The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
A Longitudinal, Population-Based, Cohort Study of Childhood Asthma Followed to Adulthood
Open accessAbstract
BACKGROUND: The outcome of childhood asthma in adults has been described in high-risk cohorts, but few population-based studies have reported the risk factors for persistence and relapse. METHODS: We assessed children born from April 1972 through March 1973 in Dunedin, New Zealand, repeatedly from 9 to 26 years of age with questionnaires, pulmonary-function tests, bronchial-challenge testing, and allergy testing. RESULTS: By the age of 26 years, 51.4 percent of 613 study members with complete respiratory data had reported wheezing at more than one assessment. Eighty-nine study members (14.5 percent) had wheezing that persisted from childhood to 26 years of age, whereas 168 (27.4 percent) had remission, but 76 (12.4 percent) subsequently relapsed by the age of 26. Sensitization to house dust mites predicted the persistence of wheezing (odds ratio, 2.41; P=0.001) and relapse (odds ratio, 2.18; P=0.01), as did airway hyperresponsiveness (odds ratio for persistence, 3.00; P<0.001; odds ratio for relapse, 3.03; P<0.001). Female sex predicted the persistence of wheezing (odds ratio, 1.71; P=0.03), as did smoking at the age of 21 years (odds ratio, 1.84; P=0.01). The earlier the age at onset, the greater the risk of relapse (odds ratio, 0.89 per year of increase in the age at onset; P<0.001). Pulmonary function was consistently lower in those with persistent wheezing than in those without persistent wheezing. CONCLUSIONS: In an unselected birth cohort, more than one in four children had wheezing that persisted from childhood to adulthood or that relapsed after remission. The factors predicting persistence or relapse were sensitization to house dust mites, airway hyperresponsiveness, female sex, smoking, and early age at onset. These findings, together with persistently low lung function, suggest that outcomes in adult asthma may be determined primarily in early childhood.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Among many factors, house dust mite (HDM) is the most prevalent cause of allergic sensitization [4, 6], and a risk factor for persistent asthma in human subjects [7, 8].”
In the citing paper
“The majority of studies have shown that persistent wheeze is related to reduced lung function development throughout adolescence (31, 45, 152, 153), while some suggest the effects of persistent wheeze and relapsed wheeze on lung function are established from mid-childhood, without further decline in tracking of FEV1 over time (154, 155).”
From Epidemiology of Asthma in Children and Adults (2019) · cites this paper as [154]
In the citing paper
“While a number of studies have reported that childhood asthma itself has no impact on adult lung function decline (154, 157, 158, 160), a study that collected childhood asthma status retrospectively has reported that it is associated with greater lung function decline, which may be related to recall bias (161).”
From Epidemiology of Asthma in Children and Adults (2019) · cites this paper as [154]
Citations
Cites
Beasley, R. W. (1998) · The Lancet · doi:10.1016/s0140-6736(97)07302-9 · Cited by 3,794
Standardization of bronchial inhalation challenge procedures
Chai, H., Farr, R. S., Froehlich, L. A., Mathison, D. A., McLean, J. A., Rosenthal, R. R., Sheffer, A. L., Spector, S. L., & Townley, R. G. (1975) · Journal of Allergy and Clinical Immunology · doi:10.1016/0091-6749(75)90107-4 · Cited by 1,452
Epidemiology Standardization Project (American Thoracic Society).
Bg, F. (1978) · PubMed · Cited by 1,344
Strachan, D. P., Butland, B. K., & ANDERSON, H. R. (1996) · BMJ · doi:10.1136/bmj.312.7040.1195 · Cited by 654
Sears, M. R., Herbison, P., Holdaway, M. D., Hewitt, C. J., Flannery, E. M., & SILVA, P. A. (1989) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.1989.tb02408.x · Cited by 597
The melbourne asthma study: 1964–1999
Phelan, P. D., Robertson, C. F., & Olinsky, A. (2002) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2002.120951 · Cited by 503
From child to adult : the Dunedin multidisciplinary health and development study
Silva, P. A., & Stanton, W. R. (1996) · Oxford University Press eBooks · Cited by 407
Factors in childhood as predictors of asthma in adult life
Jenkins, M. A., Hopper, J. L., Bowes, G., Carlin, J. B., Flander, L. B., & Giles, G. G. (1994) · BMJ · doi:10.1136/bmj.309.6947.90 · Cited by 257
Continued increase in the prevalence of asthma and atopy
Downs, S. H. (2001) · Archives of Disease in Childhood · doi:10.1136/adc.84.1.20 · Cited by 236
Early life risk factors for adult asthma: A birth cohort study of subjects at risk
Rhodes, H. L., Sporik, R. B., Thomas, P., Holgate, S. T., & Cogswell, J. J. (2001) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2001.119151 · Cited by 231
Research works printed but not linked: 2
- Ferris BG, 1978, Am Rev Respir Dis, 118, 1
- Sinclair SW, 1980, N Z Med J, 91, 1
Cited by
Sorted by citations
Items 301–400 of 1,000
Predictors of lung function trajectories in population‐based studies: A systematic review
Okyere, D. O., Bui, D., Washko, G. R., Lodge, C., Lowe, A. J., Cassim, R., Perret, J. L., Abramson, M. J., Walters, E. H., Waidyatillake, N. T., et al. (2021) · Respirology · doi:10.1111/resp.14142 · Cited by 58
Disparities in Pulmonary Function in Healthy Children across the Indian Urban–Rural Continuum
Sonnappa, S., Lum, S., Kirkby, J. C., Bonner, R., Wade, A. M., Subramanya, V., Lakshman, P. T., Rajan, B., Nooyi, S. C., & Stocks, J. (2014) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201406-1049oc · Cited by 56
Hallas, H. W., Chawes, B., Rasmussen, M. A., Arianto, L., Stokholm, J., Bønnelykke, K., & Bisgaard, H. F. (2019) · PLoS Medicine · doi:10.1371/journal.pmed.1002722 · Cited by 60
Pediatric asthma incidence rates in the United States from 1980 to 2017
Johnson, C. C., Havstad, S. L., Ownby, D. R., Joseph, C. L. M., Sitarik, A. R., Myers, J. M. B., Gebretsadik, T. S., Hartert, T. V., Hershey, G. K. K., Jackson, D. J., et al. (2021) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2021.04.027 · Cited by 56
Edwards, M. R., Saglani, S., Schwarze, J., Skevaki, C., Smith, J. A., Ainsworth, B., Almond, M., Andreakos, E., Belvisi, M. G., Chung, K. F., et al. (2017) · European Respiratory Journal · doi:10.1183/13993003.02448-2016 · Cited by 55
The Critically Ill Asthmatic—from ICU to Discharge
Louie, S., Morrissey, B. M., Kenyon, N. J., Albertson, T. E., & Avdalovic, M. V. (2011) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-011-8274-y · Cited by 55
“The majority of adult patients seen in asthma referral clinics are women and this is in contrast to the pediatric population where boys are more prevalent [14].”
BackgroundAnalyzing atopic and non-atopic asthma
Pekkanen, J., Lampi, J., Genuneit, J., Hartikainen, A., & Järvelin, M. (2012) · European Journal of Epidemiology · doi:10.1007/s10654-012-9649-y · Cited by 55
“Allergens are major triggers of asthma attacks and being atopic increases the risk of persistent asthma [1, 2].”
BackgroundKanemitsu, Y., Ito, I., Niimi, A., Izuhara, K., Ohta, S., Ono, J., Iwata, T., Matsumoto, H., & Mishima, M. (2014) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201403-0562le · Cited by 55
Transition for Adolescents and Young Adults With Asthma
Withers, A., & Green, R. (2019) · Frontiers in Pediatrics · doi:10.3389/fped.2019.00301 · Cited by 57
Fetal Origins of Asthma: A Longitudinal Study from Birth to Age 36 Years
Guerra, S., Lombardi, E., Stern, D. A., Sherrill, D. L., Gilbertson-Dahdal, D. L., Wheatley, C. M., Snyder, E. M., Wright, A. L., Martínez, F. D., & Morgan, W. J. (2020) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202001-0194oc · Cited by 55
“Our findings have also potential implications for risk stratification because they could contribute to the early identification of patients with persistent asthma who are at high risk for long-term sequelae of the disease (43, 44), although the feasibility of programs to measure infant lung function indices derived fr…”
BackgroundPreschool oscillometry and lung function at adolescence in asthmatic children
Knihtilä, H. M., Kotaniemi‐Syrjänen, A., Mäkelä, M. J., Bondestam, J., Pelkonen, A. S., & Malmberg, L. P. (2015) · Pediatric Pulmonology · doi:10.1002/ppul.23188 · Cited by 54
Predictors for wheezing phenotypes in the first decade of life
Midodzi, W. K., Rowe, B. H., Majaesic, C. M., Saunders, L. D., & Senthilselvan, A. (2008) · Respirology · doi:10.1111/j.1440-1843.2008.01284.x · Cited by 54
Kirenga, B., de Jong, C., Katagira, W., Kasozi, S., Mugenyi, L., Boezen, M., van der Molen, T., & Kamya, M. R. (2019) · BMC Public Health · doi:10.1186/s12889-019-6562-2 · Cited by 54
Trajectories of Lung Function in Infants and Children: Setting a Course for Lifelong Lung Health
Jordan, B. K., & McEvoy, C. T. (2020) · PEDIATRICS · doi:10.1542/peds.2020-0417 · Cited by 55
“individuals, lung function increases throughout childhood, plateaus in early adulthood, and declines in adulthood with the normal aging process.(6,29,39,55) Longitudinal studies of lung function have demonstrated that these trajectories of lung function are established in early infancy and that lung function measured…”
BackgroundChildhood asthma and GOLD‐defined chronic obstructive pulmonary disease
Shirtcliffe, P., Marsh, S., Travers, J., Weatherall, M., & Beasley, R. W. (2010) · Internal Medicine Journal · doi:10.1111/j.1445-5994.2010.02238.x · Cited by 54
Wennergren, G., Ekerljung, L., Alm, B., Eriksson, J., Lötvall, J. O., & Lundbäck, B. (2010) · Pediatric Allergy and Immunology · doi:10.1111/j.1399-3038.2010.01057.x · Cited by 54
“The strong relationship between allergy and asthma is consistently shown in long-term follow-ups of asthma from childhood to adulthood (2, 3, 26).”
BackgroundFedele, D. A., Barnett, T. E., Dekevich, D., Gibson‐Young, L., Martinasek, M. P., & Jagger, M. A. (2016) · Annals of Epidemiology · doi:10.1016/j.annepidem.2016.10.004 · Cited by 54
Challenges in the treatment of asthma in children and adolescents
Szefler, S. J., & Chipps, B. E. (2018) · Annals of Allergy Asthma & Immunology · doi:10.1016/j.anai.2018.01.003 · Cited by 56
Paternal History of Asthma and Airway Responsiveness in Children with Asthma
Raby, B. A., Steen, K. V., Celedon, J. C., Litonjua, A. A., Lange, C., & Weiss, S. T. (2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200501-010oc · Cited by 54
“org viduals with asthma, AHR is directly correlated with pulmonary symptoms and disease severity (2) and is an important determinant of long-term outcome, not only with respect to asthma symptoms (3) but also to airway growth and maturation (4) and lung function decline (5).”
BackgroundRemission of asthma: The next therapeutic frontier?
Upham, J. W., & James, A. L. (2011) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2011.01.002 · Cited by 52
“…asthma is commonly defined as the current absence of asthma symptoms for a prolonged period of time, as outlined in Table 1 (Bronnimann & Burrows, 1986; Boulet et al., 1994; Ronmark et al., 1999; De Marco et al., 2002; Horak et al., 2003; Sears et al., 2003; Vonk et al., 2004; Holm et al., 2007).”
BackgroundMosnaim, G. S. (2023) · New England Journal of Medicine · doi:10.1056/nejmcp2304871 · Cited by 52
Gerlich, J., Dressel, H., Vogelberg, C., Leupold, W., Windstetter, D., Weinmayr, G., Genuneit, J., Heumann, C., Nowak, D., von Mutius, E., et al. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.08.016 · Cited by 52
Genome-wide association study of the age of onset of childhood asthma
Forno, E., Lasky-Su, J. A., Himes, B. E., Howrylak, J. A., Ramsey, C. D., Brehm, J. M., Klanderman, B. J., Ziniti, J. P., Melén, E., Pershagen, G., et al. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.03.020 · Cited by 52
Chawes, B., Buchvald, F. F., Bischoff, A. L., Loland, L., Hermansen, M. N., Halkjær, L. B., Bønnelykke, K., & Bisgaard, H. F. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200909-1377oc · Cited by 52
Duijts, L., Granell, R., Sterne, J. A. C., & Henderson, A. J. (2015) · European Respiratory Journal · doi:10.1183/13993003.00718-2015 · Cited by 53
Predicting Asthma Using Clinical Indexes
Castro-Rodríguez, J. A., Cifuentes, L. I., & Martinez, F. D. (2019) · Frontiers in Pediatrics · doi:10.3389/fped.2019.00320 · Cited by 52
Childhood Chest Illness and the Rate of Decline of Adult Lung Function between Ages 35 and 45 Years
Marossy, A., Strachan, D. P., Rudnicka, A. R., & ANDERSON, H. R. (2006) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200607-1023oc · Cited by 52
“Sears et al ( 16 ) drew a similar conclusion, finding the slopes of”
BackgroundResultInfluentialWheezing and Asthma in childhood: an epidemiology approach
Castro-Rodríguez, J. A., & García‐Marcos, L. (2008) · Allergologia et Immunopathologia · doi:10.1016/s0301-0546(08)75224-8 · Cited by 51
Early Origins of Chronic Obstructive Pulmonary Disease: Prenatal and Early Life Risk Factors
Deolmi, M., Decarolis, N. M., Motta, M., Makrinioti, H., Fainardi, V., Pisi, G., & Esposito, S. (2023) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20032294 · Cited by 60
Omalizumab in Japanese children with severe allergic asthma uncontrolled with standard therapy
Odajima, H., Ebisawa, M., Nagakura, T., Fujisawa, T., Akasawa, A., Ito, K., Doi, S., Yamaguchi, K., Katsunuma, T., Kurihara, K., et al. (2015) · Allergology International · doi:10.1016/j.alit.2015.05.006 · Cited by 51
Has the time come to rethink the pathogenesis of asthma?
Holgate, S. T. (2010) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/aci.0b013e3283347be5 · Cited by 51
Epidemiology of asthma: risk factors for development
Subbarao, P., Becker, A. B., Brook, J. R., Daley, D., Mandhane, P. J., Miller, G. E., Turvey, S. E., & Sears, M. R. (2008) · Expert Review of Clinical Immunology · doi:10.1586/1744666x.5.1.77 · Cited by 55
“Increased effects of smoking and obesity on asthma among female Canadians: the National Population Health Survey, 1994–1995. Am. J. Epidemiol.150(3), 255–262 (1999).”
InfluentialThe Effect of Cigarette Smoking on Lung Function in Young Adults with Asthma
Hancox, R. J., Gray, A. R., Poulton, R., & Sears, M. R. (2016) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201512-2492oc · Cited by 52
Pediatric Asthma: A Different Disease
Gelfand, E. W. (2009) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200808-090rm · Cited by 51
ENVIRONMENTAL FACTORS AND GENE–ENVIRONMENT INTERACTIONS IN THE AETIOLOGY OF ASTHMA
Marks, G. B. (2006) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2006.04360.x · Cited by 51
Exhaled nitric oxide, lung function, and exacerbations in wheezy infants and toddlers
Debley, J. S., Stamey, D., Cochrane, E. S., Gama, K. L., & Redding, G. J. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.03.023 · Cited by 50
“Data from large longitudinal pediatric cohort studies suggest that decreases in lung function in asthmatic subjects occur early in childhood, with little decrease from age 6 years onward.(33-35) Although our results clearly demonstrate an association between FENO and change in lung function, we do not believe that the…”
Childhood Respiratory Illness and Lung Function at Ages 14 and 50 Years
Tennant, P. W. G., Gibson, G. J., Parker, L., & Pearce, M. S. (2009) · CHEST Journal · doi:10.1378/chest.09-0352 · Cited by 50
Defining Impaired Respiratory Health. A Paradigm Shift for Pulmonary Medicine
Reyfman, P. A., Washko, G. R., Dransfield, M. T., Spira, A. E., Han, M. K., & Kalhan, R. (2018) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201801-0120pp · Cited by 52
Improving the global diagnosis and management of asthma in children
Lenney, W., Bush, A., Fitzgerald, D. A., Fletcher, M. J., Østrem, A., Pedersen, S., Szefler, S. J., & Zar, H. J. (2018) · Thorax · doi:10.1136/thoraxjnl-2018-211626 · Cited by 52
Epithelial-interleukin-1 inhibits collagen formation by airway fibroblasts: Implications for asthma
Osei, E. T., Mostaço-Guidolin, L. B., Hsieh, A., Warner, S., Fouadi, M., Wang, M. X., Cole, D. J., Maksym, G. N., Hallstrand, T. S., Timens, W., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-65567-z · Cited by 55
Wheeze trajectories: Determinants and outcomes in the CHILD Cohort Study
Dai, R., Miliku, K., Gaddipati, S., Choi, J., Ambalavanan, A., Tran, M. M., Reyna, M. E., Sbihi, H., Lou, W. Y. W., Parvulescu, P., et al. (2021) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2021.10.039 · Cited by 56
Agreement between parental and self‐completed questionnaires about asthma in teenagers
Hedman, L., Lindgren, B., Perzanowski, M. S., & Rönmark, E. (2005) · Pediatric Allergy and Immunology · doi:10.1111/j.1399-3038.2005.00231.x · Cited by 50
Early predictors of asthma and allergy in children
DeVries, A., & Vercelli, D. (2015) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/aci.0000000000000201 · Cited by 50
“Epidemiologic studies [3,4] indicate that asthma begins in the preschool years even when chronic symptoms do not appear until early adulthood.”
BackgroundLessons learned from birth cohort studies conducted in diverse environments
Jackson, D. J., Gern, J. E., & Lemanske, R. F. (2017) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2016.12.941 · Cited by 51
“A long-term prospective study evaluating the natural history of lung function in various wheezing phenotypes has been conducted by investigators in Melbourne, Australia.(35,39) Although the participants began being observed at age 9 years, follow-up has been out to age 26 years.”
InfluentialEarly life determinants of lung function change from childhood to adolescence
Schultz, E. S., Hallberg, J., Andersson, N., Thacher, J. D., Pershagen, G., Bellander, T., Bergström, A., Kull, I., Guerra, S., Thunqvist, P., et al. (2018) · Respiratory Medicine · doi:10.1016/j.rmed.2018.04.009 · Cited by 51
The irreversible component of persistent asthma
Pascual, R. M., & Peters, S. P. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.09.047 · Cited by 49
Genetic Variation in Vascular Endothelial Growth Factor-A and Lung Function
Simpson, A., Čustović, A., Tepper, R. S., Graves, P. E., Stern, D. A., Jones, M. H., Hankinson, J., Curtin, J. A., Wu, J., Blekić, M., et al. (2012) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201112-2191oc · Cited by 48
“Longitudinal cohort studies indicate that lung function tracks throughout childhood into adult life (6, 7) and poor lung function is associated with adverse outcomes, including increased mortality (8).”
Indicators, O. (2009) · Cited by 48
Garden, F. L., Simpson, J. M., Mellis, C. M., & Marks, G. B. (2015) · European Respiratory Journal · doi:10.1183/13993003.00284-2015 · Cited by 48
Inflammatory mechanisms linking maternal and childhood asthma
Lebold, K. M., Jacoby, D. B., & Drake, M. G. (2020) · Journal of Leukocyte Biology · doi:10.1002/jlb.3mr1219-338r · Cited by 54
Borrego, L. M., Stocks, J., Pinto, P., Peralta, I., Romeira, A., Neuparth, N. M. B., Rosado‐Pinto, J., & Hoo, A. (2008) · Thorax · doi:10.1136/thx.2008.099903 · Cited by 48
“3 4 5–7 A recently described clinical index considers young children with recurrent wheezing in the first 3 years of life to be at high risk of developing asthma if there is a parental history of asthma or personal history of eczema, or if two of the following are present: personal history of…”
BackgroundAsthma Remission by Age at Diagnosis and Gender in a Population-Based Study
Honkamäki, J., Piirilä, P. L., Hisinger‐Mölkänen, H., Tuomisto, L. E., Andersén, H., Huhtala, H., Sovijärvi, A. R. A., Lindqvist, A. E., Bäckman, H., Lundbäck, B., et al. (2020) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2020.12.015 · Cited by 47
Leigh, R., & Proud, D. (2014) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2014.12.005 · Cited by 47
“Although asthma can occur at any age, it is usually already evident in childhood in themajority of patients (Gern et al., 1999; Sears et al., 2003).”
BackgroundBaumann, L. M., Robinson, C. L., Combe, J., Gomez, A., Romero, K. M., Gilman, R. H., Cabrera, L. Z., Hansel, N. N., Wise, R. A., Breysse, P. N., et al. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.11.031 · Cited by 47
“Measures of airflow limitation (27) decreased with closer proximity to the avenue in girls but not in boys.”
BackgroundHasnain, S. M., Al-Frayh, A. R., Subiza, J. L., Fernández‐Caldas, E., Casanovas, M., Geith, T., El-Rab, M. O. G., Koshak, E. A., Almehdar, H. A., Alsowaidi, S., et al. (2012) · Europe PMC (PubMed Central) · doi:10.1097/wox.0b013e31825a73cd · Cited by 47
“Sensitization to their allergens has been repeatedly associated with severe and persistent asthma.(10) In Saudi Arabia, there is considerable variation in temperature and humidity because of the influence of subtropical high-pressure systems and the many fluctuations in elevation.”
BackgroundMohr, L. B., Luo, S., Mathias, E., Tobing, R., Homan, S. M., & Sterling, D. A. (2008) · Journal of Asthma · doi:10.1080/02770900802404082 · Cited by 46
Age at asthma onset and subsequent asthma outcomes among adults with active asthma
Mirabelli, M. C., Beavers, S. F., Chatterjee, A. B., & Moorman, J. E. (2013) · Respiratory Medicine · doi:10.1016/j.rmed.2013.09.022 · Cited by 46
Fitzpatrick, A. M., & Teague, W. G. (2010) · Pediatric Allergy Immunology and Pulmonology · doi:10.1089/ped.2010.0021 · Cited by 46
“The Dunedin Multidisciplinary Health and Development Study was one of the first to highlight abnormalities in pulmonary function in school-age children according to clinical phenotype.(41) In this birth cohort study, children with persistent wheezing or wheezing that relapsed (ie, reappeared after symptom cessation) s…”
BackgroundAl-Shamrani, A., Bagais, K., Alenazi, A. M., Alqwaiee, M. M., & Alharbi, A. S. (2019) · International Journal of Pediatrics and Adolescent Medicine · doi:10.1016/j.ijpam.2019.02.003 · Cited by 52
Role of Type2 Inflammatory Biomarkers in Chronic Obstructive Pulmonary Disease
Oishi, K., Matsunaga, K., Shirai, T., Hirai, K., & Gon, Y. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9082670 · Cited by 49
The significance of early recurrent wheeze for asthma outcomes in late childhood
Hovland, V., Riiser, A., Mowinckel, P., Carlsen, K., & Carlsen, K. C. L. (2012) · European Respiratory Journal · doi:10.1183/09031936.00071512 · Cited by 45
Epigenetics in allergic diseases
DeVries, A., & Vercelli, D. (2015) · Current Opinion in Pediatrics · doi:10.1097/mop.0000000000000285 · Cited by 45
“Although epidemiologic studies indicate that the disease begins in the preschool years even when chronic symptoms appear in early adulthood [4,5], firm diagnostic criteria to distinguish children who will wheeze transiently during early-life lower respiratory illnesses from children who will wheeze persistently, and t…”
BackgroundSmoking exposure and allergic sensitization in children according to maternal allergies
Rahérison, C., Pénard-Morand, C., Moreau, D., Caillaud, D. M., Charpin, D., Kopferschmitt, C., Lavaud, F., Taytard, A., & Annesi‐Maesano, I. (2008) · Annals of Allergy Asthma & Immunology · doi:10.1016/s1081-1206(10)60598-4 · Cited by 44
Krauss‐Etschmann, S., Bush, A., Bellusci, S., Brusselle, G., Dahlén, S. E., Dehmel, S., Eickelberg, O., Gibson, G. C., Hylkema, M. N., Knaus, P. I., et al. (2012) · Thorax · doi:10.1136/thoraxjnl-2012-201902 · Cited by 43
Jackson, C. M., Mukherjee, S., Wilburn, A. N., Cates, C., Lewkowich, I. P., Deshmukh, H. S., Zacharias, W. J., & Chougnet, C. A. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01285 · Cited by 45
Using genetics to predict the natural history of asthma?
Holloway, J. W., Arshad, S. H., & Holgate, S. T. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.06.006 · Cited by 47
“Nonatopic asthma is not uncommon in childhood(9) but is more prevalent in adults, especially among women.(5) Thus most asthma starts during the first decade of life, and as one goes through adolescence, it persists in some and improves in others.”
BackgroundInfluentialPathophysiological characterization of asthma transitions across adolescence
Arshad, S. H., Raza, A., Lau, L. C. K., Bawakid, K. O., Karmaus, W., Zhang, H., Ewart, S., Patil, V., Roberts, G. C., & Kurukulaaratchy, R. J. (2014) · Respiratory Research · doi:10.1186/s12931-014-0153-7 · Cited by 43
“The rate of asthma remission during adolescence has been variably reported to range from 30 to 65% [4-7].”
BackgroundLong-term exposure to indoor air pollution and wheezing symptoms in infants
Raaschou‐Nielsen, O., Hermansen, M. N., Loland, L., Buchvald, F. F., Pipper, C. B., Sørensen, M., Loft, S. H., & Bisgaard, H. F. (2009) · Indoor Air · doi:10.1111/j.1600-0668.2009.00635.x · Cited by 44
Question 3: Can we diagnose asthma in children under the age of 5 years?
Yang, C. L., Gaffin, J. M., & Radhakrishnan, D. (2018) · Paediatric Respiratory Reviews · doi:10.1016/j.prrv.2018.10.003 · Cited by 47
“Long term cohort studies have found that lung function trajectory is established in childhood [20,21] and that children with asthma are at risk for irreversible airways obstruction in adulthood with pathologic findings of airways remodeling developing between 12 months and 3 years of age [22,23].”
BackgroundLinking COPD epidemiology with pediatric asthma care: Implications for the patient and the physician
Melén, E., Guerra, S., Hallberg, J., Jarvis, D., & Stanojevic, S. (2019) · Pediatric Allergy and Immunology · doi:10.1111/pai.13054 · Cited by 44
Increased Impact of Air Pollution on Lung Function in Preterm versus Term Infants: The BILD Study
Decrue, F., Gorlanova, O., Salem, Y., Vienneau, D., de Hoogh, K., Gisler, A., Usemann, J., Korten, I., Nahum, U., Sinues, P., et al. (2021) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202102-0272oc · Cited by 44
Blume‐Peytavi, U., & Wahn, U. (2010) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/j.1468-3083.2010.03942.x · Cited by 43
Comorbidities in childhood-onset and adult-onset asthma
Mendy, A., & Baye, T. M. (2022) · Annals of Allergy Asthma & Immunology · doi:10.1016/j.anai.2022.05.005 · Cited by 42
Zhang, X., Morrison-Carpenter, T., Holt, J. B., & Callahan, D. B. (2013) · BMC Public Health · doi:10.1186/1471-2458-13-1156 · Cited by 42
“, age and race status) risk factors [7-11,26-30]; however, the extent to which these risk factors contribute to increasing prevalence at the state level over time has not been analyzed or determined.”
BackgroundInfant lung function predicts asthma persistence and remission in young adults
Owens, L., Laing, I. A., Zhang, G., & Souëf, P. N. L. (2016) · Respirology · doi:10.1111/resp.12901 · Cited by 43
The burden of asthma in children: an Australian perspective
Poulos, L. M., Toelle, B. G., & Marks, G. B. (2005) · Paediatric Respiratory Reviews · doi:10.1016/j.prrv.2004.11.004 · Cited by 42
Silva, J. M., Câmara, A. A., Tobias, K. R. C., Macedo, I. S., Cardoso, M. R. A., Arruda, E., Chapman, M. D., Platts‐Mills, T. A. E., Arruda, L. K., & Ferriani, V. P. L. (2005) · Pediatric Allergy and Immunology · doi:10.1111/j.1399-3038.2005.00308.x · Cited by 42
“Pulmonary function was found to be decreased in individuals with persistent or relapsing symptoms, as compared to those without persistent wheezing (3).”
BackgroundA multi-center ring trial of allergen analysis using fluorescent multiplex array technology
King, E. M., Filep, S. C., Smith, B., Platts‐Mills, T. A. E., Hamilton, R. G., Schmechel, D., Sordillo, J. E., Milton, D. K., van Ree, R., Krop, E. J. M., et al. (2012) · Journal of Immunological Methods · doi:10.1016/j.jim.2012.09.015 · Cited by 42
“…essential role in multiple epidemiologic studies of asthma in the US, Europe and New Zealand (Eggleston et al., 1998; Phipatanakul et al., 2000; Arbes et al., 2003, 2004; Zock et al., 2006; Sears et al., 2003; Almqvist et al., 2003; Woodcock et al., 2004; Illi et al., 2006; Celedon et al., 2002).”
BackgroundRecurrent severe exacerbations in early life and reduced lung function at school age
O’Brian, A. L., Lemanske, R. F., Evans, M. D., Gangnon, R. E., Gern, J. E., & Jackson, D. J. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.11.046 · Cited by 42
“These findings have important potential implications because prior studies have shown that abnormalities in lung function present at school age persist at least into early adulthood.(2,3) The reductions in lung function present in this high-risk cohort are consistent with the effects of severe exacerbations on lung fu…”
ResultClinical practice guidelines: Medical follow-up of patients with asthma—Adults and adolescents
Roche, N., Morel, H., Martel, P., & Godard, P. (2005) · Respiratory Medicine · doi:10.1016/j.rmed.2005.03.011 · Cited by 42
Gestational age at birth and wheezing trajectories at 3–11 years
Leps, C., Carson, C., & QUIGLEY, M. A. (2018) · Archives of Disease in Childhood · doi:10.1136/archdischild-2017-314541 · Cited by 41
Bracken, S. J., Adami, A. J., Szczepanek, S. M., Ehsan, M., Natarajan, P., Guernsey, L. A., Shahriari, N., Rafti, E., Matson, A. P., Schramm, C. M., et al. (2015) · International Archives of Allergy and Immunology · doi:10.1159/000381058 · Cited by 41
Zhang, L., He, L., Gong, J. G., & Liu, C. (2016) · BioMed Research International · doi:10.1155/2016/9868704 · Cited by 42
“Incidence of IAO Asthma Twelve articles with the data of risk factors for IAO were retrieved [3–6, 8, 11, 33, 34, 36, 38, 39, 41].”
BackgroundMethodAsthma phenotypes in childhood
Deliu, M., Belgrave, D. C. M., Sperrin, M., Buchan, I. E., & Čustović, A. (2016) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2017.1257940 · Cited by 41
“Using similar subjective methods to characterize children, study groups from New Zealand [20] and Australia [29], observed that children who were categorized as persistent wheezers continued to wheeze into adulthood and had consistently lower lung function.”
MethodLong-Term Trajectories of Mild Asthma in Adulthood and Risk Factors of Progression
Chen, W., FitzGerald, J. M., Lynd, L. D., Sin, D. D., & Sadatsafavi, M. (2018) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2018.04.027 · Cited by 43
Soto‐Martínez, M. E., & Sly, P. D. (2009) · Chronic Respiratory Disease · doi:10.1177/1479972309345929 · Cited by 40
“Similar data are available from other longitudinal birth cohort studies.(42,45) Thus lung function growth in childhood is one determinant of lung function in adulthood, thus having a lifelong effect on respiratory disease risk.”
MethodPediatric Asthma: Natural History, Assessment, and Treatment
Herzog, R., & Cunningham–Rundles, S. (2011) · Mount Sinai Journal of Medicine A Journal of Translational and Personalized Medicine · doi:10.1002/msj.20285 · Cited by 41
High Risk of Gastrointestinal Hemorrhage in Patients With Epilepsy: A Nationwide Cohort Study
Yeh, C.-C., Wang, H.-H., Chou, Y.-C., Hu, C., Chou, W.-H., Chen, T.-L., & Liao, C. (2013) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2013.06.024 · Cited by 40
Wheeze phenotypes in young children have different courses during the preschool period
Just, J., Saint-Pierre, P., Gouvis-Echraghi, R., Boutin, B., Panayotopoulos, V., Chebahi, N., Ousidhoum-Zidi, A., & Khau, C.-A. (2013) · Annals of Allergy Asthma & Immunology · doi:10.1016/j.anai.2013.07.002 · Cited by 42
Cazzoletti, L., Corsico, A. G., Albicini, F., Vincenzo, E. M. G. D., Gini, E., Grosso, A., Ronzoni, V., Bugiani, M., Pirina, P., & Cerveri, I. (2014) · PLoS ONE · doi:10.1371/journal.pone.0086956 · Cited by 40
“However, other investigators used the same time frame [7,11,12,25], and a longer period could raise the problem of recall bias.”
BackgroundArshad, S. H., Hodgekiss, C., Holloway, J. W., Kurukulaaratchy, R. J., Karmaus, W., Zhang, H., & Roberts, G. C. (2019) · European Respiratory Journal · doi:10.1183/13993003.00477-2019 · Cited by 43
Matsunaga, K., Harada, M., Suizu, J., Oishi, K., Asami‐Noyama, M., & Hirano, T. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9103078 · Cited by 41
The relationship between infant lung function and the risk of wheeze in the preschool years
Pike, K. C., Rose-Zerilli, M. J. J., Osvald, E. C., Inskip, H. M., Godfrey, K. M., Crozier, S., Roberts, G. C., CLOUGH, J. B., Holloway, J. W., Lucas, J. S., et al. (2010) · Pediatric Pulmonology · doi:10.1002/ppul.21327 · Cited by 40
Epidemiology of the Origins of Airflow Limitation in Asthma
Guerra, S., & Martinez, F. D. (2009) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200908-085dp · Cited by 40
“Prospective studies have shown that the degree of asthmarelated phenotypes, such as eosinophilic inflammation—assessed both in the airways and in blood—bronchial hyperresponsiveness, and bronchodilator response appear positively associated with subsequent low lung function and development of airflow limitation in subj…”
BackgroundResultŞekerel, B. E., Civelek, E., Karabulut, E., Yıldırım, S., Tuncer, A., & Adalıoğlu, G. (2006) · Allergy · doi:10.1111/j.1398-9995.2006.01082.x · Cited by 40
Allergic Asthma in the Era of Personalized Medicine
Papapostolou, N., & Makris, M. P. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12071162 · Cited by 39
“Although individuals with childhood asthma are expected to outgrow their asthma before adulthood, in about 30% of children with asthma the condition persists [22,23].”
BackgroundDiagnosing asthma in children: What is the role for methacholine bronchoprovocation testing?
Liem, J. J., Kozyrskyj, A. L., Cockroft, D. W., & Becker, A. B. (2008) · Pediatric Pulmonology · doi:10.1002/ppul.20801 · Cited by 39
Murphy, T. M., Wong, C. C. Y., Arseneault, L., Burrage, J., Macdonald, R., Hannon, E. J., Fisher, H. L., Ambler, A. P., Moffitt, T. E., Caspi, A., et al. (2015) · Clinical Epigenetics · doi:10.1186/s13148-015-0163-4 · Cited by 39
The 100 most influential publications in asthma from 1960 to 2017: A bibliometric analysis
Qu, Y., Zhang, C., Hu, Z., Li, S., Chen, K., Ning, Y., Shang, Y., & Bai, C. (2018) · Respiratory Medicine · doi:10.1016/j.rmed.2018.03.014 · Cited by 41
“The 100 articles are listed in Table 1 and are in descending order, according 85 to the number of citations that they have received [12-111].”
BackgroundAsthma across the lifespan: Time for a paradigm shift
Szefler, S. J. (2018) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2018.03.010 · Cited by 39
Metadata
- Authors
- Sears, M. R., Greene, J. M., Willan, A. R., Wiecek, E. M., Taylor, D. R., Flannery, E. M., Cowan, J. O., Herbison, G. P., Silva, P. A., & Poulton, R.
- Affiliations
- St. Joseph’s Healthcare Hamilton (CA)
- McMaster University (CA)
- University of Otago (NZ)
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2003-10-09
- Volume
- 349
- Issue
- 15
- Pages
- 1414-1422
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2104537618
- Cited by
- 1,460
- References
- 28
- Citations by year
- 2026: 21 · 2025: 29 · 2024: 39 · 2023: 42 · 2022: 41 · 2021: 56 · 2020: 51 · 2019: 62 · 2018: 54 · 2017: 38 · 2016: 53 · 2015: 72 · 2014: 86 · 2013: 59 · 2012: 70
- FWCI
- 40.25
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Occupational exposure and asthma
- Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
- Keywords
- childhood asthma, adult asthma, asthma persistence, asthma relapse, wheezing, house dust mite sensitization, airway hyperresponsiveness, sex differences, smoking, age at asthma onset, lung function, Dunedin birth cohort
- MeSH terms
- Adolescent, Adult, Asthma, Child, Child, Preschool, Environmental Exposure, Female, Humans, Longitudinal Studies, Male, New Zealand, Surveys and Questionnaires, Recurrence, Respiratory Function Tests, Respiratory Sounds, Risk Factors, Sex Factors, Smoking, Cohort Studies, Bronchial Hyperreactivity, Age of Onset, Disease Progression, Pyroglyphidae
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
