Cited by 1,859Cardiac pacing and defibrillation studiesHeart Failure Treatment and ManagementCardiac Arrest and Resuscitation

The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.

Cardiac-Resynchronization Therapy for Mild-to-Moderate Heart Failure

Tang, Anthony S.L., Wells, George A., Talajic, Mario, Arnold, Malcolm O., Sheldon, Robert, Connolly, Stuart, Hohnloser, Stefan H., Nichol, Graham, Birnie, David H., Sapp, John L., Yee, Raymond, Healey, Jeffrey S., Rouleau, Jean L.·2010·New England Journal of Medicine

DOI 10.1056/nejmoa1009540

Open this paper in CoChat — free account

Abstract

BACKGROUND: Cardiac-resynchronization therapy (CRT) benefits patients with left ventricular systolic dysfunction and a wide QRS complex. Most of these patients are candidates for an implantable cardioverter-defibrillator (ICD). We evaluated whether adding CRT to an ICD and optimal medical therapy might reduce mortality and morbidity among such patients. METHODS: We randomly assigned patients with New York Heart Association (NYHA) class II or III heart failure, a left ventricular ejection fraction of 30% or less, and an intrinsic QRS duration of 120 msec or more or a paced QRS duration of 200 msec or more to receive either an ICD alone or an ICD plus CRT. The primary outcome was death from any cause or hospitalization for heart failure. RESULTS: We followed 1798 patients for a mean of 40 months. The primary outcome occurred in 297 of 894 patients (33.2%) in the ICD-CRT group and 364 of 904 patients (40.3%) in the ICD group (hazard ratio in the ICD-CRT group, 0.75; 95% confidence interval [CI], 0.64 to 0.87; P<0.001). In the ICD-CRT group, 186 patients died, as compared with 236 in the ICD group (hazard ratio, 0.75; 95% CI, 0.62 to 0.91; P = 0.003), and 174 patients were hospitalized for heart failure, as compared with 236 in the ICD group (hazard ratio, 0.68; 95% CI, 0.56 to 0.83; P<0.001). However, at 30 days after device implantation, adverse events had occurred in 124 patients in the ICD-CRT group, as compared with 58 in the ICD group (P<0.001). CONCLUSIONS: Among patients with NYHA class II or III heart failure, a wide QRS complex, and left ventricular systolic dysfunction, the addition of CRT to an ICD reduced rates of death and hospitalization for heart failure. This improvement was accompanied by more adverse events. (Funded by the Canadian Institutes of Health Research and Medtronic of Canada; ClinicalTrials.gov number, NCT00251251.).

Integrity signals

Registry

Crossref · 10.1056/nejmoa1009540

Cites

29 of 29 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Prophylactic Implantation of a Defibrillator in Patients with Myocardial Infarction and Reduced Ejection Fraction
Moss, A. J., Zaręba, W., Hall, W. J., Klein, H., Wilber, D. J., Cannom, D. S., Daubert, J. P., Higgins, S. L., Brown, M. W., & Andrews, M. L. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa013474 · Cited by 6,885
Amiodarone or an Implantable Cardioverter–Defibrillator for Congestive Heart Failure
Bardy, G. H., Lee, K. L., Mark, D. B., Poole, J. E., Packer, D. L., Boineau, R., Domanski, M., Troutman, C., Anderson, J., Johnson, G., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa043399 · Cited by 6,552
The Effect of Cardiac Resynchronization on Morbidity and Mortality in Heart Failure
Cleland, J. G. F., Daubert, J., Erdmann, E., Freemantle, N., Gras, D., KAPPENBERGER, L. J., & Tavazzi, L. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa050496 · Cited by 6,300
Cardiac-resynchronization therapy with or without an implantable defibrillator in advanced chronic heart failure
Bristow, M. R., Saxon, L. A., Boehmer, J., Krueger, S., Kass, D. A., De Marco, T., Carson, P., DiCarlo, L., DeMets, D., White, B. G., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa032423 · Cited by 5,812
Cardiac Resynchronization in Chronic Heart Failure
Abraham, W. T., Fisher, W. G., Smith, A. L., Delurgio, D. B., Leon, A. R., Loh, E., Kocovic, D. Z., Packer, M., Clavell, A. L., Hayes, D. L., et al. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa013168 · Cited by 4,648
ACC/AHA 2005 Guideline Update for the Diagnosis and Management of Chronic Heart Failure in the Adult
Hunt, S. A. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.08.022 · Cited by 4,137
CARDIAC RESYNCHRONIZATION IN CHRONIC HEART FAILURE
Braham, W. I. T. A., Isher, W. E. G. F., Mith, L. S., Elurgio, D. A. B. D., Eon, A. N. R. L., Oh, E., Ocovic, D. U. Z. K., Acker, M. G., Lavell, L. C., Ayes, D. A. L. H., et al. (2002) · Cited by 3,808
2009 Focused Update Incorporated Into the ACC/AHA 2005 Guidelines for the Diagnosis and Management of Heart Failure in Adults
Hunt, S. A., Abraham, W. T., Chin, M. H., Feldman, A. M., Francis, G. S., Ganiats, T. G., Jessup, M. L., Konstam, M. A., MANCINI, D. M., Michl, K., et al. (2009) · Circulation · doi:10.1161/circulationaha.109.192065 · Cited by 3,739
Cardiac-Resynchronization Therapy for the Prevention of Heart-Failure Events
Moss, A. J., Hall, W. J., Cannom, D. S., Klein, H., Brown, M. W., Daubert, J. P., Estes, N. A. M., Foster, E., Greenberg, H., Higgins, S. L., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0906431 · Cited by 3,157
Effects of Multisite Biventricular Pacing in Patients with Heart Failure and Intraventricular Conduction Delay
Cazeau, S., Leclercq, C., Lavergne, T., Walker, S., Varma, C., Linde, C. M., Garrigue, S., KAPPENBERGER, L. J., Haywood, G. A., Santini, M., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200103223441202 · Cited by 2,718

Flagged first, then by citations

Show all 28 references

Research works printed but not linked: 1

Chan KL, 2003, Can J Cardiol, 19, 387

Sorted by citations

Items 601–700 of 1,000

Underrepresentation of Women in Reduced Ejection Heart Failure Clinical Trials With Improved Mortality or Hospitalization
Ekpo, E., Balla, S., Ngo, S., Witting, C. S., Sarraju, A., Furst, A., & Rodríguez, F. (2023) · JACC Advances · doi:10.1016/j.jacadv.2023.100743 · Cited by 18
Improved all-cause mortality with left bundle branch area pacing compared to biventricular pacing in cardiac resynchronization therapy: a meta-analysis
Díaz, J. C., Gabr, M., Tedrow, U. B., Duque, M., Aristizábal, J. M., Marín, J. E., Niño, C. D., Bastidas, O., Koplan, B. A., Hoyos, C., et al. (2024) · Journal of Interventional Cardiac Electrophysiology · doi:10.1007/s10840-024-01785-z · Cited by 17
Implantable Cardioverter Defibrillator and Resynchronization Therapy in Patients With Overt Chronic Kidney Disease
Varga, C. R., Cleland, J. G. F., Abraham, W. T., Lip, G. Y. H., Leyva, F., & Hatamizadeh, P. (2024) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2024.05.081 · Cited by 17
Chinese Guidelines for the Diagnosis and Treatment of Heart Failure 2024
Chinese Society of Cardiology, C. M. A., Chinese College of Cardiovascular Physician, Chinese Heart Failure Association of Chinese Medical Doctor Association, & Editorial Board of Chinese Journal of Cardiology (2025) · Cardiology Discovery · doi:10.1097/cd9.0000000000000146 · Cited by 17
Treatment of Heart Failure in Real‐World Clinical Practice: Findings From the REFLECT‐HF Registry in Patients With NYHA Class II Symptoms and a Reduced Ejection Fraction
Böhm, M., Tschöpe, C., Wirtz, J. H., Lokies, J., Turgonyi, E., Bramlage, P., Lins, K., Strunz, A. M., & Tebbe, U. (2015) · Clinical Cardiology · doi:10.1002/clc.22375 · Cited by 17
Heart Failure Society of South Africa (HeFSSA) perspective on the European Society of Cardiology (ESC) 2012 chronic heart failure guideline
Mpe, M., Klug, E., Silwa, K., Hitzeroth, J., & Smith, D. (2013) · South African Medical Journal · doi:10.7196/samj.7319 · Cited by 17
Cardiac dysfunction in the CABG patient
Siribaddana, S. (2012) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2012.01.010 · Cited by 17
Association of Rate-Controlled Persistent Atrial Fibrillation With Clinical Outcome and Ventricular Remodelling in Recipients of Cardiac Resynchronization Therapy
Wilton, S. B., Kavanagh, K. M., Aggarwal, S., Philippon, F., Yee, R. K., Cowan, K. F., & Exner, D. V. (2011) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2011.06.004 · Cited by 17
Self-citation
Development and feasibility testing of decision support for patients who are candidates for a prophylactic implantable defibrillator: a study protocol for a pilot randomized controlled trial
Carroll, S. L., McGillion, M. H., Stacey, D., Healey, J. S., BROWNE, G. B., Arthur, H. M., & Thabane, L. (2013) · Trials · doi:10.1186/1745-6215-14-346 · Cited by 17
Self-citation
Oral anticoagulation management in patients with atrial fibrillation undergoing cardiac implantable electronic device implantation
Black‐Maier, E., Kim, S., Steinberg, B. A., Fonarow, G. C., Freeman, J. V., Kowey, P. R., Ansell, J., Gersh, B. J., Mahaffey, K. W., Naccarelli, G. V., et al. (2017) · Clinical Cardiology · doi:10.1002/clc.22726 · Cited by 17
Meta-Analysis of the Effects of Cardiac Rehabilitation on Exercise Tolerance and Cardiac Function in Heart Failure Patients Undergoing Cardiac Resynchronization Therapy
Chen, Z.-B., Fan, L.-B., Liu, Y.-J., & Zheng, Y.-R. (2019) · BioMed Research International · doi:10.1155/2019/3202838 · Cited by 17
QRS Narrowing Following CRT Implantation: Predictors, Dynamics, and Association with Improved Long-Term Outcome
Lapidot, D., Rav-Acha, M., Bdolah‐Abram, T., Farkash, R., Glikson, M., & Hasin, T. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11051279 · Cited by 17
Quantification of Survival Gain From Cardiac Resynchronization Therapy
Finegold, J. A., Raphael, C. E., Levy, W. C., Whinnett, Z. I., & Francis, D. P. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.07.080 · Cited by 17
Chronic Heart Failure in Older Adults
Ahmed, A. (2011) · Medical Clinics of North America · doi:10.1016/j.mcna.2011.02.001 · Cited by 17
Frequency and Outcomes of Postrandomization Atrial Tachyarrhythmias in the Resynchronization/Defibrillation in Ambulatory Heart Failure Trial
Wilton, S. B., Exner, D. V., Wyse, D. G., Yetisir, E., Wells, G. A., TANG, A. S. L., & Healey, J. S. (2016) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.115.003807 · Cited by 17
Self-citation
Effects of epicardial versus transvenous left ventricular lead placement on left ventricular function and cardiac perfusion in cardiac resynchronization therapy: A randomized clinical trial
van Dijk, V. F., Fanggiday, J., Balt, J. C., WIJFFELS, M. C. E. F., Daeter, E. J., Kelder, J. C., & Boersma, L. V. A. (2017) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.13242 · Cited by 17
Prediction of clinical outcome in patients treated with cardiac resynchronization therapy - the role of NT-ProBNP and a combined response score
Bakos, Z., Chatterjee, N. C., Reitan, C., Singh, J. P., & Borgquist, R. (2018) · BMC Cardiovascular Disorders · doi:10.1186/s12872-018-0802-8 · Cited by 17
Clinical outcomes after implantation of quadripolar compared to bipolar left ventricular leads in patients undergoing cardiac resynchronization therapy: a systematic review and meta-analysis
Erath, J. W., Benz, A. P., Hohnloser, S. H., & Vámos, M. (2019) · EP Europace · doi:10.1093/europace/euz196 · Cited by 17
Self-citation
Cardiac Resynchronization Therapy and QRS Duration: Systematic Review, Meta-analysis, and Meta-regression
Kang, S., Oh, I., Kang, D., Cha, M., Cho, Y., Choi, E., Hahn, S., & Oh, S. (2014) · Journal of Korean Medical Science · doi:10.3346/jkms.2015.30.1.24 · Cited by 17
Primary Prevention of Sudden Cardiac Death With Device Therapy in Urban and Rural Populations
Parkash, R., Wightman, H., Miles, G., Sapp, J. L., Gardner, M. J., Gray, C., Brownell, B., Giddens, K., & Rajda, M. (2017) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2016.10.020 · Cited by 17
Self-citation
Heart Failure Readmission Prevention Strategies—A Comparative Review of Medications, Devices, and Other Interventions
Baris, R. O., & Tabit, C. E. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14165894 · Cited by 17
The Effect of Weight Loss on Clinical Outcomes in Patients Implanted With a Cardiac Resynchronization Therapy Device—A MADIT-CRT Substudy
Aktaş, M. K., Zaręba, W., Huang, D. T.-C., McNitt, S. A., Polonsky, S., Chen, L., Stockburger, M. A., Merkely, B. P., Moss, A. J., & Kutyifa, V. (2013) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2013.12.012 · Cited by 16
Electrocardiogram Belt guidance for left ventricular lead placement and biventricular pacing optimization
Rickard, J., JACKSON, K. P., Gold, M. R., Biffi, M., Ziacchi, M., Silverstein, J., Ramza, B. M., Metzl, M. D., Grubman, E. M., Abben, R. P., et al. (2022) · Heart Rhythm · doi:10.1016/j.hrthm.2022.11.015 · Cited by 16
Ultra-High-Frequency ECG in Cardiac Pacing and Cardiac Resynchronization Therapy: From Technical Concept to Clinical Application
Nguyên, U. C., Rijks, J. H. J., Plešinger, F., Rademakers, L. M., LUERMANS, J. G. L. M., Smits, K. C., van Stipdonk, A. M. W., Prinzen, F. W., Vernooy, K., Halámek, J., et al. (2024) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd11030076 · Cited by 16
Cardiac Resynchronization Therapy in Ischemic Versus Nonischemic Cardiomyopathy
Sudesh, S., Abraham, W. T., Cleland, J. G. F., Curtis, A. B., Friedman, D. J., Gold, M. R., Kutyifa, V., Linde, C. M., Tang, A., Olivas‐Martínez, A., et al. (2024) · JACC Heart Failure · doi:10.1016/j.jchf.2024.08.010 · Cited by 16
Self-citation
The mismatch between patient life expectancy and the service life of implantable devices in current cardioverter-defibrillator therapy: a call for larger device batteries
Neuzner, J. (2015) · Clinical Research in Cardiology · doi:10.1007/s00392-014-0807-y · Cited by 16
Systolic heart failure in the elderly: optimizing medical management
Man, J. P., & Jugdutt, B. I. (2011) · Heart Failure Reviews · doi:10.1007/s10741-011-9282-y · Cited by 17
Frequent Premature Ventricular Contractions
Eugenio, P. L. (2015) · Cardiology in Review · doi:10.1097/crd.0000000000000063 · Cited by 16
HRS Policy Statement: Clinical Cardiac Electrophysiology Fellowship Curriculum: Update 2011
Link, M. S., Exner, D. V., Anderson, M. E., Ackerman, M., Al‐Ahmad, A., Knight, B. P., Markowitz, S. M., Kaufman, E. S., Haines, D. E., Asirvatham, S. J., et al. (2011) · Heart Rhythm · doi:10.1016/j.hrthm.2011.06.008 · Cited by 16
Hemodynamic and neurochemical determinates of renal function in chronic heart failure
Gilbert, C. J., Cherney, D. Z. I., Parker, A. B., Mak, S. S., Floras, J. S., Al‐Hesayen, A., & Parker, J. D. (2015) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00190.2015 · Cited by 16
Early Right Ventricular Response To Cardiac Resynchronization Therapy: Impact on Clinical Outcomes
Stolfo, D., Tonet, E., Merlo, M., Barbati, G., Gigli, M., Pinamonti, B., Ramani, F., Zecchin, M., & Sinagra, G. (2015) · European Journal of Heart Failure · doi:10.1002/ejhf.450 · Cited by 16
Overview of implantable cardioverter defibrillator and cardiac resynchronisation therapy in heart failure management
Chia, P., & Foo, D. C. G. (2016) · Singapore Medical Journal · doi:10.11622/smedj.2016117 · Cited by 16
Cardiac Resynchronization Therapy
Boriani, G., Nesti, M., Ziacchi, M., & Padeletti, L. (2016) · Heart Failure Clinics · doi:10.1016/j.hfc.2016.07.010 · Cited by 16
Future research prioritization in cardiac resynchronization therapy
Fudim, M., Dalgaard, F., Al‐Khatib, S. M., Friedman, D. J., Lallinger, K. R., Abraham, W. T., Cleland, J. G. F., Curtis, A. B., Gold, M. R., Kutyifa, V., et al. (2020) · American Heart Journal · doi:10.1016/j.ahj.2020.02.011 · Cited by 16
Self-citation
Sex-related differences in the prognosis of patients with cardiac sarcoidosis treated with cardiac resynchronization therapy
Nakasuka, K., Ishibashi, K., Hattori, Y., Mori, K., Nakajima, K., Nagayama, T., Kamakura, T., Wada, M., Inoue, Y. Y., Miyamoto, K., et al. (2022) · Heart Rhythm · doi:10.1016/j.hrthm.2022.02.027 · Cited by 16
Renal Dysfunction and Clinical Outcomes of Patients Undergoing ICD and CRTD Implantation: Data from the Israeli ICD Registry
Eisen, A., Suleiman, M. A., Strasberg, B., Sela, R., Rosenheck, S., FREEDBERG, N. A., GEIST, M., Ben‐Zvi, S., Goldenberg, I., Glikson, M., et al. (2014) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.12442 · Cited by 16
Cardiac Implantable Electronic Device Removal in Patients with Left Ventricular Assist Device Associated Infections
Krishnamoorthy, A., Pokorney, S. D., Lewis, R. K., Daubert, J. P., Greenfield, R. A., Hegland, D. D., Milano, C. A., Rogers, J. G., Schroder, J. N., Patel, C. B., et al. (2014) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.12461 · Cited by 16
“Are CRT upgrade procedures more complex and associated with more complications than de novo CRT implantations?” A single centre experience
Horst, I. A., Kuijpers, Y. A. M., Sant, J. V. ’., Tuinenburg, A. E., Cramer, M. J., & Meine, M. (2015) · Netherlands Heart Journal · doi:10.1007/s12471-015-0771-9 · Cited by 16
Performance of Anatomically Designed Quadripolar Left Ventricular Leads: Results from the NAVIGATE X4 Clinical Trial
Mittal, S., Nair, D. G., Padanilam, B. J., Ciuffo, A., Gupta, N., Gallagher, P. L., Goldner, B. G., Hammill, E. F., WOLD, N., Stein, K., et al. (2016) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.13044 · Cited by 16
ECG Patterns In Cardiac Resynchronization Therapy.
van Stipdonk, A. M. W., Wijers, S. C., Meine, M., & Vernooy, K. (2015) · Europe PMC (PubMed Central) · doi:10.4022/jafib.1214 · Cited by 16
Updates in Cardiac Resynchronization Therapy for Chronic Heart Failure: Review of Multisite Pacing
Antoniadis, A. P., Sieniewicz, B., Gould, J., Porter, B., Webb, J., Claridge, S., Behar, J. M., & Rinaldi, C. A. (2017) · Current Heart Failure Reports · doi:10.1007/s11897-017-0350-z · Cited by 16
Right Ventricular Pacing Increases Risk of Appropriate Implantable Cardioverter–Defibrillator Shocks Asymmetrically
Cronin, E. M., Jones, P. W., Seth, M., & Varma, N. (2017) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.116.004711 · Cited by 16
The Past, Present and Future of Cardiac Resynchronization Therapy
O’Brien, T. M., Park, M. S., Youn, J., & Chung, E. S. (2019) · Korean Circulation Journal · doi:10.4070/kcj.2019.0114 · Cited by 16
Comments on the ESC Guidelines for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012. A Report of the Task Force of the Clinical Practice Guidelines Committee of the Spanish Society of Cardiology
Anguita, M. P., Colet, J. C., Almenar, L., Crespo, M., Delgado, J. F., González‐Costello, J., Hernández‐Madrid, A., Manito, N., de la Sota, E. P., Segovia, J., et al. (2012) · Revista Española de Cardiología (English Edition) · doi:10.1016/j.rec.2012.07.005 · Cited by 16
Frequency of in‐hospital adverse outcomes and cost utilization associated with cardiac resynchronization therapy defibrillator implantation in the United States
Patel, N., Viles-González, J. F., Agnihotri, K., Arora, S., Patel, N., Aneja, E., Shah, M. K., Badheka, A. O., Pothineni, N. V. K., Kancharla, K., et al. (2018) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.13701 · Cited by 15
Resumen de los ensayos clínicos presentados en las Sesiones Científicas Anuales de la American Heart Association (Chicago, Estados Unidos, 13-17 de noviembre de 2010)
y, P. A., Bayés‐Genís, A., de Isla, L. P., Sanchís, J. M., & Heras, M. (2011) · Revista Española de Cardiología · doi:10.1016/j.recesp.2010.12.001 · Cited by 15
Determinants of Response to Cardiac Resynchronization Therapy
Allison, J. D., Biton, Y., & Mela, T. (2022) · Journal of Innovations in Cardiac Rhythm Management · doi:10.19102/icrm.2022.130503 · Cited by 15
Success rates, challenges and troubleshooting of left bundle branch area pacing as a cardiac resynchronization therapy for treating patients with heart failure
Zhang, J., Zhang, Y., Sun, Y., Chen, M., Wang, Z., & Ma, C. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.1062372 · Cited by 15
Benefits of upgrading right ventricular to biventricular pacing in heart failure patients with atrial fibrillation
Merkely, B. P., Hatala, R., Merkel, E. D., Szigeti, M., Veres, B., Fábián, A., Osztheimer, I., Gellér, L., Šašov, M., Wranicz, J. K., et al. (2024) · EP Europace · doi:10.1093/europace/euae179 · Cited by 15
Heart Failure and All-Cause Hospitalizations in Patients With Heart Failure
Sayed, A. A., ElRefaei, M., Awad, K., Salah, H., Mandrola, J. M., & Foy, A. (2024) · JAMA Network Open · doi:10.1001/jamanetworkopen.2024.46684 · Cited by 15
Left Ventricular Dyssynchrony Assessment Using Myocardial Single-Photon Emission CT
Soman, P., & Chen, J. (2014) · Seminars in Nuclear Medicine · doi:10.1053/j.semnuclmed.2014.04.004 · Cited by 15
Chronic heart failure: epidemiology, investigation and management
Gardner, R. S., & McDonagh, T. A. (2014) · Medicine · doi:10.1016/j.mpmed.2014.07.008 · Cited by 15
Current Treatment Strategies for Heart Failure: Role of Device Therapy and LV Reconstruction
Janaswamy, P., Walters, T. E., Nazer, B., & Lee, R. J. (2016) · Current Treatment Options in Cardiovascular Medicine · doi:10.1007/s11936-016-0479-1 · Cited by 15
Implantable Cardioverter-Defibrillators With Versus Without Resynchronization Therapy in Patients With a QRS Duration >180 ms
Sundaram, V., Sahadevan, J., Waldo, A. L., Stukenborg, G. J., Reddy, Y. N. V., Asirvatham, S. J., Mackall, J. A., Intini, A., Wilson, B. M., Simon, D. I., et al. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.02.042 · Cited by 15
Prognostic effect and modulation of cardiac sympathetic function in heart failure patients treated with cardiac resynchronization therapy
Moreira, R. I., Abreu, A., Portugal, G., Oliveira, L., Oliveira, M., Rodrigues, I., Cruz, M. C., Cunha, P. S., Santos, V., Clara, S., et al. (2018) · Journal of Nuclear Cardiology · doi:10.1007/s12350-018-1357-x · Cited by 15
The Effect of Iron Deficiency on Cardiac Resynchronization Therapy: Results from the RIDE-CRT Study
Lacour, P., Dang, P. L., Morris, D. A., Parwani, A. S., Doehner, W., Schuessler, F., Hohendanner, F., Heinzel, F. R., Stroux, A., Tschöepe, C., et al. (2020) · ESC Heart Failure · doi:10.1002/ehf2.12675 · Cited by 15
Acute Hemodynamic Effects of Cardiac Resynchronization Therapy Versus Alternative Pacing Strategies in Patients With Left Ventricular Assist Devices
Tomashitis, B. M., Baicu, C. F., Butschek, R. A., Jackson, G. R., Winterfield, J. R., Tedford, R. J., Zile, M. R., Gold, M. R., & Houston, B. A. (2021) · Journal of the American Heart Association · doi:10.1161/jaha.120.018127 · Cited by 15
Left bundle branch pacing in heart failure patients with left bundle branch block: A systematic review and meta‐analysis
Cheng, Y., Wang, Z., Li, Y., Qi, J., & Liu, J. (2021) · Pacing and Clinical Electrophysiology · doi:10.1111/pace.14405 · Cited by 15
Current status of cardiac resynchronization therapy with defibrillators and factors influencing its prognosis in Japan
Shimizu, A., Mihashi, T., Furushima, H., Sekiguchi, Y., Manaka, T., Nishii, N., Ueyama, T., Yokoshiki, H., Morita, N., Nitta, T., et al. (2013) · Journal of Arrhythmia · doi:10.1016/j.joa.2013.04.006 · Cited by 15
Differing effects of cardiac resynchronization therapy on long-term mortality in patient subgroups of MADIT-CRT defined by baseline conduction and 1-year post-treatment left ventricular remodeling
Goldstein, R. E., Haigney, M. C., Krone, R. J., McNitt, S. A., Zaręba, W., & Moss, A. J. (2012) · Heart Rhythm · doi:10.1016/j.hrthm.2012.11.020 · Cited by 15
Long-term outcomes of cardiac resynchronization therapy are worse in patients who require atrioventricular junction ablation for atrial fibrillation than in those with sinus rhythm
Jędrzejczyk‐Patej, E., Lenarczyk, R., Pruszkowska, P., Kowalski, O., Mazurek, M., Sokal, A., Boidol, J., Woźniak, A., Pluta, S., Szulik, M., et al. (2013) · Cardiology Journal · doi:10.5603/cj.a2013.0110 · Cited by 15
Left Ventricular Epicardial Electrograms Show Divergent Changes in Action Potential Duration in Responders and Nonresponders to Cardiac Resynchronization Therapy
Chen, Z., Hanson, B. M., Sohal, M., Sammut, E. C., Child, N., Shetty, A., Boucher, R., Bostock, J., Gill, J. S., Carr‐White, G., et al. (2013) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.112.000148 · Cited by 15
Effect of obesity on the effectiveness of cardiac resynchronization to reduce the risk of first and recurrent ventricular tachyarrhythmia events
Szepietowska, B., Polonsky, B., Sherazi, S., Biton, Y., Kutyifa, V., McNitt, S. A., Aktaş, M. K., Moss, A. J., & Zaręba, W. (2016) · Cardiovascular Diabetology · doi:10.1186/s12933-016-0401-x · Cited by 15
Right heart-pulmonary circulation unit and cardiac resynchronization therapy
Ricci, F., Mele, D., Bianco, F., Bucciarelli, V., Caterina, R. D., & Gallina, S. (2016) · American Heart Journal · doi:10.1016/j.ahj.2016.11.005 · Cited by 15
Impact of baseline renal function on all‐cause mortality in patients who underwent cardiac resynchronization therapy: A systematic review and meta‐analysis
Bazoukis, G., Letsas, Κ. P., Korantzopoulos, P. G., Thomopoulos, C., Vlachos, K. G., Georgopoulos, S., Karamichalakis, N., Saplaouras, A., Efremidis, M., & Sideris, A. (2017) · Journal of Arrhythmia · doi:10.1016/j.joa.2017.04.005 · Cited by 15
Cardiac Resynchronization Therapy in Women
Costanzo, M. R. (2016) · Heart Failure Clinics · doi:10.1016/j.hfc.2016.07.013 · Cited by 15
What’s new in heart failure therapy 2018?†
Westphal, J. G., Bekfani, T., & Schulze, P. C. (2018) · Interactive Cardiovascular and Thoracic Surgery · doi:10.1093/icvts/ivy282 · Cited by 15
Cardiac resynchronization therapy reprogramming to improve electrical synchrony in patients with existing devices
AlTurki, A., Lima, P. Y. P., Garcia, D., Montemezzo, M., Aldosari, A., Vidal, A., Toscani, B., Díaz-Tostado, S., Bernier, M., Hadjis, T., et al. (2019) · Journal of Electrocardiology · doi:10.1016/j.jelectrocard.2019.07.008 · Cited by 15
Long-Term Outcomes in Patients With a Left Ejection Fraction ≤15% Undergoing Cardiac Resynchronization Therapy
Rickard, J., Patel, D. R., Park, C. J., Marine, J. E., Sinha, S. K., Tang, W. H. W., Varma, N., Wilkoff, B. L., & SPRAGG, D. D. (2020) · JACC. Clinical electrophysiology · doi:10.1016/j.jacep.2020.07.025 · Cited by 15
2025 Clinical practice guidelines for Ventricular arrhythmias of the heart and Sudden cardiac death
Mikhailov, E. N., Gizatulina, T. P., Lebedev, D. S., Golukhova, E. Z., Kharlap, M. S., Лебедева, В. К., Bagnenko, S. F., Artyukhina, Е. А., Babokin, V. E., Batalov, R. E., et al. (2026) · Russian Journal of Cardiology · doi:10.15829/1560-4071-2025-6670 · Cited by 14
New and Emerging Drugs and Device Therapies for Chronic Heart Failure in Patients With Systolic Ventricular Dysfunction
Rouleau, J. L. (2011) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2011.02.010 · Cited by 14
Self-citation
Case Selection for Cardiac Resynchronization in Atrial Fibrillation
Cleland, J. G. F., Keshavarzi, F., Pellicori, P., & Dicken, B. (2013) · Heart Failure Clinics · doi:10.1016/j.hfc.2013.07.001 · Cited by 14
Conduction system pacing on track to replace CRT? Review of current evidence and prospects of conduction system pacing
Moustafa, A. T., TANG, A. S. L., & Khan, H. R. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1220709 · Cited by 14
Self-citation
Metabolic flexibility and reverse remodelling of the failing human heart
Green, P. G., Watson, W. D., Bussmann, B. M., Maria, G. L. D., Neubauer, S., Lewis, A., Rider, O. J., & Herring, N. (2025) · European Heart Journal · doi:10.1093/eurheartj/ehaf033 · Cited by 14
Extraordinarily Favorable Left Ventricular Reverse Remodeling through Long‐Term Cardiac Resynchronization: Super‐Response to Cardiac Resynchronization
Çelebi, Ö. Ö., Knaus, T., Blaschke, F., Habedank, D., Doehner, W., Nitardy, A., & Stockburger, M. A. (2012) · Pacing and Clinical Electrophysiology · doi:10.1111/j.1540-8159.2012.03417.x · Cited by 14
Comparison of clinical trials evaluating cardiac resynchronization therapy in mild to moderate heart failure.
Zaręba, W. (2010) · PubMed · Cited by 14
Outcomes in pacemaker-dependent patients upgraded from conventional pacemakers to cardiac resynchronization therapy-defibrillators
ADELSTEIN, E. C., SCHWARTZMAN, D. S., Bazaz, R. R., Jain, S. K., Gorcsan, J., & Saba, S. (2014) · Heart Rhythm · doi:10.1016/j.hrthm.2014.03.024 · Cited by 14
Is Defibrillation Testing Necessary for Implantable Transvenous Defibrillators?
Healey, J. S., & Brambatti, M. (2014) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.113.000373 · Cited by 14
Self-citation
Survival in Octogenarians Undergoing Cardiac Resynchronization Therapy Compared to the General Population
Rickard, J., Cheng, A., SPRAGG, D. D., Green, A., Leff, B. A., Tang, W. H. W., Cantillon, D. J., Baranowski, B. J., Wilkoff, B. L., & TCHOU, P. J. (2014) · Pacing and Clinical Electrophysiology · doi:10.1111/pace.12337 · Cited by 14
Strategies to Prevent Postdischarge Adverse Events Among Hospitalized Patients with Heart Failure
Psotka, M. A., & Teerlink, J. R. (2013) · Heart Failure Clinics · doi:10.1016/j.hfc.2013.04.005 · Cited by 14
Mid-regional pro-atrial natriuretic peptide to predict clinical course in heart failure patients undergoing cardiac resynchronization therapy
Arrigo, M., Truong, Q. A., Szymonifka, J. D., Rivas‐Lasarte, M., Tolppanen, H., Sadoune, M., Gayat, É., Solal, A. C., Ruschitzka, F. T., Januzzi, J. L., et al. (2017) · EP Europace · doi:10.1093/europace/euw305 · Cited by 14
Efficacy of Pharmacologic and Cardiac Implantable Electronic Device Therapies in Patients With Heart Failure and Reduced Ejection Fraction
Tseng, A. S., Kunze, K. L., Lee, J. Z., Amin, M., Neville, M. R., Almader‐Douglas, D., Killu, A. M., Madhavan, M., Cha, Y., Asirvatham, S. J., et al. (2019) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.118.006951 · Cited by 14
The Benefit of Atrioventricular Junction Ablation for Permanent Atrial Fibrillation and Heart Failure Patients Receiving Cardiac Resynchronization Therapy: An Updated Systematic Review and Meta-analysis
Waranugraha, Y., Rizal, A., Setiawan, D., & Aziz, I. J. (2021) · Indian Pacing and Electrophysiology Journal · doi:10.1016/j.ipej.2020.12.005 · Cited by 14
Long-Term Extrapolation of Clinical Benefits Among Patients With Mild Heart Failure Receiving Cardiac Resynchronization Therapy
Gold, M. R., Padhiar, A., Mealing, S., Sidhu, M. K., Tsintzos, S. I., & Abraham, W. T. (2015) · JACC Heart Failure · doi:10.1016/j.jchf.2015.05.005 · Cited by 14
Is Cardiac Resynchronization Therapy for Right Ventricular Failure in Pulmonary Arterial Hypertension of Benefit?
Rasmussen, J. T., Thenappan, T., Benditt, D. G., Weir, Ε. K., & PRITZKER, M. R. (2014) · Pulmonary Circulation · doi:10.1086/678470 · Cited by 14
Standardization of QRS Duration Measurement and LBBB Criteria in CRT Trials and Clinical Practice
Turagam, M. K., Velagapudi, P., & Kocheril, A. G. (2013) · Current Cardiology Reviews · doi:10.2174/157340313805076269 · Cited by 14
Impact of Current Versus Previous Cardiac Resynchronization Therapy Guidelines on the Proportion of Patients With Heart Failure Eligible for Therapy
Lyons, K. J., Ezekowitz, J. A., Liang, L., Heidenreich, P. A., Yancy, C. W., DeVore, A. D., Hernandez, A. F., & Fonarow, G. C. (2017) · JACC Heart Failure · doi:10.1016/j.jchf.2017.02.018 · Cited by 14
A troubled marriage: When electrical and mechanical dyssynchrony don’t go along
Fudim, M., & Borges‐Neto, S. (2018) · Journal of Nuclear Cardiology · doi:10.1007/s12350-018-1227-6 · Cited by 14
Long-Term Outcomes in Patients With Ambulatory New York Heart Association Class III and IV Heart Failure Undergoing Cardiac Resynchronization Therapy
Rickard, J., Bassiouny, M., Tedford, R. J., Baranowski, B. J., SPRAGG, D. D., Cantillon, D. J., Varma, N., Wilkoff, B. L., & Tang, W. H. W. (2014) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2014.09.052 · Cited by 13
Potential Role of Biventricular Pacing Beyond Advanced Systolic Heart Failure
Fang, F., Sanderson, J. E., & Yu, C. (2013) · Circulation Journal · doi:10.1253/circj.cj-13-0398 · Cited by 13
Recent advances in the management of chronic heart failure
Haddad, H. A., Mielniczuk, L. M., & Davies, R. A. (2012) · Current Opinion in Cardiology · doi:10.1097/hco.0b013e32834fdc98 · Cited by 13
Relation of QRS Duration to Response to Cardiac Resynchronization Therapy in Patients With Left Bundle Branch Block
Sassone, B., Bertini, M., Beltrami, M., Malagù, M., Pasanisi, G., Kuwornu, H., Avigni, N., Fucă, G., Pacchioni, F., Minarelli, M., et al. (2017) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2017.02.043 · Cited by 13
Implantable cardioverter-defibrillator use in elderly patients receiving cardiac resynchronization: A meta-analysis
AlTurki, A., Proietti, R., Alturki, H., Essebag, V., & Huynh, T. T. (2017) · Hellenic Journal of Cardiology · doi:10.1016/j.hjc.2017.12.003 · Cited by 13
Novel two‐lead cardiac resynchronization therapy system provides equivalent CRT responses with less complications than a conventional three‐lead system: Results from the QP ExCELs lead registry
Shaik, N. A., Drucker, M., Pierce, C. A., Duray, G. Z., Gillett, S., Miller, C., Harrell, C., & Thomas, G. (2020) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.14552 · Cited by 13
The Heart Failure and Optimal Outcomes from Pharmacy Study (HOOPS): Rationale, Design, and Baseline Characteristics
Lowrie, R., Mair, F. S., Greenlaw, N., Forsyth, P., McConnachie, A., Richardson, J., Khan, N., Morrison, D., Messow, C., Rae, B., et al. (2011) · European Journal of Heart Failure · doi:10.1093/eurjhf/hfr083 · Cited by 13
Cardiac resynchronization therapy: a breakthrough in heart failure management
Ståhlberg, M., Lund, L. H., Zabarovskaja, S., Gadler, F., Braunschweig, F., & Linde, C. M. (2012) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2012.02580.x · Cited by 13
Impact of Cardiac Resynchronization Therapy on Hospitalizations in the Resynchronization-Defibrillation for Ambulatory Heart Failure Trial
Gillis, A. M., Kerr, C. R., Philippon, F., Newton, G. E., Talajic, M. R., Froeschl, M. P. V., Froeschl, S., Swiggum, E., Yetisir, E., Wells, G. A., et al. (2014) · Circulation · doi:10.1161/circulationaha.112.000417 · Cited by 13
Self-citation
Upgrading pacemaker to cardiac resynchronization therapy: an option for patients with chronic right ventricular pacing and heart failure.
Sideris, S. K., Poulidakis, E., Aggeli, C., Gatzoulis, K. A., Vlasseros, I., Dilaveris, P., Sotiropoulos, I., Papoutis, D., Xristakopoulos, S., Manakos, K., et al. (2014) · PubMed · Cited by 13
Comparison of Conventional versus Steerable-Catheter Guided Coronary Sinus Lead Positioning in Patients Undergoing Cardiac Resynchronization Device Implantation
Er, F., Yüksel, D., Hellmich, M., & Gassanov, N. (2015) · PLoS ONE · doi:10.1371/journal.pone.0143292 · Cited by 13
Toward Sex-Specific Guidelines for Cardiac Resynchronization Therapy?
Zusterzeel, R., Selzman, K. A., Sanders, W. E., O’Callaghan, K. M., Caños, D., Vernooy, K., Prinzen, F. W., Gorgels, A. P. M., & Strauss, D. G. (2015) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-015-9663-z · Cited by 13

Authors: Tang, A. S. L., Wells, G. A., Talajic, M., Arnold, M. O., Sheldon, R., Connolly, S., Hohnloser, S. H., Nichol, G., Birnie, D. H., Sapp, J. L., Yee, R., Healey, J. S., & Rouleau, J. L.
Affiliations: University of British Columbia (CA)
Ottawa Heart Institute (CA)
Montreal Heart Institute (CA)
London Health Sciences Centre (CA)
University of Calgary (CA)
Hamilton Health Sciences (CA)
Goethe University Frankfurt (DE)
University of Washington (US)
Queen Elizabeth II Health Sciences Centre (CA)
ORCID: Tang, Anthony S.L.
Wells, George A.
Talajic, Mario
Sheldon, Robert
Connolly, Stuart
Hohnloser, Stefan H.
Nichol, Graham
Birnie, David H.
Sapp, John L.
Yee, Raymond
Rouleau, Jean L.
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 2010-12-16
Volume: 363
Issue: 25
Pages: 2385-2395
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejmoa1009540
OpenAlex: W2141895646
Cited by: 1,859
References: 28
Citations by year: 2026: 55 · 2025: 67 · 2024: 73 · 2023: 109 · 2022: 76 · 2021: 88 · 2020: 107 · 2019: 99 · 2018: 100 · 2017: 121 · 2016: 141 · 2015: 154 · 2014: 149 · 2013: 190 · 2012: 176
FWCI: 113.15
Type: journal article
Language: en
Open access: closed
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
Funders: Canadian Institutes of Health Research
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac pacing and defibrillation studies
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
Health Sciences › Medicine › Emergency Medicine › Cardiac Arrest and Resuscitation
Keywords: cardiac resynchronization therapy, implantable cardioverter-defibrillator, heart failure, wide QRS complex, left ventricular systolic dysfunction, mortality, heart failure hospitalization, device implantation complications, optimal medical therapy, left ventricular ejection fraction
MeSH terms: Aged, Cardiac Pacing, Artificial, Double-Blind Method, Electrocardiography, Female, Heart Failure, Hospitalization, Humans, Male, Middle Aged, Severity of Illness Index, Defibrillators, Implantable, Ventricular Dysfunction, Left, Kaplan-Meier Estimate, Intention to Treat Analysis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Cardiac-Resynchronization Therapy for Mild-to-Moderate Heart Failure

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks