Cited by 540Thyroid Disorders and TreatmentsVascular Malformations and HemangiomasGrowth Hormone and Insulin-like Growth Factors

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Severe Hypothyroidism Caused by Type 3 Iodothyronine Deiodinase in Infantile Hemangiomas

Huang, Stephen A., Tu, Helen M., Harney, John W., Venihaki, Maria, Butte, Atul J., Kozakewich, Harry P.W., Fishman, Steven J., Larsen, P. Reed·2000·New England Journal of Medicine

DOI 10.1056/nejm200007203430305

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Abstract

Hemangiomas are the most common tumors of infancy, with a prevalence of 5 to 10 percent among one-year-olds. They are characterized by rapid growth in the first year of life, followed by involution and gradual regression by adolescence.1,2 We recently treated a three-month-old infant with massive hepatic hemangiomas and primary hypothyroidism who needed very high doses of thyroid hormone to restore euthyroidism and normal thyrotropin secretion. This finding suggested that the rate of degradation of thyroid hormone was accelerated. We subsequently identified high levels of type 3 iodothyronine deiodinase activity in the hemangioma tissue. This selenoenzyme, normally present in . . .

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Authors: Huang, S. A., Tu, H. M., Harney, J. W., Venihaki, M., Butte, A. J., Kozakewich, H. P. W., Fishman, S. J., & Larsen, P. R.
Affiliations: Boston Children's Hospital (US)
Brigham and Women's Hospital (US)
Children's Hospital (TN)
ORCID: Huang, Stephen A.
Venihaki, Maria
Butte, Atul J.
Kozakewich, Harry P.W.
Fishman, Steven J.
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 2000-07-20
Volume: 343
Issue: 3
Pages: 185-189
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejm200007203430305
OpenAlex: W2320158996
Cited by: 540
References: 27
Citations by year: 2026: 12 · 2025: 12 · 2024: 12 · 2023: 5 · 2022: 17 · 2021: 30 · 2020: 22 · 2019: 27 · 2018: 22 · 2017: 32 · 2016: 28 · 2015: 20 · 2014: 31 · 2013: 23 · 2012: 26
FWCI: 10.44
Type: journal article
Language: en
Open access: closed
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (DK 07699, R01DK044128, DK-44128, T32DK007529, T32DK007699, DK-07529)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
Health Sciences › Medicine › Surgery › Vascular Malformations and Hemangiomas
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
Keywords: type 3 iodothyronine deiodinase, infantile hemangioma, hepatic hemangioma, primary hypothyroidism, severe hypothyroidism, selenoenzymes, thyroid hormone replacement, thyrotropin secretion
MeSH terms: Hemangioma, Humans, Hypothyroidism, Infant, Iodide Peroxidase, Liver Neoplasms, Magnetic Resonance Imaging, Male, Neoplasms, Multiple Primary, Retrospective Studies, Thyrotropin

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Severe Hypothyroidism Caused by Type 3 Iodothyronine Deiodinase in Infantile Hemangiomas

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