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The Epidemiology of Sepsis in the United States from 1979 through 2000
Open accessAbstract
BACKGROUND: Sepsis represents a substantial health care burden, and there is limited epidemiologic information about the demography of sepsis or about the temporal changes in its incidence and outcome. We investigated the epidemiology of sepsis in the United States, with specific examination of race and sex, causative organisms, the disposition of patients, and the incidence and outcome. METHODS: We analyzed the occurrence of sepsis from 1979 through 2000 using a nationally representative sample of all nonfederal acute care hospitals in the United States. Data on new cases were obtained from hospital discharge records coded according to the International Classification of Diseases, Ninth Revision, Clinical Modification. RESULTS: Review of discharge data on approximately 750 million hospitalizations in the United States over the 22-year period identified 10,319,418 cases of sepsis. Sepsis was more common among men than among women (mean annual relative risk, 1.28 [95 percent confidence interval, 1.24 to 1.32]) and among nonwhite persons than among white persons (mean annual relative risk, 1.90 [95 percent confidence interval, 1.81 to 2.00]). Between 1979 and 2000, there was an annualized increase in the incidence of sepsis of 8.7 percent, from about 164,000 cases (82.7 per 100,000 population) to nearly 660,000 cases (240.4 per 100,000 population). The rate of sepsis due to fungal organisms increased by 207 percent, with gram-positive bacteria becoming the predominant pathogens after 1987. The total in-hospital mortality rate fell from 27.8 percent during the period from 1979 through 1984 to 17.9 percent during the period from 1995 through 2000, yet the total number of deaths continued to increase. Mortality was highest among black men. Organ failure contributed cumulatively to mortality, with temporal improvements in survival among patients with fewer than three failing organs. The average length of the hospital stay decreased, and the rate of discharge to nonacute care medical facilities increased. CONCLUSIONS: The incidence of sepsis and the number of sepsis-related deaths are increasing, although the overall mortality rate among patients with sepsis is declining. There are also disparities among races and between men and women in the incidence of sepsis. Gram-positive bacteria and fungal organisms are increasingly common causes of sepsis.
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“This approach follows the methods validated by many studies on the epidemiology of sepsis26, 27, 28, 29 and was used by Rudd and colleagues.10”
From Global burden of bacterial antimicrobial resistance 1990–2021: a systematic analysis with forecasts to 2050 (2024) · cites this paper as [28]
In the citing paper
“This trend continued with a greater than 200% increase from 1979 to 2000.23”
From Fungal Sepsis: Optimizing Antifungal Therapy in the Critical Care Setting (2011) · cites this paper as [23]
In the citing paper
“McNeil et al. (154) published an analysis of trends in infectious disease mortality in the United States and found a dramatic increase in multiple-cause mortality due to mycoses, from 1,557 deaths in 1980 to 6,534 deaths in 1997; the majority of these mycoses-related deaths were associated with Candida , Aspergillus , and Cryptococcus sp. infection.”
From Epidemiology of Invasive Candidiasis: a Persistent Public Health Problem (2007) · cites this paper as [154]
In the citing paper
“At the same time, they showed an almost exponential increase in the mortality rates associated with IA, with a 357% increase in mortality between 1980 and 1996.”
From Epidemiology of Invasive Candidiasis: a Persistent Public Health Problem (2007) · cites this paper as [154]
In the citing paper
“Previously, McNeil et al. (154) demonstrated that mortality rates associated with IC increased steadily from 1980 to a peak in 1989, followed by a gradual decline through 1996.”
From Epidemiology of Invasive Candidiasis: a Persistent Public Health Problem (2007) · cites this paper as [154]
In the citing paper
“These data are directly comparable to those of McNeil et al. (154) and extend the data reported in that study beyond 1996 to the year 2003.”
From Epidemiology of Invasive Candidiasis: a Persistent Public Health Problem (2007) · cites this paper as [154]
In the citing paper
“Again, the limitations of such data are well known, most notably the lack of validation of the mycotic infection and the failure to clinically diagnose IA and IC, resulting in an underestimation of mortality (154).”
From Epidemiology of Invasive Candidiasis: a Persistent Public Health Problem (2007) · cites this paper as [154]
In the citing paper
“As stated by McNeil and colleagues (154), mortality associated with invasive mycoses is best represented by multiplecause-of-death data, which capture any mention of the mycotic disease on the death certificate.”
From Epidemiology of Invasive Candidiasis: a Persistent Public Health Problem (2007) · cites this paper as [154]
In the citing paper
“Although this approach provides a much more generalizable sample of U.S. hospitals than many other methods of surveillance, it is likely to underestimate both incidence and mortality because of miscoding of IC, use of codes not captured by the analysis, or failure to code the infection at all (79, 154).”
From Epidemiology of Invasive Candidiasis: a Persistent Public Health Problem (2007) · cites this paper as [154]
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Cites
Bone, R. C., BALK, R. A., Cerra, F. B., Dellinger, R. P., Fein, A. M., Knaus, W. A., Schein, R. M. H., & Sibbald, W. J. (1992) · CHEST Journal · doi:10.1378/chest.101.6.1644 · Cited by 13,317
Angus, D. C., Linde-Zwirble, W. T., Lidicker, J., Clermont, G., Carcillo, J., & Pinsky, M. R. (2001) · Critical Care Medicine · doi:10.1097/00003246-200107000-00002 · Cited by 8,503
Efficacy and Safety of Recombinant Human Activated Protein C for Severe Sepsis
Bernard, G. R., Vincent, J., Laterre, P., LaRosa, S. P., Dhainaut, J.-F., Lopez-Rodriguez, A., Steingrub, J. S., Garber, G. E., Helterbrand, J. D., Ely, E. W., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200103083441001 · Cited by 6,124
Rising Incidence of Hepatocellular Carcinoma in the United States
El‐Serag, H. B., & Mason, A. C. (1999) · New England Journal of Medicine · doi:10.1056/nejm199903113401001 · Cited by 2,865
The Natural History of the Systemic Inflammatory Response Syndrome (SIRS)
Rangel-Frausto, M. S., Pittet, D., Costigan, M., Hwang, T., Davis, C. S., & Wenzel, R. P. (1995) · JAMA · doi:10.1001/jama.273.2.117 · Cited by 2,090
High-Dose Antithrombin III in Severe Sepsis
Warren, B., Eid, A. A., Singer, P., Pillay, S., Carl, P., Novák, I., Chalupa, P., Atherstone, A., Pénzes, I., Kübler, A., et al. (2001) · JAMA · doi:10.1001/jama.286.15.1869 · Cited by 1,422
Parrillo, J. E., Parker, M. M., Natanson, C., Suffredini, A. F., Danner, R. L., Cunnion, R. E., & Ognibene, F. P. (1990) · Annals of Internal Medicine · doi:10.7326/0003-4819-113-3-227 · Cited by 1,188
Secular Trends in the Epidemiology of Nosocomial Fungal Infections in the United States, 1980-1990
Beck‐Sagué, C. M., Jarvis, W. R., & System, N. N. I. S. (1993) · The Journal of Infectious Diseases · doi:10.1093/infdis/167.5.1247 · Cited by 1,140
Incidence, Risk Factors, and Outcome of Severe Sepsis and Septic Shock in Adults
Brun‐Buisson, C. (1995) · JAMA · doi:10.1001/jama.274.12.968 · Cited by 1,079
Treating Patients with Severe Sepsis
Wheeler, A. P., & Bernard, G. R. (1999) · New England Journal of Medicine · doi:10.1056/nejm199901213400307 · Cited by 992
Research works printed but not linked: 2
- 1990, MMWR Morb Mortal Wkly Rep, 39, 31
- Eaton S, 2002, Am J Respir Crit Care Med, 165, A471
Cited by
Sorted by citations
Items 601–700 of 1,032
Madoiwa, S., Nunomiya, S., Ono, T., Shintani, Y., Ohmori, T., Mimuro, J., & Sakata, Y. (2006) · International Journal of Hematology · doi:10.1532/ijh97.05190 · Cited by 134
Jawhara, S., & Poulain, D. (2007) · Medical Mycology · doi:10.1080/13693780701523013 · Cited by 129
Recent advances and challenges in the treatment of invasive fungal infections
Shao, P., Huang, L., & Hsueh, P. (2007) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2007.07.019 · Cited by 131
Complexity of complement activation in sepsis
Markiewski, M. M., DeAngelis, R. A., & Lambris, J. D. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00504.x · Cited by 133
Lichtenauer, M., Wernly, B., Ohnewein, B., Franz, M., Kabisch, B., Muessig, J. M., Masyuk, M., Lauten, A., Schulze, P. C., Hoppe, U. C., et al. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18091893 · Cited by 133
Epidemiology of sepsis in intensive care units in Turkey: a multicenter, point-prevalence study
Sepsis Study Group, Baykara, N., Akalın, H., Arslantaş, M. K., Hancı, V., Çağlayan, Ç., Kahveci, F., Demırağ, K., Baydemır, C., & Ünal, N. (2018) · Critical Care · doi:10.1186/s13054-018-2013-1 · Cited by 129
Gene expression profiles of peripheral blood leukocytes after endotoxin challenge in humans
Talwar, S., Munson, P. J., Barb, J. J., Fiuza, C., Cintron, A. D. P., Logun, C., Tropea, M., Khan, S. S., Reda, D., Shelhamer, J. H., et al. (2006) · Physiological Genomics · doi:10.1152/physiolgenomics.00192.2005 · Cited by 131
Association between hyperkalemia at critical care initiation and mortality
McMahon, G. M., Mendu, M. L., Gibbons, F. K., & Christopher, K. B. (2012) · Intensive Care Medicine · doi:10.1007/s00134-012-2636-7 · Cited by 127
Effects of aging on the immunopathologic response to sepsis
Turnbull, I. R., Clark, A. T., Stromberg, P. E., Dixon, D. J., Woolsey, C. A., Davis, C. G., Hotchkiss, R. S., Buchman, T. G., & Coopersmith, C. M. (2009) · Critical Care Medicine · doi:10.1097/ccm.0b013e3181968f3a · Cited by 127
Photodynamic inactivation for controlling Candida albicans infections
Gonzales, F. P., & Maisch, T. (2011) · Fungal Biology · doi:10.1016/j.funbio.2011.10.001 · Cited by 129
Sex and gender differences in intensive care medicine
Merdji, H., Long, M. T., Ostermann, M., Herridge, M. S., Myatra, S. N., Rosa, S. D., Metaxa, V., Kotfis, K., Robba, C., JONG, A. D., et al. (2023) · Intensive Care Medicine · doi:10.1007/s00134-023-07194-6 · Cited by 129
Rehospitalizations Following Sepsis
Chang, D., Tseng, C., & Shapiro, M. F. (2015) · Critical Care Medicine · doi:10.1097/ccm.0000000000001159 · Cited by 127
Neutrophil CD64 expression as a diagnostic marker for sepsis in adult patients: a meta-analysis
Wang, X., Li, Z.-Y., Zeng, L., Zhang, A., Pan, W., Gu, W., & Jiang, J. (2015) · Critical Care · doi:10.1186/s13054-015-0972-z · Cited by 126
Nasa, P., Juneja, D., Singh, O., Dang, R., & Arora, V. (2011) · Journal of Intensive Care Medicine · doi:10.1177/0885066610397116 · Cited by 130
Kalil, A. C., Syed, A., Rupp, M. E., Chambers, H. E., Vargas, L. M., Maskin, A., Miles, C. D., Langnas, A. N., & Florescu, D. F. (2014) · Clinical Infectious Diseases · doi:10.1093/cid/ciu789 · Cited by 126
Hartung, H.-P., Mouthon, L., Ahmed, R. A., Jordan, S. C., Laupland, K. B., & Jolles, S. R. A. (2009) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2009.04024.x · Cited by 127
Liu, Y., Hou, J.-H., Li, Q., Chen, K., Wang, S., & Wang, J. (2016) · SpringerPlus · doi:10.1186/s40064-016-3591-5 · Cited by 126
Owen, A. M., Patel, S. P., Smith, J. D., Balasuriya, B. K., Mori, S. F., Hawk, G. S., Stromberg, A. J., Kuriyama, N., Kaneki, M., Rabchevsky, A. G., et al. (2019) · eLife · doi:10.7554/elife.49920 · Cited by 132
Diagnostic and prognostic value of red blood cell distribution width in sepsis: A narrative review
Hu, Z.-D., Lippi, G., & Montagnana, M. (2020) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2020.01.001 · Cited by 126
ADMISSION ANGIOPOIETIN LEVELS IN CHILDREN WITH SEPTIC SHOCK
Giuliano, J. S., Lahni, P. M., Harmon, K., Wong, H. R., Doughty, L., Carcillo, J. A., Zingarelli, B., Sukhatme, V. P., Parikh, S. M., & Wheeler, D. S. (2007) · Shock · doi:10.1097/shk.0b013e318123867b · Cited by 127
Pre-existing renal disease promotes sepsis-induced acute kidney injury and worsens outcome
Doi, K., Leelahavanichkul, A., Hu, X., Sidransky, K. L., Zhou, H., Qin, Y., Eisner, C. B., Schnermann, J. B., Yuen, P. S. T., & Star, R. A. (2008) · Kidney International · doi:10.1038/ki.2008.346 · Cited by 127
The chronic consequences of severe sepsis
Benjamim, C. F., Hogaboam, C. M., & Kunkel, S. L. (2003) · Journal of Leukocyte Biology · doi:10.1189/jlb.0503214 · Cited by 126
Dang, V. D., Hilgenberg, E., Ries, S., Shen, P., & Fillatreau, S. (2014) · Current Opinion in Immunology · doi:10.1016/j.coi.2014.02.009 · Cited by 128
Comstedt, P., Storgaard, M., & Lassen, A. T. (2009) · Scandinavian Journal of Trauma Resuscitation and Emergency Medicine · doi:10.1186/1757-7241-17-67 · Cited by 131
Targeting the Blood-Brain Barrier to Prevent Sepsis-Associated Cognitive Impairment
Nwafor, D. C., Brichacek, A. L., Mohammad, A. S., Griffith, J. I. G., Lucke-Wold, B. P., Benkovic, S. A., Geldenhuys, W. J., Lockman, P. R., & Brown, C. M. (2019) · Journal of Central Nervous System Disease · doi:10.1177/1179573519840652 · Cited by 126
LiSep LSTM: A Machine Learning Algorithm for Early Detection of Septic Shock
Fagerström, J., Bång, M., Wilhelms, D., & Chew, M. S. (2019) · Scientific Reports · doi:10.1038/s41598-019-51219-4 · Cited by 127
Nolan, A., Kobayashi, H., Naveed, B., Kelly, A., Hoshino, Y., Hoshino, S., Karulf, M., Rom, W. N., Weiden, M. D., & Gold, J. A. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006600 · Cited by 125
Sui, D.-M., Xie, Q., Yi, W.-J., Gupta, S., Yu, X.-Y., Li, J.-B., Wang, J., Wang, J.-F., & Deng, X.-M. (2016) · Mediators of Inflammation · doi:10.1155/2016/1045657 · Cited by 124
Kim, Y., & Park, W. (2016) · Molecules · doi:10.3390/molecules21040450 · Cited by 125
Glutamine: role in critical illness and ongoing clinical trials
Wischmeyer, P. E. (2008) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e3282f4db94 · Cited by 125
Cardoso, T., Carneiro, A. H., Ribeiro, O., Teixeira-Pinto, A. M., & Costa‐Pereira, A. (2010) · Critical Care · doi:10.1186/cc9008 · Cited by 125
Wang, J., Li, J., Zhao, Y.-J., Yi, W., Bian, J., Wan, X., Zhu, K., & Deng, X. (2014) · Anesthesiology · doi:10.1097/aln.0000000000000525 · Cited by 124
Sepsis: Current Definition, Pathophysiology, Diagnosis, and Management
Taeb, A. M., Hooper, M. H., & Marik, P. E. (2017) · Nutrition in Clinical Practice · doi:10.1177/0884533617695243 · Cited by 133
Glucocorticoid regulation of the inflammatory response to injury
Yeager, M. P., Guyre, P. M., & Munck, A. U. (2004) · Acta Anaesthesiologica Scandinavica · doi:10.1111/j.1399-6576.2004.00434.x · Cited by 127
Practice and perception—A nationwide survey of therapy habits in sepsis*
Brunkhorst, F. M., Engel, C., Ragaller, M., Welte, T., Rossaint, R., Gerlach, H., Mayer, K., John, S., Stuber, F., Weiler, N., et al. (2008) · Critical Care Medicine · doi:10.1097/ccm.0b013e318186b6f3 · Cited by 108
Subsequent Infections in Survivors of Sepsis
Wang, T. S., Derhovanessian, A., Cruz, S. D., Belperio, J. A., Deng, J. C., & Hoo, G. W. S. (2012) · Journal of Intensive Care Medicine · doi:10.1177/0885066612467162 · Cited by 123
Legrand, M. M., Gits‐Muselli, M., Boutin, L., Garcia‐Hermoso, D., Maurel, V., Soussi, S., Benyamina, M., Ferry, A., Chaussard, M., Hamane, S., et al. (2016) · Clinical Infectious Diseases · doi:10.1093/cid/ciw563 · Cited by 123
The Mechanism of Superantigen-Mediated Toxic Shock: Not a Simple Th1 Cytokine Storm
Faulkner, L., Cooper, A., Fantino, C., Altmann, D. M., & Sriskandan, S. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.10.6870 · Cited by 122
Autocrine Regulation of Macrophage Activation via Exocytosis of ATP and Activation of P2Y11 Receptor
Sakaki, H., Tsukimoto, M., Harada, H., Moriyama, Y., & Kojima, S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059778 · Cited by 122
Rahman, M., Zhang, S., Chew, M. S., Ersson, A., Jeppsson, B. W., & Thorlacius, H. (2009) · Annals of Surgery · doi:10.1097/sla.0b013e3181bd95b7 · Cited by 122
Quercetin Prevents LPS-Induced High-Mobility Group Box 1 Release and Proinflammatory Function
Tang, D., Kang, R., Xiao, W., Zhang, H., Lotze, M. T., Wang, H., & Xiao, X. (2009) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2008-0119oc · Cited by 124
Zhang, H., Moochhala, S., & Bhatia, M. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.6.4320 · Cited by 122
Timing of Specimen Collection for Blood Cultures from Febrile Patients with Bacteremia
Riedel, S. F., Bourbeau, P. P., Swartz, B., Brecher, S., Carroll, K. C., Stamper, P. D., Dunne, W. M., McCardle, T. W., Walk, N., Fiebelkorn, K. R., et al. (2008) · Journal of Clinical Microbiology · doi:10.1128/jcm.02033-07 · Cited by 122
Hooper, M. H., Weavind, L., Wheeler, A. P., Martin, J. B., Gowda, S. S., Semler, M. W., Hayes, R. M., Albert, D. W., Deane, N. B., Nian, H., et al. (2012) · Critical Care Medicine · doi:10.1097/ccm.0b013e318250a887 · Cited by 121
Sepsis: Something old, something new, and a systems view
Namas, R. A., Zamora, R., Namas, R. A., An, G. C., Doyle, J. C., Dick, T. E., Jacono, F. J., Androulakis, I. P., Nieman, G. F., Chang, S., et al. (2011) · Journal of Critical Care · doi:10.1016/j.jcrc.2011.05.025 · Cited by 123
Schramm, G. E., Kashyap, R., Mullon, J. J., Gajic, O., & Afessa, B. (2010) · Critical Care Medicine · doi:10.1097/ccm.0b013e3181ffde08 · Cited by 124
Chao, P.-W., Shih, C.-J., Lee, Y.-J., Tseng, C.-M., Kuo, S., Shih, Y.-N., Chou, K., Tarng, D., Li, S., Ou, S., et al. (2014) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201406-1170oc · Cited by 122
Mouncey, P., Osborn, T. M., Power, G. S., Harrison, D. A., Sadique, Z., Grieve, R., Jahan, R., Tan, J. C., Harvey, S. E., Bell, D., et al. (2015) · Health Technology Assessment · doi:10.3310/hta19970 · Cited by 125
Klein, E. Y., Mojica, N., Jiang, W., Cosgrove, S. E., Septimus, E. J., Morgan, D. J., & Laxminarayan, R. (2017) · Clinical Infectious Diseases · doi:10.1093/cid/cix640 · Cited by 121
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Hensley, M. K., Donnelly, J. P., Carlton, E. F., & Prescott, H. C. (2019) · Critical Care Medicine · doi:10.1097/ccm.0000000000003896 · Cited by 124
Domadia, P. N., Bhunia, A., Ramamoorthy, A., & Bhattacharjya, S. (2010) · Journal of the American Chemical Society · doi:10.1021/ja1083255 · Cited by 121
Statin Use and Hospitalization for Sepsis in Patients With Chronic Kidney Disease
Gupta, R., Plantinga, L., Fink, N. E., Melamed, M. L., Coresh, J., Fox, C. S., Levin, N. W., & Powe, N. R. (2007) · JAMA · doi:10.1001/jama.297.13.1455 · Cited by 121
Coeliac disease and risk of sepsis
Ludvigsson, J. F., Olén, O., Bell, M., Ekbom, A., & Montgomery, S. (2008) · Gut · doi:10.1136/gut.2007.133868 · Cited by 121
Qian, W., Jacobs, J., Camp, D., Monroe, M. E., Moore, R., Gritsenko, M. A., Calvano, S. E., Lowry, S. F., Xiao, W., Moldawer, L. L., et al. (2005) · PROTEOMICS · doi:10.1002/pmic.200400942 · Cited by 125
Kim, E. Y., Rajasekaran, G., & Shin, S. Y. (2017) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2017.05.028 · Cited by 120
Simon, L., Saint-Louis, P., Amre, D. K., Lacroix, J., & Gauvin, F. (2008) · Pediatric Critical Care Medicine · doi:10.1097/pcc.0b013e31817285a6 · Cited by 120
Rodríguez, F., Barrera, L., Rosa, G. D. L., Dennis, R., Castell, C. R. D., Granados, M., Londoño, D., Molina, F., Ortíz, G., & Jaimes, F. A. (2011) · Critical Care Medicine · doi:10.1097/ccm.0b013e318218a35e · Cited by 119
Future Challenges And Treatment Of Staphylococcus Aureus Bacteremia With Emphasis On MRSA
Rasmussen, R. V., Fowler, V. G., Skov, R. L., & Bruun, N. E. (2010) · Future Microbiology · doi:10.2217/fmb.10.155 · Cited by 121
Janz, D. R., Bastarache, J. A., Rice, T. W., Bernard, G. R., Warren, M. A., Wickersham, N. E., Sills, G., Oates, J. A., Roberts, L. J., & Ware, L. B. (2014) · Critical Care Medicine · doi:10.1097/ccm.0000000000000718 · Cited by 121
Wu, Y., Wang, F., Fan, X., Bao, R., Bo, L., Li, J., & Deng, X. (2012) · Critical Care · doi:10.1186/cc11884 · Cited by 119
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Mathias, B. J., Szpila, B. E., Moore, F. A., Efron, P. A., & Moldawer, L. L. (2015) · Medicine · doi:10.1097/md.0000000000002044 · Cited by 123
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Dorsett, M., Kroll, M., Smith, C. S., Asaro, P. V., Liang, S. Y., & Moy, H. P. (2017) · Prehospital Emergency Care · doi:10.1080/10903127.2016.1274348 · Cited by 128
Donnelly, J. P., Safford, M. M., Shapiro, N. I., Baddley, J. W., & Wang, H. E. (2017) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(17)30117-2 · Cited by 119
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Jaimes, F. A., Farbiarz, J. F., Álvarez, D., & Martínez, C. (2005) · Critical Care · doi:10.1186/cc3054 · Cited by 119
Lin, S., Wang, Y.-M., Lin, H.-C., Lee, K., Huang, C., Liu, C., Wang, C., & Kuo, H.-P. (2008) · Critical Care Medicine · doi:10.1097/ccm.0b013e31816537d8 · Cited by 119
Maternal sepsis: a Scottish population‐based case–control study
Acosta, C., Bhattacharya, S., Tuffnell, D. J., Kurinczuk, J. J., & Knight, M. (2012) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2011.03239.x · Cited by 119
Escames, G., Acuña-Castroviejo, D., López, L. C., Tan, D.-X., Maldonado, M. D., Sánchez-Hidalgo, M., León, J., & Reiter, R. J. (2006) · Journal of Pharmacy and Pharmacology · doi:10.1211/jpp.58.9.0001 · Cited by 118
Defining the frontiers between antifungal resistance, tolerance and the concept of persistence
Delarze, E., & Sanglard, D. (2015) · Drug Resistance Updates · doi:10.1016/j.drup.2015.10.001 · Cited by 118
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Kraneveld, E. A., Buijs, M. J., Bonder, M. J., Visser, M., Keijser, B. J. F., Crielaard, W., & Zaura, E. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042770 · Cited by 118
Mortality in sepsis versus non-sepsis induced acute lung injury
Sevransky, J., Martin, G. S., Shanholtz, C. B., Méndez-Téllez, P. A., Pronovost, P. J., Brower, R. G., & Needham, D. M. (2009) · Critical Care · doi:10.1186/cc8048 · Cited by 119
Self-citationWilhelms, S. B., Huss, F. R. M., Granath, G., & Sjöberg, F. (2010) · Critical Care Medicine · doi:10.1097/ccm.0b013e3181de4406 · Cited by 118
Association of low serum 25-hydroxyvitamin D levels and acute kidney injury in the critically ill*
Braun, A. B., Litonjua, A. A., Moromizato, T., Gibbons, F. K., Giovannucci, E. L., & Christopher, K. B. (2012) · Critical Care Medicine · doi:10.1097/ccm.0b013e318260c928 · Cited by 118
Epidemiology of severe sepsis in Japanese intensive care units: A prospective multicenter study
Ogura, H., Gando, S., Saitoh, D., Takeyama, N., Kushimoto, S., Fujishima, S., Mayumi, T., Araki, T., Ikeda, H., Kotani, J., et al. (2013) · Journal of Infection and Chemotherapy · doi:10.1016/j.jiac.2013.07.006 · Cited by 118
Bhagirath, V. C., Dwivedi, D. J., & Liaw, P. C. (2015) · Shock · doi:10.1097/shk.0000000000000397 · Cited by 118
Endotoxin-Induced Myocardial Dysfunction
Chagnon, F., Metz, C. N., Bucala, R., & Lesur, O. (2005) · Circulation Research · doi:10.1161/01.res.0000168327.22888.4d · Cited by 118
Stimulated Production of Proinflammatory Cytokines Covaries Inversely With Heart Rate Variability
Marsland, A. L., Gianaros, P. J., Prather, A. A., Jennings, J. R., Neumann, S. A., & Manuck, S. B. (2007) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181576118 · Cited by 122
Li, Q., Wang, C., Tang, C. X., He, Q., Zhao, X., Li, N., & Li, J. (2015) · Critical Care · doi:10.1186/s13054-015-0738-7 · Cited by 120
Brekke, O., Christiansen, D., Fure, H., Fung, M. S. C., & Mollnes, T. E. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.0806538 · Cited by 118
Lewis, D. H., Chan, D. L., Pinheiro, D., Armitage‐Chan, E. A., & Garden, O. A. (2012) · Journal of Veterinary Internal Medicine · doi:10.1111/j.1939-1676.2012.00905.x · Cited by 125
Bloodstream Infections: The peak of the iceberg
Viscoli, C. (2016) · Virulence · doi:10.1080/21505594.2016.1152440 · Cited by 118
The Heart in Sepsis: From Basic Mechanisms to Clinical Management
Rudiger, A., & Singer, M. (2013) · Current Vascular Pharmacology · doi:10.2174/1570161111311020008 · Cited by 118
Epidemiologic Trend of Severe Sepsis in Taiwan From 1997 Through 2006
Shen, H.-N., Lu, C., & Yang, H.-H. (2010) · CHEST Journal · doi:10.1378/chest.09-2205 · Cited by 117
Extracorporeal membrane oxygenation for refractory septic shock in adults
Park, T. K., Yang, J. H., Jeon, K., Choi, S., Choi, J., Gwon, H., Chung, C. R., Park, C.-M., Cho, Y. H., Sung, K., et al. (2014) · European Journal of Cardio-Thoracic Surgery · doi:10.1093/ejcts/ezu462 · Cited by 117
Prevalence and risk factors of sepsis-induced cardiomyopathy
Sato, R., Kuriyama, A., Takada, T., Nasu, M., & Luthe, S. K. (2016) · Medicine · doi:10.1097/md.0000000000005031 · Cited by 119
Surviving Sepsis Campaign: Research Priorities for Sepsis and Septic Shock
Coopersmith, C. M., Backer, D. D., Deutschman, C. S., Ferrer, R., Lat, I., Machado, F. R., Martin, G. S., Martín‐Loeches, I., Nunnally, M., Antonelli, M. M., et al. (2018) · Critical Care Medicine · doi:10.1097/ccm.0000000000003225 · Cited by 117
Self-citationLi, Y., Li, H., & Zhang, D. (2020) · Critical Care · doi:10.1186/s13054-020-03204-x · Cited by 122
Prevalence and incidence of severe sepsis in Dutch intensive care units
van Gestel, A., Bakker, J., Veraart, C. P. W. M., & van Hout, B. A. (2004) · Critical Care · doi:10.1186/cc2858 · Cited by 117
Endocarditis Caused by Staphylococcus aureus
Guerrero, M. L. F., González‐López, J. J., Goyenechea, A., Fraile, J., & Górgolas, M. (2009) · Medicine · doi:10.1097/md.0b013e318194da65 · Cited by 120
Terblanche, M., Almog, Y., Rosenson, R. S., Smith, T. S., & Hackam, D. G. (2006) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(06)70439-x · Cited by 118
Lee, S. J., Ramar, K., Park, J. G., Gajic, O., Li, G., & Kashyap, R. (2014) · CHEST Journal · doi:10.1378/chest.13-2702 · Cited by 118
Linder, A., Arnold, R., Boyd, J. H., Zindovic, M., Zindovic, I., Lange, A., Paulsson, M., Nyberg, P. B., Russell, J. A., Pritchard, D. M., et al. (2015) · Critical Care Medicine · doi:10.1097/ccm.0000000000001265 · Cited by 116
Sinha, S., Zheng, L., Mu, Y., Ng, W. J., & Bhattacharjya, S. (2017) · Scientific Reports · doi:10.1038/s41598-017-18102-6 · Cited by 119
the SepNet Critical Care Trials Group, Elke, G., Bloos, F., Wilson, D. C., Brunkhorst, F. M., Briegel, J., Reinhart, K., Loeffler, M., Kluge, S., Nierhaus, A., et al. (2018) · Critical Care · doi:10.1186/s13054-018-2001-5 · Cited by 116
ELEVATED SERUM ANGIOPOIETIN 2 LEVELS ARE ASSOCIATED WITH INCREASED MORTALITY IN SEPSIS
Siner, J. M., Bhandari, V., Engle, K. M., Elias, J. A., & Siegel, M. D. (2009) · Shock · doi:10.1097/shk.0b013e318188bd06 · Cited by 116
Molecular Epidemiology of Candidemia: Evidence of Clusters of Smoldering Nosocomial Infections
Ásmundsdóttir, L. R., Erlendsdóttir, H., Haraldsson, G., Guo, H., Xu, J., & Gottfreðsson, M. (2008) · Clinical Infectious Diseases · doi:10.1086/589298 · Cited by 118
Inflammasome-mediated GSDMD activation facilitates escape of Candida albicans from macrophages
Ding, X., Kambara, H., Guo, R., Kanneganti, A., Acosta-Zaldívar, M., Li, J., Liu, F., Bei, T., Qi, W., Xie, X., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-27034-9 · Cited by 115
Natural products as antifungal agents against clinically relevant pathogens
Di Santo, R. (2010) · Natural Product Reports · doi:10.1039/b914961a · Cited by 115
Park, I. H., Kim, K., Andrade, A. L., Briles, D. E., McDaniel, L. S., & Nahm, M. H. (2012) · mBio · doi:10.1128/mbio.00035-12 · Cited by 115
Diagnosis of infection in sepsis: An evidence-based review
Cohen, J., Brun‐Buisson, C., Torres, A., & Jorgensen, J. (2004) · Critical Care Medicine · doi:10.1097/01.ccm.0000145917.89975.f5 · Cited by 118
Metadata
- Authors
- Martin, G. S., Mannino, D. M., Eaton, S., & Moss, M.
- Affiliations
- Emory University (US)
- Centers for Disease Control and Prevention (US)
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2003-04-17
- Volume
- 348
- Issue
- 16
- Pages
- 1546-1554
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2145577370
- Cited by
- 5,841
- References
- 48
- Citations by year
- 2026: 67 · 2025: 128 · 2024: 149 · 2023: 168 · 2022: 167 · 2021: 253 · 2020: 231 · 2019: 211 · 2018: 226 · 2017: 329 · 2016: 292 · 2015: 341 · 2014: 381 · 2013: 436 · 2012: 365
- FWCI
- 123.48
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- UKnowledge (University of Kentucky) (submittedVersion)
- Funders
- National Institute on Alcohol Abuse and Alcoholism (AA R01-11660, R01AA011660)
- National Heart, Lung, and Blood Institute (K23HL067739, HL K23-67739)
- National Center for Research Resources (L30 RR020488)
- Topics
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Sepsis Diagnosis and Treatment
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and Maternal Infections
- Life Sciences › Immunology and Microbiology › Microbiology › Bacterial Infections and Vaccines
- Keywords
- PSIS, sepsis incidence, sepsis mortality, temporal trends, racial disparities, sex differences, Gram-positive bacteria, fungal infection, sepsis pathogens, organ failure, length of hospital stay, hospital discharge disposition, Black men, hospital discharge data, acute care hospitals, healthcare burden
- MeSH terms
- Female, Humans, Male, Middle Aged, Multiple Organ Failure, Sex Factors, United States, Incidence, Survival Rate, Hospital Mortality, Sepsis, Racial Groups
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