxicological Reviews · doi:10.2165/00139709-200625010-00004 · Cited by 23
Coffee and serum lipids: Findings from the Olivetti heart study
Jossa, F., Krogh, V., Farinaro, E., Panico, S., Giumetti, D., Galasso, R., Celentano, E., Mancini, M., & Trevisan, M. (1993) · Annals of Epidemiology · doi:10.1016/1047-2797(93)90027-2 · Cited by 22
Boiled coffee fails to raise serum cholesterol in hamsters and rats
Beynen, A. C., Wouw, M. P. M. E. W.-V. D., de Roos, B., & Katan, M. (1996) · British Journal Of Nutrition · doi:10.1079/bjn19960081 · Cited by 22
Association between espresso coffee and serum total cholesterol: the Tromsø Study 2015–2016
Svatun, Å. L., Løchen, M., Thelle, D. S., & Wilsgaard, T. (2022) · Open Heart · doi:10.1136/openhrt-2021-001946 · Cited by 21
Effect of a coffee lipid (cafestol) on regulation of lipid metabolism in CaCo-2 cells.
Ranheim, T., Halvorsen, B. L., Huggett, A. C., Blomhoff, R., & Drevon, C. A. (1996) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)39193-8 · Cited by 21
The cholesterol-raising effect of coffee in the Syrian hamster
Sanders, T. A. B., & Sandaradura, S. (1992) · British Journal Of Nutrition · doi:10.1079/bjn19920100 · Cited by 21
Coffee, caffeine and hemostasis: results from two randomized studies
Bak, A. A. A., van Vliet, H. H. D. M., & Grobbee, D. E. (1990) · Atherosclerosis · doi:10.1016/0021-9150(90)90170-n · Cited by 20
Self-citation
Impact of Coffee Consumption on Physiological Markers of Cardiovascular Risk: A Systematic Review
Daneschvar, H. L., Smetana, G. W., Brindamour, L. J., Bain, P. A., & Mukamal, K. J. (2020) · The American Journal of Medicine · doi:10.1016/j.amjmed.2020.09.036 · Cited by 18
Pathophysiology of Atherosclerosis
Prasad, K. (2000) · Springer eBooks · doi:10.1007/978-1-4612-1190-7_6 · Cited by 18
Coffee: A Selected Overview of Beneficial or Harmful Effects on the Cardiovascular System?
Whayne, T. F. (2014) · Current Vascular Pharmacology · doi:10.2174/1570161112666141002121429 · Cited by 18
Chemistry I: Non‐Volatile Compounds
Speer, K., & Kölling-Speer, I. (2001) · doi:10.1002/9780470690499.ch1c · Cited by 18
Association of Lifestyle with Serum Lipid Levels: a Study of Middle-Aged Japanese Men.
Nakanishi, N., Tatara, K., Nakamura, K., & SUZUKI, K. S. (2000) · Journal of Epidemiology · doi:10.2188/jea.10.216 · Cited by 17
Investigation of the effect of coffee lipids on serum cholesterol in hamsters
Ratnayake, W. M. N., Pelletier, G., Hollywood, R., Malcolm, S., & Stavrić, B. (1995) · Food and Chemical Toxicology · doi:10.1016/0278-6915(94)00131-7 · Cited by 17
Coffee: Brew or Bane?
Thompson, W. G. (1994) · The American Journal of the Medical Sciences · doi:10.1097/00000441-199407000-00011 · Cited by 17
A Study of the Impact of Arabic Coffee Consumption on Serum Cholesterol
Ali, M. E. S., & Felimban, F. (1993) · Journal of the Royal Society of Health · doi:10.1177/146642409311300602 · Cited by 16
Coronary risk factors in middle-aged men as related to smoking, coffee intake and physical activity
Høstmark, A. T., Berg, J. E., Brudal, S., Berge, S. R., Kierulf, P., & Bjérkedal, T. (1992) · Scandinavian Journal of Social Medicine · doi:10.1177/140349489202000402 · Cited by 16

Authors: Bak, A. A. A., & Grobbee, D. E.
Affiliations: Erasmus MC (NL)
ORCID: Grobbee, Diederick E.
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 1989-11-23
Volume: 321
Issue: 21
Pages: 1432-1437
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejm198911233212103
OpenAlex: W2332265208
Cited by: 194
References: 38
Citations by year: 2026: 2 · 2025: 4 · 2024: 5 · 2023: 4 · 2022: 1 · 2021: 2 · 2020: 5 · 2019: 5 · 2018: 6 · 2017: 5 · 2016: 4 · 2015: 4 · 2014: 3 · 2013: 5 · 2012: 1
FWCI: 15.18
Type: journal article
Language: en
Open access: closed
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Coffee research and impacts
Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
Life Sciences › Agricultural and Biological Sciences › Food Science › Coconut Research and Applications
Keywords: coffee, brewing technology, filtered coffee, boiled coffee, serum cholesterol, LDL cholesterol, serum lipids, HDL cholesterol, apolipoproteins, dietary fat intake
MeSH terms: Adult, Apolipoproteins, Cholesterol, Coffee, Cooking, Female, Filtration, Humans, Cholesterol, HDL, Cholesterol, LDL, Male, Random Allocation

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The Effect on Serum Cholesterol Levels of Coffee Brewed by Filtering or Boiling

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks