Activation of ang-(1-7)/mas receptor is a possible strategy to treat coronavirus (SARS-CoV-2) infection
Open accessAbstract
The renin-angiotensin system is involved in the pathophysiology of inflammatory diseases through an increase in angiotensin converting enzyme (ACE)/angiotensin (Ang) II/AT1 receptor axis activity. It has been shown that ACE activity is increased in acute respiratory distress syndrome and there is a strong correlation between the level of ACE activity and the degree of lung injury. SARS-CoV-2, the new coronavirus that causes COVID-19, similar to other coronaviruses, was recently shown to use ACE2 as a receptor to get into host cells. However, it has been reported that most of the treatments that stimulates the ACE2/Ang-(1-7)/Mas axis induces beneficial effects, such as, antihypertensive, anti-inflammatory, anti-proliferative, anti-thrombotic and anti-fibrotic. Here we discussed the potential of activation of Ang-(1-7)/Mas pathway as strategy to treat COVID-19.
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Increased angiotensin-II levels and reduced angiotensin-(1-7) production due to lower ACE2 activity could provoke multiple COVID-19 symptoms, including vasoconstriction, thrombosis, inflammation, and potentially fatal respiratory failure.
“Increased levels of Ang-II and reduced production of Ang-1-7 due to the lower ACE2 activity could provoke multiple COVID-19 symptoms, including vasoconstriction, thrombosis, inflammation, and potentially fatal respiratory failure.14,18, 19, 20, 21”
An imbalance between levels of Ang-II and Ang-1-7 could provoke multiple pathophysiological features of COVID-19, including vasoconstriction, thrombosis, and inflammatory reaction.
“An imbalance between levels of Ang-II and of Ang-1-7 could provoke multiple pathophysiological features of COVID-19, including vasoconstriction, thrombosis, inflammatory reaction, which is potentially ultimately responsible for the respiratory symptoms observed during COVID-19.18, 19, 20, 21”
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- Authors
- Magalhaes, G. S., Rodrigues-Machado, M. D. G., Motta-Santos, D., Campagnole-Santos, M. J., & Santos, R. A. S.
- Affiliations
- Instituto Nacional de Ciência e Tecnologia em Nano-Biofarmacêutica (BR)
- Corresponding author
- Santos, Robson A. Souza
- Venue
- Frontiers in Physiology
- Publisher
- Frontiers Media SA
- Published
- 2020-06-19
- Volume
- 11
- Pages
- 730-730
- ISSN
- 1664-042X (ISSN-L)
- PMC
- PMC7318839
- OpenAlex
- W3036238702
- Cited by
- 44
- References
- 38
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 5 · 2023: 4 · 2022: 9 · 2021: 14 · 2020: 8 · 2013: 1
- FWCI
- 5.41
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Physiology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação de Amparo à Pesquisa do Estado de Minas Gerais
- Instituto Nacional de Ciência e Tecnologia de Nanobiofarmacêutica
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Health Sciences › Medicine › Genetics › Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Keywords
- SARS-CoV-2, COVID-19 treatment, renin-angiotensin system, ACE2, angiotensin II, angiotensin II type 1 receptor, angiotensin-converting enzyme inhibition, lung injury, anti-inflammatory activity, antithrombotic activity, antifibrotic effect
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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