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Coffee consumption and the incidence of coronary heart disease.

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LaCroix, Andrea Z., Mead, Lucy A., Liang, Kung-Yee, Thomas, Caroline Bedell, Pearson, Thomas A.·1986·New England Journal of Medicine
DOI 10.1056/nejm198610163151601
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Abstract

We conducted a prospective investigation of the effect of coffee consumption on coronary heart disease in 1130 male medical students who were followed for 19 to 35 years. Changes in coffee consumption and cigarette smoking during follow-up were examined in relation to the incidence of clinically evident coronary disease in comparisons of three measures of coffee intake--base-line intake, average intake, and most recent intake reported before the manifestation of coronary disease. Clinical evidence of coronary disease included myocardial infarction, angina, and sudden cardiac death. In separate analyses for each measure of coffee intake, the relative risks for men drinking five or more cups of coffee per day, as compared with nondrinkers, were approximately 2.80 for all three measures in the univariate analyses (maximum width of 95 percent confidence intervals, 1.27 to 6.51). After adjustment for age, current smoking, hypertension status, and base-line level of serum cholesterol, the estimated relative risk for men drinking five or more cups of coffee per day (using the most recent coffee intake measure), as compared with those drinking none, was 2.49 (maximum width of 95 percent confidence interval, 1.08 to 5.77). The association between coffee and coronary disease was strongest when the time between the reports of coffee intake and the coronary event was shortest. These findings support an independent, dose-responsive association of coffee consumption with clinically evident coronary heart disease, which is consistent with a twofold to threefold elevation in risk among heavy coffee drinkers.

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  • Among possible explanations for the discrepancy is that some earlier hospital based case-control studies included patients among the controls who may have reduced their intake of coffee after a diagnosis of chronic illness, for example digestive diseases.

    “Among the possible explanations for this dis- crepancy is that some earlier hospital based case-control studies included patients among the controls who may have reduced their intake of coffee after a diagnosis of chronic illness-for example, digestive diseases.'035”

    From Does coffee drinking increase the risk of coronary heart disease? Results from a meta‐analysis (1994) · cites this paper as [10]

  • Case-control studies that included control patients admitted for chronic conditions may have overestimated the association between coffee consumption and risk of heart disease.

    “Thus case-control studies that included control patients admitted for chronic conditions may have overestimated the association between coffee consumption and risk of heart disease.'035”

    From Does coffee drinking increase the risk of coronary heart disease? Results from a meta‐analysis (1994) · cites this paper as [10]

  • In cohort studies with repeated measurements of exposure assessment, the association between heart disease and coffee intake was strongest when the exposure measurement used was nearest to the outcome.

    “In cohort studies with repeated measurements of exposure assess- ment, the association between heart disease and coffee intake was strongest when the exposure measurement used was nearest to the outcome.'042”

    From Does coffee drinking increase the risk of coronary heart disease? Results from a meta‐analysis (1994) · cites this paper as [10]

  • In the study by LaCroix et al, the relative risk for five or more cups/day compared with none increased from 1.8 (95% CI 0.8 to 4.0) when intake was assessed 10 or more years previously, to 2.5 (95% CI 1.1 to 5.8) when the intake within the past five years was used.

    “In the study by LaCroix et al the relative risk for five or more cups/day compared with none increased from 1-8 (95% CI 0-8 to 4 0) when intake was assessed 10 or more years previously, to 2-5 (95% CI 1-1 to 5 8) when the intake within the past five years was used.'0”

    From Does coffee drinking increase the risk of coronary heart disease? Results from a meta‐analysis (1994) · cites this paper as [10]

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Research works printed but not linked: 3

  1. [1]1. Coffee drinking and acute myocardial infarction: report from the Boston Collaborative Drug Surveillance Program. Lancet 1972; 2:1278-81.
  2. [22]22. Thomas CB. Observations on some possible precursors of essential hypertension and coronary artery disease. Bull Johns Hopkins Hosp 1951; 89: 419-41.
  3. [24]24. Peto R, Peto J. Asymptotically efficient rank invariant test procedures. J R Stat Soc Ser (A) 1972; 135:185-207.

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Authors
LaCroix, A. Z., Mead, L. A., Liang, K.-Y., Thomas, C. B., & Pearson, T. A.
Affiliations
Johns Hopkins University (US)
ORCID
Venue
New England Journal of Medicine
Publisher
Massachusetts Medical Society
Published
1986-10-16
Volume
315
Issue
16
Pages
977-982
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
DOI
10.1056/nejm198610163151601
OpenAlex
W2054987034
Cited by
183
References
36
Citations by year
2025: 3 · 2022: 3 · 2021: 3 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 5 · 2016: 3 · 2015: 2 · 2014: 3 · 2013: 6 · 2012: 2
FWCI
15.50
Type
journal article
Language
en
Open access
Locations
  • New England Journal of Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • eScholarship (California Digital Library) (submittedVersion)
Funders
  • National Institute on Aging (R01AG001760)
  • National Heart, Lung, and Blood Institute (5-T32 HL07024-10, T32HL007024)
Topics
  • Health Sciences › Medicine › Pharmacology › Coffee research and impacts
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Keywords
coffee consumption, coronary artery disease, myocardial infarction, angina pectoris, sudden cardiac death, dose-response relationship, cigarette smoking, serum cholesterol, hypertension, men, medical students
MeSH terms
Adult, Angina Pectoris, Coffee, Coronary Disease, Death, Sudden, Dose-Response Relationship, Drug, Humans, Hypertension, Male, Middle Aged, Myocardial Infarction, Prospective Studies, Risk, Smoking

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