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Severe Hypothyroidism Caused by Type 3 Iodothyronine Deiodinase in Infantile Hemangiomas
Abstract
Hemangiomas are the most common tumors of infancy, with a prevalence of 5 to 10 percent among one-year-olds. They are characterized by rapid growth in the first year of life, followed by involution and gradual regression by adolescence.1,2 We recently treated a three-month-old infant with massive hepatic hemangiomas and primary hypothyroidism who needed very high doses of thyroid hormone to restore euthyroidism and normal thyrotropin secretion. This finding suggested that the rate of degradation of thyroid hormone was accelerated. We subsequently identified high levels of type 3 iodothyronine deiodinase activity in the hemangioma tissue. This selenoenzyme, normally present in . . .
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“In that patient, the high serum levels of rT3 (413 ng/mL), followed by the demonstration of high expression of deiodinase type 3 (D3) in hemangioma tissue, were crucial to the diagnosis.”
From Can Reverse T3 Assay Be Employed to Guide T4 vs. T4/T3 Therapy in Hypothyroidism? (2019) · cites this paper as [22]
In the citing paper
“Increased type 3 deiodinase activity in large hemangiomas can cause increased metabolic clearance of administered LT4 and, with that, necessitate a higher LT4 dose (120–122).”
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Metadata
- Authors
- Huang, S. A., Tu, H. M., Harney, J. W., Venihaki, M., Butte, A. J., Kozakewich, H. P. W., Fishman, S. J., & Larsen, P. R.
- Affiliations
- Boston Children's Hospital (US)
- Brigham and Women's Hospital (US)
- Children's Hospital (TN)
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2000-07-20
- Volume
- 343
- Issue
- 3
- Pages
- 185-189
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2320158996
- Cited by
- 540
- References
- 27
- Citations by year
- 2026: 12 · 2025: 12 · 2024: 12 · 2023: 5 · 2022: 17 · 2021: 30 · 2020: 22 · 2019: 27 · 2018: 22 · 2017: 32 · 2016: 28 · 2015: 20 · 2014: 31 · 2013: 23 · 2012: 26
- FWCI
- 10.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 07699, R01DK044128, DK-44128, T32DK007529, T32DK007699, DK-07529)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Surgery › Vascular Malformations and Hemangiomas
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Keywords
- type 3 iodothyronine deiodinase, infantile hemangioma, hepatic hemangioma, primary hypothyroidism, severe hypothyroidism, selenoenzymes, thyroid hormone replacement, thyrotropin secretion
- MeSH terms
- Hemangioma, Humans, Hypothyroidism, Infant, Iodide Peroxidase, Liver Neoplasms, Magnetic Resonance Imaging, Male, Neoplasms, Multiple Primary, Retrospective Studies, Thyrotropin
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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