The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Lifestyle Change and Mobility in Obese Adults with Type 2 Diabetes
Open accessAbstract
BACKGROUND: Adults with type 2 diabetes mellitus often have limitations in mobility that increase with age. An intensive lifestyle intervention that produces weight loss and improves fitness could slow the loss of mobility in such patients. METHODS: We randomly assigned 5145 overweight or obese adults between the ages of 45 and 74 years with type 2 diabetes to either an intensive lifestyle intervention or a diabetes support-and-education program; 5016 participants contributed data. We used hidden Markov models to characterize disability states and mixed-effects ordinal logistic regression to estimate the probability of functional decline. The primary outcome was self-reported limitation in mobility, with annual assessments for 4 years. RESULTS: At year 4, among 2514 adults in the lifestyle-intervention group, 517 (20.6%) had severe disability and 969 (38.5%) had good mobility; the numbers among 2502 participants in the support group were 656 (26.2%) and 798 (31.9%), respectively. The lifestyle-intervention group had a relative reduction of 48% in the risk of loss of mobility, as compared with the support group (odds ratio, 0.52; 95% confidence interval, 0.44 to 0.63; P<0.001). Both weight loss and improved fitness (as assessed on treadmill testing) were significant mediators of this effect (P<0.001 for both variables). Adverse events that were related to the lifestyle intervention included a slightly higher frequency of musculoskeletal symptoms at year 1. CONCLUSIONS: Weight loss and improved fitness slowed the decline in mobility in overweight adults with type 2 diabetes. (Funded by the Department of Health and Human Services and others; ClinicalTrials.gov number, NCT00017953.).
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“As is the case for persons with T2D, studies have demonstrated beneficial effects of both aerobic and resistance exercise and additive benefits when both forms of exercise are combined.727,847–852”
From American Association of Clinical Endocrinology Clinical Practice Guideline: Developing a Diabetes Mellitus Comprehensive Care Plan-2022 Update. (2022) · cites this paper as [727]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Increased physical activity is an important component of lifestyle therapy.674,727”
From American Association of Clinical Endocrinology Clinical Practice Guideline: Developing a Diabetes Mellitus Comprehensive Care Plan-2022 Update. (2022) · cites this paper as [727]
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In the citing paper
“Sustaining weight loss for longer periods may further improve the prevention of type 2 diabetes in at-risk individuals,34 as well as maintain improvements in sleep apnea,5 physical mobility,6 and other health conditions ameliorated by weight loss.7–9”
From Eight-year weight losses with an intensive lifestyle intervention: The look AHEAD study (2014) · cites this paper as [6]
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In the citing paper
“Physical activity and aerobic exercise guidelines are similar in persons with T2D independent of lean vs overweight/obese BMI.431,674,727,728”
From American Association of Clinical Endocrinology Clinical Practice Guideline: Developing a Diabetes Mellitus Comprehensive Care Plan-2022 Update. (2022) · cites this paper as [727]
Experimental — accuracy not yet measuredIn the citing paper
“The pathogenesis of the syndrome in children is also critically determined by β-cell function loss with the degree of residual β-cell function determining glucose control in recently diagnosed patients160.”
From Pathophysiology and treatment of type 2 diabetes: perspectives on the past, present, and future (2014) · cites this paper as [160]
In the citing paper
“The disease’s course in youth appears to be more aggressive than in adults, with the differential impact of the interventions being the result of a greater improvement in β-cell function160.”
From Pathophysiology and treatment of type 2 diabetes: perspectives on the past, present, and future (2014) · cites this paper as [160]
In the citing paper
“Other benefits include slowing the decline in mobility among overweight people with diabetes (251).”
From 5. Facilitating Positive Health Behaviors and Well-being to Improve Health Outcomes:Standards of Care in Diabetes—2023 (2023) · cites this paper as [251]
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Citations
Cites
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PHYSICAL ACTIVITY AS AN INDEX OF HEART ATTACK RISK IN COLLEGE ALUMNI1
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Self-citationPrevalence of diabetes and impaired fasting glucose in adults in the U.S. population
Cowie, C. C., Rust, K. F., Byrd-Holt, D. D., Eberhardt, M. S., Flegal, K. M., Engelgau, M. M., Saydah, S. H., Williams, D. E., Geiss, L. S., & Gregg, E. W. (2006) · Diabetes Care · doi:10.2337/dc06-0062 · Cited by 1,210
Self-citation(2010) · Archives of Internal Medicine · doi:10.1001/archinternmed.2010.334 · Cited by 1,162
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- 10.2337/diacare.23.9.1272 · DOI
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Items 301–301 of 301
Mori, H., Ko, K., Notomi, S., Yoshida, S., Yasuda, T., Umayahara, Y., Shimizu, S., Ryomoto, K., Yoshiuchi, K., Osawa, S., et al. (2026) · Journal of Diabetes Investigation · doi:10.1111/jdi.70383
“25, 26 Sarcopenic obesity was de fi ned based on the Japanese Working Group criteria as the combination of high BMI or WC with low grip strength, low SMM/BMI, and high BF%.”
Metadata
- Authors
- Rejeski, W. J., Ip, E. H., Bertoni, A. G., Bray, G. A., Evans, G., Gregg, E. W., & Zhang, Q.
- Affiliations
- Wake Forest University (US)
- Pennington Biomedical Research Center (US)
- Baylor College of Medicine (US)
- Centers for Disease Control and Prevention (US)
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2012-03-29
- Volume
- 366
- Issue
- 13
- Pages
- 1209-1217
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- PMC
- PMC3339039
- OpenAlex
- W2143015497
- Cited by
- 301
- References
- 41
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 6 · 2023: 14 · 2022: 18 · 2021: 16 · 2020: 17 · 2019: 17 · 2018: 17 · 2017: 38 · 2016: 29 · 2015: 21 · 2014: 40 · 2013: 34 · 2012: 17
- FWCI
- 28.75
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- University Libraries (University of Maryland) (submittedVersion)
- Digital Repository at the University of Maryland (University of Maryland College Park)
- Funders
- National Institutes of Health (5p30dk046204-15)
- National Institute on Aging (R01-AG031827A, R01AG031827, P30AG021332)
- National Heart, Lung, and Blood Institute (U01HL101066, HL076441-01A1, R18HL076441, R01HL076441)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-57171, DK 57136, DK57149, DK 57002, DK57182, DK56990, (DK 046204, DK57008, DK57177, DK 57078, DK57219, U01DK057149, DK-57178, U01DK057151, U01DK057135, U01DK057131, U01DK056990, DK-57135, U01DK057136, DK-56992, DK57154, U01DK057178, U01DK057182, U01DK057078, U01DK057154, U01DK057008, U01DK057171, DK57131, U01DK057002, U01DK057219, U01DK056992, U01DK057177, P30DK017047, P30DK048520, DK 57151, P30-DK046204, P30-DK 48520)
- National Center for Research Resources (M01-RR-0021140, M01RR-00051, M01RR002719, M01RR-00211, M01RR000056, M01RR01346, M01RR000051, M01RR001066, M01RR001346, UL1RR024153, M0-1-RR-02719, M01RR000211, M01-RR01066)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
- Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Balance, Gait, and Falls Prevention
- Keywords
- type 2 diabetes, obesity, mobility (physical function), functional decline, lifestyle intervention, weight loss, physical fitness, diabetes support and education, older adults, musculoskeletal symptoms
- MeSH terms
- Aged, Diabetes Mellitus, Type 2, Disability Evaluation, Female, Persons with Disabilities, Humans, Life Style, Male, Middle Aged, Motor Activity, Obesity, Patient Education as Topic, Physical Fitness, Risk, Weight Loss, Overweight, Mobility Limitation
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