The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Subclinical Hyperthyroidism
Abstract
Persons with subclinical hyperthyroidism are at increased risk for cardiovascular and skeletal conditions. Decisions regarding treatment depend on age, menopausal status in women, and the presence of symptoms of and risk factors for cardiovascular disease or bone loss.
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In the citing paper
“LT4 over-treated patients are exposed to a chronic state of excess iodothyronines in the more sensitive target tissues, mainly the heart and bones (5)”
From ETA guidelines for the use of levothyroxine sodium preparations in monotherapy to optimize the treatment of hypothyroidism (2025) · cites this paper as [5]
In the citing paper
“Analyses of real-world data from patient registries have demonstrated that the levels of serum TSH outside the reference intervals, in patients with LT4-treated hypothyroidism, are associated with adverse health outcomes, including ischemic heart disease events, cardiac dysrhythmias, fractures, and heart failure (5, 72, 73).”
From ETA guidelines for the use of levothyroxine sodium preparations in monotherapy to optimize the treatment of hypothyroidism (2025) · cites this paper as [5]
In the citing paper
“These risks were particularly more pronounced in those with serum TSH levels that are consistently at the extremes (<0.1 or >10.0 mU/L).”
From ETA guidelines for the use of levothyroxine sodium preparations in monotherapy to optimize the treatment of hypothyroidism (2025) · cites this paper as [5]
Citations
Cites
1 retracted
Yang, R., Yao, L., Fang, Y., Sun, J., Guo, T., Yang, K., & Tian, L. (2017) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-017-0828-5 · Cited by 35
RetractedRoss, D. S., Burch, H. B., Cooper, D. S., Greenlee, M. C., Laurberg, P., Maia, A. L., Rivkees, S. A., Samuels, M., Sosa, J. A., Stan, M. N., et al. (2016) · Thyroid® · doi:10.1089/thy.2016.0229 · Cited by 2,938
Self-citationThe Clinical Significance of Subclinical Thyroid Dysfunction
Biondi, B., & Cooper, D. S. (2008) · Endocrine Reviews · doi:10.1210/er.2006-0043 · Cited by 1,418
Self-citationCooper, D. S., & Biondi, B. (2012) · The Lancet · doi:10.1016/s0140-6736(11)60276-6 · Cited by 1,039
Self-citationCooper, D. S. (2005) · New England Journal of Medicine · doi:10.1056/nejmra042972 · Cited by 1,008
Self-citationThyroid Status, Cardiovascular Risk, and Mortality in Older Adults
Cappola, A. R., Fried, L. P., Arnold, A. M., Danese, M. D., Kuller, L. H., Burke, G. L., Tracy, R. P., & Ladenson, P. W. (2006) · JAMA · doi:10.1001/jama.295.9.1033 · Cited by 862
Subclinical hyperthyroidism and the risk of coronary heart disease and mortality
Collet, T.-H., Gussekloo, J., Bauer, D. C., den Elzen, W. P. J., Cappola, A. R., Balmer, P., Iervasi, G., Åsvold, B. O., Sgarbi, J. A., Völzke, H., et al. (2012) · Archives of Internal Medicine · doi:10.1001/archinternmed.2012.402 · Cited by 572
Gencer, B., Collet, T.-H., Virgini, V., Bauer, D. C., Gussekloo, J., Cappola, A. R., Nanchen, D., den Elzen, W. P. J., Balmer, P., Luben, R. N., et al. (2012) · Circulation · doi:10.1161/circulationaha.112.096024 · Cited by 517
Flynn, R. W., Bonellie, S. R., Jung, R. T., MacDonald, T. M., Morris, A. D., & Leese, G. P. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-1625 · Cited by 415
Biondi, B. (2000) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.85.12.4701 · Cited by 356
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Rosário, P. W. (2021) · Clinical Endocrinology · doi:10.1111/cen.14579 · Cited by 1
The Relationship and Research Progress be-tween Subclinical Thyroid Dysfunction and Osteoporosis
杨, 贤. (2023) · Advances in Clinical Medicine · doi:10.12677/acm.2023.1361416 · Cited by 1
García, K. J. G., Alvear, C. H. C., Herrera, D. E. G., Cevallos, M. G. R., Checa, G. X. V., & Matute, C. M. R. (2023) · doi:10.36015/cambios.v22.n2.2023.927 · Cited by 1
Passagerer Morbus Basedow bei einer Patientin mit multinodulärer Struma
WEISSEL, M. (2018) · Journal für Klinische Endokrinologie und Stoffwechsel · doi:10.1007/s41969-018-0047-2
Dominguez, L. J., & Barbagallo, M. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.11338-8
Biondi, B. (2020) · Clinical Thyroidology · doi:10.1089/ct.2020;32.471-473
Self-citationSchilddrüsenfunktionsstörungen im Alter
Iwen, A. (2021) · DMW - Deutsche Medizinische Wochenschrift · doi:10.1055/a-1239-3066
汚染防止形ふっ素樹脂塗料「Vフロン#200クリーン」 建築外装用ふっ素樹脂塗料で塗膜の汚れ防止
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Dominguez, L. J., & Barbagallo, M. (2022) · Wiley eBooks · doi:10.1002/9781119484288.ch83
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Raverot, V., & d’Herbomez, M. (2022) · Elsevier eBooks · doi:10.1016/b978-2-294-77583-3.00003-4
Jackson, K., Simons, Z., & Moseley, K. F. (2022) · Cambridge University Press eBooks · doi:10.1017/9781108942751.031
Trattamento dell’ipertiroidismo subclinico: quando?
Mauro, M. D., Paola, G., & Moleti, M. (2022) · L Endocrinologo · doi:10.1007/s40619-022-01100-w
Apathetic hyperthyroidism in an elderly patient presenting with psychomotor retardation
Delacroix, R., & Umberger, J. M. (2022) · Journal of the American Association of Nurse Practitioners · doi:10.1097/jxx.0000000000000767
Aksu, Y., Kahveci, S., Tiryaki, Ş., Şahin, M., & Mutlu, F. (2022) · Current Medical Imaging Formerly Current Medical Imaging Reviews · doi:10.2174/1573405619666221222105801
LaVine, N. (2022) · Springer eBooks · doi:10.1007/978-3-031-15353-2_8
Subclinical Hypothyroidism Diagnosis and Management in Primary Care settings
Elgharib, M. I. M., & Mokibel, M. A. K. (2023) · Scholars Journal of Dental Sciences · doi:10.36347/sjds.2023.v10i05.006
Schilddrüsenfunktionsstörungen im Alter
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Vaghela, N. N., Jadav, N. B., Shah, Y. R., Parmar, A. C., Munnangi, P. R., & Madhupalli, R. N. (2024) · Journal of Family Medicine and Primary Care · doi:10.4103/jfmpc.jfmpc_1236_23
Trespalacios, R. H. D. J. F., & Suárez-Guerrero, J. L. (2024) · Revista Colombiana de Endocrinología Diabetes & Metabolismo · doi:10.53853/encr.11.2.854 · Cited by 1
Cherella, C. E., & Smith, J. R. (2024) · Springer eBooks · doi:10.1007/978-3-031-66296-6_15
Ursem, S. R., Noordam, R., van den Berg, J. M., Boelen, A., Elders, P. J. M., den Elzen, W. P. J., & Heijboer, A. C. (2025) · Thyroid · doi:10.1177/10507256261449444
Characteristics and Dynamics of Thyroid Dysfunction in the Bulgarian Population - Screening 2024
Borissova, A.-M., Trifonova, B., Dakovska, L. N., & Vukov, M. I. (2025) · Clinical Medicine Research · doi:10.11648/j.cmr.20251403.14
翔子, 新., Furuya, R., 剛, 大., & 弘志, 宮. (2025) · Nihon Kyukyu Igakukai Zasshi Journal of Japanese Association for Acute Medicine · doi:10.1002/jja2.13018
Svensson, J., Ohlsson, C., Karlsson, M. K., Tivesten, Å., Herlitz, H., Lorentzon, M., Lewerin, C., & Mellström, D. (2025) · Journal of the Endocrine Society · doi:10.1210/jendso/bvaf121
Zheng, Q., Wu, J., Xia, R., Wang, Z.-T., Zhu, Q., Ren, S., Zhang, X., Li, S., & Fu, T. (2025) · Journal of Otology · doi:10.26599/joto.2025.9540042
Tian, L., Lu, C., & 滕卫平 (2024) · Figshare · doi:10.6084/m9.figshare.26718540
Muhammad, Y. A., & Muhaidi, M. J. (2025) · F1000Research · doi:10.12688/f1000research.173609.1
Hipertiroidizmin Kalp Sağlığına Etkisi Hakkında Yapılan Çalışmaların Bibliyometrik Analizi
Basançelebi, B. C., Demir, G., & Ekici, M. (2025) · Dicle Üniversitesi Veteriner Fakültesi Dergisi · doi:10.47027/duvetfd.1645073
Inman, B. L., & Long, B. (2026) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2025.02.005
Thyroid dysfunction alters gut microbiota composition and alveolar bone levels in female mice
Thompson, L., Coulter, B., & VanPutte, C. L. (2026) · Physiological Reports · doi:10.14814/phy2.70817
Selim, S., Mustari, M., Lona, H., Mahmood, S. A., Raunak, A. I. B., & Rana, M. M. (2026) · Bangladesh Journal of Endocrinology and Metabolism · doi:10.4103/bjem.bjem_43_25
Muhammad, Y. A., & Muhaidi, M. J. (2026) · F1000Research · doi:10.12688/f1000research.173609.2
Can Thyroid Dysfunction Contribute to Infertility via Lipid Abnormalities?
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Athyreosis and Thyroid Hormone Signaling: A System-Based Framework for Long-Term Endocrine Health
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Metadata
- Authors
- Biondi, B., & Cooper, D. S.
- Affiliations
- Johns Hopkins University (US)
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2018-06-21
- Volume
- 378
- Issue
- 25
- Pages
- 2411-2419
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W4246335980
- Semantic Scholar
- d89d164d3bdb8cfd7d1e88a1593ecc89aec5dbe3
- Cited by
- 135
- References
- 44
- Citations by year
- 2026: 7 · 2025: 14 · 2024: 18 · 2023: 20 · 2022: 24 · 2021: 20 · 2020: 19 · 2019: 9 · 2018: 3
- FWCI
- 1.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
- Keywords
- subclinical hyperthyroidism, cardiovascular risk, bone loss, osteoporosis, menopause, treatment decision-making, age, cardiovascular risk factors
- MeSH terms
- Aged, Female, Humans, Hyperthyroidism, Iodine Radioisotopes, Methimazole, Reference Values, Antithyroid Agents, Thyroid Hormones, Thyrotropin, Thyroxine, Disease Progression
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