Normal fasting plasma glucose levels and type 2 diabetes in young men
Open accessAbstract
BACKGROUND: The normal fasting plasma glucose level was recently defined as less than 100 mg per deciliter (5.55 mmol per liter). Whether higher fasting plasma glucose levels within this range independently predict type 2 diabetes in young adults is unclear. METHODS: We obtained blood measurements, data from physical examinations, and medical and lifestyle information from men in the Israel Defense Forces who were 26 to 45 years of age. RESULTS: A total of 208 incident cases of type 2 diabetes occurred during 74,309 person-years of follow-up (from 1992 through 2004) among 13,163 subjects who had baseline fasting plasma glucose levels of less than 100 mg per deciliter. A multivariate model, adjusted for age, family history of diabetes, body-mass index, physical-activity level, smoking status, and serum triglyceride levels, revealed a progressively increased risk of type 2 diabetes in men with fasting plasma glucose levels of 87 mg per deciliter (4.83 mmol per liter) or more, as compared with those whose levels were in the bottom quintile (less than 81 mg per deciliter [4.5 mmol per liter], P for trend <0.001). In multivariate models, men with serum triglyceride levels of 150 mg per deciliter (1.69 mmol per liter) or more, combined with fasting plasma glucose levels of 91 to 99 mg per deciliter (5.05 to 5.50 mmol per liter), had a hazard ratio of 8.23 (95 percent confidence interval, 3.6 to 19.0) for diabetes, as compared with men with a combined triglyceride level of less than 150 mg per deciliter and fasting glucose levels of less than 86 mg per deciliter (4.77 mmol per liter). The joint effect of a body-mass index (the weight in kilograms divided by the square of the height in meters) of 30 or more and a fasting plasma glucose level of 91 to 99 mg per deciliter resulted in a hazard ratio of 8.29 (95 percent confidence interval, 3.8 to 17.8), as compared with a body-mass index of less than 25 and a fasting plasma glucose level of less than 86 mg per deciliter. CONCLUSIONS: Higher fasting plasma glucose levels within the normoglycemic range constitute an independent risk factor for type 2 diabetes among young men, and such levels may help, along with body-mass index and triglyceride levels, to identify apparently healthy men at increased risk for diabetes.
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Men with FPG values of 4.83-5.05 mmol/L have a significantly increased risk of type 2 diabetes compared with men with FPG values <4.5 mmol/L.
“Men with FPG values of 4.83-5.05mmol/L (87-91 mg/dL) have a significantly increased risk of type 2 diabetes, compared with men with FPG values ,4.5 mmol/L (81 mg/dL).”
From Guidelines and recommendations for laboratory analysis in the diagnosis and management of diabetes mellitus (2011) · cites this paper as [41]
More-recent evidence indicates that FPG concentrations even lower than 5.6 mmol/L are associated with a graded risk for type 2 diabetes.
“More-recent evidence indicates that FPG concentrations even lower than 5.6 mmol/L (100 mg/dL) are associated with a graded risk for type 2 diabetes (41).”
From Guidelines and recommendations for laboratory analysis in the diagnosis and management of diabetes mellitus (2011) · cites this paper as [41]
The data support the concept of a continuum between FPG and the risk of diabetes.
“Although the prevalence of diabetes is low at these glucose concentrations, the data support the concept of a continuum between FPG and the risk of diabetes.”
From Guidelines and recommendations for laboratory analysis in the diagnosis and management of diabetes mellitus (2011) · cites this paper as [41]
Categorising people as either normal or prediabetic neglects the fact that diabetes risk significantly increases for FPG values within the normal range.
“A categorisation of persons as either ‘normal’ or ‘prediabetic’ (IFG, IGT) neglects the fact that diabetes risk significantly increases for FPG values within the normal range.31”
From Prediabetes: a high-risk state for diabetes development (2012) · cites this paper as [31]
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Cites
Expert Panel on Detection, E. (2001) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.285.19.2486 · Cited by 26,011 · see citing works
Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
(2002) · New England Journal of Medicine · doi:10.1056/nejmoa012512 · Cited by 19,011 · see citing works
Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus
The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus (1997) · Diabetes Care · doi:10.2337/diacare.20.7.1183 · Cited by 6,220 · see citing works
Follow-up report on the diagnosis of diabetes mellitus
The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus* (2003) · Diabetes Care · doi:10.2337/diacare.26.11.3160 · Cited by 3,784 · see citing works
Acarbose for prevention of type 2 diabetes mellitus: the STOP-NIDDM randomised trial
Chiasson, J.-L., Josse, R. G., Gomis, R., Hanefeld, M., Karasik, A., & Laakso, M. (2002) · The Lancet · doi:10.1016/s0140-6736(02)08905-5 · Cited by 2,543 · see citing works
XENical in the Prevention of Diabetes in Obese Subjects (XENDOS) Study
Torgerson, J. S., Hauptman, J., Boldrin, M. N., & Sjöström, L. (2004) · Diabetes Care · doi:10.2337/diacare.27.1.155 · Cited by 1,915 · see citing works
Obesity-induced inflammatory changes in adipose tissue
Wellen, K. E., & Hotamisligil, G. S. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200320514 · Cited by 1,823 · see citing works
Role of Fatty Acids in the Pathogenesis of Insulin Resistance and NIDDM
Boden, G. (1997) · Diabetes · doi:10.2337/diab.46.1.3 · Cited by 1,728 · see citing works
Unwin, N., Shaw, J., Zimmet, P., & Alberti, K. (2002) · Diabetic Medicine · doi:10.1046/j.1464-5491.2002.00835.x · Cited by 1,133 · see citing works
Regulation of Fasted Blood Glucose by Resistin
Banerjee, R. R., Rangwala, S. M., Shapiro, J. S., Rich, A. S., Rhoades, B., Qi, Y., Wang, J., Rajala, M. W., Pocai, A., Scherer, P. E., et al. (2004) · Science · doi:10.1126/science.1092341 · Cited by 727 · see citing works
Stamler, J., Stamler, R., Neaton, J. D., Wentworth, D. N., Daviglus, M. L., Garside, D., Dyer, A. R., Liu, K., & Greenland, P. (1999) · JAMA · doi:10.1001/jama.282.21.2012 · Cited by 725 · see citing works
Gabir, M. M., Hanson, R. L., Dabelea, D., Imperatore, G., Roumain, J., Bennett, P. H., & Knowler, W. C. (2000) · Diabetes Care · doi:10.2337/diacare.23.8.1108 · Cited by 568 · see citing works
Lowering the Criterion for Impaired Fasting Glucose Is in Order
GENUTH, S. M. (2003) · Diabetes Care · doi:10.2337/diacare.26.12.3331 · Cited by 559 · see citing works
Rothman, D. L., Magnusson, I., Katz, L. D., Shulman, R. G., & Shulman, G. I. (1991) · Science · doi:10.1126/science.1948033 · Cited by 546 · see citing works
D, M. P. S. M., Williams, K., & Haffner, S. M. (2002) · Annals of Internal Medicine · doi:10.7326/0003-4819-136-8-200204160-00006 · Cited by 506 · see citing works
Role of fatty acids in the pathogenesis of insulin resistance and NIDDM
Boden, G. (1997) · Diabetes · doi:10.2337/diabetes.46.1.3 · Cited by 479 · see citing works
American Diabetes Association (2004) · Diabetes Care · doi:10.2337/diacare.27.2007.s11 · Cited by 443 · see citing works
Hypothalamic sensing of circulating fatty acids is required for glucose homeostasis
Lam, T. K. T., Pocai, A., Gutierrez-Juarez, R., Obici, S., Bryan, J., Aguilar-Bryan, L., Schwartz, G. J., & Rossetti, L. (2005) · Nature Medicine · doi:10.1038/nm1201 · Cited by 432 · see citing works
Role of resistin in diet-induced hepatic insulin resistance
Muse, E. D., Obici, S., Bhanot, S., Monia, B. P., McKay, R. A., Rajala, M. W., Scherer, P. E., & Rossetti, L. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21270 · Cited by 371 · see citing works
Bloomgarden, Z. T. (2004) · Diabetes Care · doi:10.2337/diacare.27.4.998 · Cited by 324 · see citing works
Juonala, M., Viikari, J. S. A., Hutri‐Kähönen, N., Pietikäinen, M., Jokinen, E. V., Taittonen, L. M., Marniemi, J., Rönnemaa, T., & Raitakari, O. T. (2004) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2004.01308.x · Cited by 195 · see citing works
Bajaj, M., Suraamornkul, S., Hardies, L. J., Pratipanawatr, T., & DeFronzo, R. A. (2004) · International Journal of Obesity · doi:10.1038/sj.ijo.0802625 · Cited by 159 · see citing works
Impaired fasting glucose: how low should it go?
Shaw, J. E., Zimmet, P., Hodge, A. M., de Courten, M., Dowse, G. K., Chitson, P., Tuomilehto, J., & Alberti, K. G. M. M. (2000) · Diabetes Care · doi:10.2337/diacare.23.1.34 · Cited by 146 · see citing works
Borch‐Johnsen, K., Colagiuri, S., Balkau, B., Gl�mer, C., Carstensen, B., Ramachandran, A., Dong, Y., & Gao, W. (2004) · Diabetologia · doi:10.1007/s00125-004-1468-6 · Cited by 140 · see citing works
Neighborhood Characteristics and Components of the Insulin Resistance Syndrome in Young Adults
Roux, A. V. D., Jacobs, D. R., & Kiefe, C. I. (2002) · Diabetes Care · doi:10.2337/diacare.25.11.1976 · Cited by 134 · see citing works
Risk Factors for Coronary Heart Disease in Men 18 to 39 Years of Age
Navas-Nacher, E. L., Colangelo, L. A., Beam, C. A., & Greenland, P. (2001) · Annals of Internal Medicine · doi:10.7326/0003-4819-134-6-200103200-00007 · Cited by 130 · see citing works
Gastaldelli, A., Miyazaki, Y., Pettiti, M., Buzzigoli, E., Mahankali, S., Ferrannini, E., & DeFronzo, R. A. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031941 · Cited by 117 · see citing works
Thomas, G. N., Chook, P., Qiao, M., Huang, X. S., Leong, H. C., Celermajer, D. S., & Woo, K. S. (2004) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000118015.26978.07 · Cited by 111 · see citing works
Durbin, R. J. (2004) · Diabetes Obesity and Metabolism · doi:10.1111/j.1462-8902.2004.0348.x · Cited by 108 · see citing works
Correlates of carotid artery stiffness in young adults: The Bogalusa Heart Study
Urbina, E. M., Srinivasan, S. R., Kieltyka, R. L., Tang, R., Bond, M. G., Chen, W., & Berenson, G. S. (2004) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2004.04.023 · Cited by 102 · see citing works
Chiasson, J. L., Josse, R. G., Gomis, R., Markolf Hanefeld, E., Karasik, A., & Laakso, M. (2004) · Diabetologia · doi:10.1007/s00125-004-1409-4 · Cited by 100 · see citing works
Lowering the Criterion for Impaired Fasting Glucose
Tai, E. S., Goh, S. Y., Lee, J. J. M., Wong, M.-S., Heng, D., Hughes, K., Chew, S. K., Cutter, J., Chew, W., Gu, K., et al. (2004) · Diabetes Care · doi:10.2337/diacare.27.7.1728 · Cited by 92 · see citing works
Fasting Plasma Glucose and Risk of Incident Ischemic Stroke or Transient Ischemic Attacks
Tanné, D., Koren‐Morag, N., & Goldbourt, U. (2004) · Stroke · doi:10.1161/01.str.0000140738.94047.55 · Cited by 86 · see citing works
Lowering the Cut Point for Impaired Fasting Glucose
Schriger, D. L., & Lorber, B. (2004) · Diabetes Care · doi:10.2337/diacare.27.2.592 · Cited by 66 · see citing works
What is a Normal Glucose Value?
Piché, M., Arcand-Bossé, J.-F., Després, J., Përusse, L., Lemieux, S., & Weisnagel, S. J. (2004) · Diabetes Care · doi:10.2337/diacare.27.10.2470 · Cited by 57 · see citing works
Bortheiry, A. L., Malerbi, D. A. C., & Franco, L. J. (1994) · Diabetes Care · doi:10.2337/diacare.17.11.1269 · Cited by 53 · see citing works
Simons, L. A., Friedlander, Y., McCallum, J. C., & Simons, J. A. (2000) · Australian and New Zealand Journal of Medicine · doi:10.1111/j.1445-5994.2000.tb01053.x · Cited by 37 · see citing works
Kim, D., Kim, K., Cho, N.-H., Noh, J.-H., Lee, M., & Lee, M. (2003) · Diabetes Care · doi:10.2337/diacare.26.12.3354 · Cited by 13 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- [5]5. Rothman KJ, Greenland S. Modern epi- demiology. 2nd ed. Philadelphia: Lippincott- Raven, 1998.
- [17]17. Rothman DL, Magnusson I, Katz LD, Shulman RG, Shulman GI. Quantitation of hepatic glycogenolysis and gluconeogene- sis in fasting humans with 13C NMR. Sci- ence 1991;254:573-6.
Cited by
Sorted by citations
Eckel, R. H., Alberti, K., Grundy, S. M., & Zimmet, P. (2010) · The Lancet · doi:10.1016/s0140-6736(09)61794-3 · Cited by 6,283 · see citing works
International Expert Committee report on the role of the A1c assay in the diagnosis of diabetes
The International Expert Committee (2009) · Diabetes Care · doi:10.2337/dc09-9033 · Cited by 3,185 · see citing works
Prediabetes: a high-risk state for diabetes development
Tabák, A. G., Herder, C., Rathmann, W., Brunner, E. J., & Kivimäki, M. (2012) · The Lancet · doi:10.1016/s0140-6736(12)60283-9 · Cited by 2,958 · see citing works
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
DIAGRAM Consortium, Dupuis, J., GIANT Consortium, Global BPgen Consortium, Anders Hamsten on behalf of Procardis Consortium, the MAGIC investigators, Langenberg, C., Prokopenko, I., Saxena, R., Soranzo, N., et al. (2010) · Nature Genetics · doi:10.1038/ng.520 · Cited by 2,166 · see citing works
Sacks, D. B., Arnold, M., Bakris, G. L., Bruns, D. E., Horvath, A. R., Kirkman, M. S., Lernmark, A., Metzger, B. E., & Nathan, D. M. (2011) · Clinical Chemistry · doi:10.1373/clinchem.2010.161596 · Cited by 1,360 · see citing works
“6 mmol/L (100 mg/dL) are associated with a graded risk for type 2 diabetes (41).”
Clinical risk factors, DNA variants, and the development of type 2 diabetes
Lyssenko, V., Jonsson, A., Almgren, P., Pulizzi, N., Isomaa, B., Tuomi, T., Berglund, G., Altshuler, D., Nilsson, P., & Groop, L. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0801869 · Cited by 938 · see citing works
Sacks, D. B., Arnold, M., Bakris, G. L., Bruns, D. E., Horvath, A. R., Kirkman, M. S., Lernmark, A., Metzger, B. E., & Nathan, D. M. (2011) · Diabetes Care · doi:10.2337/dc11-9998 · Cited by 718 · see citing works
“6 mmol/L (100 mg/dL) are associated with a graded risk for type 2 diabetes (41).”
Adolescent BMI Trajectory and Risk of Diabetes versus Coronary Disease
Tirosh, A., Shai, I., Afek, A. B., Dubnov‐Raz, G., Ayalon, N., Gordon, B., Derazne, E., Tzur, D., Shamis, A., Vinker, S., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1006992 · Cited by 705 · see citing works
Self-citationHandelsman, Y., Bloomgarden, Z. T., Grunberger, G., Umpierrez, G. E., Zimmerman, R. S., Bailey, T. S., Blonde, L., Bray, G. A., Cohen, A. J., Dagogo-Jack, S. E., et al. (2015) · Endocrine Practice · doi:10.4158/ep15672.gl · Cited by 631 · see citing works
Bouatia-Naji, N., Bonnefond, A., Cavalcanti-Proença, C., Sparsø, T., Holmkvist, J., Marchand, M., Delplanque, J., Lobbens, S., Rocheleau, G., Durand, E., et al. (2009) · Nature Genetics · doi:10.1038/ng.277 · Cited by 611 · see citing works
“are an independent risk factor for type 2 diabetes (T2D”
BackgroundThe medical complications of obesity
Malnick, S. D. H. (2006) · QJM · doi:10.1093/qjmed/hcl085 · Cited by 579 · see citing works
“29 for developing diabetes, compared to those men with a BMI <25 kg/m(2) and a fasting plasma glucose <86mg/dl.(31) 566 S.”
BackgroundHandelsman, Y., Bloomgarden, Z. T., Grunberger, G., Umpierrez, G., Zimmerman, R. S., Bailey, T. S., Blonde, L., Bray, G. A., Cohen, A. J., Dagogo-Jack, S., et al. (2015) · Endocrine Practice · doi:10.4158/ep15672.glsuppl · Cited by 559 · see citing works
Kong, L., Zhu, J., Han, W., Jiang, X., Xu, M., Zhao, Y., Dong, Q., Pang, Z., Guan, Q., Gao, L., et al. (2010) · Acta Diabetologica · doi:10.1007/s00592-010-0226-0 · Cited by 529 · see citing works
“diabetes over the next 5–10 years [39–41].”
Pathogenesis of Type 2 Diabetes Mellitus
Leahy, J. L. (2005) · Archives of Medical Research · doi:10.1016/j.arcmed.2005.01.003 · Cited by 469 · see citing works
Kraus, W. E., Bhapkar, M., Huffman, K. M., Pieper, C. F., Krupa Das, S., Redman, L. M., Villareal, D. T., Rochon, J., Roberts, S. B., Ravussin, E., et al. (2019) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(19)30151-2 · Cited by 407 · see citing works
Navarro‐González, D., Sánchez‐Íñigo, L., Delgado, J. P., Fernández‐Montero, A., & Martínez, J. A. (2016) · Preventive Medicine · doi:10.1016/j.ypmed.2016.01.022 · Cited by 403 · see citing works
Salsalate Improves Glycemia and Inflammatory Parameters in Obese Young Adults
Fleischman, A., Shoelson, S. E., Bernier, R., & Goldfine, A. B. (2008) · Diabetes Care · doi:10.2337/dc07-1338 · Cited by 352 · see citing works
Sacks, D. B., Arnold, M., Bakris, G. L., Bruns, D. E., Horvath, A. R., Lernmark, Å., Metzger, B. E., Nathan, D. M., & Kirkman, M. S. (2023) · Diabetes Care · doi:10.2337/dci23-0036 · Cited by 351 · see citing works
“6 mmol/L (100 mg/dL) are associated with a graded risk for type 2 diabetes (41).”
Vascular NAD(P)H oxidase activation in diabetes: a double-edged sword in redox signalling
Gao, L., & Mann, G. E. (2009) · Cardiovascular Research · doi:10.1093/cvr/cvp031 · Cited by 330 · see citing works
“150 mg/dL was present.(47) Activation of NAD(P)H oxidase is implicated in oxidative stress associated with hyperglycaemia.”
BackgroundHandelsman, Y., Mechanick, J. I., Blonde, L., Grunberger, G., Bloomgarden, Z. T., Bray, G. A., Dagogo-Jack, S., Davidson, J. A., Einhorn, D., Ganda, O., et al. (2011) · Endocrine Practice · doi:10.4158/ep.17.s2.1 · Cited by 513 · see citing works
n−3 Fatty acids and the metabolic syndrome
Carpentier, Y., Portois, L., & Malaisse, W. J. (2006) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.6.1499s · Cited by 283 · see citing works
“These values may need to be modified for particular ethnic groups (eg, groups of Asian origin) (2) and to become more restrictive according to recent reports of an increased risk of type 2 diabetes at glucose concentrations 100 mg/dL (3).”
BackgroundEmerging role of GLP-1 agonists in obesity: A comprehensive review of randomised controlled trials
Popoviciu, M.-S., Păduraru, L., Yahya, G., Metwally, K., & Cavalu, S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241310449 · Cited by 280 · see citing works
“clude T2DM [16,17], dyslipidemias [18], hyperuricemia, and metabolic syndrome [19].”
BackgroundFirst-Trimester Fasting Hyperglycemia and Adverse Pregnancy Outcomes
Riskin‐Mashiah, S., Younes, G., Damti, A., & Auslender, R. (2009) · Diabetes Care · doi:10.2337/dc09-0688 · Cited by 276 · see citing works
“, 100 mg/dl), constitute an independent risk factor for the development of type 2 diabetes within a few years (25).”
BackgroundLee, S., Kwon, H., Park, Y., Ha, H., Jeong, S. H., Yang, H. K., Lee, J., Yim, H., Kang, M., Lee, W., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0090430 · Cited by 277 · see citing works
“Higher FPG levels have been shown to be an independent risk factor for developing type 2 diabetes even when subjects are within the normoglycemic range [9,10].”
BackgroundForouhi, N. G., Luan, J., Hennings, S., & Wareham, N. J. (2007) · Diabetic Medicine · doi:10.1111/j.1464-5491.2007.02068.x · Cited by 262 · see citing works
Predicting Type 2 Diabetes Using Logistic Regression and Machine Learning Approaches
Joshi, R., & Dhakal, C. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18147346 · Cited by 262 · see citing works
“A higher BMI, reduced insulin secretion and action, a family history of diabetes, blood pressure, smoking status, and pregnancy status are considered common risk factors for type 2 diabetes [33,34].”
BackgroundBock, G., Dalla Man, C., Campioni, M., Chittilapilly, E., Basu, R., Toffolo, G., Cobelli, C., & Rizza, R. (2006) · Diabetes · doi:10.2337/db06-0319 · Cited by 230 · see citing works
Risstad, H., Søvik, T. T., Engström, M., Aasheim, E. T., Fagerland, M. W., Olsén, M. F., Kristinsson, J. A., le Roux, C. W., Bøhmer, T., Birkeland, K. I., et al. (2015) · JAMA Surgery · doi:10.1001/jamasurg.2014.3579 · Cited by 229 · see citing works
Electrochemical detection of glucose from whole blood using paper-based microfluidic devices
Noiphung, J., Songjaroen, T., Dungchai, W., Henry, C. S., Chailapakul, O., & Laiwattanapaisal, W. (2013) · Analytica Chimica Acta · doi:10.1016/j.aca.2013.06.021 · Cited by 227 · see citing works
Changes in Triglyceride Levels Over Time and Risk of Type 2 Diabetes in Young Men
Tirosh, A., Shai, I., Bitzur, R., Kochba, I., Tekes-Manova, D., Israeli, E., Shochat, T., & Rudich, A. (2008) · Diabetes Care · doi:10.2337/dc08-0825 · Cited by 226 · see citing works
Self-citationHoresh, A., Tsur, A. M., Bardugo, A., & Twig, G. (2021) · Current Obesity Reports · doi:10.1007/s13679-021-00439-9 · Cited by 242 · see citing works
Associations of Diet with Albuminuria and Kidney Function Decline
Lin, J., Hu, F. B., & Curhan, G. C. (2010) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.08001109 · Cited by 216 · see citing works
“more (22,23), we considered a participant who was diagnosed with”
BackgroundXue, M., Weickert, M. O., Qureshi, S. A., Kandala, N., Anwar, A., Waldron, M., Shafie, A., Messenger, D. J., Fowler, M. I., Jenkins, G., et al. (2016) · Diabetes · doi:10.2337/db16-0153 · Cited by 213 · see citing works
“The 5% decrease in FPG herein exceeds and matches effects of metformin and Olristat, respectively, in similar intervention trials in overweight/obese subjects (45; 46), Decrease in FPG in the normal range is associated with reduced risk of developing type 2 diabetes (47).”
ResultStefan, N., & Schulze, M. B. (2023) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(23)00086-4 · Cited by 215 · see citing works
Trans Fat Diet Induces Abdominal Obesity and Changes in Insulin Sensitivity in Monkeys
Kavanagh, K., Jones, K. L., Sawyer, J., Kelley, K., Carr, J. J., Wagner, J. D., & Rudel, L. L. (2007) · Obesity · doi:10.1038/oby.2007.200 · Cited by 208 · see citing works
“It has been shown that higher fasting plasma glucose levels within the normal glycemic range constitutes an independent risk factor for T2DM among young men (36).”
BackgroundZheng, S., Shi, S., Ren, X., Tingting, H., Li, Y., Chen, Y., Liu, W., Hou, P. C., & Hu, Y. (2016) · Journal of Translational Medicine · doi:10.1186/s12967-016-1020-8 · Cited by 203 · see citing works
Jia, W., Pang, C., Chen, L., Bao, Y., Lu, J., Lu, H., Tang, J., Wu, Y., Zuo, Y. H., Jiang, S., et al. (2006) · Diabetologia · doi:10.1007/s00125-006-0503-1 · Cited by 194 · see citing works
Effects of Metformin on Body Weight and Body Composition in Obese Insulin-Resistant Children
Yanovski, J. A., Krakoff, J., Salaita, C. G., McDuffie, J. R., Kozlosky, M., Sebring, N. G., Reynolds, J. C., Brady, S. M., & Calis, K. A. (2011) · Diabetes · doi:10.2337/db10-1185 · Cited by 193 · see citing works
Cardiovascular Disease Risk Factors, Type 2 Diabetes Mellitus, and the Framingham Heart Study
Fox, C. S. (2010) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2010.08.001 · Cited by 191 · see citing works
“A fasting blood sugar well into the “reference range” has been shown to be a risk factor for diabetes (Tirosh et al. 2005).”
BackgroundAnalysis of factors related to extraction of endodontically treated teeth
Zadik, Y., Sandler, V., Bechor, R., & Salehrabi, R. (2008) · Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology · doi:10.1016/j.tripleo.2008.06.017 · Cited by 184 · see citing works
Mazze, R. S., Strock, E. S., Wesley, D., Borgman, S. K., Morgan, B., Bergenstal, R. M., & Cuddihy, R. M. (2008) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2007.0293 · Cited by 183 · see citing works
Rabbani, N., Xue, M., & Thornalley, P. J. (2016) · Clinical Science · doi:10.1042/cs20160025 · Cited by 173 · see citing works
Bergman, M., Manco, M., Satman, İ., Chan, J. C. N., Schmidt, M. I., Sesti, G., Fiorentino, T. V., Abdul-Ghani, M. A., Jagannathan, R., Pramodkumar, T. A., et al. (2024) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2024.111589 · Cited by 183 · see citing works
Normal Fasting Plasma Glucose and Risk of Type 2 Diabetes Diagnosis
Nichols, G. A., Hillier, T. A., & Brown, J. B. (2008) · The American Journal of Medicine · doi:10.1016/j.amjmed.2008.02.026 · Cited by 165 · see citing works
Fasting Glucose Level and the Risk of Incident Atherosclerotic Cardiovascular Diseases
Park, C., Güallar, E., Linton, J. A., Lee, D., Jang, Y., Son, D. K., Han, E., Baek, S. J., Yun, Y. D., Jee, S. H., et al. (2013) · Diabetes Care · doi:10.2337/dc12-1577 · Cited by 166 · see citing works
“It is unclear whether there is an optimum fasting glucose level associated with the lowest level of CVD risk (12,13), or whether risk increases at very low fasting glucose levels (14).”
BackgroundEarly diabetic neuropathy: Triggers and mechanisms
Dobretsov, M. G. (2007) · World Journal of Gastroenterology · doi:10.3748/wjg.v13.i2.175 · Cited by 153 · see citing works
Adolescent Obesity and Early-Onset Type 2 Diabetes
Twig, G., Zucker, I., Afek, A., Cukierman-Yaffe, T., Bendor, C. D., Derazne, E., Lutski, M., Shohat, T., Mosenzon, O., Tzur, D., et al. (2020) · Diabetes Care · doi:10.2337/dc19-1988 · Cited by 161 · see citing works
Self-citationChanges in triglyceride levels and risk for coronary heart disease in young men.
Tirosh, A., Rudich, A., Shochat, T., Tekes-Manova, D., Israeli, E., Henkin, Y., Kochba, I., & Shai, I. (2007) · Annals of Internal Medicine · doi:10.7326/0003-4819-147-6-200709180-00007 · Cited by 151 · see citing works
“For 13 953 apparently healthy young adult men (mean age, 32 years; range, 26 to 45 years) from the MELANY (Metabolic, Lifestyle, and Nutrition Assessment in Young Adults) study (14), we obtained 2 measurements of fasting serum triglycerides and lifestyle variables 5 years apart and followed for incident cases of angio…”
MethodSelf-citationSacks, D. B., Arnold, M. A., Bakris, G. L., Bruns, D. E., Horvath, A. R., Lernmark, Å., Metzger, B. E., Nathan, D. M., & Kirkman, M. S. (2023) · Clinical Chemistry · doi:10.1093/clinchem/hvad080 · Cited by 157 · see citing works
“6 mmol/L (100 mg/dL) are associated with a graded risk for type 2 diabetes (41).”
Increased sympathetic reactivity may predict insulin resistance: an 18-year follow-up study
Flaa, A., Aksnes, T. A., Kjeldsen, S. E., Eide, I. A., & Rostrup, M. (2008) · Metabolism · doi:10.1016/j.metabol.2008.05.012 · Cited by 150 · see citing works
“However, we included fasting plasma glucose in the multiple regression analyses, which has been shown to be an independent risk factor for type 2 diabetes mellitus in young men [26].”
MethodProgression of Normotensive Adolescents to Hypertensive Adults
Tirosh, A., Afek, A. B., Rudich, A., Percik, R., Gordon, B., Ayalon, N., Derazne, E., Tzur, D., Gershnabel, D., Grossman, E., et al. (2010) · Hypertension · doi:10.1161/hypertensionaha.109.146415 · Cited by 145 · see citing works
Self-citationGupta, A. K., Dahlof, B., Dobson, J., Sever, P. S., Wedel, H., Poulter, N. R., & on behalf of the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) Investigators (2008) · Diabetes Care · doi:10.2337/dc07-1768 · Cited by 146 · see citing works
White Blood Cells Count and Incidence of Type 2 Diabetes in Young Men
Twig, G., Afek, A. B., Shamiss, A., Derazne, E., Tzur, D., Gordon, B., & Tirosh, A. (2012) · Diabetes Care · doi:10.2337/dc11-2298 · Cited by 145 · see citing works
Self-citationMerino, J., Leong, A., Liu, C., Porneala, B., Walford, G. A., von Grotthuss, M., Wang, T. J., Flannick, J. A., Dupuis, J., Levy, D. A., et al. (2018) · Diabetologia · doi:10.1007/s00125-018-4599-x · Cited by 144 · see citing works
“9) compared with normoglycaemic individuals [6].”
Cefalu, W. T., Buse, J. B., Tuomilehto, J. O., Fleming, G. A., Ferrannini, E., Gerstein, H. C., Bennett, P. H., Ramachandran, A., Raz, I., Rosenstock, J., et al. (2016) · Diabetes Care · doi:10.2337/dc16-0873 · Cited by 143 · see citing works
Genetic dissection of type 2 diabetes
Ridderstråle, M., & Groop, L. (2008) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2008.10.002 · Cited by 140 · see citing works
“In addition, an elevated glucose concentration per se is a strong predictor of future T2D (5,13).”
BackgroundOn behalf of, E. D. E. G., Forouhi, N. G., Balkau, B., Borch-Johnsen, K., Dekker, J., Glumer, C., Qiao, Q., Spijkerman, A., Stolk, R., Tabac, A., et al. (2006) · Diabetologia · doi:10.1007/s00125-006-0189-4 · Cited by 140 · see citing works
“Indeed, recent evidence suggests that higher fasting glucose levels within the normoglycaemic range constitute an independent risk factor for type 2 diabetes among young men [8].”
Haak, T., Meinicke, T. W., Jones, R., Weber, S., von Eynatten, M., & Woerle, H. J. (2012) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2012.01590.x · Cited by 140 · see citing works
Reference Values for Continuous Glucose Monitoring in Chinese Subjects
Zhou, J., Li, H., Ran, X., Yang, W., Li, Q., Peng, Y., Li, Y., Gao, X., Luan, X., Wang, W., et al. (2009) · Diabetes Care · doi:10.2337/dc09-0076 · Cited by 138 · see citing works
“Different from reference data derived from epidemiologic studies of large populations (18), the present study completed glucose measurement under routine living conditions,”
MethodPeng, C., Bind, M., Colicino, E., Kloog, I., Byun, H., Cantone, L., Trevisi, L., Zhong, J., Brennan, K. J. M., Dereix, A. E., et al. (2016) · Environmental Health Perspectives · doi:10.1289/ehp183 · Cited by 133 · see citing works
“Finally, we measured DNA methylation in candidate genes by pyrosequencing, which yields high precision (Tost and Gut 2007).”
Swarbrick, M. M., Stanhope, K. L., Elliott, S. S., Graham, J. L., Krauss, R. M., Christiansen, M. P., Griffen, S. C., Keim, N. L., & Havel, P. J. (2008) · British Journal Of Nutrition · doi:10.1017/s0007114508968252 · Cited by 132 · see citing works
“Increases of fasting plasma glucose concentrations, within the normoglycaemic range, have been reported to independently predict the development of type 2 diabetes in men((36)).”
BackgroundBergman, M. (2012) · Endocrine · doi:10.1007/s12020-012-9830-9 · Cited by 132 · see citing works
Plasma Glucose Concentration and Prediction of Future Risk of Type 2 Diabetes
Abdul‐Ghani, M. A., & DeFronzo, R. A. (2009) · Diabetes Care · doi:10.2337/dc09-s309 · Cited by 131 · see citing works
Role of Podocyte B7-1 in Diabetic Nephropathy
Fiorina, P., Vergani, A., Bassi, R., Niewczas, M. A., Altintas, M. M., Pezzolesi, M. G., D’Addio, F., Chin, M., Tezza, S., Nasr, M. B., et al. (2014) · Journal of the American Society of Nephrology · doi:10.1681/asn.2013050518 · Cited by 131 · see citing works
Chamroonkiadtikun, P., Ananchaisarp, T., & Wanichanon, W. (2019) · Primary care diabetes · doi:10.1016/j.pcd.2019.08.004 · Cited by 131 · see citing works
Lee, W., Lee, E. S., Kim, J. H., Park, S. E., Park, C., Oh, K.-W., Park, S., Rhee, E., & Lee, W. (2016) · PLoS ONE · doi:10.1371/journal.pone.0163465 · Cited by 130 · see citing works
Association of Genetic Loci With Glucose Levels in Childhood and Adolescence
Barker, A., Sharp, S. J., Timpson, N. J., Bouatia-Naji, N., Warrington, N. M., Kanoni, S., Beilin, L. J., Brage, S., Deloukas, P., Evans, D. M., et al. (2011) · Diabetes · doi:10.2337/db10-1575 · Cited by 117 · see citing works
“Elevated fasting glucose levels within the normal nondiabetic range predict future risk of diabetes (1,2) and are associated with incident cardiovascular disease in nondiabetic individuals (3).”
BackgroundDiabetes Risk Among Overweight and Obese Metabolically Healthy Young Adults
Twig, G., Afek, A. B., Derazne, E., Tzur, D., Cukierman‐Yaffe, T., Gerstein, H. C., & Tirosh, A. (2014) · Diabetes Care · doi:10.2337/dc14-0869 · Cited by 116 · see citing works
Self-citationBiological Factors in the Pathogenesis of Rotator Cuff Tears
Maffulli, N., Longo, U. G., Berton, A., Loppini, M., & Denaro, V. (2011) · Sports Medicine and Arthroscopy Review · doi:10.1097/jsa.0b013e3182250cad · Cited by 116 · see citing works
Platelet Microparticles Mediate Glomerular Endothelial Injury in Early Diabetic Nephropathy
Zhang, Y., Ma, K. L., Gong, Y. X., Wang, G. H., Hu, Z. B., Liu, L., Lü, J., Chen, P. P., Lu, C., Ruan, X. Z., et al. (2018) · Journal of the American Society of Nephrology · doi:10.1681/asn.2018040368 · Cited by 115 · see citing works
Characterization and Heritability of Obesity and Associated Risk Factors in Vervet Monkeys
Kavanagh, K., Fairbanks, L. A., Bailey, J. N., Jorgensen, M. J., Wilson, M. D., Zhang, L., Rudel, L. L., & Wagner, J. D. (2007) · Obesity · doi:10.1038/oby.2007.199 · Cited by 110 · see citing works
“Incident diabetes risk increases with increasing fasting glucose concentrations even within the normal range (34), so establishment of species-specific reference values as described here will allow detection of individuals with marginally elevated glucose values, along with other risk factors for MS.”
BackgroundGenetic and Environmental Interactions in Obesity and Type 2 Diabetes
Romao, I., & Roth, J. (2008) · Journal of the American Dietetic Association · doi:10.1016/j.jada.2008.01.022 · Cited by 111 · see citing works
Higher fasting plasma glucose levels within the normoglycaemic range and rotator cuff tears
Longo, U. G., Franceschi, F., Ruzzini, L., Spiezia, F., Maffulli, N., & Denaro, V. (2008) · British Journal of Sports Medicine · doi:10.1136/bjsm.2008.049320 · Cited by 109 · see citing works
Riskin‐Mashiah, S., Damti, A., Younes, G., & Auslender, R. (2010) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2010.05.036 · Cited by 105 · see citing works
“, <100 mg/dl) constitute an independent risk factor for the development of type 2 diabetes mellitus within a few years [16].”
BackgroundPredictors of new onset diabetes after renal transplantation
Joss, N., Staatz, C. E., Thomson, A. H., & Jardine, A. G. (2007) · Clinical Transplantation · doi:10.1111/j.1399-0012.2006.00580.x · Cited by 102 · see citing works
“In healthy individuals, fasting plasma glucose concentrations in the upper range of normal are associated with the development of type 2 diabetes mellitus (20).”
BackgroundNguyen, Q. M., Srinivasan, S. R., Xu, J.-H., Chen, W., & Berenson, G. S. (2010) · Archives of Pediatrics & Adolescent Medicine · doi:10.1001/archpediatrics.2009.268 · Cited by 93 · see citing works
Fasting glucose levels within the high normal range predict cardiovascular outcome
Shaye, K., TIROSH, A., Segev, S., & Sidi, Y. (2012) · American Heart Journal · doi:10.1016/j.ahj.2012.03.023 · Cited by 100 · see citing works
“d 6-year follow-up study.(2) Although there is a wealth of epidemiological data on the correlation between fasting plasma glucose (FPG) and DM risk, its association with cardiovascular disease (CVD) risk is less clear.”
Self-citationGlyoxalase 1 Modulation in Obesity and Diabetes
Rabbani, N., & Thornalley, P. J. (2019) · Antioxidants & Redox Signaling · doi:10.1089/ars.2017.7424 · Cited by 102 · see citing works
“The increase in OGIS of obese subjects was + 58 mL/min/m 2 , which is a change similar to that found with pharmaceutical treatment of patients with T2DM ( e.g. , 1.7 g metformin per day, D OGIS = + 54 mL/min/m 2 ) (82) and extreme weight loss with gastric band surgery in morbid obesity ( D OGIS = + 62 mL/min/m 2 ) (72…”
InfluentialNguyen, Q. M., Srinivasan, S., Xu, J.-H., Chen, W., Kieltyka, L., & Berenson, G. (2009) · Diabetes Care · doi:10.2337/dc09-1635 · Cited by 61 · see citing works
Chiu, C., Milton, R. C., Gensler, G. R., & Taylor, A. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.1.180 · Cited by 101 · see citing works
Classification and Diagnosis of Diabetes
GENUTH, S. M., Palmer, J. P., & Nathan, D. M. (2018) · Cited by 95 · see citing works
Ibrahim, N. K., Mahnashi, M., Aldhaheri, A., Al-Zahrani, B., Al-Wadie, E., Aljabri, M. K., Alshanketi, R. M., Alshehri, R. S., Al-Sayes, F. M. O., & Bashawri, J. (2014) · BMC Public Health · doi:10.1186/1471-2458-14-411 · Cited by 93 · see citing works
“BMI was then divided into normal (< 25), overweight (25 - < 30), and obese (≥ 30) [13].”
BackgroundLin, J., & Curhan, G. C. (2010) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.03260410 · Cited by 92 · see citing works
“Because the onset of abnormalities in glucose handling can precede the diagnosis of type 2 diabetes by 10 years or more (23,24), we considered a participant who was diagnosed with diabetes up through the year 2000 as having diabetes.”
BackgroundHsueh, W., McLellan, K., Wyne, K., & Villagomez, E. (2014) · Therapeutics and Clinical Risk Management · doi:10.2147/tcrm.s39564 · Cited by 91 · see citing works
“Furthermore, different cohort studies indicate that diabetes risk increases at a fasting plasma glucose (FPG) below currently recommended thresholds for diagnosis of prediabetes.(34,35) The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus examined the sensitivity and specificity of a wide rang…”
Catalase Deficiency and Type 2 Diabetes
Góth, L. (2008) · Diabetes Care · doi:10.2337/dc08-1607 · Cited by 91 · see citing works
Takeuchi, F., Katsuya, T., Chackrewarthy, S., Yamamoto, K., Fujioka, A., Serizawa, M., Fujisawa, T., Nakashima, E., Ohnaka, K., Ikegami, H., et al. (2009) · Diabetologia · doi:10.1007/s00125-009-1595-1 · Cited by 90 · see citing works
“Fasting plasma glucose (FPG) levels are associated with the future risk of type 2 diabetes and cardiovascular diseases [ 1 , 2] and are tightly regulated despite considerable variation in food intake [3].”
BackgroundLotta, L. A., Abbasi, A., Sharp, S. J., Sahlqvist, A., Waterworth, D. M., Brosnan, J. M., Scott, R. A., Langenberg, C., & Wareham, N. J. (2015) · Diabetes Care · doi:10.2337/dc15-1218 · Cited by 90 · see citing works
Zelber‐Sagi, S., Lotan, R., Shibolet, O., Webb, M., Buch, A., Nitzan, D., Halpern, Z., Santo, E., & Oren, R. (2013) · Liver International · doi:10.1111/liv.12200 · Cited by 88 · see citing works
“of higher fasting plasma glucose levels within the normoglycaemic range, of 91–99 mg/dl, has been demonstrated before to independently increase DM risk (44).”
BackgroundLee, C., Colagiuri, S., Woodward, M., Gregg, E. W., Adams, R. J., Azizi, F., Gabriel, R., Gill, T. K., González, C., Hodge, A. M., et al. (2019) · BMJ Open Diabetes Research & Care · doi:10.1136/bmjdrc-2019-000794 · Cited by 85 · see citing works
Bozorgmanesh, M., Hadaegh, F., Ghaffari, S., Harati, H., & Azizi, F. (2010) · European Journal of Public Health · doi:10.1093/eurpub/ckq074 · Cited by 82 · see citing works
The Prediabetic Period: Review of Clinical Aspects
Rhee, S. Y., & Woo, J. (2011) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2011.35.2.107 · Cited by 77 · see citing works
Otsuki, M., Kasayama, S., Morita, S., Asanuma, N., Saito, H., Mukai, M., & Koga, M. (2007) · Menopause The Journal of The North American Menopause Society · doi:10.1097/01.gme.0000247014.56254.12 · Cited by 73 · see citing works
White Blood Cell Count and the Risk for Coronary Artery Disease in Young Adults
Twig, G., Afek, A. B., Shamiss, A., Derazne, E., Tzur, D., Gordon, B., & Tirosh, A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047183 · Cited by 73 · see citing works
“…Life-Style, and Nutrition Assessment in Young Adults (MELANY) Cohort has been conducted at the Israel Defense Forces Staff Periodic Examination Center (SPEC) to which all career service personnel older than 25 years of age are referred every three to five year as described previously [20– 24].”
MethodSelf-citationCognitive Function and the Risk for Diabetes Among Young Men
Twig, G., Gluzman, I., Tirosh, A., Gerstein, H. C., Yaniv, G., Afek, A. B., Derazne, E., Tzur, D., Karasik, A., Gordon, B., et al. (2014) · Diabetes Care · doi:10.2337/dc14-0715 · Cited by 72 · see citing works
Self-citationAcatalasemia and diabetes mellitus
Góth, L., & Nagy, T. (2012) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2012.02.005 · Cited by 71 · see citing works
Bock, G., Man, C. D., Micheletto, F., Basu, R., Giesler, P. D., Laugen, J. M., Deacon, C. F., Holst, J. J., TOFFOLO, G. M., Cobelli, C., et al. (2009) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2009.03764.x · Cited by 71 · see citing works
“Impaired fasting glucose (IFG) confers a high risk of progression to diabetes [1].”
BackgroundRisk of malignancy in women with systemic lupus erythematosus.
Dm, S., Manzi, S., Janosky, J. E., Kj, S., Ferri, W. A., Ta, M., & Ramsey‐Goldman, R. (1995) · PubMed · Cited by 71 · see citing works
Perreault, L., & Færch, K. (2013) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2013.10.008 · Cited by 71 · see citing works
“8 mmol/L) is associated with an increased risk of future diabetes (Tirosh et al. 2005).”
BackgroundThe potential of novel biomarkers to improve risk prediction of type 2 diabetes
Herder, C., Kowall, B., Tabák, Á. G., & Rathmann, W. (2013) · Diabetologia · doi:10.1007/s00125-013-3061-3 · Cited by 69 · see citing works
“Although a clearly increased diabetes risk can be observed for individuals with isolated IFG and those with isolated IGT, the categorisation of individuals as either ‘normal’ or ‘prediabetic’ (IFG, IGT) neglects the fact that a significant increase in diabetes risk also exists for increasing fasting glucose levels wit…”
Controversies in stable coronary artery disease
Opie, L. H., Commerford, P., & Gersh, B. J. (2006) · The Lancet · doi:10.1016/s0140-6736(06)67927-0 · Cited by 69 · see citing works
- Authors
- Tirosh, A., Shai, I., Tekes-Manova, D., Israeli, E., Pereg, D., Shochat, T., Kochba, I., & Rudich, A.
- Affiliations
- Sheba Medical Center (IL)
- Israel Defense Forces Medical Corps (IL)
- Meir Medical Center (IL)
- Ben-Gurion University of the Negev (IL)
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2005-10-06
- Volume
- 353
- Issue
- 14
- Pages
- 1454-1462
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2022852506
- Semantic Scholar
- 6bb2371f0d6168ca3c8b7a7910714ce03e565a83
- Cited by
- 508
- References
- 37
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 17 · 2023: 28 · 2022: 11 · 2021: 17 · 2020: 24 · 2019: 15 · 2018: 24 · 2017: 14 · 2016: 24 · 2015: 21 · 2014: 33 · 2013: 35 · 2012: 31
- FWCI
- 21.52
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- fasting blood glucose, type 2 diabetes, prediabetes, young men, diabetes risk prediction, serum triglycerides, body mass index, hypertriglyceridemia, military personnel, new-onset diabetes
- MeSH terms
- Adult, Blood Glucose, Diabetes Mellitus, Type 2, Fasting, Follow-Up Studies, Humans, Male, Middle Aged, Reference Values, Risk Factors, Triglycerides, Body Mass Index, Multivariate Analysis, Proportional Hazards Models
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