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Cited by 386

The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.

Bortezomib-Based Therapy for Newly Diagnosed Mantle-Cell Lymphoma

Open access
Robak, Tadeusz, Huang, Huiqiang, Jin, Jie, Zhu, Jun, Liu, Ting, Samoilova, Olga, Pylypenko, Halyna, Verhoef, Gregor, Siritanaratkul, Noppadol, Osmanov, Evgenii, Alexeeva, Julia, Pereira, Juliana, Drach, Johannes, Mayer, Jiri, Hong, Xiaonan, Okamoto, Rumiko, Pei, Lixia, Rooney, Brendan, van de Velde, Helgi, Cavalli, Franco·2015·New England Journal of Medicine
DOI 10.1056/nejmoa1412096
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Abstract

BACKGROUND: The proteasome inhibitor bortezomib was initially approved for the treatment of relapsed mantle-cell lymphoma. We investigated whether substituting bortezomib for vincristine in frontline therapy with R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) could improve outcomes in patients with newly diagnosed mantle-cell lymphoma. METHODS: In this phase 3 trial, we randomly assigned 487 adults with newly diagnosed mantle-cell lymphoma who were ineligible or not considered for stem-cell transplantation to receive six to eight 21-day cycles of R-CHOP intravenously on day 1 (with prednisone administered orally on days 1 to 5) or VR-CAP (R-CHOP regimen, but replacing vincristine with bortezomib at a dose of 1.3 mg per square meter of body-surface area on days 1, 4, 8, and 11). The primary end point was progression-free survival. RESULTS: After a median follow-up of 40 months, median progression-free survival (according to independent radiologic review) was 14.4 months in the R-CHOP group versus 24.7 months in the VR-CAP group (hazard ratio favoring the VR-CAP group, 0.63; P<0.001), a relative improvement of 59%. On the basis of investigator assessment, the median durations of progression-free survival were 16.1 months and 30.7 months, respectively (hazard ratio, 0.51; P<0.001), a relative improvement of 96%. Secondary end points were consistently improved in the VR-CAP group, including the complete response rate (42% vs. 53%), the median duration of complete response (18.0 months vs. 42.1 months), the median treatment-free interval (20.5 months vs. 40.6 months), and the 4-year overall survival rate (54% vs. 64%). Rates of neutropenia and thrombocytopenia were higher in the VR-CAP group. CONCLUSIONS: VR-CAP was more effective than R-CHOP in patients with newly diagnosed mantle-cell lymphoma but at the cost of increased hematologic toxicity. (Funded by Janssen Research and Development and Millennium Pharmaceuticals; LYM-3002 ClinicalTrials.gov number, NCT00722137.).

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Metadata

Authors
Robak, T., Huang, H., Jin, J., Zhu, J., Liu, T., Samoilova, O., Pylypenko, H., Verhoef, G., Siritanaratkul, N., Osmanov, E., Alexeeva, J., Pereira, J., Drach, J., Mayer, J., Hong, X., Okamoto, R., Pei, L., Rooney, B., van de Velde, H., & Cavalli, F.
Venue
New England Journal of Medicine
Publisher
Massachusetts Medical Society
Published
2015-03-05
Volume
372
Issue
10
Pages
944-953
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
DOI
10.1056/nejmoa1412096
OpenAlex
W2158945674
Cited by
386
References
30
FWCI
39.23
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Bortezomib-Based Therapy for Newly Diagnosed Mantle-Cell Lymphoma. https://app.cochat.ai/papers/10.1056/nejmoa1412096
The paper
Robak, T., Huang, H., Jin, J., Zhu, J., Liu, T., Samoilova, O., Pylypenko, H., Verhoef, G., Siritanaratkul, N., Osmanov, E., Alexeeva, J., Pereira, J., Drach, J., Mayer, J., Hong, X., Okamoto, R., Pei, L., Rooney, B., van de Velde, H., & Cavalli, F. (2015). Bortezomib-Based Therapy for Newly Diagnosed Mantle-Cell Lymphoma. New England Journal of Medicine. https://doi.org/10.1056/nejmoa1412096

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.