CoChat
Sign Up
Cited by 151Lipoproteins and Cardiovascular HealthDiabetes, Cardiovascular Risks, and LipoproteinsLipid metabolism and disorders

The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.

Changes in triglyceride levels and risk for coronary heart disease in young men.

Tirosh, Amir, Rudich, Assaf, Shochat, Tzippora, Tekes-Manova, Dorit, Israeli, Eran, Henkin, Yaakov, Kochba, Ilan, Shai, Iris·2007·Annals of Internal Medicine
DOI 10.7326/0003-4819-147-6-200709180-00007
Open this paper in CoChat — free account

Abstract

BACKGROUND: Current triglyceride levels might be only a weak predictor of risk for coronary heart disease (CHD). OBJECTIVE: To assess the association between changes over time in fasting triglyceride levels and CHD risk in young adults. DESIGN: Follow-up study over 5.5 years after 2 measurements of fasting triglycerides 5 years apart. SETTING: The Staff Periodic Examination Center of the Israel Defense Forces, Zrifin, Israel. PATIENTS: 13,953 apparently healthy, untreated, young men (age 26 to 45 years) with triglyceride levels less than 3.39 mmol/L (<300 mg/dL). MEASUREMENTS: Two triglyceride measurements (at enrollment [time 1] and 5 years later [time 2]), lifestyle variables, and incident cases of angiography-proven CHD. RESULTS: Within 5.5 years, 158 new cases of CHD were identified. The multivariate model was adjusted for age; family history; fasting glucose; high-density lipoprotein cholesterol; blood pressure; body mass index; and changes between time 1 and time 2 in body mass index, physical activity, smoking status, and habit of eating breakfast. Investigators categorized triglyceride levels according to low, intermediate, and high tertiles (as measured at time 1 and time 2 [expressed as tertile at time 1/tertile at time 2]). The risk for CHD in men with high-tertile triglyceride levels at time 1 changed depending on the tertile at time 2 (hazard ratios, 8.23 [95% CI, 2.50 to 27.13] for high/high, 6.84 [CI, 1.95 to 23.98] for high/intermediate, and 4.90 [CI, 1.01 to 24.55] for high/low, compared with the stable low/low group). The risk for CHD in men with low-tertile levels at time 1 also changed depending on the tertile at time 2 (hazard ratios, 3.81 [CI, 0.96 to 15.31] for low/intermediate and 6.76 [CI, 1.34 to 33.92] for low/high, compared with the stable low/low group). LIMITATIONS: Participants were healthy and had a low incidence rate of CHD. The study was observational. CONCLUSIONS: Two triglyceride measurements obtained 5 years apart may assist in assessing CHD risk in young men. A decrease in initially elevated triglyceride levels is associated with a decrease in CHD risk compared with stable high triglyceride levels. However, this risk remains higher than in those with persistently low triglyceride levels.

Overview

Integrity signals

Registry

Crossref · 10.7326/0003-4819-147-6-200709180-00007

Cites

31 of 31 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • In the MELANY study, after multivariate adjustment, men in the top quintile of triglyceride levels had a hazard ratio for coronary heart disease of 4.05 (95% CI, 2.68-8.61) compared with the lowest quintile.

    “After multivariate adjustment (including age, body mass index, HDL cholesterol, physical activity, fasting glucose, mean arterial blood pressure, smoking), men in the top quintile of triglyceride levels had a hazard ratio for coronary heart disease of 4.05 (95% CI, 2.68 -8.61) compared with the lowest quintile (P ϭ 0.001 for trend) (135).”

    From Evaluation and Treatment of Hypertriglyceridemia: An Endocrine Society Clinical Practice Guideline (2012) · cites this paper as [135]

  • Beyond fasting triglyceride levels, the change in triglyceride levels strongly predicted incident coronary heart disease.

    “Beyond fasting triglyceride levels, the change in triglyceride levels strongly predicted incident coronary heart disease (135).”

    From Evaluation and Treatment of Hypertriglyceridemia: An Endocrine Society Clinical Practice Guideline (2012) · cites this paper as [135]

  • At baseline, triglyceride levels in the top quintile were associated with a 4-fold increased risk of CVD compared with the lowest triglyceride quintile, even after adjustment for other risk factors, including HDL-C.

    “At baseline, triglyceride levels in the top quintile were associated with a 4-fold increased risk of CVD compared with the lowest triglyceride quintile, even after adjustment for other risk factors, including HDL-C.”

    From Triglycerides and Cardiovascular Disease: A Scientific Statement From the American Heart Association (2011) · cites this paper as [37]

  • In 13,953 men 26 to 45 years old followed for 10.5 years, there were significant correlations between adoption of a favorable lifestyle and a decrease in triglyceride levels.

    “In 13 953 men 26 to 45 years old who were followed up for 10.5 years, there were significant correlations between adoption of a favorable lifestyle (eg, weight loss, physical activity) and a decrease in triglyceride levels.”

    From Triglycerides and Cardiovascular Disease: A Scientific Statement From the American Heart Association (2011) · cites this paper as [37]

  • Increases in triglyceride levels over 5 years were directly correlated with incident CVD in the next 5 years.

    “Evaluation of the change in triglyceride levels over the first 5 years and incident CVD in the next 5 years found a direct correlation between increases in triglyceride levels and CVD risk.”

    From Triglycerides and Cardiovascular Disease: A Scientific Statement From the American Heart Association (2011) · cites this paper as [37]

Citations

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Metadata

Authors
Tirosh, A., Rudich, A., Shochat, T., Tekes-Manova, D., Israeli, E., Henkin, Y., Kochba, I., & Shai, I.
Affiliations
Ben-Gurion University of the Negev (IL)
ORCID
Venue
Annals of Internal Medicine
Publisher
American College of Physicians
Published
2007-09-18
Volume
147
Issue
6
Pages
377-385
ISSN
  • 0003-4819 (ISSN-L)
  • 1539-3704
DOI
10.7326/0003-4819-147-6-200709180-00007
OpenAlex
W2034235812
Cited by
151
References
31
Citations by year
2026: 1 · 2025: 1 · 2024: 3 · 2023: 5 · 2022: 4 · 2021: 6 · 2020: 2 · 2019: 9 · 2018: 8 · 2017: 7 · 2016: 6 · 2015: 14 · 2014: 7 · 2013: 11 · 2012: 16
FWCI
11.95
Type
journal article
Language
en
Open access
closed
Licence
www.acpjournals.org/journal/aim/text-and-data-mining (tdm)
Locations
  • Annals of Internal Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Keywords
coronary artery disease, young men, cardiovascular risk, incident coronary heart disease
MeSH terms
Adult, Coronary Disease, Electrocardiography, Exercise Test, Fasting, Follow-Up Studies, Humans, Israel, Life Style, Male, Middle Aged, Risk Factors, Triglycerides, Incidence

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review