Cited by 1,574Heart Rate Variability and Autonomic ControlSleep and Wakefulness ResearchNeuroscience of respiration and sleep

The DOI matches its Crossref record; 34 of the 35 references it cites were found in a registry or an index.

Sympathetic-Nerve Activity during Sleep in Normal Subjects

Open access

Somers, Virend K., Dyken, Mark E., Mark, Allyn L., Abboud, Francois M.·1993·New England Journal of Medicine

DOI 10.1056/nejm199302043280502

Open this paper in CoChat — free account Open PDF

Abstract

BACKGROUND: The early hours of the morning after awakening are associated with an increased frequency of events such as myocardial infarction and ischemic stroke. The triggering mechanisms for these events are not clear. We investigated whether autonomic changes occurring during sleep, particularly rapid-eye-movement (REM) sleep, contribute to the initiation of such events. METHODS: We measured blood pressure, heart rate, and sympathetic-nerve activity (using microneurography, which provides direct measurements of efferent sympathetic-nerve activity related to muscle blood vessels) in eight normal subjects while they were awake and while in the five stages of sleep. RESULTS: The mean (+/- SE) amplitude of bursts of sympathetic-nerve activity and levels of blood pressure and heart rate declined significantly (P < 0.001), from 100 +/- 9 percent, 90 +/- 4 mm Hg, and 64 +/- 2 beats per minute, respectively, during wakefulness to 41 +/- 9 percent, 80 +/- 4 mm Hg, and 59 +/- 2 beats per minute, respectively, during stage 4 of non-REM sleep. Arousal stimuli during stage 2 sleep elicited high-amplitude deflections on the electroencephalogram (called K complexes), which were frequently associated with bursts of sympathetic-nerve activity and transient increases in blood pressure. During REM sleep, sympathetic-nerve activity increased significantly (to 215 +/- 11 percent; P < 0.001) and the blood pressure and heart rate returned to levels similar to those during wakefulness. Momentary restorations of muscle tone during REM sleep (REM twitches) were associated with cessation of sympathetic-nerve discharge and surges in blood pressure. CONCLUSIONS: REM sleep is associated with profound sympathetic activation in normal subjects, possibly linked to changes in muscle tone. The hemodynamic and sympathetic changes during REM sleep could play a part in triggering ischemic events in patients with vascular disease.

Integrity signals

Registry

Crossref · 10.1056/nejm199302043280502

Cites

34 of 34 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

A manual for standardized terminology, techniques and scoring system for sleep stages in human subjects
Rechtschaffen, A. (1968) · Medical Entomology and Zoology · Cited by 11,772
A Manual of Standardized Terminology, Techniques and Scoring System for Sleep Stages of Human Subjects.
Wolpert, E. (1969) · Archives of General Psychiatry · doi:10.1001/archpsyc.1969.01740140118016 · Cited by 9,850
Circadian Variation in the Frequency of Onset of Acute Myocardial Infarction
Muller, J. E., Stone, P. H., Turi, Z. G., Rutherford, J. D., Czeisler, C. A., Parker, C., Poole, W. K., Passamani, E., Roberts, R., Robertson, T., et al. (1985) · New England Journal of Medicine · doi:10.1056/nejm198511213132103 · Cited by 1,884
Cyclic variations in EEG during sleep and their relation to eye movements, body motility, and dreaming
Dement, W., & Kleitman, N. (1957) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(57)90088-3 · Cited by 1,876
Circadian variation and triggers of onset of acute cardiovascular disease.
Muller, J. E., Tofler, G. H., & Stone, P. H. (1989) · Circulation · doi:10.1161/01.cir.79.4.733 · Cited by 1,426
Reflex Regulation of Arterial Pressure during Sleep in Man
Smyth, H. S., Sleight, P., & Pickering, G. W. (1969) · Circulation Research · doi:10.1161/01.res.24.1.109 · Cited by 1,278
Circadian variation in the frequency of sudden cardiac death.
Muller, J. E., Ludmer, P. L., Willich, S. N., Tofler, G. H., Aylmer, G., Klangos, I., & Stone, P. H. (1987) · Circulation · doi:10.1161/01.cir.75.1.131 · Cited by 1,083
Concurrent Morning Increase in Platelet Aggregability and the Risk of Myocardial Infarction and Sudden Cardiac Death
Tofler, G. H., Brezinski, D., Schafer, A. I., Czeisler, C. A., Rutherford, J. D., Willich, S. N., Gleason, R. E., Williams, G. H., & Muller, J. E. (1987) · New England Journal of Medicine · doi:10.1056/nejm198706113162405 · Cited by 1,072
Comparison of finger and intra-arterial blood pressure monitoring at rest and during laboratory testing.
Parati, G., Casadei, R., Groppelli, A., Di Rienzo, M., & Mancia, G. (1989) · Hypertension · doi:10.1161/01.hyp.13.6.647 · Cited by 899
Changes in autonomic regulation induced by physical training in mild hypertension.
Pagani, M., Somers, V. K., Furlan, R., Dell’Orto, S., Conway, J., Baselli, G., Cerutti, S., Sleight, P., & Malliani, A. (1988) · Hypertension · doi:10.1161/01.hyp.12.6.600 · Cited by 749
Self-citation

Show all 35 references

Research works printed but not linked: 2

Wallin G. Intraneural recording and autonomic function in man. In: Bannister R, ed. Autonomic failure: a textbook of clinical disorders of the autonomic nervous system. Oxford, England: Oxford University Press, 1983:36-51.
Snedecor GW, Cochran WG. Statistical methods. 7th ed. Ames: Iowa State University Press, 1980:265-7.

Sorted by citations

Items 501–600 of 997

REM-related bradyarrhythmia syndrome
Holty, J.-E. C., & Guilleminault, C. (2010) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2010.09.001 · Cited by 41
Time‐courses in renin and blood pressure during sleep in humans
Charloux, A., Piquard, F., Ehrhart, J., Mettauer, B., Gény, B., Simon, C., & BRANDENBERGER, G. (2002) · Journal of Sleep Research · doi:10.1046/j.1365-2869.2002.00277.x · Cited by 38
Relationship between nocturnal hypoxaemia, tachycardia and myocardial ischaemia after major abdominal surgery
Gögenür, I., Rosenberg-Adamsen, S., Lie, C., Carstensen, M., Rasmussen, V., & Rosenberg, J. (2004) · British Journal of Anaesthesia · doi:10.1093/bja/aeh208 · Cited by 38
Effects of aging on glucose regulation during wakefulness and sleep
Frank, S. A., Roland, D. C., Sturis, J., Byrne, M. M., Refetoff, S., Polonsky, K. S., & Cauter, E. V. (1995) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1995.269.6.e1006 · Cited by 38
Nocturnal Cluster Headache Associated with Sleep Apnea. A Case Report
Buckle, P., Kerr, P., & Kryger, M. H. (1993) · SLEEP · doi:10.1093/sleep/16.5.487 · Cited by 38
Sleep and Diabetes
Bopparaju, S., & Surani, S. (2010) · International Journal of Endocrinology · doi:10.1155/2010/759509 · Cited by 37
Validation of Five Minimally Obstructive Methods to Estimate Physical Activity Energy Expenditure in Young Adults in Semi-Standardized Settings
Schneller, M. B., Pedersen, M. T., Gupta, N., Aadahl, M., & Holtermann, A. (2015) · Sensors · doi:10.3390/s150306133 · Cited by 37
The impact of early compared to late morning hours on brachial endothelial function and long-term cardiovascular events in healthy subjects with no apparent coronary heart disease
Hirsch, L., Shechter, A., Feinberg, M. S., Koren‐Morag, N., & Shechter, M. (2010) · International Journal of Cardiology · doi:10.1016/j.ijcard.2010.08.069 · Cited by 37
The Breakdown of Fractal Heart Rate Dynamics Predicts Prolonged Postoperative Myocardial Ischemia
Laitio, T. T., Huikuri, H. V., kikallio, T. H. M., Jalonen, J. R., Kentala, E., Helenius, H. Y. M., Pullisaar, O., Hartiala, J., & Scheinin, H. (2004) · Anesthesia & Analgesia · doi:10.1213/01.ane.0000112311.94466 · Cited by 37
Reduced sympathetically driven heart rate variability during sleep in Parkinson's disease: A case‐control polysomnography‐based study
Sauvageot, N., Vaillant, M., & Diederich, N. J. (2011) · Movement Disorders · doi:10.1002/mds.23479 · Cited by 37
Skin sympathetic nerve function during sleep—a study with effector responses
Kobayashi, R., Koike, Y., Hirayama, M., Ito, H., & Sobue, G. (2003) · Autonomic Neuroscience · doi:10.1016/s1566-0702(02)00261-8 · Cited by 37
Sleep, death, and the heart
Mansukhani, M. P., Wang, S., & Somers, V. K. (2015) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00285.2015 · Cited by 35
Self-citation
CrossTalk proposal: Most of the cardiovascular consequences of OSA are due to increased sympathetic activity
Kohler, M., & Stradling, J. R. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2012.229633 · Cited by 36
Sympathetic and angiotensinergic responses mediated by paradoxical sleep loss in rats
Perry, J. C., Bergamaschi, C. T., Campos, R. R., Andersen, M. L., Montano, N., Casarini, D. E., & Tufik, S. (2011) · Journal of the Renin-Angiotensin-Aldosterone System · doi:10.1177/1470320310391504 · Cited by 35
The nasal cycle during wakefulness and sleep and its relation to body position
Rohrmeier, C., Schittek, S., Ettl, T., Herzog, M., & Kuehnel, T. S. (2013) · The Laryngoscope · doi:10.1002/lary.24546 · Cited by 36
Sleep duration and quality in relation to chronic kidney disease and glomerular hyperfiltration in healthy men and women
Kim, C., Chang, Y., Sung, E., Yun, K. E., Jung, H. S., Ko, B., Kwon, M., Hyun, Y. Y., Lee, K., Kim, H. Y., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0175298 · Cited by 36
Sleep-Wake Cycling and Energy Conservation: Role of Hypocretin and the Lateral Hypothalamus in Dynamic State-Dependent Resource Optimization
Latifi, B., Adamantidis, A., Bassetti, C. L., & Schmidt, M. H. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.00790 · Cited by 35
Time‐varying correlations between delta EEG power and heart rate variability in midlife women: The SWAN S leep S tudy
Rothenberger, S. D., Krafty, R. T., Taylor, B. J., Cribbet, M. R., Thayer, J. F., Buysse, D. J., Kravitz, H. M., Buysse, E. D., & Hall, M. H. (2014) · Psychophysiology · doi:10.1111/psyp.12383 · Cited by 36
Sympathetic nerve activity during sleep, exercise, and mental stress
Miki, K., & Yoshimoto, M. (2013) · Autonomic Neuroscience · doi:10.1016/j.autneu.2012.12.007 · Cited by 36
Assessment of depth of midazolam sedation using objective parameters
Haberthür, C., Lehmann, F., & Ritz, R. (1996) · Intensive Care Medicine · doi:10.1007/bf01709555 · Cited by 36
Caffeine: Implications for Alertness in Athletes
Rogers, N. L., & Dinges, D. F. (2005) · Clinics in Sports Medicine · doi:10.1016/j.csm.2004.12.012 · Cited by 35
Sleepiness in Obstructive Sleep Apnea: A Harbinger of Impaired Cardiac Function?
Choi, J., Nelesen, R. A., Loredo, J. S., Mills, P. J., Ancoli‐Israel, S., Ziegler, M. G., & Dimsdale, J. E. (2006) · SLEEP · doi:10.1093/sleep/29.12.1531 · Cited by 36
Eating Around the Clock: Circadian Rhythms of Eating and Metabolism
McHill, A. W., & Butler, M. P. (2024) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-062122-014528 · Cited by 43
Sympathetic Withdrawal Augments Cerebral Blood Flow During Acute Hypercapnia in Sleeping Lambs
Cassaglia, P. A., Griffiths, R. I., & WALKER, A. M. (2008) · SLEEP · doi:10.1093/sleep/31.12.1729 · Cited by 34
Investigating the mechanism for maintaining eucalcemia despite immobility and anuria in the hibernating American black bear (Ursus americanus)
Seger, R. L., Cross, R. A., Rosen, C. J., Causey, R. C., Gundberg, C. M., Carpenter, T. O., Chen, T. C., Halteman, W. A., Holick, M. F., Jakubas, W. J., et al. (2011) · Bone · doi:10.1016/j.bone.2011.08.017 · Cited by 37
Amyloid burden and sleep blood pressure in amnestic mild cognitive impairment
Tarumi, T., Harris, T. S., Hill, C., German, Z., Riley, J. R., Turner, M., Womack, K. B., Kerwin, D. R., Monson, N. L., Stowe, A. M., et al. (2015) · Neurology · doi:10.1212/wnl.0000000000002167 · Cited by 35
Functional Role of Diverse Changes in Sympathetic Nerve Activity in Regulating Arterial Pressure during REM Sleep
Yoshimoto, M., Yoshida, I., & Miki, K. (2011) · SLEEP · doi:10.5665/sleep.1168 · Cited by 35
A deep learning-based algorithm for detection of cortical arousal during sleep
Li, A., Chen, S., Quan, S. F., Powers, L. S., & Roveda, J. M. (2020) · SLEEP · doi:10.1093/sleep/zsaa120 · Cited by 34
Experimental study of the negative effects of raised bedroom temperature and reduced ventilation on the sleep quality of elderly subjects
Yan, Y., Zhang, H., Kang, M., Lan, L., Wang, Z., & Lin, Y. (2022) · Indoor Air · doi:10.1111/ina.13159 · Cited by 35
Submaximal exercise in patients with severe obstructive sleep apnea
Alameri, H. F., Al-Kabab, Y., & BaHammam, A. S. (2009) · Sleep And Breathing · doi:10.1007/s11325-009-0300-4 · Cited by 35
Low-level vagosympathetic trunk stimulation inhibits atrial fibrillation in a rabbit model of obstructive sleep apnea
Gao, M., Zhang, L., Scherlag, B. J., Huang, B. S., Stavrakis, S., Hou, Y., Hou, Y., & Po, S. S. (2014) · Heart Rhythm · doi:10.1016/j.hrthm.2014.12.024 · Cited by 35
Comments on Point:Counterpoint: Sympathetic activity does/does not influence cerebral blood flow
Levine, B. D., & Zhang, R. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.zdg-8199.pcpcomm.2008 · Cited by 35
Clinical significance of pulse rate rise during sleep as a screening marker for the assessment of sleep fragmentation in sleep-disordered breathing
Adachi, H., Mikami, A., Kumano‐go, T., Suganuma, N., Matsumoto, H., Shigedo, Y., Sugita, Y., & Takeda, M. (2003) · Sleep Medicine · doi:10.1016/j.sleep.2003.06.003 · Cited by 35
Etiopathogenetic Mechanisms of Pulmonary Hypertension in Sleep-Related Breathing Disorders
Adegunsoye, A., & Ramachandran, S. K. (2012) · Pulmonary Medicine · doi:10.1155/2012/273591 · Cited by 35
Altered Cardiovascular Rhythmicity in Children With White Coat and Ambulatory Hypertension
Litwin, M., Simonetti, G. D., Niemirska, A., Ruzicka, M., Wühl, E., Schaefer, F. S., & Feber, J. (2010) · Pediatric Research · doi:10.1203/pdr.0b013e3181d00b5b · Cited by 35
Time‐ and state‐dependent analysis of autonomic control in narcolepsy: higher heart rate with normal heart rate variability independent of sleep fragmentation
van der Meijden, W. P., Fronczek, R., Reijntjes, R. H. A. M., Corssmit, E. P. M., Biermasz, N. R., Lammers, G. J., van Dijk, J. G., & Thijs, R. D. (2014) · Journal of Sleep Research · doi:10.1111/jsr.12253 · Cited by 35
Hemodynamic and Autonomic Changes in Adults with Obstructive Sleep Apnea
(2011) · Advances in cardiology · doi:10.1159/000325109 · Cited by 35
Influence of methotrexate on radiographic progression in rheumatoid arthritis: a sixty-month prospective study.
Drosos, A. A., Tsifetaki, N., Tsiakou, E. K., Timpanidou, M., Tsampoulas, C., Tatsis, C. K., Kotoulas, K., & Moutsopoulos, H. Μ. (1997) · PubMed · Cited by 35
Orexin, Sleep, Sympathetic Neural Activity, and Cardiovascular Function
Bigalke, J. A., Shan, Z. J., & Carter, J. R. (2022) · Hypertension · doi:10.1161/hypertensionaha.122.19796 · Cited by 34
Relationship between sleep duration and hypertension in northeast China: a cross-sectional study
Li, M., Yan, S., Jiang, S., Ma, X., Gao, T., & Li, B. (2019) · BMJ Open · doi:10.1136/bmjopen-2018-023916 · Cited by 34
Sleep Apnea Classification Algorithm Development Using a Machine-Learning Framework and Bag-of-Features Derived from Electrocardiogram Spectrograms
Lin, C.-Y., Wang, Y.-W., Setiawan, F., Trang, N. T. H., & Lin, C. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm11010192 · Cited by 34
Obstructive sleep apnea and cardiovascular risk.
Dorasamy, P. (2007) · PubMed Central · Cited by 34
Newly diagnosed atrial fibrillation linked to wake-up stroke and TIA
Riccio, P. M., Klein, F., Cassará, F. P., Giacomelli, F. M., Toledo, M. E. G., Racosta, J. M., Delfitto, M., Roberts, E., Bahit, M. C., & Sposato, L. A. (2013) · Neurology · doi:10.1212/wnl.0b013e318292a330 · Cited by 34
Cardiac Activity and Sympathovagal Balance During Sleep
Trinder, J. C. (2007) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2007.04.001 · Cited by 34
Is Adenosine Action Common Ground for NREM Sleep, Torpor, and Other Hypometabolic States?
Silvani, A., Cerri, M., Zoccoli, G., & Swoap, S. J. (2018) · Physiology · doi:10.1152/physiol.00007.2018 · Cited by 34
Daily, weekly, monthly, and seasonal patterns in the occurrence of vasovagal syncope in an older population
van Dijk, N., Boer, M. C., Santo, T. D., Grovale, N., AERTS, A. J. J., Boersma, L. V. A., & Wieling, W. (2007) · EP Europace · doi:10.1093/europace/eum104 · Cited by 34
Sleep and Hypertension
Legramante, J. M., & Galante, A. (2005) · Circulation · doi:10.1161/circulationaha.105.555714 · Cited by 34
Cardiopulmonary Sleep Spectrograms Open a Novel Window Into Sleep Biology—Implications for Health and Disease
Ashry, H. S. A., Ni, Y.-N., & THOMAS, R. J. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.755464 · Cited by 33
Effects of a 24‐hr‐shift‐related short‐term sleep deprivation on cardiac function: A cardiac magnetic resonance‐based study
Kuetting, D. L. R., Feißt, A., Sprinkart, A. M., Homsi, R., Luetkens, J. A., Thomas, D., Schild, H. H., & Dabir, D. (2018) · Journal of Sleep Research · doi:10.1111/jsr.12665 · Cited by 33
Snore Sound Analysis Can Detect the Presence of Obstructive Sleep Apnea Specific to NREM or REM Sleep
Akhter, S., Abeyratne, U. R., Swarnkar, V. R., & Hukins, C. (2018) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.7168 · Cited by 35
1º Posicionamento Brasileiro sobre o Impacto dos Distúrbios de Sono nas Doenças Cardiovasculares da Sociedade Brasileira de Cardiologia
Drager, L. F., Lorenzi‐Filho, G., Cintra, F. D., Pedrosa, R. P., Bittencourt, L., Poyares, D. R., Gonzaga, C. C., Togeiro, S. M., Santos‐Silva, R., de Bruin, P. F. C., et al. (2018) · Arquivos Brasileiros de Cardiologia · doi:10.5935/abc.20180154 · Cited by 38
The control mechanisms of heart rate dynamics in a new heart rate nonlinear time series model
He, Z. (2020) · Scientific Reports · doi:10.1038/s41598-020-61562-6 · Cited by 37
Morning sympathetic activity after evening binge alcohol consumption
Greenlund, I. M., Cunningham, H. A., Tikkanen, A. L., Bigalke, J. A., Smoot, C. A., Durocher, J. J., & Carter, J. R. (2020) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00743.2020 · Cited by 33
Poor sleep as a pathophysiological pathway underlying the association between stressful experiences and the diurnal cortisol profile among children and adolescents
Ly, J., McGrath, J. J., & Gouin, J. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.03.006 · Cited by 35
Neurological Aspects of Obstructive Sleep Apnea
Broderick, M. J., & Guilleminault, C. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1444.003 · Cited by 34
Does systolic and diastolic blood pressure follow Golden Ratio?
Yetkın, E., Topbaş, U., Yanık, A. M., & Yetkin, G. (2014) · International Journal of Cardiology · doi:10.1016/j.ijcard.2014.08.065 · Cited by 32
Sleep-related changes in hemodynamic and autonomic regulation in human hypertension
Drager, L. F., Ueno, L. M., Lessa, P. S., Negrão, C. E., Lorenzi‐Filho, G., & Krieger, E. M. (2009) · Journal of Hypertension · doi:10.1097/hjh.0b013e32832c6982 · Cited by 32
Effect of Slow Wave Sleep Disruption on Metabolic Parameters in Adolescents
Shaw, N. D., McHill, A. W., Schiavon, M., Kangarloo, T., Mankowski, P. W., Cobelli, C., Klerman, E. B., & Hall, J. E. (2016) · SLEEP · doi:10.5665/sleep.6028 · Cited by 33
Sleep and the Autonomic Nervous System
Miglis, M. G. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804074-4.00018-2 · Cited by 32
REM sleep estimation based on autonomic dynamics using R–R intervals
Yoon, H., Hwang, S. H., Choi, J., Lee, Y. J., Jeong, D. U., & Park, K. S. (2017) · Physiological Measurement · doi:10.1088/1361-6579/aa63c9 · Cited by 32
Entropy Analysis of Heart Rate Variability in Different Sleep Stages
Yan, C., Li, P., Yang, M., Li, Y., Li, J., Zhang, H., & Liu, C. (2022) · Entropy · doi:10.3390/e24030379 · Cited by 32
Heart rate variability and body temperature during the sleep onset period
Okamoto-Mizuno, K., Yamashiro, Y., Tanaka, H., Komada, Y., Mizuno, K., Tamaki, M., Kitado, M., Inoue, Y., & Shirakawa, S. (2008) · Sleep and Biological Rhythms · doi:10.1111/j.1479-8425.2008.00335.x · Cited by 34
Sleep and critical care
Bijwadia, J. S., & Ejaz, M. S. (2009) · Current Opinion in Critical Care · doi:10.1097/mcc.0b013e3283220dc7 · Cited by 32
Cardiovascular Effects of Sleep-Related Breathing Disorders
Somers, V. K., & Javaheri, S. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4160-6645-3.00119-5 · Cited by 32
Self-citation
Sleep disordered breathing in REM sleep reverses the downward trend in glucose concentration
Białasiewicz, P., Czupryniak, L., Pawlowski, M., & Nowak, D. (2010) · Sleep Medicine · doi:10.1016/j.sleep.2010.04.017 · Cited by 32
Disorders of Sleep: An Overview
Ting, L., & Malhotra, A. (2005) · Primary Care Clinics in Office Practice · doi:10.1016/j.pop.2005.02.004 · Cited by 33
Obstructive Sleep Apnea and Hypertension
Okcay, A., Somers, V. K., & Caples, S. M. (2008) · Journal of Clinical Hypertension · doi:10.1111/j.1751-7176.2008.07811.x · Cited by 33
Self-citation
The Rhythms of Blood Pressure in Humans
Portaluppi, F., Waterhouse, J. M., & Minors, D. S. (1996) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1996.tb26703.x · Cited by 32
Quantifying peripheral sympathetic activations during sleep by means of an automatic method for pulse wave amplitude drop detection
Betta, M., Handjaras, G., Ricciardi, E., Pietrini, P., Haba‐Rubio, J., Siclari, F., Heinzer, R. C., & Bernardi, G. (2020) · Sleep Medicine · doi:10.1016/j.sleep.2019.12.030 · Cited by 30
Insomnia and cardiovascular autonomic control
Grimaldi, D., Goldstein, M. R., & Carter, J. R. (2019) · Autonomic Neuroscience · doi:10.1016/j.autneu.2019.05.003 · Cited by 33
COVID-19 Stressors and Poor Sleep Quality: The Mediating Role of Rumination and the Moderating Role of Emotion Regulation Strategies
Ye, B., Wu, D., Wang, P., Im, H., Liu, M., Wang, X., & Yang, Q. (2021) · International Journal of Behavioral Medicine · doi:10.1007/s12529-021-10026-w · Cited by 31
Reading multifractal spectra: Aging by multifractal analysis of heart rate
Makowiec, D., Rynkiewicz, A., Gałąska, R., Wdowczyk‐Szulc, J., & Żarczyńska-Buchowiecka, M. (2011) · Europhysics Letters (EPL) · doi:10.1209/0295-5075/94/68005 · Cited by 31
REM sleep-related brady-arrhythmia syndrome
Janssens, W., Willems, R., Pevernagie, D., & Buyse, B. (2007) · Sleep And Breathing · doi:10.1007/s11325-007-0105-2 · Cited by 31
Time-varying Analysis of the Heart Rate Variability during REM and Non REM Sleep Stages
Mendez, M. O., Bianchi, A. M., Villantieri, O. P., & Cerutti, S. (2006) · Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) · doi:10.1109/iembs.2006.260067 · Cited by 33
Sleep duration and quality in heart failure patients
Türoff, A., Thiem, U., Fox, H., Spießhöfer, J., Bitter, T., Tamisier, R., Punjabi, N. M., Horstkotte, D., & Oldenburg, O. (2017) · Sleep And Breathing · doi:10.1007/s11325-017-1501-x · Cited by 32
Hypopnea definitions, determinants and dilemmas: a focused review
Shamim-Uzzaman, Q. A., Singh, S., & Chowdhuri, S. (2018) · Sleep Science and Practice · doi:10.1186/s41606-018-0023-1 · Cited by 34
Short-term Variability of Blood Pressure During Sleep in Snorers With or Without Apnea
Leroy, M., Surell, C. V., Pillière, R., Hagenmuller, M. P., Aegerter, P., Raffestin, B., & Foucher, A. (1996) · Hypertension · doi:10.1161/01.hyp.28.6.937 · Cited by 31
Sleep Apnea:
Garrigue, S., BORDIER, P., Barold, S. S., & Clémenty, J. (2004) · Pacing and Clinical Electrophysiology · doi:10.1111/j.1540-8159.2004.00411.x · Cited by 32
Influence of Glucose Metabolism on Nycthemeral Blood Pressure Variability in Hypertensives With an Elevated Waist-Hip Ratio A Link With Arterial Distensibility
AMAR, J. (1995) · American Journal of Hypertension · doi:10.1016/0895-7061(94)00186-f · Cited by 31
Independent Autonomic Modulation of the Human Sinus and AV Nodes: Evidence From Beat‐to‐Beat Measurements of PR and PP Intervals During Sleep
KOWALLIK, P., & Meesmann, M. (1995) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.1995.tb00376.x · Cited by 31
Effects of a lifestyle intervention on REM sleep‐related OSA severity in obese individuals with type 2 diabetes
Shechter, A., Foster, G. D., Lang, W., Reboussin, D. M., St‐Onge, M., Zammit, G., Newman, A. B., Millman, R. P., Wadden, T. A., Jakicic, J. M., et al. (2017) · Journal of Sleep Research · doi:10.1111/jsr.12559 · Cited by 30
Modeling cardiorespiratory interaction during human sleep with complex networks
Long, X., Fonseca, P. M., Aarts, R. M., Haakma, R., & Foussier, J. (2014) · Applied Physics Letters · doi:10.1063/1.4902026 · Cited by 30
The effects of aquatic and land exercise on resting blood pressure and post-exercise hypotension response in elderly hypertensives
Júnior, F. D. A. D. M., Gomes, S. G., da Silva, F. F., Souza, P. M. D. S., de Oliveira, E. C., Coelho, D. B., do Nascimento-Neto, R. M., de Lima, W. G., & Becker, L. K. (2020) · Cardiovascular journal of South Africa/Cardiovascular journal of Southern Africa · doi:10.5830/cvja-2019-051 · Cited by 40
Obstructive Sleep Apnea Syndrome: The Effect of Acute and Chronic Responses of Exercise
Stavrou, V. T., Astara, K., Tourlakopoulos, K. N., Papayianni, E., Boutlas, S., Vavougios, G. D., Daniil, Z. D., & Gourgoulianis, K. I. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.806924 · Cited by 30
The relationship between sleep-disordered breathing, blood pressure, and urinary cortisol and catecholamines in children
Brooks, D. M., Kelly, A. T., Sorkin, J. D., Koren, D., Chng, S. Y., Gallagher, P. R., Amin, R., Dougherty, S., Guo, R., Marcus, C. L., et al. (2020) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.8360 · Cited by 32
Non-dipping in hypertension
Palatini, P. (2004) · Journal of Hypertension · doi:10.1097/00004872-200412000-00007 · Cited by 30
Diabetic autonomic neuropathy
Spallone, V., Uccioli, L., & Menzinger, G. (1995) · Diabetes/Metabolism Reviews · doi:10.1002/dmr.5610110305 · Cited by 30
Slow wave electroencephalic activity parallels renin oscillations during sleep in humans
Luthringer, R., BRANDENBERGER, G., Schaltenbrand, N., Muller, G., Spiegel, K., Macher, J. P., Muzet, A. G., & FOLLENIUS, M. (1995) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(94)00119-6 · Cited by 30
Heart rate circadian profile in the differential diagnosis between Parkinson disease and multiple system atrophy
Pilleri, M., Levedianos, G., Weis, L., Gasparoli, E., Facchini, S., Biundo, R., Formento‐Dojot, P., & Antonini, A. (2013) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2013.11.006 · Cited by 29
Circadian variation in renal blood flow and kidney function in healthy volunteers monitored with noninvasive magnetic resonance imaging
Eckerbom, P., Hansell, P., Cox, E. F., Buchanan, C. E., Weis, J., Palm, F., Francis, S., & Liss, P. (2020) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00311.2020 · Cited by 28
Obstructive sleep apnea and ambulatory blood pressure monitoring: current evidence and research gaps
Pio-Abreu, A., Moreno, H., & Drager, L. F. (2021) · Journal of Human Hypertension · doi:10.1038/s41371-020-00470-8 · Cited by 35
Baroreflex Sensitivity During Sleep in Infants: Impact of Sleeping Position and Sleep State
Yiallourou, S. R., Sands, S. A., WALKER, A. M., & Horne, R. S. C. (2011) · SLEEP · doi:10.5665/sleep.1036 · Cited by 29
Comparison of postnatal development of heart rate responses to trigeminal stimulation in sleeping preterm and term infants
Tuladhar, R., Harding, R., Adamson, T. M., & Horne, R. S. C. (2005) · Journal of Sleep Research · doi:10.1111/j.1365-2869.2004.00434.x · Cited by 29
Reduced heart rate variability during sleep in long-duration spaceflight
Xu, D., Shoemaker, J. K., Blaber, A. P., Arbeille, P., Fraser, K. S., & Hughson, R. L. (2013) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00423.2012 · Cited by 29
Clinical Characteristics in Two Subgroups of Obstructive Sleep Apnea Syndrome in the Elderly
Kobayashi, M., Namba, K., Tsuiki, S., Matsuo, A., Sugiura, T., & Inoue, Y. (2010) · CHEST Journal · doi:10.1378/chest.09-2251 · Cited by 29
Phenotypic differences in the hemodynamic response during REM sleep in six strains of inbred mice
Campen, M. J., Tagaito, Y., Jenkins, T. P., Smith, P. L., Schwartz, A. R., & O'Donnell, C. P. (2002) · Physiological Genomics · doi:10.1152/physiolgenomics.00031.2002 · Cited by 29
The effects of day‐time exogenous melatonin administration on cardiac autonomic activity
Harris, A. S., Burgess, H. J., & Dawson, D. (2001) · Journal of Pineal Research · doi:10.1034/j.1600-079x.2001.310302.x · Cited by 29
Sleep and the Immune System
Opp, M. R., Jan Born, A., & Irwin, M. R. (2007) · Elsevier eBooks · doi:10.1016/b978-012088576-3/50034-4 · Cited by 29
Overnight Changes in Lung Function of Obese Patients with Obstructive Sleep Apnoea
Kunos, L., Lázár, Z., Martinovszky, F., Tárnoki, Á. D., Tárnoki, D. L., Kovacs, D., Forgó, B., Horváth, P., Losonczy, G., & Bikov, A. (2016) · Lung · doi:10.1007/s00408-016-9957-1 · Cited by 29
Polysomnography‐derived sleep parameters as a determinant of nocturnal blood pressure profile in patients with obstructive sleep apnea
Kuwabara, M., Tomitani, N., Shiga, T., & Kario, K. (2018) · Journal of Clinical Hypertension · doi:10.1111/jch.13308 · Cited by 29

Authors: Somers, V. K., Dyken, M. E., Mark, A. L., & Abboud, F. M.
Affiliations: University of Iowa (US)
ORCID: Somers, Virend K.
Dyken, Mark E.
Mark, Allyn L.
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 1993-02-04
Volume: 328
Issue: 5
Pages: 303-307
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejm199302043280502
OpenAlex: W2316139099
Cited by: 1,574
References: 35
Citations by year: 2026: 43 · 2025: 67 · 2024: 68 · 2023: 56 · 2022: 68 · 2021: 75 · 2020: 58 · 2019: 70 · 2018: 64 · 2017: 57 · 2016: 53 · 2015: 56 · 2014: 57 · 2013: 44 · 2012: 63
FWCI: 25.34
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
Funders: National Heart, Lung, and Blood Institute (HL-24962, HL-14388, P01HL014388)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
Keywords: sympathetic activity, REM sleep, NREM sleep, blood pressure, heart rate, K-complexes, muscle tone, autonomic nervous system, sleep arousal, myocardial infarction, ischemic stroke
MeSH terms: Adult, Blood Pressure, Blood Vessels, Electrocardiography, Female, Heart Rate, Humans, Male, Nitroprusside, Sleep, Sleep Stages, Sleep, REM, Sympathetic Nervous System, Wakefulness

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Sympathetic-Nerve Activity during Sleep in Normal Subjects

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks