Cited by 1,859Cardiac pacing and defibrillation studiesHeart Failure Treatment and ManagementCardiac Arrest and Resuscitation

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Cardiac-Resynchronization Therapy for Mild-to-Moderate Heart Failure

Tang, Anthony S.L., Wells, George A., Talajic, Mario, Arnold, Malcolm O., Sheldon, Robert, Connolly, Stuart, Hohnloser, Stefan H., Nichol, Graham, Birnie, David H., Sapp, John L., Yee, Raymond, Healey, Jeffrey S., Rouleau, Jean L.·2010·New England Journal of Medicine

DOI 10.1056/nejmoa1009540

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Abstract

BACKGROUND: Cardiac-resynchronization therapy (CRT) benefits patients with left ventricular systolic dysfunction and a wide QRS complex. Most of these patients are candidates for an implantable cardioverter-defibrillator (ICD). We evaluated whether adding CRT to an ICD and optimal medical therapy might reduce mortality and morbidity among such patients. METHODS: We randomly assigned patients with New York Heart Association (NYHA) class II or III heart failure, a left ventricular ejection fraction of 30% or less, and an intrinsic QRS duration of 120 msec or more or a paced QRS duration of 200 msec or more to receive either an ICD alone or an ICD plus CRT. The primary outcome was death from any cause or hospitalization for heart failure. RESULTS: We followed 1798 patients for a mean of 40 months. The primary outcome occurred in 297 of 894 patients (33.2%) in the ICD-CRT group and 364 of 904 patients (40.3%) in the ICD group (hazard ratio in the ICD-CRT group, 0.75; 95% confidence interval [CI], 0.64 to 0.87; P<0.001). In the ICD-CRT group, 186 patients died, as compared with 236 in the ICD group (hazard ratio, 0.75; 95% CI, 0.62 to 0.91; P = 0.003), and 174 patients were hospitalized for heart failure, as compared with 236 in the ICD group (hazard ratio, 0.68; 95% CI, 0.56 to 0.83; P<0.001). However, at 30 days after device implantation, adverse events had occurred in 124 patients in the ICD-CRT group, as compared with 58 in the ICD group (P<0.001). CONCLUSIONS: Among patients with NYHA class II or III heart failure, a wide QRS complex, and left ventricular systolic dysfunction, the addition of CRT to an ICD reduced rates of death and hospitalization for heart failure. This improvement was accompanied by more adverse events. (Funded by the Canadian Institutes of Health Research and Medtronic of Canada; ClinicalTrials.gov number, NCT00251251.).

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Cleland, J. G. F., Bristow, M. R., Freemantle, N., Olshansky, B., Gras, D., Saxon, L. A., Tavazzi, L., BOEHMER, J. P., Ghio, S., Feldman, A. M., et al. (2022) · European Journal of Heart Failure · doi:10.1002/ejhf.2524 · Cited by 38
Management of Heart Failure in Patients with Chronic Kidney Disease
Ryan, D. K., Banerjee, D., & Jouhra, F. (2022) · European Cardiology Review · doi:10.15420/ecr.2021.33 · Cited by 44
Outcomes of conduction system pacing for cardiac resynchronization therapy in patients with heart failure: A multicenter experience
Ezzeddine, F. M., Pistiolis, S., Pujol‐López, M., Lavelle, M. T., Wan, E. Y., Patton, K. K., Robinson, M., Lador, A., Tamirisa, K. P., Karim, S., et al. (2023) · Heart Rhythm · doi:10.1016/j.hrthm.2023.02.018 · Cited by 38
Clinical Effectiveness of CRT and ICD Therapy in Heart Failure Patients by Racial/Ethnic Classification
Ziaeian, B., Zhang, Y., Albert, N. M., Curtis, A. B., Gheorghiade, M., Heywood, J. T., Mehra, M. R., O’Connor, C. M., REYNOLDS, D. W., Walsh, M. N., et al. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.05.060 · Cited by 38
Sex-related similarities and differences in responses to heart failure therapies
Chyou, J. Y., Qin, H., Butler, J., Voors, A. A., & Lam, C. S. P. (2024) · Nature Reviews Cardiology · doi:10.1038/s41569-024-00996-1 · Cited by 37
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Rush, C. J., Campbell, R. T., Jhund, P. S., Connolly, E. C., Preiss, D., Gardner, R. S., Petrie, M. C., & McMurray, J. J. V. (2015) · JACC Heart Failure · doi:10.1016/j.jchf.2015.03.013 · Cited by 37
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Animal Models of Dyssynchrony
Strik, M., van Middendorp, L. B., & Vernooy, K. (2011) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-011-9336-5 · Cited by 37
Digoxin therapy and associated clinical outcomes in the MADIT-CRT trial
Lee, A. Y., Kutyifa, V., Ruwald, M. H., McNitt, S. A., Polonsky, B., Zaręba, W., Moss, A. J., & Ruwald, A. (2015) · Heart Rhythm · doi:10.1016/j.hrthm.2015.05.016 · Cited by 37
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Gold, M. R., Padhiar, A., Mealing, S., Sidhu, M. K., Tsintzos, S. I., & Abraham, W. T. (2017) · JACC Heart Failure · doi:10.1016/j.jchf.2016.10.014 · Cited by 37
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Miller, R. J. H., Howlett, J. G., Exner, D. V., Campbell, P. M., Grant, A. D., & Wilton, S. B. (2015) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2014.12.031 · Cited by 36
Effect of cardiac resynchronization therapy and implantable cardioverter defibrillator on quality of life in patients with heart failure: a meta-analysis
Chen, S., Yin, Y., & Krucoff, M. W. (2012) · EP Europace · doi:10.1093/europace/eus168 · Cited by 36
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Barra, S., Providencia, R. A., TANG, A. S. L., Heck, P. M., Virdee, M., & Agarwal, S. (2015) · Journal of the American Heart Association · doi:10.1161/jaha.115.002539 · Cited by 36
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Verbrugge, F. H., Dupont, M., Rivero‐Ayerza, M., Vusser, P. D., Herendael, H. V., Vercammen, J., Jacobs, L., Verhaert, D., Vandervoort, P. M., Tang, W. H. W., et al. (2012) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2012.09.003 · Cited by 36
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Linde, C. M., Daubert, J., Abraham, W. T., Sutton, M. S. J., Ghio, S., Hassager, C., Herre, J. M., Bergemann, T. L., & Gold, M. R. (2013) · Circulation Heart Failure · doi:10.1161/circheartfailure.113.000326 · Cited by 35
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Features of diagnostics and treatment of chronic heart failure in elderly and senile patients. Expert opinion of the Society of Experts in Heart Failure, Russian Association of Gerontologists, and Euroasian Association of Therapists
Orlova, Y. A., Tkacheva, O. N., Arutyunov, G. P., Kotovskaya, Y. V., Lopatin, Y. M., Mareev, V. Y., Mareev, Y. V., Рунихина, Н. К., Skvortsov, A. A., Strazhesko, I. D., et al. (2018) · Kardiologiia · doi:10.18087/cardio.2560 · Cited by 35
Predictors of Long-Term Outcome in Heart Failure with Preserved Ejection Fraction: A Follow-Up from the KaRen Study
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Röger, S., Schneider, R., Rudic, B., Liebe, V., Stach, K., Schimpf, R., Borggrefe, M. M., & Kuschyk, J. (2014) · EP Europace · doi:10.1093/europace/euu050 · Cited by 35
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Biffi, M., Bertini, M., Ziacchi, M., Diemberger, I., Martignani, C., & Boriani, G. (2013) · EP Europace · doi:10.1093/europace/eut300 · Cited by 35
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Gula, L. J., Wells, G. A., Yee, R. K., Koehler, J. L., Sarkar, S., Sharma, V., Skanes, A. C., Sapp, J. L., Redfearn, D., Manlucu, J., et al. (2014) · Heart Rhythm · doi:10.1016/j.hrthm.2014.05.015 · Cited by 34
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Carità, P., Corrado, E., Pontone, G., Curnis, A., Bontempi, L., Novo, G., Guglielmo, M., Ciaramitaro, G., Assennato, P., Novo, S., et al. (2016) · International Journal of Cardiology · doi:10.1016/j.ijcard.2016.09.037 · Cited by 34
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Regoli, F. D., Scopigni, F. R., Leyva, F., Landolina, M., Ghio, S., Tritto, M. V., Calò, L., Klersy, C., Auricchio, A., & for the collaborative study group (2012) · European Journal of Heart Failure · doi:10.1093/eurjhf/hfs162 · Cited by 34
Treatment for Pulmonary Arterial Hypertension–Associated Right Ventricular Dysfunction
Gomez‐Arroyo, J. G., Sandoval, J., Simon, M. A. M., Dominguez-Cano, E., Voelkel, N. F., & Bogaard, H. J. (2014) · Annals of the American Thoracic Society · doi:10.1513/annalsats.201312-425fr · Cited by 35
Safety, efficacy, and performance of new discrimination algorithms to reduce inappropriate and unnecessary shocks: the PainFree SST clinical study design
Auricchio, A., Meijer, A., Kurita, T., Schloss, E. J., Brinkman, K., Ooijen, M. C.-V., & Sterns, L. D. (2011) · EP Europace · doi:10.1093/europace/eur133 · Cited by 34
Primary prevention implantable cardioverter defibrillator in patients with non-ischaemic cardiomyopathy: a meta-analysis of randomised controlled trials
Barakat, A. F., Saad, M. S., Elgendy, A. Y., Mentias, A. G., Abuzaid, A., Mahmoud, A. N., & Elgendy, I. Y. (2017) · BMJ Open · doi:10.1136/bmjopen-2017-016352 · Cited by 34
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Padfield, G. J., Steinberg, C., Bennett, M. T., Chakrabarti, S., Deyell, M. W., Bashir, J. G., & Krahn, A. D. (2015) · Heart Rhythm · doi:10.1016/j.hrthm.2015.06.043 · Cited by 33
Comentarios a la guía de práctica clínica de la ESC sobre diagnóstico y tratamiento de la insuficiencia cardiaca aguda y crónica 2012. Un informe del Grupo de Trabajo del Comité de Guías de Práctica Clínica de la Sociedad Española de Cardiología
Anguita, M. P., Colet, J. C., Almenar, L., Crespo, M., Delgado, J. F., González-Costello, J., Hernández‐Madrid, A., Manito, N., de la Sota, E. P., Segovia, J. R., et al. (2012) · Revista Española de Cardiología · doi:10.1016/j.recesp.2012.07.013 · Cited by 33
Prognostic implication of baseline PR interval in cardiac resynchronization therapy recipients
Januszkiewicz, Ł. J., Végh, É., Borgquist, R., Bose, A., Sharma, A., Orencole, M. P., Mela, T., Singh, J. P., & Parks, K. A. (2015) · Heart Rhythm · doi:10.1016/j.hrthm.2015.06.016 · Cited by 33

Authors: Tang, A. S. L., Wells, G. A., Talajic, M., Arnold, M. O., Sheldon, R., Connolly, S., Hohnloser, S. H., Nichol, G., Birnie, D. H., Sapp, J. L., Yee, R., Healey, J. S., & Rouleau, J. L.
Affiliations: University of British Columbia (CA)
Ottawa Heart Institute (CA)
Montreal Heart Institute (CA)
London Health Sciences Centre (CA)
University of Calgary (CA)
Hamilton Health Sciences (CA)
Goethe University Frankfurt (DE)
University of Washington (US)
Queen Elizabeth II Health Sciences Centre (CA)
ORCID: Tang, Anthony S.L.
Wells, George A.
Talajic, Mario
Sheldon, Robert
Connolly, Stuart
Hohnloser, Stefan H.
Nichol, Graham
Birnie, David H.
Sapp, John L.
Yee, Raymond
Rouleau, Jean L.
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 2010-12-16
Volume: 363
Issue: 25
Pages: 2385-2395
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejmoa1009540
OpenAlex: W2141895646
Cited by: 1,859
References: 28
Citations by year: 2026: 55 · 2025: 67 · 2024: 73 · 2023: 109 · 2022: 76 · 2021: 88 · 2020: 107 · 2019: 99 · 2018: 100 · 2017: 121 · 2016: 141 · 2015: 154 · 2014: 149 · 2013: 190 · 2012: 176
FWCI: 113.15
Type: journal article
Language: en
Open access: closed
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
Funders: Canadian Institutes of Health Research
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac pacing and defibrillation studies
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
Health Sciences › Medicine › Emergency Medicine › Cardiac Arrest and Resuscitation
Keywords: cardiac resynchronization therapy, implantable cardioverter-defibrillator, heart failure, wide QRS complex, left ventricular systolic dysfunction, mortality, heart failure hospitalization, device implantation complications, optimal medical therapy, left ventricular ejection fraction
MeSH terms: Aged, Cardiac Pacing, Artificial, Double-Blind Method, Electrocardiography, Female, Heart Failure, Hospitalization, Humans, Male, Middle Aged, Severity of Illness Index, Defibrillators, Implantable, Ventricular Dysfunction, Left, Kaplan-Meier Estimate, Intention to Treat Analysis

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Cardiac-Resynchronization Therapy for Mild-to-Moderate Heart Failure

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