Bedside monitoring to adjust antiplatelet therapy for coronary stenting
Open accessAbstract
BACKGROUND: Patients' responses to oral antiplatelet therapy are subject to variation. Bedside monitoring offers the opportunity to improve outcomes after coronary stenting by individualizing therapy. METHODS: We randomly assigned 2440 patients scheduled for coronary stenting at 38 centers to a strategy of platelet-function monitoring, with drug adjustment in patients who had a poor response to antiplatelet therapy, or to a conventional strategy without monitoring and drug adjustment. The primary end point was the composite of death, myocardial infarction, stent thrombosis, stroke, or urgent revascularization 1 year after stent implantation. For patients in the monitoring group, the VerifyNow P2Y12 and aspirin point-of-care assays were used in the catheterization laboratory before stent implantation and in the outpatient clinic 2 to 4 weeks later. RESULTS: In the monitoring group, high platelet reactivity in patients taking clopidogrel (34.5% of patients) or aspirin (7.6%) led to the administration of an additional bolus of clopidogrel, prasugrel, or aspirin along with glycoprotein IIb/IIIa inhibitors during the procedure. The primary end point occurred in 34.6% of the patients in the monitoring group, as compared with 31.1% of those in the conventional-treatment group (hazard ratio, 1.13; 95% confidence interval [CI], 0.98 to 1.29; P=0.10). The main secondary end point, stent thrombosis or any urgent revascularization, occurred in 4.9% of the patients in the monitoring group and 4.6% of those in the conventional-treatment group (hazard ratio, 1.06; 95% CI, 0.74 to 1.52; P=0.77). The rate of major bleeding events did not differ significantly between groups. CONCLUSIONS: This study showed no significant improvements in clinical outcomes with platelet-function monitoring and treatment adjustment for coronary stenting, as compared with standard antiplatelet therapy without monitoring. (Funded by Allies in Cardiovascular Trials Initiatives and Organized Networks and others; ARCTIC ClinicalTrials.gov number, NCT00827411.).
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Large, superiority RCTs have failed to show a higher efficacy of routine platelet-function testing in guiding antiplatelet therapy post-PCI.
“Moreover, large, superiority RCTs have failed to show a higher efficacy of routine platelet-function testing in guiding antiplatelet therapy post-PCI.322,322a”
From 2023 ESC guidelines for the management of cardiovascular disease in patients with diabetes. (2023) · cites this paper as [322]
Current evidence does not support platelet function testing to adjust DAPT.
“Current evidence does not support platelet function testing to adjust DAPT.”
From 2023 ESC guidelines for the management of cardiovascular disease in patients with diabetes. (2023) · cites this paper as [322]
Several large randomized trials found no clinical benefit from adjusting antithrombotic regimens according to platelet function testing.
“Despite initial enthusiasm, multiple large, randomized studies have failed to show any clinical benefit when antithrombotic regimens are adjusted on the basis of platelet function testing.60–62”
From Clinical management of stable coronary artery disease in patients with type 2 diabetes mellitus: a scientific statement from the American Heart Association (2020) · cites this paper as [62]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Ticagrelor versus clopidogrel in patients with acute coronary syndromes
Wallentin, L., Becker, R. C., Budaj, A., Cannon, C. P., Emanuelsson, H., Held, C., Horrow, J., Husted, S., James, S., Katus, H., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0904327 · Cited by 7,117 · see citing works
Prasugrel versus clopidogrel in patients with acute coronary syndromes
Wiviott, S. D., Braunwald, E., McCabe, C. H., Montalescot, G., Ruzyllo, W., Gottlieb, S., Neumann, F.-J., Ardissino, D., De Servi, S., Murphy, S. A., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa0706482 · Cited by 6,790 · see citing works
Self-citationGuidelines on myocardial revascularization
Wijns, W. C., Kolh, P. H., Danchin, N., Mario, C. D., Falk, V., Folliguet, T. A., Garg, S., Huber, K., James, S. K., Knuuti, J., et al. (2010) · European Heart Journal · doi:10.1093/eurheartj/ehq277 · Cited by 3,230 · see citing works
Price, M. J. (2011) · JAMA · doi:10.1001/jama.2011.290 · Cited by 1,311 · see citing works
Lincoff, A. M., Bittl, J. A., Harrington, R. A., Feit, F., Kleiman, N. S., Jackman, J. D., Sarembock, I. J., Cohen, D. J., Spriggs, D. J., Ebrahimi, R., et al. (2003) · JAMA · doi:10.1001/jama.289.7.853 · Cited by 1,158 · see citing works
Bonello, L., Tantry, U. S., Marcucci, R., Blindt, R., Angiolillo, D. J., Becker, R. C., Bhatt, D. L., Cattaneo, M., Collet, J., Cuisset, T., et al. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.04.047 · Cited by 1,145 · see citing works
Self-citationPrasugrel versus clopidogrel for acute coronary syndromes without revascularization
Roe, M. T., Armstrong, P. W., Fox, K. A. A., White, H. D., Prabhakaran, D., Goodman, S. G., Cornel, J. H., Bhatt, D. L., Clemmensen, P., Martinez, F., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1205512 · Cited by 874 · see citing works
Breet, N. J., van Werkum, J. W., Bouman, H. J., Kelder, J. C., Ruven, H. J. T., Bal, E. T., Deneer, V. H. M., Harmsze, A. M., der Heyden, J. A. S. V., Rensing, B. J. W. M., et al. (2010) · JAMA · doi:10.1001/jama.2010.181 · Cited by 850 · see citing works
Mehta, S. R., Tanguay, J., Eikelboom, J. W., Jolly, S. S., Joyner, C. D., Granger, C. B., Faxon, D. P., Rupprecht, H., Budaj, A., Avezum, Á., et al. (2010) · The Lancet · doi:10.1016/s0140-6736(10)61088-4 · Cited by 822 · see citing works
Self-citationThrombin-Receptor Antagonist Vorapaxar in Acute Coronary Syndromes
Tricoci, P., Huang, Z., Held, C., Moliterno, D. J., Armstrong, P. W., de Werf, F. V., White, H. D., Aylward, P. E., Wallentin, L. C., Chen, E., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1109719 · Cited by 756 · see citing works
Self-citationCannon, C. P., Harrington, R. A., James, S. K., Ardissino, D., Becker, R. C., Emanuelsson, H., Husted, S., Katus, H. A., Keltai, M., Khurmi, N. S., et al. (2010) · The Lancet · doi:10.1016/s0140-6736(09)62191-7 · Cited by 664 · see citing works
Impact of Platelet Reactivity After Clopidogrel Administration on Drug-Eluting Stent Thrombosis
Buonamici, P., Marcucci, R., Migliorini, A., Gensini, G. F., Santini, A., Paniccia, R., Moschi, G., Gori, A. M., Abbate, R., & Antoniucci, D. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.01.094 · Cited by 655 · see citing works
Price, M. J., Endemann, S., Gollapudi, R. R., Valencia, R., Stinis, C. T., Levisay, J. P., Ernst, A., Sawhney, N. S., Schatz, R. A., & Teirstein, P. S. (2008) · European Heart Journal · doi:10.1093/eurheartj/ehn046 · Cited by 651 · see citing works
A hierarchical Bayesian meta-analysis of randomised clinical trials of drug-eluting stents
Babapulle, M. N., Joseph, L., Bélisle, P., Brophy, J. M., & Eisenberg, M. J. (2004) · The Lancet · doi:10.1016/s0140-6736(04)16850-5 · Cited by 645 · see citing works
Trenk, D., Stone, G. W., Gawaz, M., Kastrati, A., Angiolillo, D. J., Müller, U., Richardt, G., Jakubowski, J. A., & Neumann, F.-J. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.02.026 · Cited by 626 · see citing works
Hochholzer, W., Trenk, D., Bestehorn, H.-P., Fischer, B., Valina, C. M., Ferenc, M., Gick, M., Caputo, A., Büttner, H. J., & Neumann, F. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.06.065 · Cited by 587 · see citing works
Impact of Platelet Reactivity on Clinical Outcomes After Percutaneous Coronary Intervention
Brar, S. S., ten Berg, J. M., Marcucci, R., Price, M. J., Valgimigli, M., Kim, H.-S., Patti, G., Breet, N. J., DiSciascio, G., Cuisset, T., et al. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.06.059 · Cited by 422 · see citing works
Self-citationPlatelet Reactivity and Cardiovascular Outcomes After Percutaneous Coronary Intervention
Price, M. J., Angiolillo, D. J., Teirstein, P. S., Lillie, E. O., Manoukian, S. V., Berger, P. B., Tanguay, J., Cannon, C. P., & Topol, E. J. (2011) · Circulation · doi:10.1161/circulationaha.111.029165 · Cited by 396 · see citing works
Roberts, J. D., Wells, G. A., May, M. R. L., Labinaz, M. X., Glover, C. A., Froeschl, M. P. V., DICK, A. J., Marquis, J.-F., O’Brien, E. R., Gonçalves, S. C., et al. (2012) · The Lancet · doi:10.1016/s0140-6736(12)60161-5 · Cited by 393 · see citing works
Enoxaparin versus Unfractionated Heparin in Elective Percutaneous Coronary Intervention
Montalescot, G., White, H. D., Gallo, R., Cohen, M. C., Steg, P. G., Aylward, P. E., Bode, C., Massimo Chiariello, A., King, S. B., Harrington, R. A., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa052711 · Cited by 359 · see citing works
Self-citationValgimigli, M., Campo, G. C., Cesare, N. D., Meliga, E., Vranckx, P., Furgieri, A., Angiolillo, D. J., Sabaté, M., Hamon, M., Repetto, A., et al. (2009) · Circulation · doi:10.1161/circulationaha.108.833236 · Cited by 225 · see citing works
Cuisset, T., Frère, C., Quilici, J., Morange, P., Mouret, J.-P., Bali, L., Moro, P.-J., Lambert, M., Alessi, M., & Bonnet, J. (2008) · JACC: Cardiovascular Interventions · doi:10.1016/j.jcin.2008.08.018 · Cited by 152 · see citing works
Self-citationAradi, D., Komócsi, A., Price, M. J., Cuisset, T., Arı, H., Hazarbasanov, D., Trenk, D., Sibbing, D., Valgimigli, M., & Bonello, L. (2012) · International Journal of Cardiology · doi:10.1016/j.ijcard.2012.05.100 · Cited by 141 · see citing works
Self-citationCollet, J., Cayla, G., Cuisset, T., Elhadad, S., Rangé, G., Vicaut, É., & Montalescot, G. (2010) · American Heart Journal · doi:10.1016/j.ahj.2010.09.029 · Cited by 92 · see citing works
Self-citationDose Effect of Clopidogrel Reloading in Patients Already on 75-mg Maintenance Dose
Collet, J., Silvain, J., Landivier, A., Tanguy, M., Cayla, G., Bellemain-Appaix, A., Vignolles, N., Gallier, S., Beygui, F., Peña, A., et al. (2008) · Circulation · doi:10.1161/circulationaha.108.776757 · Cited by 87 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 1
- Wijns W, Kolh P, Danchin N, et al. Guidelines on myocardial revasculariza- tion: The Task Force on Myocardial Re- vascularization of the European Society of Cardiology (ESC) and the European As- sociation for Cardio-Thoracic Surgery (EACTS). Eur Heart J 2010;31:2501-55.
Cited by
Sorted by citations
Roffi, M., Patrono, C., Collet, J.-P., Mueller, C., Valgimigli, M., Andreotti, F., Bax, J. J., Borger, M. A., Brotons, C., Chew, D. P., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehv320 · Cited by 8,261 · see citing works
Self-citationKernan, W. N., Ovbiagele, B., Black, H. R., Bravata, D. M., Chimowitz, M. I., Ezekowitz, M. D., Fang, M. C., Fisher, M., Furie, K. L., Heck, D. V., et al. (2014) · Stroke · doi:10.1161/str.0000000000000024 · Cited by 5,170 · see citing works
2013 ESC guidelines on the management of stable coronary artery disease
Task Force Members, Montalescot, G., Sechtem, U., Achenbach, S., Andreotti, F., Arden, C., Budaj, A., Bugiardini, R., Crea, F., Cuisset, T., et al. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht296 · Cited by 4,510 · see citing works
Self-citation2014 ESC/EACTS Guidelines on myocardial revascularization
Authors Task Force Members, Windecker, S., Kolh, P., Alfonso, F., Collet, J., Cremer, J., Falk, V., Filippatos, G., Hamm, C. W., Head, S. J., et al. (2014) · European Heart Journal · doi:10.1093/eurheartj/ehu278 · Cited by 4,340 · see citing works
Self-citation2014 ESC/EACTS Guidelines on myocardial revascularization
Kolh, P. H., Windecker, S., Alfonso, F., Collet, J., Cremer, J., Falk, V., Filippatos, G. S., Hamm, C. W., Head, S. J., Jüni, P., et al. (2014) · European Journal of Cardio-Thoracic Surgery · doi:10.1093/ejcts/ezu366 · Cited by 4,211 · see citing works
Self-citation2014 AHA/ACC Guideline for the Management of Patients With Non–ST-Elevation Acute Coronary Syndromes
Amsterdam, E. A., Wenger, N. K., Brindis, R. G., Casey, D. E., Ganiats, T. G., Holmes, D. R., Jaffe, A. S., Jneid, H., Kelly, R. F., Kontos, M. C., et al. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.09.017 · Cited by 3,595 · see citing works
Valgimigli, M., Bueno, H., Byrne, R. A., Collet, J., Costa, F., Jeppsson, A., Jüni, P., Kastrati, A., Kolh, P. H., Mauri, L., et al. (2017) · European Heart Journal · doi:10.1093/eurheartj/ehx419 · Cited by 2,999 · see citing works
Self-citation2023 ESC guidelines for the management of cardiovascular disease in patients with diabetes.
Marx, N., Federici, M., Schütt, K., Müller-Wieland, D., Ajjan, R. A., Antunes, M. J., Christodorescu, R. M., Crawford, C., Di Angelantonio, E., Eliasson, B., et al. (2023) · European Heart Journal · doi:10.1093/eurheartj/ehad192 · Cited by 1,642 · see citing works
Amsterdam, E. A., Wenger, N. K., Brindis, R. G., Casey, D. E., Ganiats, T. G., Holmes, D. R., Jaffe, A. S., Jneid, H., Kelly, R. F., Kontos, M. C., et al. (2014) · Circulation · doi:10.1161/cir.0000000000000134 · Cited by 1,059 · see citing works
Scott, S. A., Sangkuhl, K., Stein, C. M., Hulot, J., Mega, J. L., Roden, D. M., Klein, T. E., Sabatine, M. S., Johnson, J. A., & Shuldiner, A. R. (2013) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.2013.105 · Cited by 962 · see citing works
Tantry, U. S., Bonello, L., Aradi, D., Price, M. J., Jeong, Y.-H., Angiolillo, D. J., Stone, G. W., Curzen, N., Geisler, T., ten Berg, J., et al. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.07.101 · Cited by 910 · see citing works
Stone, G. W., Witzenbichler, B., Weisz, G., Rinaldi, M. J., Neumann, F., Metzger, D. C., Henry, T. D., Cox, D. A., Duffy, P. L., Mazzaferri, E. L., et al. (2013) · The Lancet · doi:10.1016/s0140-6736(13)61170-8 · Cited by 858 · see citing works
Defining High Bleeding Risk in Patients Undergoing Percutaneous Coronary Intervention
Urban, P. M., Mehran, R., Colleran, R., Angiolillo, D. J., Byrne, R. A., Capodanno, D., Cuisset, T., Cutlip, D. E., Eerdmans, P. H. A., Eikelboom, J. W., et al. (2019) · Circulation · doi:10.1161/circulationaha.119.040167 · Cited by 842 · see citing works
Self-citationUrban, P. M., Mehran, R., Colleran, R., Angiolillo, D. J., Byrne, R. A., Capodanno, D., Cuisset, T., Cutlip, D. E., Eerdmans, P. H. A., Eikelboom, J. W., et al. (2019) · European Heart Journal · doi:10.1093/eurheartj/ehz372 · Cited by 638 · see citing works
Self-citationByrne, R. A., Joner, M., & Kastrati, A. (2015) · European Heart Journal · doi:10.1093/eurheartj/ehv511 · Cited by 619 · see citing works
Sibbing, D., Aradi, D., Jacobshagen, C., Gross, L., Trenk, D., Geisler, T., Orban, M., Hadamitzky, M., Merkely, B., Kiss, R. G., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(17)32155-4 · Cited by 615 · see citing works
Cattaneo, M., Cerletti, C., Harrison, P., Hayward, C. P. M., Kenny, D. J., Nugent, D. J., Nurden, P., Rao, A. K., Schmaier, A. H., Watson, S. P., et al. (2013) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.12231 · Cited by 573 · see citing works
Sibbing, D., Aradi, D., Alexopoulos, D. K., ten Berg, J. M., Bhatt, D. L., Bonello, L., Collet, J., Cuisset, T., Franchi, F., Groß, L., et al. (2019) · JACC: Cardiovascular Interventions · doi:10.1016/j.jcin.2019.03.034 · Cited by 542 · see citing works
Self-citationRoffi, M., Patrono, C., Collet, J., Mueller, C. E., Valgimigli, M., Andreotti, F., Bax, J. J., Borger, M. A., Brotons, C., Chew, D. P., et al. (2015) · Kardiologia Polska · doi:10.5603/kp.2015.0243 · Cited by 459 · see citing works
Self-citation2014 ESC/EACTS Guidelines on myocardial revascularization
Windecker, S., Kolh, P. H., Alfonso, F., Collet, J., Cremer, J., Falk, V., Filippatos, G. S., Hamm, C. W., Head, S. J., Jüni, P., et al. (2014) · Kardiologia Polska · doi:10.5603/kp.2014.0224 · Cited by 416 · see citing works
Self-citationValgimigli, M., Bueno, H., Byrne, R. A., Collet, J., Costa, F., Jeppsson, A., Jüni, P., Kastrati, A., Kolh, P. H., Mauri, L., et al. (2017) · European Journal of Cardio-Thoracic Surgery · doi:10.1093/ejcts/ezx334 · Cited by 416 · see citing works
Self-citationInternational Expert Consensus on Switching Platelet P2Y 12 Receptor–Inhibiting Therapies
Angiolillo, D. J., Rollini, F., Storey, R. F., Bhatt, D. L., James, S. K., Schneider, D. J., Sibbing, D., So, D. Y. F., Trenk, D., Alexopoulos, D. K., et al. (2017) · Circulation · doi:10.1161/circulationaha.117.031164 · Cited by 406 · see citing works
Self-citation2017 EACTS Guidelines on perioperative medication in adult cardiac surgery
Sousa‐Uva, M., Head, S. J., Milojevic, M., Collet, J., Landoni, G., Castellà, M., Dunning, J., Guðbjartsson, T., Linker, N., Sandoval, E., et al. (2017) · European Journal of Cardio-Thoracic Surgery · doi:10.1093/ejcts/ezx314 · Cited by 402 · see citing works
Self-citationOpportunities and Challenges for Biosensors and Nanoscale Analytical Tools for Pandemics: COVID-19
Bhalla, N., Pan, Y., Yang, Z., & Payam, A. F. (2020) · ACS Nano · doi:10.1021/acsnano.0c04421 · Cited by 385 · see citing works
Cayla, G., Cuisset, T., Silvain, J., Leclercq, F., Manzo-Silberman, S., Saint-Etienne, C., Delarche, N., Bellemain-Appaix, A., Range, G., El Mahmoud, R., et al. (2016) · The Lancet · doi:10.1016/s0140-6736(16)31323-x · Cited by 380 · see citing works
Self-citationAradi, D., Kirtane, A. J., Bonello, L., Gurbel, P. A., Tantry, U. S., Huber, K., Freynhofer, M. K., ten Berg, J. M., Janssen, P. W. A., Angiolillo, D. J., et al. (2015) · European Heart Journal · doi:10.1093/eurheartj/ehv104 · Cited by 372 · see citing works
Self-citationACC/AHA Versus ESC Guidelines on Dual Antiplatelet Therapy
Capodanno, D., Alfonso, F., Levine, G. N., Valgimigli, M., & Angiolillo, D. J. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.09.057 · Cited by 371 · see citing works
Novel antiplatelet agents in acute coronary syndrome
Franchi, F., & Angiolillo, D. J. (2014) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2014.156 · Cited by 352 · see citing works
Levine, G. N., Jeong, Y., Goto, S., Anderson, J. L., Huo, Y., Mega, J. L., Taubert, K. A., & Smith, S. C. (2014) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2014.104 · Cited by 337 · see citing works
2014 ESC/EACTS Guidelines on myocardial revascularization
Windecker, S., Kolh, P. H., Alfonso, F., Collet, J., Cremer, J., Falk, V., Filippatos, G. S., Hamm, C. W., Head, S. J., Jüni, P., et al. (2015) · EuroIntervention · doi:10.4244/eijy14m09_01 · Cited by 332 · see citing works
Self-citationKumbhani, D. J., Cannon, C. P., Beavers, C. J., Bhatt, D. L., Cuker, A. C., Gluckman, T. J., Marine, J. E., Mehran, R., Messe, S. R., Patel, N. S., et al. (2020) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2020.09.011 · Cited by 314 · see citing works
Han, Y., Guo, J., Zheng, Y., Zang, H., Su, X., Wang, Y., Chen, S., Jiang, T., Yang, P. C., Chen, J., et al. (2015) · JAMA · doi:10.1001/jama.2015.2323 · Cited by 311 · see citing works
Antiplatelet therapy after percutaneous coronary intervention
Angiolillo, D. J., Galli, M., Collet, J., Kastrati, A., & O'Donoghue, M. O. (2022) · EuroIntervention · doi:10.4244/eij-d-21-00904 · Cited by 311 · see citing works
Self-citationArnold, S. V., Bhatt, D. L., Barsness, G. W., Beatty, A. L., Deedwania, P. C., Inzucchi, S. E., Kosiborod, M., Leiter, L. A., Lipska, K. J., Newman, J. D., et al. (2020) · Circulation · doi:10.1161/cir.0000000000000766 · Cited by 304 · see citing works
Collet, J., Silvain, J., Barthélémy, O., Rangé, G., Cayla, G., BELLE, E. V., Cuisset, T., Elhadad, S., Schiele, F., Lhoest, N., et al. (2014) · The Lancet · doi:10.1016/s0140-6736(14)60612-7 · Cited by 300 · see citing works
Self-citationMega, J. L., & Simon, T. (2015) · The Lancet · doi:10.1016/s0140-6736(15)60243-4 · Cited by 291 · see citing works
Aradi, D., Storey, R. F., Komócsi, A., Trenk, D., Gulba, D. C., Kiss, R. G., Husted, S., Bonello, L., Sibbing, D., Collet, J., et al. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht375 · Cited by 275 · see citing works
Self-citationGalli, M., Benenati, S., Capodanno, D., Franchi, F., Rollini, F., D’Amario, D., Porto, I., & Angiolillo, D. J. (2021) · The Lancet · doi:10.1016/s0140-6736(21)00533-x · Cited by 243 · see citing works
Sarafoff, N., Martischnig, A., Wealer, J., Mayer, K., Mehilli, J., Sibbing, D., & Kastrati, A. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.02.036 · Cited by 236 · see citing works
Bittl, J. A., Baber, U., Bradley, S. M., & Wijeysundera, D. N. (2016) · Circulation · doi:10.1161/cir.0000000000000405 · Cited by 229 · see citing works
Pereira, N. L., Rihal, C. S., So, D. Y. F., Rosenberg, Y., Lennon, R. J., Mathew, V., Goodman, S. G., Weinshilboum, R. M., Wang, L., Baudhuin, L. M., et al. (2019) · Circulation Cardiovascular Interventions · doi:10.1161/circinterventions.119.007811 · Cited by 228 · see citing works
Antiplatelet Agents for the Treatment and Prevention of Coronary Atherothrombosis
Patrono, C., Morais, J., Baigent, C., Collet, J., Fitzgerald, D. J., Halvorsen, S., Rocca, B., Siegbahn, A., Storey, R. F., & Vilahur, G. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.08.037 · Cited by 220 · see citing works
Self-citationBittl, J. A., Baber, U., Bradley, S. M., & Wijeysundera, D. N. (2016) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2016.03.512 · Cited by 197 · see citing works
Pharmacogenomic Approach to Selecting Antiplatelet Therapy in Patients With Acute Coronary Syndromes
Notarangelo, F. M., Maglietta, G., Bevilacqua, P., Cereda, M., Merlini, P. A., VILLANI, G. Q., Moruzzi, P., Patrizi, G., Tagliazucchi, G. M., Crocamo, A., et al. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.02.029 · Cited by 196 · see citing works
P2Y12 receptors: structure and function
Cattaneo, M. (2015) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.12952 · Cited by 185 · see citing works
Switching P2Y12-receptor inhibitors in patients with coronary artery disease
Rollini, F., Franchi, F., & Angiolillo, D. J. (2015) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2015.113 · Cited by 179 · see citing works
Capodanno, D., Mehran, R., Krucoff, M. W., Baber, U., Bhatt, D. L., Capranzano, P., Collet, J., Cuisset, T., Luca, G. D., Luca, L. D., et al. (2023) · Circulation · doi:10.1161/circulationaha.123.064473 · Cited by 177 · see citing works
Self-citationMechanisms of aspirin resistance
Floyd, C. N., & Ferro, A. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.08.005 · Cited by 165 · see citing works
Nicolau, J. C., Feitosa, G. S., Petriz, J. L. F., Furtado, R. H. D. M., Précoma, D. B., Lemke, W., Lópes, R. D., Timerman, A., Marin‐Neto, J. A., Bezerra, L., et al. (2021) · Arquivos Brasileiros de Cardiologia · doi:10.36660/abc.20210180 · Cited by 163 · see citing works
Rocca, B., Fox, K. A. A., Ajjan, R., Andreotti, F., Baigent, C., Collet, J., Grove, E. L., Halvorsen, S., Huber, K., Morais, J., et al. (2018) · European Heart Journal · doi:10.1093/eurheartj/ehy066 · Cited by 149 · see citing works
Self-citationResponse Variability to P2Y12 Receptor Inhibitors
Siller-Matula, J. M., Trenk, D., Schrör, K., Gawaz, M., Kristensen, S. D., Storey, R. F., & Huber, K. (2013) · JACC: Cardiovascular Interventions · doi:10.1016/j.jcin.2013.06.011 · Cited by 148 · see citing works
Use of Platelet Function Testing Before Pipeline Embolization Device Placement
Adeeb, N., Griessenauer, C. J., Foreman, P. M., Moore, J. M., Shallwani, H., Motiei-Langroudi, R., Alturki, A. Y., Siddiqui, A. H., Levy, E. I., Harrigan, M. R., et al. (2017) · Stroke · doi:10.1161/strokeaha.116.015308 · Cited by 148 · see citing works
Halvorsen, S., Storey, R. F., Rocca, B., Sibbing, D., ten Berg, J. M., Grove, E. L., Weiss, T. W., Collet, J., Andreotti, F., Gulba, D. C., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw454 · Cited by 144 · see citing works
Self-citationRoffi, M., Patrono, C., Collet, J., Mueller, C. E., Valgimigli, M., Andreotti, F., Bax, J. J., Borger, M. A., Brotons, C., Chew, D. P., et al. (2015) · Revista Española de Cardiología (English Edition) · doi:10.1016/j.rec.2015.10.009 · Cited by 136 · see citing works
Self-citationOral Antiplatelet Therapy After Acute Coronary Syndrome
Kamran, H., Jneid, H. M., Kayani, W. T., Virani, S. S., Levine, G. N., Nambi, V., & Khalid, U. (2021) · JAMA · doi:10.1001/jama.2021.0716 · Cited by 134 · see citing works
Angiolillo, D. J., Galli, M., Alexopoulos, D. K., Aradi, D., Bhatt, D. L., Bonello, L., Capodanno, D., Cavallari, L. H., Collet, J., Cuisset, T., et al. (2024) · JACC: Cardiovascular Interventions · doi:10.1016/j.jcin.2024.08.027 · Cited by 130 · see citing works
Self-citationBrown, S.-A. N., & Pereira, N. L. (2018) · Journal of Personalized Medicine · doi:10.3390/jpm8010008 · Cited by 123 · see citing works
The Role of Clopidogrel in 2020: A Reappraisal
Patti, G., Micieli, G., Cimminiello, C., & Bolognese, L. (2020) · Cardiovascular Therapeutics · doi:10.1155/2020/8703627 · Cited by 122 · see citing works
Duration of Dual Antiplatelet Therapy After Coronary Stenting
Montalescot, G., Brieger, D. B., Dalby, A. J., Park, S., & Mehran, R. (2015) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2015.05.053 · Cited by 112 · see citing works
Self-citationUrban, P. M., Gregson, J., Owen, R., Mehran, R., Windecker, S., Valgimigli, M., Varenne, O., Krucoff, M. W., Saito, S., Baber, U., et al. (2021) · JAMA Cardiology · doi:10.1001/jamacardio.2020.6814 · Cited by 112 · see citing works
Capodanno, D., & Angiolillo, D. J. (2013) · Circulation · doi:10.1161/circulationaha.113.003675 · Cited by 109 · see citing works
Silvain, J., Storey, R. F., Cayla, G., Estève, J.-B., Dillinger, J., Rousseau, H., Tsatsaris, A., Baradat, C., Salhi, N., Hamm, C. W., et al. (2016) · Thrombosis and Haemostasis · doi:10.1160/th15-12-0944 · Cited by 106 · see citing works
Self-citationWisman, P. P., Roest, M., Asselbergs, F. W., de Groot, P. G., Moll, F. L., van der Graaf, Y., & de Borst, G. J. (2014) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.12538 · Cited by 104 · see citing works
Medical Therapy for Long-Term Prevention of Atherothrombosis Following an Acute Coronary Syndrome
Gallone, G., Baldetti, L., Pagnesi, M., Latib, A., Colombo, A., Libby, P., & Giannini, F. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.09.052 · Cited by 104 · see citing works
EHA Guidelines on Management of Antithrombotic Treatments in Thrombocytopenic Patients With Cancer
Falanga, A., Leader, A., Ambaglio, C., Bagoly, Z., Castaman, G., Elalamy, I., Lecumberri, R., Niessner, A., Pabinger, I., Szmit, S., et al. (2022) · HemaSphere · doi:10.1097/hs9.0000000000000750 · Cited by 103 · see citing works
Cao, D., Chandiramani, R., Chiarito, M., Claessen, B. E. P. M., & Mehran, R. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehaa824 · Cited by 98 · see citing works
Aspirin Treatment and Outcomes After Percutaneous Coronary Intervention
Mayer, K., Bernlochner, I., Braun, S., Schulz, S., Orban, M., Morath, T., Cala, L., Hoppmann, P., Schunkert, H., Laugwitz, K., et al. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.05.049 · Cited by 96 · see citing works
Klein, M. D., Williams, A. K., Lee, C. R., & Stouffer, G. A. (2019) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.118.311963 · Cited by 95 · see citing works
Aradi, D., Tornyos, A., Pintér, T., Vorobcsuk, A., Kónyi, A., Faluközy, J., Veress, G., Magyari, B., Horváth, I., & Komócsi, A. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.12.023 · Cited by 90 · see citing works
Medical Management After Coronary Stent Implantation
Brilakis, E. S., PATEL, V. G., & Banerjee, S. (2013) · JAMA · doi:10.1001/jama.2013.7086 · Cited by 90 · see citing works
Angiolillo, D. J., Goodman, S. G., Bhatt, D. L., Eikelboom, J. W., Price, M. J., Moliterno, D. J., Cannon, C. P., Tanguay, J., Granger, C. B., Mauri, L., et al. (2016) · Circulation Cardiovascular Interventions · doi:10.1161/circinterventions.116.004395 · Cited by 90 · see citing works
Tang, Y., Wang, W., Yang, M. H., Zhang, K., Chen, J., Qiao, S., Yan, H., Wu, Y., Huang, X., Xu, B., et al. (2018) · Circulation · doi:10.1161/circulationaha.117.030190 · Cited by 89 · see citing works
Li, Y., Sun, K., Ye, G., Liang, Y., Pan, H., Wang, G., Zhao, Y., Pan, J., Zhang, J., & Fang, J. (2015) · Journal of Endodontics · doi:10.1016/j.joen.2014.10.020 · Cited by 87 · see citing works
Sousa‐Uva, M., Storey, R. F., Huber, K., Falk, V., Leite-Moreira, A. F., Amour, J., Al‐Attar, N., Ascione, R., Taggart, D. P., Collet, J. ‐., et al. (2014) · European Heart Journal · doi:10.1093/eurheartj/ehu158 · Cited by 86 · see citing works
Self-citationNew oral anticoagulants and regional anaesthesia
Benzon, H. T., Avram, M. J., Green, D., & Bonow, R. O. (2013) · British Journal of Anaesthesia · doi:10.1093/bja/aet401 · Cited by 85 · see citing works
Bagai, A., Peterson, E. D., Honeycutt, E. F., Effron, M. B., Cohen, D. J., Goodman, S. G., Anstrom, K. J., Gupta, A., Messenger, J. C., & Wang, T. Y. (2014) · European Heart Journal Acute Cardiovascular Care · doi:10.1177/2048872614564082 · Cited by 83 · see citing works
Bergmeijer, T. O., Janssen, P. W. A., Schipper, J., Qaderdan, K., Ishak, M., Ruitenbeek, R. S., Asselbergs, F. W., Hof, A. W. J. V. ’., Dewilde, W. J. M., Spanó, F., et al. (2014) · American Heart Journal · doi:10.1016/j.ahj.2014.03.006 · Cited by 83 · see citing works
Variability of Individual Platelet Reactivity Over Time in Patients Treated With Clopidogrel
Hochholzer, W., Ruff, C. T., Mesa, R. A., Mattimore, J. F., Cyr, J. F., Lei, L., Frelinger, A. L., Michelson, A. D., Berg, D. D., Angiolillo, D. J., et al. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.03.051 · Cited by 81 · see citing works
Prevalence and Impact of High Platelet Reactivity in Chronic Kidney Disease
Baber, U., Mehran, R., Kirtane, A. J., Gurbel, P. A., Christodoulidis, G., Maehara, A., Witzenbichler, B., Weisz, G., Rinaldi, M., Metzger, D. C., et al. (2015) · Circulation Cardiovascular Interventions · doi:10.1161/circinterventions.115.001683 · Cited by 79 · see citing works
Daou, B. J., Starke, R. M., Chalouhi, N., Barros, G., Tjoumakaris, S. I., Rosenwasser, R. H., & Jabbour, P. M. (2015) · Neurosurgery · doi:10.1227/neu.0000000000000978 · Cited by 79 · see citing works
Acute thrombus formation on phosphorilcholine surface modified flow diverters
Marosfoi, M. G., Clarençon, F., Langan, E. T., King, R. M., Brooks, O. W., Tamura, T., Wainwright, J. M., Gounis, M. J., Vedantham, S., & Puri, A. S. (2017) · Journal of NeuroInterventional Surgery · doi:10.1136/neurintsurg-2017-013175 · Cited by 78 · see citing works
Current State and Novel Approaches of Antiplatelet Therapy
Metharom, P., Berndt, M. C., Baker, R. I., & Andrews, R. K. (2015) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.114.303413 · Cited by 77 · see citing works
Gurbel, P. A., Jeong, Y., Navarese, E. P., & Tantry, U. S. (2016) · Circulation Research · doi:10.1161/circresaha.115.307016 · Cited by 77 · see citing works
Texakalidis, P., Bekelis, K., Atallah, E., Tjoumakaris, S. I., Rosenwasser, R. H., & Jabbour, P. M. (2017) · Clinical Neurology and Neurosurgery · doi:10.1016/j.clineuro.2017.08.003 · Cited by 76 · see citing works
Armstrong, E. J., Anderson, D. R., Yeo, K. K., Singh, G. D., Bang, H., Amsterdam, E. A., Freischlag, J. A., & Laird, J. R. (2015) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2015.01.051 · Cited by 75 · see citing works
Kang, J., & Kim, H.-S. (2018) · Korean Circulation Journal · doi:10.4070/kcj.2018.0166 · Cited by 74 · see citing works
Crescente, M., Menke, L., Chan, M. V., Armstrong, P. C. J., & Warner, T. D. (2018) · British Journal of Pharmacology · doi:10.1111/bph.14196 · Cited by 70 · see citing works
Randomized Assessment of Ticagrelor Versus Prasugrel Antiplatelet Effects in Patients With Diabetes
Alexopoulos, D. K., Xanthopoulou, I., Mavronasiou, E., Stavrou, K., Siapika, A., Tsoni, E., & Davlouros, P. A. (2013) · Diabetes Care · doi:10.2337/dc12-2510 · Cited by 69 · see citing works
A brief review on resistance to P2Y12 receptor antagonism in coronary artery disease
Warlo, E. M. K., Arnesen, H., & Seljeflot, I. (2019) · Thrombosis Journal · doi:10.1186/s12959-019-0197-5 · Cited by 68 · see citing works
Yi, X., Wang, C., Liu, P., Fu, C., Lin, J., & Chen, Y. (2016) · Journal of Neurology · doi:10.1007/s00415-016-8181-5 · Cited by 67 · see citing works
Role of genetic testing in patients undergoing percutaneous coronary intervention
Moon, J. Y., Franchi, F., Rollini, F., Rios, J. R. R., Kureti, M., Cavallari, L. H., & Angiolillo, D. J. (2017) · Expert Review of Clinical Pharmacology · doi:10.1080/17512433.2017.1353909 · Cited by 67 · see citing works
Grosdidier, C., Quilici, J., Loosveld, M., Camoin‐Jau, L., Moro, P.-J., Saut, N., Gaborit, B., Pankert, M., Cohen, W., Lambert, M., et al. (2013) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2012.12.013 · Cited by 66 · see citing works
Self-citationKwon, O., & Park, D. (2022) · JACC Asia · doi:10.1016/j.jacasi.2021.12.005 · Cited by 65 · see citing works
Antithrombotic treatment strategies in patients with established coronary atherosclerotic disease
Valgimigli, M., Aboyans, V., Angiolillo, D. J., Atar, D., Capodanno, D., Halvorsen, S., James, S. K., Jüni, P., Kunadian, V., Landi, A., et al. (2023) · European Heart Journal - Cardiovascular Pharmacotherapy · doi:10.1093/ehjcvp/pvad032 · Cited by 65 · see citing works
Self-citationMayer, K., Bernlochner, I., Braun, S., Schulz, S., Orban, M., Morath, T., Cala, L., Hoppmann, P., Schunkert, H., Laugwitz, K., et al. (2015) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2015.02.067 · Cited by 65 · see citing works
Clinical evidence for oral antiplatelet therapy in acute coronary syndromes
Wiviott, S. D., & Steg, P. G. (2015) · The Lancet · doi:10.1016/s0140-6736(15)60213-6 · Cited by 64 · see citing works
Amin, A. M., Chin, L. S., Noor, D. A. M., Kader, M. A. S. A., Yuen, K. H., & Ibrahim, B. (2017) · Cardiology Research and Practice · doi:10.1155/2017/8062796 · Cited by 64 · see citing works
Mean platelet volume: a potential biomarker of the risk and prognosis of heart disease
Choi, D.-H., Kang, S., & Song, H. (2016) · The Korean Journal of Internal Medicine · doi:10.3904/kjim.2016.078 · Cited by 63 · see citing works
Clinical Efficacy and Safety of Cilostazol: A Critical Review of the Literature
Rogers, K. C., Oliphant, C. S., & Finks, S. W. (2015) · Drugs · doi:10.1007/s40265-015-0364-3 · Cited by 62 · see citing works
Zheng, Y., Wu, T., Yang, Y., Hou, X., Gao, Y., Chen, Y., Yang, Y., Li, X., Ma, X., Ma, Y., et al. (2019) · European Heart Journal - Cardiovascular Pharmacotherapy · doi:10.1093/ehjcvp/pvz059 · Cited by 62 · see citing works
- Authors
- Collet, J.-P., Cuisset, T., Rangé, G., Cayla, G., Elhadad, S., Pouillot, C., Henry, P., Motreff, P., Carrié, D., Boueri, Z., Belle, L., Van Belle, E., Rousseau, H., Aubry, P., Monségu, J., Sabouret, P., O'Connor, S. A., Abtan, J., Kerneis, M., Saint-Etienne, C., Barthélémy, O., Beygui, F., Silvain, J., Vicaut, E., & Montalescot, G.
- Affiliations
- Pitié-Salpêtrière Hospital (FR)
- Hôpital de la Timone (FR)
- Les Hôpitaux de Chartres (FR)
- Centre Hospitalier Universitaire de Nîmes (FR)
- Hôpital Lariboisière (FR)
- Centre Hospitalier Universitaire de Clermont-Ferrand (FR)
- Hôpital Rangueil (FR)
- Hôpital Bichat-Claude-Bernard (FR)
- HIA du Val-de-Grâce à Paris (FR)
- ORCID
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2012-11-29
- Volume
- 367
- Issue
- 22
- Pages
- 2100-2109
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2145323902
- Cited by
- 887
- References
- 26
- Citations by year
- 2026: 15 · 2025: 20 · 2024: 22 · 2023: 31 · 2022: 31 · 2021: 47 · 2020: 44 · 2019: 52 · 2018: 72 · 2017: 77 · 2016: 80 · 2015: 123 · 2014: 122 · 2013: 141 · 2012: 8
- FWCI
- 81.10
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Antiplatelet Therapy and Cardiovascular Diseases
- Health Sciences › Medicine › Surgery › Coronary Interventions and Diagnostics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
- Keywords
- antiplatelet therapy, coronary stenting, platelet function monitoring, VerifyNow P2Y12 assay, clopidogrel, prasugrel, aspirin, stent thrombosis, bleeding events, glycoprotein IIb/IIIa inhibitors, individualized dosing, major adverse cardiovascular events
- MeSH terms
- Prasugrel Hydrochloride, Clopidogrel, Aged, Aspirin, Coronary Disease, Coronary Thrombosis, Female, Humans, Male, Middle Aged, Myocardial Infarction, Piperazines, Platelet Aggregation Inhibitors, Pyridines, Thiophenes, Ticlopidine, Stents, Drug Monitoring, Point-of-Care Systems, Retreatment
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
