Cited by 1,859Cardiac pacing and defibrillation studiesHeart Failure Treatment and ManagementCardiac Arrest and Resuscitation

The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.

Cardiac-Resynchronization Therapy for Mild-to-Moderate Heart Failure

Tang, Anthony S.L., Wells, George A., Talajic, Mario, Arnold, Malcolm O., Sheldon, Robert, Connolly, Stuart, Hohnloser, Stefan H., Nichol, Graham, Birnie, David H., Sapp, John L., Yee, Raymond, Healey, Jeffrey S., Rouleau, Jean L.·2010·New England Journal of Medicine

DOI 10.1056/nejmoa1009540

Open this paper in CoChat — free account

Abstract

BACKGROUND: Cardiac-resynchronization therapy (CRT) benefits patients with left ventricular systolic dysfunction and a wide QRS complex. Most of these patients are candidates for an implantable cardioverter-defibrillator (ICD). We evaluated whether adding CRT to an ICD and optimal medical therapy might reduce mortality and morbidity among such patients. METHODS: We randomly assigned patients with New York Heart Association (NYHA) class II or III heart failure, a left ventricular ejection fraction of 30% or less, and an intrinsic QRS duration of 120 msec or more or a paced QRS duration of 200 msec or more to receive either an ICD alone or an ICD plus CRT. The primary outcome was death from any cause or hospitalization for heart failure. RESULTS: We followed 1798 patients for a mean of 40 months. The primary outcome occurred in 297 of 894 patients (33.2%) in the ICD-CRT group and 364 of 904 patients (40.3%) in the ICD group (hazard ratio in the ICD-CRT group, 0.75; 95% confidence interval [CI], 0.64 to 0.87; P<0.001). In the ICD-CRT group, 186 patients died, as compared with 236 in the ICD group (hazard ratio, 0.75; 95% CI, 0.62 to 0.91; P = 0.003), and 174 patients were hospitalized for heart failure, as compared with 236 in the ICD group (hazard ratio, 0.68; 95% CI, 0.56 to 0.83; P<0.001). However, at 30 days after device implantation, adverse events had occurred in 124 patients in the ICD-CRT group, as compared with 58 in the ICD group (P<0.001). CONCLUSIONS: Among patients with NYHA class II or III heart failure, a wide QRS complex, and left ventricular systolic dysfunction, the addition of CRT to an ICD reduced rates of death and hospitalization for heart failure. This improvement was accompanied by more adverse events. (Funded by the Canadian Institutes of Health Research and Medtronic of Canada; ClinicalTrials.gov number, NCT00251251.).

Integrity signals

Registry

Crossref · 10.1056/nejmoa1009540

Cites

29 of 29 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Prophylactic Implantation of a Defibrillator in Patients with Myocardial Infarction and Reduced Ejection Fraction
Moss, A. J., Zaręba, W., Hall, W. J., Klein, H., Wilber, D. J., Cannom, D. S., Daubert, J. P., Higgins, S. L., Brown, M. W., & Andrews, M. L. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa013474 · Cited by 6,885
Amiodarone or an Implantable Cardioverter–Defibrillator for Congestive Heart Failure
Bardy, G. H., Lee, K. L., Mark, D. B., Poole, J. E., Packer, D. L., Boineau, R., Domanski, M., Troutman, C., Anderson, J., Johnson, G., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa043399 · Cited by 6,552
The Effect of Cardiac Resynchronization on Morbidity and Mortality in Heart Failure
Cleland, J. G. F., Daubert, J., Erdmann, E., Freemantle, N., Gras, D., KAPPENBERGER, L. J., & Tavazzi, L. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa050496 · Cited by 6,300
Cardiac-resynchronization therapy with or without an implantable defibrillator in advanced chronic heart failure
Bristow, M. R., Saxon, L. A., Boehmer, J., Krueger, S., Kass, D. A., De Marco, T., Carson, P., DiCarlo, L., DeMets, D., White, B. G., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa032423 · Cited by 5,812
Cardiac Resynchronization in Chronic Heart Failure
Abraham, W. T., Fisher, W. G., Smith, A. L., Delurgio, D. B., Leon, A. R., Loh, E., Kocovic, D. Z., Packer, M., Clavell, A. L., Hayes, D. L., et al. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa013168 · Cited by 4,648
ACC/AHA 2005 Guideline Update for the Diagnosis and Management of Chronic Heart Failure in the Adult
Hunt, S. A. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.08.022 · Cited by 4,137
CARDIAC RESYNCHRONIZATION IN CHRONIC HEART FAILURE
Braham, W. I. T. A., Isher, W. E. G. F., Mith, L. S., Elurgio, D. A. B. D., Eon, A. N. R. L., Oh, E., Ocovic, D. U. Z. K., Acker, M. G., Lavell, L. C., Ayes, D. A. L. H., et al. (2002) · Cited by 3,808
2009 Focused Update Incorporated Into the ACC/AHA 2005 Guidelines for the Diagnosis and Management of Heart Failure in Adults
Hunt, S. A., Abraham, W. T., Chin, M. H., Feldman, A. M., Francis, G. S., Ganiats, T. G., Jessup, M. L., Konstam, M. A., MANCINI, D. M., Michl, K., et al. (2009) · Circulation · doi:10.1161/circulationaha.109.192065 · Cited by 3,739
Cardiac-Resynchronization Therapy for the Prevention of Heart-Failure Events
Moss, A. J., Hall, W. J., Cannom, D. S., Klein, H., Brown, M. W., Daubert, J. P., Estes, N. A. M., Foster, E., Greenberg, H., Higgins, S. L., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0906431 · Cited by 3,157
Effects of Multisite Biventricular Pacing in Patients with Heart Failure and Intraventricular Conduction Delay
Cazeau, S., Leclercq, C., Lavergne, T., Walker, S., Varma, C., Linde, C. M., Garrigue, S., KAPPENBERGER, L. J., Haywood, G. A., Santini, M., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200103223441202 · Cited by 2,718

Flagged first, then by citations

Show all 28 references

Research works printed but not linked: 1

Chan KL, 2003, Can J Cardiol, 19, 387

Sorted by citations

Items 401–500 of 1,000

Outcomes of cardiac resynchronization therapy in patients with intermittent atrial fibrillation or atrial flutter in the COMPANION trial
Kalscheur, M. M., Saxon, L. A., Lee, B. K., Steinberg, J. S., Mei, C., Buhr, K. A., DeMets, D. L., Bristow, M. R., & Singh, S. N. (2017) · Heart Rhythm · doi:10.1016/j.hrthm.2017.03.024 · Cited by 33
Representation of black patients in randomized clinical trials of heart failure with reduced ejection fraction
Sullivan, L. T., Randolph, T. C., Merrill, P., Jackson, L. R., Egwim, C., Starks, M. A., & Thomas, K. L. (2017) · American Heart Journal · doi:10.1016/j.ahj.2017.10.025 · Cited by 35
Devices in Heart Failure Patients—Who Benefits From ICD and CRT?
Breitenstein, A., & Steffel, J. (2019) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2019.00111 · Cited by 33
Cardiac resynchronization therapy in chronic heart failure with moderately reduced left ventricular ejection fraction: Lessons from the Multicenter InSync Randomized Clinical Evaluation MIRACLE EF study
Linde, C. M., Curtis, A. B., Fonarow, G. C., Lee, K. L., Little, W. C., TANG, A. S. L., Levya, F., Momomura, S., Manrodt, C., Bergemann, T. L., et al. (2015) · International Journal of Cardiology · doi:10.1016/j.ijcard.2015.09.023 · Cited by 33
Self-citation
The Effect of Intermittent Atrial Tachyarrhythmia on Heart Failure or Death in Cardiac Resynchronization Therapy With Defibrillator Versus Implantable Cardioverter-Defibrillator Patients
Ruwald, A., Pietrasik, G. M., Goldenberg, I., Kutyifa, V., Daubert, J. P., Ruwald, M. H., Jøns, C., McNitt, S. A., Wang, P. J., Zaręba, W., et al. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.10.074 · Cited by 33
Utilization of cardiac resynchronization therapy in eligible patients hospitalized for heart failure and its association with patient outcomes
Randolph, T. C., Hellkamp, A. S., Zeitler, E. P., Fonarow, G. C., Hernandez, A. F., Thomas, K. L., Peterson, E. D., Yancy, C. W., & Al‐Khatib, S. M. (2017) · American Heart Journal · doi:10.1016/j.ahj.2017.04.001 · Cited by 33
Dilated Cardiomyopathy: From Genetics to Clinical Management
(2019) · doi:10.1007/978-3-030-13864-6 · Cited by 32
Left ventricular mechanical dyssynchrony by cardiac magnetic resonance is greater in patients with strict vs nonstrict electrocardiogram criteria for left bundle-branch block
Andersson, L. G., Wu, K. C., Wieslander, B., Loring, Z., Frank, T. F., Maynard, C. C., Gerstenblith, G., Tomaselli, G. F., Weiss, R. G., Wagner, G. S., et al. (2013) · American Heart Journal · doi:10.1016/j.ahj.2013.03.013 · Cited by 32
European Cardiac Resynchronization Therapy Survey II: rationale and design
Dickstein, K., Normand, C., Anker, S. D., Auricchio, A., Blomström‐Lundqvist, C., Bogale, N., Cleland, J. G. F., Filippatos, G. S., Gasparini, M., Gitt, A., et al. (2014) · EP Europace · doi:10.1093/europace/euu312 · Cited by 32
Reflections on EchoCRT: sound guidance on QRS duration and morphology for CRT?: Figure 1
Cleland, J. G. F., Mareev, Y. V., & Linde, C. M. (2015) · European Heart Journal · doi:10.1093/eurheartj/ehv264 · Cited by 32
Sinergy between drugs and devices in the fight against sudden cardiac death and heart failure
Boriani, G., Ponti, R. D., Guerra, F., Palmisano, P., Zanotto, G., D’Onofrio, A., & Ricci, R. P. (2020) · European Journal of Preventive Cardiology · doi:10.1093/eurjpc/zwaa015 · Cited by 32
Efficacy of His Bundle Pacing on LV Relaxation and Clinical Improvement in HF and LBBB
Kato, H., Yanagisawa, S., Sakurai, T., Mizuno, C., Ota, R., Watanabe, R., Suga, K., Okada, T., Murakami, H., Kada, K., et al. (2021) · JACC. Clinical electrophysiology · doi:10.1016/j.jacep.2021.06.011 · Cited by 32
Cardiac Resynchronization Therapy
Chatterjee, N. A., & Singh, J. P. (2015) · Heart Failure Clinics · doi:10.1016/j.hfc.2014.12.007 · Cited by 32
QRS Axis and the Benefit of Cardiac Resynchronization Therapy in Patients with Mildly Symptomatic Heart Failure Enrolled in MADIT‐CRT
brenyo, A. J., Rao, M. C., Barsheshet, A., Cannom, D. S., Quesada, A., McNitt, S. A., Huang, D. T.-C., Moss, A. J., & Zaręba, W. (2012) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.12057 · Cited by 32
The implantable cardioverter–defibrillator: An update
Miller, J. D., Yousuf, O. K., & Berger, R. D. (2015) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2015.01.015 · Cited by 32
Use of Primary Prevention Implantable Cardioverter-Defibrillators in a Population-Based Cohort Is Associated With a Significant Survival Benefit
Parkash, R., Sapp, J. L., Basta, M. N., Doucette, S. P., Thompson, K. J., Gardner, M. J., Gray, C., Brownell, B., Kidwai, H., & Cox, J. L. (2012) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.112.970798 · Cited by 31
Self-citation
Gender Differences in Ischemic Cardiomyopathy
Divoky, L., Maran, A., & Ramu, B. (2018) · Current Atherosclerosis Reports · doi:10.1007/s11883-018-0750-x · Cited by 31
What Are the Expectations for Cardiac Resynchronization Therapy? A Validation of Two Response Definitions
Nakai, T., Ikeya, Y., Kogawa, R., Otsuka, N., Wakamatsu, Y., Kurokawa, S., Ohkubo, K., Nagashima, K., & Okumura, Y. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10030514 · Cited by 31
The European cardiac resynchronization therapy survey: patient selection and implantation practice vary according to centre volume
Bogale, N., Priori, S. G., Gitt, A., Alings, M., Linde, C., Dickstein, K., Dickstein, K., Priori, S. G., Auricchio, A., Bogale, N., et al. (2011) · EP Europace · doi:10.1093/europace/eur173 · Cited by 31
Cardiac Venous Left Ventricular Lead Removal and Reimplantation Following Device Infection: A Large Single‐Center Experience
Rickard, J., Tarakji, K. G., Cronin, E. M., BRUNNER, M. P., Jackson, G. R., Baranowski, B. J., Borek, P., Martin, D. O., Wazni, O. M., & Wilkoff, B. L. (2012) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.2012.02392.x · Cited by 31
Baseline Characteristics of Patients in the Reduction of Events with Darbepoetin Alfa in Heart Failure Trial (RED-HF)
McMurray, J. J. V., Anand, I. S., Díaz, R., Maggioni, A. P., O’Connor, C. M., Pfeffer, M. A., Solomon, S. D., Tendera, M., van Veldhuisen, D. J., Albizem, M. B., et al. (2013) · European Journal of Heart Failure · doi:10.1093/eurjhf/hfs204 · Cited by 31
Why QRS Duration Should Be Replaced by Better Measures of Electrical Activation to Improve Patient Selection for Cardiac Resynchronization Therapy
Engels, E. B., Mafi-Rad, M., van Stipdonk, A. M. W., Vernooy, K., & Prinzen, F. W. (2016) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-016-9693-1 · Cited by 31
Neuerungen der ESC-Leitlinien zur akuten und chronischen Herzinsuffizienz 2016
Oeing, C. U., Tschöpe, C., & Pieske, B. M. (2016) · Herz · doi:10.1007/s00059-016-4496-3 · Cited by 33
The impact of gender difference on clinical and echocardiographic outcomes in patients with heart failure after cardiac resynchronization therapy: A systematic review and meta-analysis
Yin, F., Fan, C., Guo, Y.-Y., Zhu, H., & Wang, Z. (2017) · PLoS ONE · doi:10.1371/journal.pone.0176248 · Cited by 33
Super-response to cardiac resynchronization therapy reduces appropriate implantable cardioverter defibrillator therapy
Killu, A. M., Mazo, A., Grupper, A., Madhavan, M., Webster, T. L., Brooke, K. L., Hodge, D. O., Asirvatham, S. J., Friedman, P. A., Glikson, M., et al. (2017) · EP Europace · doi:10.1093/europace/eux235 · Cited by 31
Left bundle branch block-induced left ventricular remodeling and its potential for reverse remodeling
Sze, E. Y., & Daubert, J. P. (2018) · Journal of Interventional Cardiac Electrophysiology · doi:10.1007/s10840-018-0407-2 · Cited by 31
Contemporary Strategies in the Diagnosis and Management of Heart Failure
Dunlay, S. M., Pereira, N. L., & Kushwaha, S. S. (2014) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2014.01.004 · Cited by 30
Implantable cardiac defibrillators for people with non-ischaemic cardiomyopathy
Moheb, M. N. E., Nicolas, J., Khamis, A. M., Iskandarani, G., Akl, E. A., & Refaat, M. M. (2018) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012738.pub2 · Cited by 30
The Emerging Role of Left Bundle Branch Area Pacing for Cardiac Resynchronisation Therapy
Díaz, J. C., Duque, M., Aristizábal, J. M., Marín, J. E., Niño, C. D., Bastidas, O., Ruíz, L. M., Matos, C. D., Hoyos, C., Hincapie, D., et al. (2023) · Arrhythmia & Electrophysiology Review · doi:10.15420/aer.2023.15 · Cited by 30
Cardiac resynchronization therapy restored ventricular septal myocardial perfusion and enhanced ventricular remodeling in patients with nonischemic cardiomyopathy presenting with left bundle branch block
Ogano, M., Iwasaki, Y., Tanabe, J., Takagi, H., Umemoto, T., Hayashi, M., Miyauchi, Y., & Shimizu, W. (2014) · Heart Rhythm · doi:10.1016/j.hrthm.2014.02.014 · Cited by 30
The amount of viable and dyssynchronous myocardium is associated with response to cardiac resynchronization therapy: initial clinical results using multiparametric ECG-gated [18F]FDG PET
Lehner, S., Uebleis, C., Schüßler, F., Haug, A. R., Kääb, S., Bartenstein, P., Kriekinge, S. D. V., Germano, G., Estner, H., & Hacker, M. (2013) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-013-2516-6 · Cited by 30
Incidence, Predictors, and Procedural Results of Upgrade to Resynchronization Therapy
Essebag, V., Joza, J. E., Birnie, D. H., Sapp, J. L., Sterns, L. D., Philippon, F., Yee, R. K., Crystal, E., Kuś, T., Rinne, C., et al. (2014) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.114.001997 · Cited by 30
Self-citation
Singular Value Decomposition Applied to Cardiac Strain from MR Imaging for Selection of Optimal Cardiac Resynchronization Therapy Candidates
Ramachandran, R., Chen, X., Kramer, C. M., Epstein, F. H., & Bilchick, K. C. (2015) · Radiology · doi:10.1148/radiol.14141578 · Cited by 30
Present Guidelines for Device Implantation
Poole, J. E. (2014) · Circulation · doi:10.1161/circulationaha.112.000762 · Cited by 30
Clinical, Laboratory, and Pacing Predictors of CRT Response
Kandala, J., Altman, R., Park, M. Y., & Singh, J. P. (2012) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-012-9352-0 · Cited by 29
Differential Clinical Characteristics and Prognosis of Intraventricular Conduction Defects in Patients With Chronic Heart Failure
Cinca, J., Méndez, A. B., Puig, T., Ferrero‐Gregori, A., Roig, E. S., Vázquez, R., González‐Juanatey, J. R., Alonso‐Pulpón, L., Delgado, J. F., Brugada, J., et al. (2013) · European Journal of Heart Failure · doi:10.1093/eurjhf/hft042 · Cited by 29
Cardiac Resynchronization Therapy - Refocus on the Electrical Substrate -
Strik, M., Ploux, S., Vernooy, K., & Prinzen, F. W. (2011) · Circulation Journal · doi:10.1253/circj.cj-11-0356 · Cited by 29
Frequency and Sequelae of Retained Implanted Cardiac Device Material Post Heart Transplantation
Martin, A., Voss, J., SHANNON, D., Ruygrok, P., & Lever, N. A. (2014) · Pacing and Clinical Electrophysiology · doi:10.1111/pace.12274 · Cited by 29
Sex Differences in Device Therapy for Heart Failure: Utilization, Outcomes, and Adverse Events
Herz, N. D., Engeda, J. C., Zusterzeel, R., Sanders, W. E., O’Callaghan, K. M., Strauss, D. G., Jacobs, S., Selzman, K. A., Piña, I. L., & Caños, D. (2015) · Journal of Women s Health · doi:10.1089/jwh.2014.4980 · Cited by 29
Late-breaking clinical trials presented at the American Heart Association Congress in Chicago 2010
Gensch, C., Hoppe, U. C., Böhm, M., & Laufs, U. (2010) · Clinical Research in Cardiology · doi:10.1007/s00392-010-0270-3 · Cited by 29
Impact of Etiology on the Outcomes in Heart Failure Patients Treated with Cardiac Resynchronization Therapy: A Meta-Analysis
Chen, Y., Duan, C., Liu, F., Shen, S., Chen, P., & Bin, J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0094614 · Cited by 29
Independent predictors of mortality in patients with advanced heart failure treated by cardiac resynchronization therapy
Kreuz, J., Horlbeck, F., Linhart, M., Mellert, F., Fimmers, R., Schrickel, J. W., Nickenig, G., & Schwab, J. O. (2012) · EP Europace · doi:10.1093/europace/eus152 · Cited by 29
Prevalence and Incidence of Intra-Ventricular Conduction Delays and Outcomes in Patients with Heart Failure and Reduced Ejection Fraction: Insights from PARADIGM-HF and ATMOSPHERE
Kristensen, S. L., Castagno, D., Shen, L., Jhund, P. S., Docherty, K. F., Rørth, R., Abraham, W. T., Desai, A. S., Dickstein, K., Rouleau, J. L., et al. (2020) · European Journal of Heart Failure · doi:10.1002/ejhf.1972 · Cited by 29
Self-citation
Cardiac Resynchronization Therapy in Heart Failure Patients with Less Severe Left Ventricular Dysfunction
Hai, O. Y., Mentz, R. J., Zannad, F. M., Gasparini, M., Ferrari, G. M. D., Daubert, J., Holzmeister, J., Lam, C. S. P., Pochet, T., Vincent, A., et al. (2014) · European Journal of Heart Failure · doi:10.1002/ejhf.208 · Cited by 28
Impact of Left Bundle Branch Block on Heart Rate and its Relationship to Treatment with Ivabradine in Chronic Heart Failure
Reil, J., Robertson, M., Ford, I., BORER, J. S., Michel Komajda, N., Swedberg, K. B., Tavazzi, L., & Böhm, M. (2013) · European Journal of Heart Failure · doi:10.1093/eurjhf/hft072 · Cited by 28
Pacing transmural scar tissue reduces left ventricle reverse remodeling after cardiac resynchronization therapy
Mele, D., Agricola, E., Monte, A. D., Galderisi, M., D’Andrea, A., Rigo, F., Citro, R., Chiodi, E., Marchese, G., Valentina, P. D., et al. (2012) · International Journal of Cardiology · doi:10.1016/j.ijcard.2011.12.006 · Cited by 28
Novel active fixation mechanism permits precise placement of a left ventricular lead: Early results from a multicenter clinical study
Yee, R. K., Gadler, F., Hussin, A., Omar, R., Khaykin, Y., Verma, A., Lazeroms, M., Hine, D. S., & Marquard, K. R. (2014) · Heart Rhythm · doi:10.1016/j.hrthm.2014.04.020 · Cited by 28
Self-citation
Cardiac Resynchronization Defibrillator Therapy for Nonspecific Intraventricular Conduction Delay Versus Right Bundle Branch Block
Kawata, H., Bao, H., Curtis, J. P., Minges, K. E., Mitiku, T. Y., Birgersdotter-Green, U. M., Feld, G. K., & Hsu, J. C. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2019.04.025 · Cited by 28
Cost-Effectiveness of Adding Cardiac Resynchronization Therapy to an Implantable Cardioverter-Defibrillator Among Patients With Mild Heart Failure
Woo, C. Y., Strandberg, E. J., Schmiegelow, M., Pitt, A. L., Hlatky, M. A., Owens, D. K., & Goldhaber‐Fiebert, J. D. (2015) · Annals of Internal Medicine · doi:10.7326/m14-1804 · Cited by 29
Gender‐Related Safety and Efficacy of Cardiac Resynchronization Therapy
Schuchert, A., Muto, C., Maounis, T., Frank, R., Ella, R. O., Polauck, A., Padeletti, L., & for the MASCOT Study Group (2013) · Clinical Cardiology · doi:10.1002/clc.22203 · Cited by 31
Pre-Capillary Pulmonary Hypertension and Right Ventricular Dilation Predict Clinical Outcome in Cardiac Resynchronization Therapy
Chatterjee, N. A., Upadhyay, G. A., Singal, G., Parks, K. A., Dec, G. W., Singh, J. P., & Lewis, G. D. (2014) · JACC Heart Failure · doi:10.1016/j.jchf.2014.02.004 · Cited by 28
Empiric versus imaging guided left ventricular lead placement in cardiac resynchronization therapy (ImagingCRT): study protocol for a randomized controlled trial
Sommer, A., Kronborg, M. B., Poulsen, S. H., Bøttcher, M., Nørgaard, B. L., Bouchelouche, K., Mortensen, P. T., Gerdes, C., & Nielsen, J. C. (2013) · Trials · doi:10.1186/1745-6215-14-113 · Cited by 29
Prognostic Value of QRS Duration After Transcatheter Aortic Valve Implantation for Aortic Stenosis Using the CoreValve
Meguro, K., Lellouche, N., Yamamoto, M., Fougères, E., Monin, J., Lim, P., Mouillet, G., Dubois‐Randé, J., & Teíger, E. (2013) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2013.02.032 · Cited by 28
Comparative Effectiveness of Cardiac Resynchronization Therapy With an Implantable Cardioverter-Defibrillator Versus Defibrillator Therapy Alone
Masoudi, F. A., Mi, X., Curtis, L. H., Peterson, P. N., Curtis, J. P., Fonarow, G. C., Hammill, S. C., Heidenreich, P. A., Al‐Khatib, S. M., Piccini, J. P., et al. (2014) · Annals of Internal Medicine · doi:10.7326/m13-1879 · Cited by 28
Profound differences in prognostic impact of left ventricular reverse remodeling after cardiac resynchronization therapy relate to heart failure etiology
Martens, P., Nijst, P., Verbrugge, F. H., Dupont, M., Tang, W. H. W., & Müllens, W. (2017) · Heart Rhythm · doi:10.1016/j.hrthm.2017.08.021 · Cited by 28
Effect of Cardiac Resynchronization Therapy on Left Ventricular Remodeling in Patients With Cardiac Sarcoidosis
Patel, D. R., Trulock, K. M., Toro, S., Grimaldi, A. S., Gonzalez, M. H., Moennich, L. A., Gorodeski, E. Z., Joyce, E., Niebauer, M. J., Wilkoff, B. L., et al. (2018) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2018.09.044 · Cited by 28
Cardiac resynchronization therapy-heart failure (CRT-HF) clinic: A novel model of care
Gorodeski, E. Z., Magnelli-Reyes, C., Moennich, L. A., Grimaldi, A. S., & Rickard, J. (2019) · PLoS ONE · doi:10.1371/journal.pone.0222610 · Cited by 28
QRS duration predicts death and hospitalization among patients with atrial fibrillation irrespective of heart failure: evidence from the AFFIRM study
Whitbeck, M. G., Charnigo, R. J., Shah, J. S., MORALES, G. X., Leung, S., Fornwalt, B. K., Bailey, A. L., Ziada, K. M., Sorrell, V. L., Zegarra, M. M., et al. (2013) · EP Europace · doi:10.1093/europace/eut335 · Cited by 28
DNA damage repair and transcription
Berardi, P., Russell, M., El‐Osta, A., & Riabowol, K. T. (2004) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-004-4179-8 · Cited by 28
JCS / JHRS 2024 Guideline Focused Update on Management of Cardiac Arrhythmias
Iwasaki, Y., Noda, T., Akao, M., Fujino, T., Hirano, T., Inoue, K., Kusano, K., Nagai, T., Satomi, K., Shinohara, T., et al. (2025) · Journal of Arrhythmia · doi:10.1002/joa3.70033 · Cited by 28
The dilemma, causes and approaches to avoid recurrent hospital readmissions for patients with chronic heart failure
Zaya, M., Phan, A., & Schwarz, E. R. (2011) · Heart Failure Reviews · doi:10.1007/s10741-011-9256-0 · Cited by 29
Current Challenges in the Management of Heart Failure
Michel Komajda, N. (2015) · Circulation Journal · doi:10.1253/circj.cj-15-0368 · Cited by 27
Predictors of Spontaneous Reverse Remodeling in Mild Heart Failure Patients With Left Ventricular Dysfunction
brenyo, A. J., Barsheshet, A., Kutyifa, V., Ruwald, A., Rao, M. C., Zaręba, W., Pouleur, A., Knappe, D., Solomon, S. D., McNitt, S. A., et al. (2014) · Circulation Heart Failure · doi:10.1161/circheartfailure.113.000929 · Cited by 27
The response to cardiac resynchronization therapy in LMNA cardiomyopathy
Sidhu, K., Castrini, A. I., Parikh, V. N., Reza, N., OWENS, A. T., Tremblay‐Gravel, M., Wheeler, M. T., Mestroni, L., Taylor, M. R. G., Graw, S. L., et al. (2022) · European Journal of Heart Failure · doi:10.1002/ejhf.2463 · Cited by 27
Baseline clinical characteristics of heart failure patients with reduced ejection fraction enrolled in the BUDAPEST‐CRT Upgrade trial
Merkely, B. P., Gellér, L., Zima, E., Osztheimer, I., Molnár, L., Földesi, C., Duray, G. Z., Wranicz, J. K., Németh, M., Gościńska-Bis, K., et al. (2022) · European Journal of Heart Failure · doi:10.1002/ejhf.2609 · Cited by 27
Efficacy of left bundle branch area pacing versus biventricular pacing in patients treated with cardiac resynchronization therapy: Select site – cohort study
Shroff, J. P., Raja, D. C., Tuan, L. Q., Abhilash, S. P., Mehta, A. B., Abhayaratna, W. P., Sanders, P., & Pathak, R. K. (2024) · Heart Rhythm · doi:10.1016/j.hrthm.2024.02.024 · Cited by 27
Cardiac Resynchronization Therapy in Adult Patients with Repaired Tetralogy of Fallot and Left Ventricular Systolic Dysfunction
Merchant, F. M., Kella, D., Book, W., Langberg, J. J., & Lloyd, M. S. (2013) · Pacing and Clinical Electrophysiology · doi:10.1111/pace.12284 · Cited by 27
Atrioventricular delay programming and the benefit of cardiac resynchronization therapy in MADIT-CRT
brenyo, A. J., Kutyifa, V., Moss, A. J., Mathias, A., Barsheshet, A., Pouleur, A., Knappe, D., McNitt, S. A., Polonsky, B., Huang, D. T.-C., et al. (2013) · Heart Rhythm · doi:10.1016/j.hrthm.2013.04.013 · Cited by 27
Revisiting diastolic filling time as mechanistic insight for response to cardiac resynchronization therapy
Verbrugge, F. H., Verhaert, D., Grieten, L., Dupont, M., Rivero‐Ayerza, M., Vusser, P. D., Herendael, H. V., Reyskens, R., Vandervoort, P. M., Tang, W. H. W., et al. (2013) · EP Europace · doi:10.1093/europace/eut130 · Cited by 27
Brain Natriuretic Peptide and Cardiac Resynchronization Therapy in Patients With Mildly Symptomatic Heart Failure
brenyo, A. J., Barsheshet, A., Rao, M. C., Huang, D. T.-C., Zaręba, W., McNitt, S. A., Hall, W. J., Peterson, D. R., Solomon, S. D., Moss, A. J., et al. (2013) · Circulation Heart Failure · doi:10.1161/circheartfailure.112.000174 · Cited by 27
Cardiac resynchronization therapy in patients with postero-lateral scar by cardiac magnetic resonance: A systematic review and meta-analysis
Daoulah, A., Alsheikh-Ali, A. A. A., Al-Faifi, S. M., Ocheltree, S., Haq, E., Asrar, F. M., Hussien, A. F., Haneef, A. A., Mousily, F. A., El-Sayed, O. M., et al. (2015) · Journal of Electrocardiology · doi:10.1016/j.jelectrocard.2015.06.012 · Cited by 27
Comparative Effectiveness of CRT-D Versus Defibrillator Alone in HF Patients With Moderate-to-Severe Chronic Kidney Disease
Friedman, D. J., Singh, J. P., Curtis, J. P., Tang, W. H. W., Bao, H., Spatz, E. S., Hernandez, A. F., Patel, U. D., & Al‐Khatib, S. M. (2015) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2015.09.097 · Cited by 27
Ventricular pacing – Electromechanical consequences and valvular function
Ebrille, E., DeSimone, C. V., Vaidya, V. R., Chahal, C. A. A., Nkomo, V. T., & Asirvatham, S. J. (2016) · Indian Pacing and Electrophysiology Journal · doi:10.1016/j.ipej.2016.02.013 · Cited by 27
Cardiac Resynchronization in Women
de Waard, D., Manlucu, J., Gillis, A. M., Sapp, J. L., Bernick, J., Doucette, S. P., Tang, A., Wells, G. A., & Parkash, R. (2019) · JACC. Clinical electrophysiology · doi:10.1016/j.jacep.2019.06.007 · Cited by 27
Self-citation
The management of atrial fibrillation in heart failure: an expert panel consensus
Farmakis, D. T., Chrysohoou, C. A., Giamouzis, G., Giannakoulas, G. A., Hamilos, M. I., Naka, K. Κ., Tzeis, S. E., Xydonas, S., Karavidas, A. I., & Parissis, J. (2020) · Heart Failure Reviews · doi:10.1007/s10741-020-09978-0 · Cited by 28
Role of echocardiography before cardiac resynchronization therapy: new advances and current developments
Maréchaux, S., Menet, A., Guyomar, Y., Ennezat, P. V., Guerbaaï, R.-A., Graux, P., & Tribouilloy, C. M. (2016) · Echocardiography · doi:10.1111/echo.13334 · Cited by 26
Novel electrocardiographic dyssynchrony criteria improve patient selection for cardiac resynchronization therapy
Vereckei, A., Szelényi, Z., Kutyifa, V., Zima, E., Szénási, G., Kiss, M., Katona, G., Karádi, I., & Merkely, B. P. (2016) · EP Europace · doi:10.1093/europace/euw326 · Cited by 26
Guía ESC 2021 sobre estimulación cardiaca y terapia de resincronización
Glikson, M., Nielsen, J. C., Kronborg, M. B., Michowitz, Y., Auricchio, A., Barbash, I. M., Barrabés, J. A., Boriani, G., Braunschweig, F., Brignole, M., et al. (2022) · Revista Española de Cardiología · doi:10.1016/j.recesp.2021.10.025 · Cited by 28
Efficacy of the antibacterial envelope to prevent cardiac implantable electronic device infection in a high-risk population
Chaudhry, U. A., Borgquist, R., Smith, J. G., & Mörtsell, D. (2022) · EP Europace · doi:10.1093/europace/euac119 · Cited by 26
The determinants of clinical outcome and clinical response to CRT are not the same
Cleland, J. G. F., & Ghio, S. (2011) · Heart Failure Reviews · doi:10.1007/s10741-011-9268-9 · Cited by 26
Complete Atrioventricular Block does not Reduce Long-Term Mortality in Patients with Permanent Atrial Fibrillation Treated with Cardiac Resynchronization Therapy
Tolosana, J. M., Trucco, E., Khatib, M., Doltra, A., Borràs, R., Castel, M., Berruezo, A., Arbelo, E., Sitges, M., Matas, M., et al. (2013) · European Journal of Heart Failure · doi:10.1093/eurjhf/hft114 · Cited by 26
Small left atrium and mild mitral regurgitation predict super-response to cardiac resynchronization therapy
Stefan, L., Sedláček, K., Cerna, D., Kryze, L., Vančura, V., Marek, T., & Kautzner, J. (2012) · EP Europace · doi:10.1093/europace/eus075 · Cited by 26
Implantable Cardioverter–Defibrillator Use in Older Adults
Kramer, D. B., Matlock, D. D., Buxton, A. E., Goldstein, N. E., Goodwin, C., Green, A. R., Kirkpatrick, J. N., Knoepke, C. E., Lampert, R. J., Mueller, P. S., et al. (2015) · Circulation Cardiovascular Quality and Outcomes · doi:10.1161/circoutcomes.114.001660 · Cited by 26
The Gender‐Paradox among Patients with Implantable Cardioverter‐Defibrillators: A Propensity‐Matched Study
Bhavnani, S. P., Pavuluri, V., Coleman, C. I., Guertin, D. C., Yarlagadda, R. K., Clyne, C. A., & Kluger, J. (2013) · Pacing and Clinical Electrophysiology · doi:10.1111/pace.12141 · Cited by 26
Clinical Outcomes According to QRS Duration and Morphology in the Eplerenone in Mild Patients: Hospitalization and SurvIval Study in Heart Failure (EMPHASIS-HF)
Cannon, J. A., Collier, T. J., Shen, L., Swedberg, K. B., Krum, H., van Veldhuisen, D. J., Vincent, J., Pocock, S., Pitt, B., Zannad, F. M., et al. (2015) · European Journal of Heart Failure · doi:10.1002/ejhf.303 · Cited by 26
Applicability of a risk score for prediction of the long-term benefit of the implantable cardioverter defibrillator in patients receiving cardiac resynchronization therapy
Barra, S., Looi, K., Gajendragadkar, P. R., Khan, F. Z., Virdee, M., & Agarwal, S. (2015) · EP Europace · doi:10.1093/europace/euv352 · Cited by 26
Device-related infective endocarditis in cardiac resynchronization therapy recipients — Single center registry with over 2500 person-years follow up
Jędrzejczyk‐Patej, E., Mazurek, M., Kowalski, O., Sokal, A., Kozieł, M., Adamczyk, K., Przybylska-Siedlecka, K., Morawski, S., Liberska, A., Szulik, M., et al. (2016) · International Journal of Cardiology · doi:10.1016/j.ijcard.2016.11.029 · Cited by 26
Impact of QRS Complex Duration and Morphology on Left Ventricular Reverse Remodelling and Left Ventricular Function Improvement After Cardiac Resynchronization Therapy
van der Bijl, P., Khidir, M., Leung, M., Mertens, B. J. A., Marsan, N. A., Delgado, V., & Bax, J. J. (2017) · European Journal of Heart Failure · doi:10.1002/ejhf.769 · Cited by 26
Survival of Patients With Biventricular Devices After Device Infection, Extraction, and Reimplantation
Rickard, J., Tarakji, K. G., Cheng, A., SPRAGG, D. D., Cantillon, D. J., Martin, D. O., Baranowski, B. J., Gordon, S. M., Tang, W. H. W., Kanj, M., et al. (2013) · JACC Heart Failure · doi:10.1016/j.jchf.2013.05.009 · Cited by 26
Performance of the Seattle Heart Failure Model in Implantable Defibrillator Patients Treated With Cardiac Resynchronization Therapy
Smith, T., Levy, W. C., Schaer, B. A., BALK, A., Sticherling, C., Jordaens, L. J. L. M., & Theuns, D. A. M. J. (2012) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2012.03.038 · Cited by 26
Physiological pacing: mechanisms, clinical indications, and perspectives
Whinnett, Z. I., Naraen, A., Vijayaraman, P., Cleland, J. G. F., & Keene, D. (2025) · European Heart Journal · doi:10.1093/eurheartj/ehaf440 · Cited by 25
Arritmias ventriculares en superrespondedores a la terapia de resincronización cardiaca
García‐Lunar, I., Castro‐Urda, V., Toquero‐Ramos, J., Mingo‐Santos, S., Moñivas‐Palomero, V., Mitroi, C. D., Sánchez-García, M., Pérez-Pereira, E., Delgado, H. E., & Lozano, I. F. (2014) · Revista Española de Cardiología · doi:10.1016/j.recesp.2014.01.017 · Cited by 25
Absolute survival after cardiac resynchronization therapy according to baseline QRS duration: A multinational 10-year experience
Gasparini, M., Leclercq, C., Yu, C., Auricchio, A., Steinberg, J. S., Lamp, B., Klersy, C., & Leyva, F. (2013) · American Heart Journal · doi:10.1016/j.ahj.2013.10.017 · Cited by 25
Active fixation mechanism complicates coronary sinus lead extraction and limits subsequent reimplantation targets
Cronin, E. M., Ingelmo, C. P., Rickard, J., Wazni, O. M., Martin, D. O., Wilkoff, B. L., & Baranowski, B. J. (2012) · Journal of Interventional Cardiac Electrophysiology · doi:10.1007/s10840-012-9704-3 · Cited by 25
Antiarrhythmic effect of cardiac resynchronization therapy with triple-site biventricular stimulation
Ogano, M., Iwasaki, Y., Tanabe, J., Takagi, H., Umemoto, T., Hayashi, M., Miyauchi, Y., & Mizuno, K. (2013) · EP Europace · doi:10.1093/europace/eut134 · Cited by 25
Cardiac resynchronization therapy: Current status and near-future prospects
Nakai, T., Ikeya, Y., Kogawa, R., & Okumura, Y. (2021) · Journal of Cardiology · doi:10.1016/j.jjcc.2021.10.021 · Cited by 25
Outcomes of Upgrading to LBBP in CRT Nonresponders
Chen, X., Jin, Q., Qiu, Z., Qian, C., Liang, Y., Wang, J., Qin, S., Bai, J., Wang, W., Chen, H., et al. (2023) · JACC. Clinical electrophysiology · doi:10.1016/j.jacep.2023.08.031 · Cited by 25
Rates of Upgrade of ICD Recipients to CRT in Clinical Practice and the Potential Impact of the More Liberal Use of CRT at Initial Implant
Scott, P. A., WHITTAKER, A., Zeb, M., WATTS, E., YUE, A. M., Roberts, P. R., & Morgan, J. M. (2011) · Pacing and Clinical Electrophysiology · doi:10.1111/j.1540-8159.2011.03255.x · Cited by 25
Impact of Using a Telescoping‐Support Catheter System for Left Ventricular Lead Placement on Implant Success and Procedure Time of Cardiac Resynchronization Therapy
JACKSON, K. P., Hegland, D. D., Frazier‐Mills, C. G., Piccini, J. P., Koontz, J. I., Atwater, B. D., Daubert, J. P., & WORLEY, S. J. (2013) · Pacing and Clinical Electrophysiology · doi:10.1111/pace.12103 · Cited by 25
Advancing Cardiovascular Research
Lauer, M. S. (2012) · CHEST Journal · doi:10.1378/chest.11-2521 · Cited by 26

Authors: Tang, A. S. L., Wells, G. A., Talajic, M., Arnold, M. O., Sheldon, R., Connolly, S., Hohnloser, S. H., Nichol, G., Birnie, D. H., Sapp, J. L., Yee, R., Healey, J. S., & Rouleau, J. L.
Affiliations: University of British Columbia (CA)
Ottawa Heart Institute (CA)
Montreal Heart Institute (CA)
London Health Sciences Centre (CA)
University of Calgary (CA)
Hamilton Health Sciences (CA)
Goethe University Frankfurt (DE)
University of Washington (US)
Queen Elizabeth II Health Sciences Centre (CA)
ORCID: Tang, Anthony S.L.
Wells, George A.
Talajic, Mario
Sheldon, Robert
Connolly, Stuart
Hohnloser, Stefan H.
Nichol, Graham
Birnie, David H.
Sapp, John L.
Yee, Raymond
Rouleau, Jean L.
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 2010-12-16
Volume: 363
Issue: 25
Pages: 2385-2395
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejmoa1009540
OpenAlex: W2141895646
Cited by: 1,859
References: 28
Citations by year: 2026: 55 · 2025: 67 · 2024: 73 · 2023: 109 · 2022: 76 · 2021: 88 · 2020: 107 · 2019: 99 · 2018: 100 · 2017: 121 · 2016: 141 · 2015: 154 · 2014: 149 · 2013: 190 · 2012: 176
FWCI: 113.15
Type: journal article
Language: en
Open access: closed
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
Funders: Canadian Institutes of Health Research
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac pacing and defibrillation studies
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
Health Sciences › Medicine › Emergency Medicine › Cardiac Arrest and Resuscitation
Keywords: cardiac resynchronization therapy, implantable cardioverter-defibrillator, heart failure, wide QRS complex, left ventricular systolic dysfunction, mortality, heart failure hospitalization, device implantation complications, optimal medical therapy, left ventricular ejection fraction
MeSH terms: Aged, Cardiac Pacing, Artificial, Double-Blind Method, Electrocardiography, Female, Heart Failure, Hospitalization, Humans, Male, Middle Aged, Severity of Illness Index, Defibrillators, Implantable, Ventricular Dysfunction, Left, Kaplan-Meier Estimate, Intention to Treat Analysis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Cardiac-Resynchronization Therapy for Mild-to-Moderate Heart Failure

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks