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Genetic Basis for In Vivo Daptomycin Resistance in Enterococci
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BACKGROUND: Daptomycin is a lipopeptide with bactericidal activity that acts on the cell membrane of enterococci and is often used off-label to treat patients infected with vancomycin-resistant enterococci. However, the emergence of resistance to daptomycin during therapy threatens its usefulness. METHODS: We performed whole-genome sequencing and characterization of the cell envelope of a clinical pair of vancomycin-resistant Enterococcus faecalis isolates from the blood of a patient with fatal bacteremia; one isolate (S613) was from blood drawn before treatment and the other isolate (R712) was from blood drawn after treatment with daptomycin. The minimal inhibitory concentrations (MICs) of these two isolates were 1 and 12 μg per milliliter, respectively. Gene replacements were made to exchange the alleles found in isolate S613 with those in isolate R712. RESULTS: Isolate R712 had in-frame deletions in three genes. Two genes encoded putative enzymes involved in phospholipid metabolism, GdpD (which denotes glycerophosphoryl diester phosphodiesterase) and Cls (which denotes cardiolipin synthetase), and one gene encoded a putative membrane protein, LiaF (which denotes lipid II cycle-interfering antibiotics protein but whose exact function is not known). LiaF is predicted to be a member of a three-component regulatory system (LiaFSR) involved in the stress-sensing response of the cell envelope to antibiotics. Replacement of the liaF allele of isolate S613 with the liaF allele from isolate R712 quadrupled the MIC of daptomycin, whereas replacement of the gdpD allele had no effect on MIC. Replacement of both the liaF and gdpD alleles of isolate S613 with the liaF and gdpD alleles of isolate R712 raised the daptomycin MIC for isolate S613 to 12 μg per milliliter. As compared with isolate S613, isolate R712--the daptomycin-resistant isolate--had changes in the structure of the cell envelope and alterations in membrane permeability and membrane potential. CONCLUSIONS: Mutations in genes encoding LiaF and a GdpD-family protein were necessary and sufficient for the development of resistance to daptomycin during the treatment of vancomycin-resistant enterococci. (Funded by the National Institute of Allergy and Infectious Diseases and the National Institutes of Health.).
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“In enterococci, work using whole genome sequencing of a clinical strain-pair of E. faecalis that developed DAP resistance (DAP-R) over the course of therapy, revealed that changes in a three-component regulatory system designated LiaFSR (which orchestrates the cell-envelope stress response in gram-positives) are paramount in the development of DAP-R (88).”
From Mechanisms of Antibiotic Resistance (2016) · cites this paper as [88]
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“For example, two enzymes, a glycerol-phosphodiester phosphodiesterase (GdpD) and cardiolipin synthase (Cls) were found to enhance the DAP-R phenotype in the background of liaFSR mutations in E. faecalis (88).”
From Mechanisms of Antibiotic Resistance (2016) · cites this paper as [88]
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Cites
Velvet: Algorithms for de novo short read assembly using de Bruijn graphsPreprint
Zerbino, D. R., & Birney, E. (2008) · Genome Research · doi:10.1101/gr.074492.107 · Cited by 9,575
Bad Bugs, No Drugs: No ESKAPE! An Update from the Infectious Diseases Society of America
Boucher, H. W., Talbot, G. H., Bradley, J. S., Edwards, J. E., Gilbert, D. N., Rice, L. B., Scheld, M., Spellberg, B. J., & Bartlett, J. (2008) · Clinical Infectious Diseases · doi:10.1086/595011 · Cited by 5,092
Performance Standards for Antimicrobial Susceptibility Testing; Eighteenth Informational Supplement
Cockerill, F. R., & Clinical (2008) · Medical Entomology and Zoology · Cited by 2,065
Principles and Techniques of Electron Microscopy: Biological Applications
Maugel, T. K., & Hayat, M. A. (1979) · Transactions of the American Microscopical Society · doi:10.2307/3226038 · Cited by 1,327
Mwangi, M. M., Wu, S. W., Zhou, Y., Sieradzki, K., de LENCASTRE, H., Richardson, P., Bruce, D. G., Rubin, E. M., Myers, E. W., Siggia, E. D., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609839104 · Cited by 538
DiazGranados, C. A., Zimmer, S. M., Mitchel, K., & Jernigan, J. A. (2005) · Clinical Infectious Diseases · doi:10.1086/430909 · Cited by 459
Genetic Changes That Correlate with Reduced Susceptibility to Daptomycin in Staphylococcus aureus
Friedman, L., Alder, J. D., & Silverman, J. A. (2006) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00039-06 · Cited by 454
Cardiolipin membrane domains in prokaryotes and eukaryotes
Mileykovskaya, E., & Dowhan, W. (2009) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2009.04.003 · Cited by 402
Principles and Techniques of Electron Microscopy: Biological Applications
Maugel, T. K., & Hayat, M. A. (1977) · Transactions of the American Microscopical Society · doi:10.2307/3226107 · Cited by 389
Ernst, C. M., Neumann‐Staubitz, P., Mishra, N. N., Yang, S. J., Hornig, G., Kalbacher, H., Bayer, A. S., Kraus, D., & Peschel, A. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000660 · Cited by 370
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Sherry, N. L., Lee, J. Y. H., Giulieri, S. G., Connor, C. H., Horan, K., Lacey, J. A., Lane, C. R., Carter, G. P., Seemann, T., Egli, A., et al. (2025) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01082-24 · Cited by 76
Dhand, A., & Sakoulas, G. (2014) · Clinical Therapeutics · doi:10.1016/j.clinthera.2014.09.005 · Cited by 76
Fodor, A., Abate, B. A., Deák, P., Fodor, L., Gyenge, E., Klein, M. G., Koncz–Kálmán, Z., Muvevi, J., Otvos, L. J., Székely, G., et al. (2020) · Pathogens · doi:10.3390/pathogens9070522 · Cited by 79
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van Opijnen, T., Dedrick, S., & Bento, J. (2016) · PLoS Pathogens · doi:10.1371/journal.ppat.1005869 · Cited by 72
Chilambi, G. S., Nordstrom, H. R., Evans, D. R., Ferrolino, J. A. A., Hayden, R. T., Marón, G. M., Vo, A. N., Gilmore, M. S., Wolf, J., Rosch, J. W., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1917130117 · Cited by 70
Munita, J. M., Mishra, N. N., Alvarez, D., Tran, T. T., Diaz, L., Panesso, D., Reyes, J., Murray, B. E., Adachi, J. A., Bayer, A. S., et al. (2014) · Clinical Infectious Diseases · doi:10.1093/cid/ciu642 · Cited by 70
Self-citationMunita, J. M., Tran, T. T., Diaz, L., Panesso, D., Reyes, J., Murray, B. E., & Arias, C. A. (2013) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00021-13 · Cited by 70
Self-citationMcKenney, P. T., Yan, J., Vaubourgeix, J., Becattini, S., Lampen, N., Motzer, A., Larson, P. J., Dannaoui, D., Fujisawa, S., Xavier, J. B., et al. (2018) · Cell Host & Microbe · doi:10.1016/j.chom.2019.03.008 · Cited by 73
Werth, B. J., Steed, M. E., Ireland, C. E., Tran, T. T., Nonejuie, P., Murray, B. E., Rose, W. E., Sakoulas, G., Pogliano, J., Arias, C. A., et al. (2014) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00098-14 · Cited by 66
Self-citationHumphries, R. M., Kelesidis, T., Tewhey, R., Rose, W. E., Schork, N. J., Nizet, V., & Sakoulas, G. (2012) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01318-12 · Cited by 68
Chatterjee, A., Willett, J. L. E., Dunny, G. M., & Duerkop, B. A. (2021) · PLoS Genetics · doi:10.1371/journal.pgen.1009204 · Cited by 68
Design principles of collateral sensitivity-based dosing strategies
Aulin, L. B. S., Liakopoulos, A., van der Graaf, P. H., Rozen, D. E., & van Hasselt, J. G. C. (2021) · Nature Communications · doi:10.1038/s41467-021-25927-3 · Cited by 63
Antimicrobial Resistance in Enterococci
Garrido, A. M. (2014) · Journal of Infectious Diseases and Therapy · doi:10.4172/2332-0877.1000150 · Cited by 66
Treatment of Enterococcus faecalis Infective Endocarditis: A Continuing Challenge
Hidalgo, L. H., Fernández-Rubio, B., Márquez, R. L., López-Cortés, L. E., Gil-Navarro, M. V., & de Alarcón, A. (2023) · Antibiotics · doi:10.3390/antibiotics12040704 · Cited by 65
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Chatterjee, A., Willett, J. L. E., Nguyen, U. T., Monogue, B., Palmer, K. L., Dunny, G. M., & Duerkop, B. A. (2020) · mBio · doi:10.1128/mbio.03120-19 · Cited by 64
The Impact of Enterococcus spp. in the Immunocompromised Host: A Comprehensive Review
Sangiorgio, G., Calvo, M., Migliorisi, G., Campanile, F., & Stefani, S. (2024) · Pathogens · doi:10.3390/pathogens13050409 · Cited by 66
Meng, L., Liu, H., Lan, T., Dong, L. H., Hu, H., Zhao, S., Zhang, Y., Zheng, N., & Wang, J. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.01005 · Cited by 61
Metadata
- Authors
- Arias, C. A., Panesso, D., McGrath, D. M., Qin, X., Mojica, M. F., Miller, C., Diaz, L., Tran, T. T., Rincon, S., Barbu, E. M., Reyes, J., Roh, J. H., Lobos, E., Sodergren, E., Pasqualini, R., Arap, W., Quinn, J. P., Shamoo, Y., Murray, B. E., & Weinstock, G. M.
- Affiliations
- Universidad El Bosque (CO)
- The University of Texas MD Anderson Cancer Center (US)
- Baylor College of Medicine (US)
- Rice University (US)
- University of Houston (US)
- Washington University in St. Louis (US)
- Pfizer (United States) (US)
- ORCID
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2011-09-08
- Volume
- 365
- Issue
- 10
- Pages
- 892-900
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- PMC
- PMC3205971
- OpenAlex
- W2129864306
- Cited by
- 377
- References
- 37
- Citations by year
- 2026: 17 · 2025: 20 · 2024: 20 · 2023: 22 · 2022: 20 · 2021: 18 · 2020: 35 · 2019: 18 · 2018: 20 · 2017: 21 · 2016: 32 · 2015: 33 · 2014: 35 · 2013: 28 · 2012: 32
- FWCI
- 14.50
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Digital Commons@Becker (Washington University School of Medicine) (submittedVersion)
- Rutgers University Community Repository (Rutgers University) (submittedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion)
- Funders
- National Human Genome Research Institute (U54HG004968)
- National Institute of Allergy and Infectious Diseases (R37AI047923, R01AI093749, R00AI072961, R01AI080714, R01AI067861)
- Topics
- Health Sciences › Medicine › Microbiology (medical) › Antibiotic Resistance in Bacteria
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
- Keywords
- daptomycin resistance, vancomycin-resistant enterococci, Enterococcus faecalis, envelope stress response, membrane permeability, membrane potential, bacteremia, gene replacement, minimum inhibitory concentration, phospholipid metabolism
- MeSH terms
- Anti-Bacterial Agents, Genes, Bacterial, Humans, Microbial Sensitivity Tests, Mutation, Enterococcus faecalis, Bacteremia, Genome, Bacterial, Gram-Positive Bacterial Infections, Sequence Analysis, DNA, Daptomycin, Vancomycin Resistance, Drug Resistance, Bacterial, Microscopy, Electron, Transmission
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