The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
A Clinical Trial of Beta Carotene to Prevent Basal-Cell and Squamous-Cell Cancers of the Skin
Open accessAbstract
BACKGROUND: Beta carotene has been associated with a decreased risk of human cancer in many studies employing dietary questionnaires or blood measurements, and it has had protective effects in some animal models of carcinogenesis. METHODS: We tested the possible cancer-preventing effects of beta carotene by randomly assigning 1805 patients who had had a recent nonmelanoma skin cancer to receive either 50 mg of beta carotene or placebo per day and by conducting annual skin examinations to determine the occurrence of new nonmelanoma skin cancer. RESULTS: Adherence to the prescribed treatment was good, and after one year the actively treated group's median plasma beta carotene level (3021 nmol per liter) was much higher than that of the control group (354 nmol per liter). After five years of follow-up, however, there was no difference between the groups in the rate of occurrence of the first new nonmelanoma skin cancer (relative rate, 1.05; 95 percent confidence interval, 0.91 to 1.22). In subgroup analyses, active treatment showed no efficacy either in the patients whose initial plasma beta carotene level was in the lowest quartile or in those who currently smoked. There was also no significant difference between treated and control groups in the mean number of new nonmelanoma skin cancers per patient-year. CONCLUSIONS: In persons with a previous nonmelanoma skin cancer, treatment with beta carotene does not reduce the occurrence of new skin cancers over a five-year period of treatment and observation.
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“In other research, treatment with β-carotene did not significantly reduce the occurrence of new skin cancers in persons with previous non-melanoma skin cancer [242].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [242]
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Cites
Cox, D. R., & Oakes, D. (2018) · Chapman & Hall/CRC eBooks · doi:10.1201/9781315137438 · Cited by 6,269
Statistical Methods for Survival Data Analysis.
Lachenbruch, P. A., & Lee, E. T. (1993) · Journal of the American Statistical Association · doi:10.2307/2290742 · Cited by 2,851
β-Carotene: an Unusual Type of Lipid Antioxidant
Burton, G. W., & Ingold, K. U. (1984) · Science · doi:10.1126/science.6710156 · Cited by 2,150
Can dietary beta-carotene materially reduce human cancer rates?
Peto, R., Doll, R., Buckley, J. D., & Sporn, M. B. (1981) · Nature · doi:10.1038/290201a0 · Cited by 1,563
A Review of Epidemiologic Evidence that Carotenoids Reduce the Risk of Cancer
Ziegler, R. G. (1989) · Journal of Nutrition · doi:10.1093/jn/119.1.116 · Cited by 552
Hirayama, T. T. (1979) · Nutrition and Cancer · doi:10.1080/01635587909513632 · Cited by 547
Serum Beta-Carotene, Vitamins a and E, Selenium, and the Risk of Lung Cancer
Menkes, M., Comstock, G. W., Vuilleumier, J. P., Helsing, K. J., Rider, A. A., & Brookmeyer, R. (1986) · New England Journal of Medicine · doi:10.1056/nejm198611133152003 · Cited by 537
Dietary vitamin a and human lung cancer
Bjelke, E. (1975) · International Journal of Cancer · doi:10.1002/ijc.2910150405 · Cited by 395
Relation of Serum Vitamins a and E and Carotenoids to the Risk of Cancer
Willett, W. C., Polk, B. F., Underwood, B. A., Stampfer, M. J., Pressel, S., ROSNER, B. A., Taylor, J. O., Schneider, K. A., & Hames, C. G. (1984) · New England Journal of Medicine · doi:10.1056/nejm198402163100705 · Cited by 356
Willett, W. C., & MacMahon, B. (1984) · New England Journal of Medicine · doi:10.1056/nejm198403083101006 · Cited by 327
Research works printed but not linked: 9
- Wald, 1987, Cancer Surv, 6, 635
- Shekelle, 1981, Lancet, 2, 1186
- Wang, 1985, Chin Med J [Engl], 98, 206
- Paganini-Hill, 1987, J Natl Cancer Inst, 79, 443
- Stahelin, 1984, J Natl Cancer Inst, 73, 1463
- Nomura, 1985, Cancer Res, 45, 2369
- Mantel, 1966, Cancer Chemother Rep, 50, 163
- SAS Institute Inc. SUGI supplemental library user's guide, version 5 edition. Cary, N.C.: SAS Institute, 1986:437–65.
- Scotto J, Fraumeni JF Jr. Skin (other than melanoma). In: Schottenfeld D, Fraumeni JF Jr, eds. Cancer epidemiology and prevention. Philadelphia: W.B. Saunders, 1982:996–1011.
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Hölzle, E. (2003) · Fortschritte der praktischen Dermatologie und Venerologie · doi:10.1007/978-3-642-55661-6_67 · Cited by 2
Jacobs, E. T., Martinez, J. A., Batai, K., Lance, P., Trejo, M. J., Saboda, K., Cordova, C. A., Chew, W. M., Habila, M. A., & Chow, H. ‐. S. (2022) · Nutrition and Cancer · doi:10.1080/01635581.2022.2135745 · Cited by 2
Lluria-Prevatt, M., & Alberts, D. S. (2005) · Springer eBooks · doi:10.1007/3-540-26337-3_9 · Cited by 2
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Isn't Skin Cancer Preventable?
Meyskens, F. L. (1992) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/84.5.286 · Cited by 2
Management of Epithelial Dermatologic Neoplasia
Kaufmann, R. (1998) · Oncology Research and Treatment · doi:10.1159/000026782 · Cited by 2
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Azad, K. (2011) · Cited by 2
Gollnick, H. P. M. (1997) · Springer eBooks · doi:10.1007/978-3-642-60622-9_9 · Cited by 2
Kim, E. S., & Lippman, S. M. (2007) · The Cancer Handbook · doi:10.1002/9780470025079.chap90.pub2 · Cited by 2
Pathak, A. K., Surendra, G., Sridhar, S. B., Jahnavi, P., Gupta, J. K., Balaji, P., Juniorsundresh, N., Reddy, K. T. K., Billah, A. A. M., & Krishnan, K. (2025) · Pathology - Research and Practice · doi:10.1016/j.prp.2025.156277 · Cited by 2
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“The role of β-carotene as an anti-cancer agent began to be questioned when a clinical intervention trial failed to find a reduction of non-melanoma skin cancer (NMSC) occurrence in those NMSC patients treated with β-carotene supplements over a five year period [6].”
BackgroundGutiérrez, C. J. (2010) · Revista Médica Clínica Las Condes · doi:10.1016/s0716-8640(10)70599-x · Cited by 1
Acosta, Á., Rueda, X., Sánchez, G., Arévalo, I., Herrera, H. E., Rodríguez, A. E., Ramírez, A. F., Jiménez, G., Segura, O. D., Cepeda, M., et al. (2015) · Revista de la Asociación Colombiana de Dermatología y Cirugía Dermatológica · doi:10.29176/2590843x.284 · Cited by 1
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Yarosh, D. B. (2001) · The Lancet · doi:10.1016/s0140-6736(01)06099-8 · Cited by 1
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Lluria-Prevatt, M., Dickinson, S. E., & Alberts, D. S. (2013) · Springer eBooks · doi:10.1007/978-3-642-38983-2_12 · Cited by 1
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Leccia, M. ‐. (2008) · Annales de Dermatologie et de Vénéréologie · doi:10.1016/j.annder.2008.07.010 · Cited by 1
Longitudinal poisson regression with disturbed random intercept
Wilson, P. D. (1998) · Communication in Statistics- Theory and Methods · doi:10.1080/03610929808832227 · Cited by 1
Antioxidants and 21st century nutrition
Astley, S. (2005) · Food Science & Technology Bulletin Functional Foods · doi:10.1616/1476-2137.13735 · Cited by 1
Vitamin C, Vitamin E, and b-Carotene in Cancer Chemoprevention
Higdon, J. V., & Frei, B. B. (2004) · CRC series in modern nutrition science · doi:10.1201/9780203506707.ch21 · Cited by 1
Prevention of Nonmelanoma Skin Cancer
Farmer, K. L., Goller, M., & Lippman, S. M. (1997) · Clinics in Plastic Surgery · doi:10.1016/s0094-1298(20)32289-6 · Cited by 1
Black, H. S. (2006) · Elsevier eBooks · doi:10.1016/b978-012088393-6/50078-6 · Cited by 1
Drug Information Analysis Service
Schroeder, D. J., Hart, L. L., & Lynch, S. S. (1994) · Annals of Pharmacotherapy · doi:10.1177/106002809402800410 · Cited by 1
Kadakia, K. C., Matusz‐Fisher, A., & Kim, E. S. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.96067-7 · Cited by 1
Monteleone, G. P., & Browning, D. G. (1997) · Primary Care Clinics in Office Practice · doi:10.1016/s0095-4543(22)00084-7 · Cited by 1
Nutrition in the Management of the Cancer Patient
Rock, C. L. (2010) · Springer eBooks · doi:10.1007/978-90-481-9704-0_26 · Cited by 1
“Results from early observational epidemiological studies have suggested that carotenoids could have a role in the prevention of skin cancer, so a trial testing the effect of beta-carotene on skin cancer recurrence was conducted [ 46 ].”
BackgroundRole of Selected Fruits and Phytochemicals in Cancer Prevention: Mechanisms of Action
Yang, J. (2007) · eCommons (Cornell University)
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Fabricius, E., Hoffmeister, B., & Raguse, J.-D. (2012) · InTech eBooks · doi:10.5772/27415
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Nixon, D. W. (2004) · doi:10.1002/9780470385043.ch31
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Odenbro, Å. (2009) · Figshare
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Stanner, S. A. (2001) · Nutrition Bulletin · doi:10.1046/j.1467-3010.2001.00197.x
Baldoni, E., Tomassoni, D., Traini, E., Indraccolo, S. R., Ricci, R. P., & Vitaioli, L. (2002) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/s1096-4959(02)00034-9
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Medizin, E., & Eppendorf, U. H. (2008)
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van Poppel, G., & Goldbohm, R. A. (1995)
Tang, J. Y., Aszterbaum, M., Athar, M., Barsanti, F. A., Cappola, C., Estevez, N., Hebert, J. L., Hwang, J., Khaimskiy, Y., Kim, A. L., et al. (2010)
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Veda, S. (2009) · CFTRI Institutional Repository
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Yamanishi, R. (2007) · Oleoscience · doi:10.5650/oleoscience.7.423
Abrishami, M., Batra, S., & Rohrer, T. E. (2009) · Elsevier eBooks · doi:10.1016/b978-1-4160-3662-3.10003-4
Törrönen, R., Lehmusaho, M., Häkkinen, S. H., Hänninen, O., & Mykkänen, H. M. (1996) · Elsevier eBooks · doi:10.1533/9780857093059.135
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Dra, I., Núñez, V. A., & Rivero, I. B. (2014)
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Kuller, L. H. (2004) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2004.09.023
Los carotenos y sus efectos sobre la salud
Peñuela, U., & Magdalena, R. (2002) · Perspectivas en Nutrición Humana
When Subjects are Not Randomly Assigned: The Cohort Approach
Karagas, M. R. (1997) · Journal of Cutaneous Medicine and Surgery · doi:10.1177/120347549700200208
SUPPORTED BY AN UNRESTRICTED EDUCATIONAL GRANT FROM
Levine, N. S., & Dermatological, O. (1998)
Chesnut, C., Rubin, A. G., Martin, S., Diehl, J. W., & Soriano, T. T. (2014) · Springer eBooks · doi:10.1007/978-3-319-12445-2_6
Gaylor, S., Ryan, J., Sanders, M. P. J., Hughes, G., Ringer, T., DeLoof, M. J., Winterrowd, G. E., & Francom, S. (1991) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/54.3.610
Risk Assessment: Likely Effect of Dietary Advice on Cancer
de Vet, H. C. W. (1992) · Springer eBooks · doi:10.1007/978-94-011-2986-2_17
Acosta, Á., Rueda, X., Sánchez, G., Arévalo, I., Herrera, H., Ramírez, A. F., Jiménez, G., Segura, O. D., Cepeda, M., Rodríguez, A. E., et al. (2015) · Revista de la Asociación Colombiana de Dermatología y Cirugía Dermatológica · doi:10.29176/2590843x.285
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Saurat, J. ‐., Lipsker, D. M., Thomas, L., Borradori, L., & Lachapelle, J. M. (2017) · Dermatologie et Infections Sexuellement Transmissibles (6e édition)#R##N#Avec Ebooks
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Protection by antioxidants against UV-induced damage.
Leccia, M. ‐., Béani, J.-C., Favier, A. E., Neve, J. D., & Faure, P. (1994)
Human Papillomavirus Infection in Men and Women: The Impact of Nutrition on Cervical Cancer
Ruffin, M. T., & Rock, C. L. (2004) · Principles of Gender-Specific Medicine · doi:10.1016/b978-012440905-7/50344-3
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Béani, J., & Leccia, M. ‐. (1994) · AOCS Publishing eBooks · doi:10.1201/9781439832110.ch20
Clinical development plan: β-Carotene and other carotenoids
(1994) · Journal of Cellular Biochemistry · doi:10.1002/jcb.240560910
Fitzmaurice, G. M., Laird, N. M., & Ware, J. H. (2011) · Wiley series in probability and statistics · doi:10.1002/9781119513469.refs
Epitheliale Präkanzerosen und Karzinome der Haut
Orfanos, C. E., & Garbe, C. (1995) · Springer eBooks · doi:10.1007/978-3-642-97602-5_37
García-Alonso, M. J., Peralta‐Pedrero, M. L., Cruz, F. J., & Morales‐Sánchez, M. A. (2022) · International Journal of Dermatology · doi:10.1111/ijd.16225
Törrönen, R., Lehmusaho, M., Häkkinen, S., Hänninen, O., & Mykkänen, H. (2012) · Royal Society of Chemistry eBooks · doi:10.1533/9781855737945.135
Najm, W. I. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4377-1793-8.00063-7
(2002) · Proceedings of The Nutrition Society · doi:10.1017/s0029665102000265
Najm, W. I. (2007) · Elsevier eBooks · doi:10.1016/b978-1-4160-2954-0.50084-3
De, S. K. (2022) · Wiley eBooks · doi:10.1002/9783527838561.ch12
Mayne, S. T., & Cartmel, B. (2004) · Humana Press eBooks · doi:10.1007/978-1-59259-767-3_33
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Mathieu, O., Chaine, A., Benassarou, M., Combes, F., Debelmas, A., Lanciaux, S., Bertolus, C., & Bouaoud, J. (2023) · SSRN Electronic Journal · doi:10.2139/ssrn.4611303
Mahamat‐Saleh, Y. (2020) · theses.fr (ABES) · doi:10.70675/da20471az7fcfz4eb8z8b73z0defe13fae63
Homocystein als kardiovaskulärer Risikofaktor
Spieker, L. E., Lüscher, T. F., & Noll, G. (2000) · Cardiovascular Medicine · doi:10.3390/cardiovascmed3030029
Kardiovaskuläre Prävention—kulinarisch oder klinisch?
Spieker, L. E., & Lüscher, T. F. (2001) · Cardiovascular Medicine · doi:10.3390/cardiovascmed4040046
Najm, W. I. (2009) · Elsevier eBooks · doi:10.1016/b978-84-458-1911-1.50080-4
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Oh, Y., & Papadimitrakopoulou, V. (2003) · Springer eBooks · doi:10.1007/978-3-642-55780-4_4
Metadata
- Authors
- Greenberg, E. R., Baron, J. A., Stukel, T. A., Stevens, M. M., Mandel, J. S., Spencer, S. K., Elias, P. M., Lowe, N., Nierenberg, D. W., Bayrd, G., Vance, J. C., Freeman, D. H., Clendenning, W. E., & Kwan, T.
- Affiliations
- Dartmouth College (US)
- University of Minnesota (US)
- University of California, San Francisco (US)
- University of California, Los Angeles (US)
- Harvard University (US)
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1990-09-20
- Volume
- 323
- Issue
- 12
- Pages
- 789-795
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2313686482
- Cited by
- 482
- References
- 35
- Citations by year
- 2025: 2 · 2024: 3 · 2023: 8 · 2022: 10 · 2021: 4 · 2020: 7 · 2019: 3 · 2018: 3 · 2017: 6 · 2016: 8 · 2015: 13 · 2014: 11 · 2013: 7 · 2012: 21
- FWCI
- 18.92
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5u01ca032934-10)
- National Cancer Institute (CA-32934, CA 23 108, P30CA023108)
- Topics
- Health Sciences › Medicine › Dermatology › Nonmelanoma Skin Cancer Studies
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Medicine › Otorhinolaryngology › Head and Neck Cancer Studies
- Keywords
- beta-carotene, non-melanoma skin cancer, basal cell carcinoma, squamous cell carcinoma, cancer prevention, chemoprevention, smoking, medication adherence
- MeSH terms
- Aged, Basal Cell Carcinoma, Carcinoma, Squamous Cell, Carotenoids, Drug Evaluation, Female, Follow-Up Studies, Humans, Male, Patient Compliance, Recurrence, Skin Neoplasms, Randomized Controlled Trials as Topic, beta Carotene
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