Therapeutic interventions to reduce the risk of progression from prediabetes to type 2 diabetes mellitus
Open accessAbstract
Clinical trials have demonstrated that it is possible to prevent diabetes through lifestyle modification, pharmacological intervention, and surgery. This review aims to summarize the effectiveness of these various therapeutic interventions in reducing the risk of progression of prediabetes to diabetes, and address the challenges to implement a diabetes prevention program at a community level. Strategies focusing on intensive lifestyle changes are not only efficient but cost-effective and/or cost-saving. Indeed, lifestyle intervention in people at high risk for type 2 diabetes mellitus (T2DM) has been successful in achieving sustained behavioral changes and a reduction in diabetes incidence even after the counseling is stopped. Although prediabetes is associated with health and economic burdens, it has not been adequately addressed by interventions or regulatory agencies in terms of prevention or disease management. Lifestyle intervention strategies to prevent T2DM should be distinct for different populations around the globe and should emphasize sex, age, ethnicity, and cultural and geographical considerations to be feasible and to promote better compliance. The translation of diabetes prevention research at a population level, especially finding the most effective methods of preventing T2DM in various societies and cultural settings remains challenging, but must be accomplished to stop this worldwide epidemic.
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Both diabetes mellitus and prediabetes are independently associated with lower heart rate variability (HRV).
“Both DM and prediabetes are independently associated with lower heart rate variability (HRV), which suggests that cardiac autonomic dysfunction may be characteristic of prediabetes2–5.”
From Sleep and temperature data from wearable devices support noninvasive detection of diabetes mellitus in a large-scale, retrospective analysis (2026) · cites this paper as [2]
The “Prediabetes is a disease” section reports increased polyneuropathy in people with impaired fasting glucose or impaired glucose tolerance, but does not discuss heart rate variability. Searches for HRV and cardiac autonomic dysfunction found no passage establishing an independent association between either diabetes or prediabetes and lower HRV. (LLM, conf=0.74)
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Liu, Y., Cotillard, A., Vatier, C., Bastard, J.-P., Fellahi, S., Stévant, M., Allatif, O., Langlois, C., Bieuvelet, S., Brochot, A., et al. (2015) · PLOS ONE · doi:10.1371/journal.pone.0138646 · Cited by 71 · see citing works
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- Authors
- Hsueh, W., McLellan, K., Wyne, K., & Villagomez, E.
- Affiliations
- Houston Methodist (US)
- Corresponding author
- Hsueh, Willa
- Venue
- Therapeutics and Clinical Risk Management
- Publisher
- Informa UK Limited
- Published
- 2014-03
- Volume
- 10
- Pages
- 173
- ISSN
- 1176-6336 (ISSN-L)
- 1178-203X
- PMC
- PMC3964168
- OpenAlex
- W2078669300
- Cited by
- 91
- References
- 191
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 3 · 2023: 2 · 2022: 4 · 2021: 8 · 2020: 5 · 2019: 12 · 2018: 9 · 2017: 10 · 2016: 14 · 2015: 12 · 2014: 6 · 2013: 1
- FWCI
- 2.23
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Therapeutics and Clinical Risk Management (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Acervo Digital da Universidade Estadual Paulista (Universidade Estadual Paulista) (submittedVersion, other-oa)
- Americanae (AECID Library) (submittedVersion, other-oa)
- Dove Medical Press (Taylor and Francis Group) (submittedVersion, cc-by-nc)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
- Funders
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Ciência sem Fronteiras
- National Institute on Minority Health and Health Disparities (R01MD007867)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Education
- Keywords
- prediabetes, type 2 diabetes, diabetes prevention, lifestyle intervention, pharmacological interventions, bariatric surgery, community-based prevention programs, cost-effectiveness, behavior change
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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