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The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.

The Association of Newly Identified Respiratory Viruses with Lower Respiratory Tract Infections in Korean Children, 2000–2005

Open access
Choi, Eun Hwa, Lee, Hoan Jong, Kim, Sun Jung, Eun, Byung Wook, Kim, Nam Hee, Lee, Jin A, Lee, Jun Ho, Song, Eun Kyung, Kim, So Hee, Park, Ji Yong, Sung, Ji Yeon·2006·Clinical Infectious Diseases

Abstract

BACKGROUND: This study was performed to evaluate the associations of newly recognized viruses, namely, human metapneumovirus (hMPV), human coronavirus (HCoV)-NL63, and human bocavirus (HBoV) with lower respiratory tract infections (LRTIs) in previously healthy children. METHODS: To determine the prevalences of 11 viruses--respiratory syncytial virus (RSV), adenovirus, rhinovirus, parainfluenza viruses (PIVs) 1 and 3, influenza viruses A and B, hMPV, HCoV, HCoV-NL63, and HBoV--among infants or children with LRTIs, in association with their epidemiologic characteristics, we performed multiplex reverse-transcriptase polymerase chain reaction on nasopharyngeal aspirates obtained from 515 children < or =5 years old with LRTIs during the period 2000-2005. RESULTS: Viruses were identified in 312 (60.6%) of the 515 patients. RSV was detected in 122 (23.7%), HBoV in 58 (11.3%), adenovirus in 35 (6.8%), PIV-3 in 32 (6.2%), rhinovirus in 30 (5.8%), hMPV in 24 (4.7%), influenza A in 24 (4.7%), PIV-1 in 9 (1.7%), influenza B in 9 (1.7%), and HCoV-NL63 in 8 (1.6%). Coinfections with > or =2 viruses were observed in 36 patients (11.5%). Twenty-two patients (37.9%) infected with HBoV had a coinfection. Bronchiolitis was frequently diagnosed in patients who tested positive for RSV, PIV-3, or rhinovirus, whereas influenza A, PIV-1, and HCoV-NL63 were commonly found in patients with croup. The age distributions of patients with viral infections differed; notably, RSV was responsible for 77% of LRTIs that occurred in infants < or =3 months old. The number of hMPV infections peaked between February and April, whereas the number of HCoV-NL63 infections peaked between April and May. CONCLUSIONS: This study describes the features of LRTIs associated with newly identified viruses in children, compared with those associated with known viruses. Additional investigations are required to define the role of HBoV in LRTI.

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Metadata

Authors
Choi, E. H., Lee, H. J., Kim, S. J., Eun, B. W., Kim, N. H., Lee, J. A., Lee, J. H., Song, E. K., Kim, S. H., Park, J. Y., & Sung, J. Y.
Venue
Clinical Infectious Diseases
Published
2006-09
Volume
43
Issue
5
Pages
585-592
ISSN
  • 1058-4838 (ISSN-L)
  • 1537-6591
OpenAlex
W2114257021
Cited by
396
References
32
FWCI
28.55
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: The Association of Newly Identified Respiratory Viruses with Lower Respiratory Tract Infections in Korean Children, 2000–2005. https://app.cochat.ai/papers/10.1086/506350
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Choi, E. H., Lee, H. J., Kim, S. J., Eun, B. W., Kim, N. H., Lee, J. A., Lee, J. H., Song, E. K., Kim, S. H., Park, J. Y., & Sung, J. Y. (2006). The Association of Newly Identified Respiratory Viruses with Lower Respiratory Tract Infections in Korean Children, 2000–2005. Clinical Infectious Diseases. https://doi.org/10.1086/506350

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