Cited by 1,950Atrial Fibrillation Management and OutcomesCardiac Arrhythmias and TreatmentsCardiac pacing and defibrillation studies

The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.

Cryoballoon or Radiofrequency Ablation for Paroxysmal Atrial Fibrillation

Open access

Kuck, Karl-Heinz, Brugada, Josep, Fürnkranz, Alexander, Metzner, Andreas, Ouyang, Feifan, Chun, K.R. Julian, Elvan, Arif, Arentz, Thomas, Bestehorn, Kurt, Pocock, Stuart J., Albenque, Jean-Paul, Tondo, Claudio·2016·New England Journal of Medicine

DOI 10.1056/nejmoa1602014

Open this paper in CoChat — free account Open PDF

Abstract

BACKGROUND: Current guidelines recommend pulmonary-vein isolation by means of catheter ablation as treatment for drug-refractory paroxysmal atrial fibrillation. Radiofrequency ablation is the most common method, and cryoballoon ablation is the second most frequently used technology. METHODS: We conducted a multicenter, randomized trial to determine whether cryoballoon ablation was noninferior to radiofrequency ablation in symptomatic patients with drug-refractory paroxysmal atrial fibrillation. The primary efficacy end point in a time-to-event analysis was the first documented clinical failure (recurrence of atrial fibrillation, occurrence of atrial flutter or atrial tachycardia, use of antiarrhythmic drugs, or repeat ablation) following a 90-day period after the index ablation. The noninferiority margin was prespecified as a hazard ratio of 1.43. The primary safety end point was a composite of death, cerebrovascular events, or serious treatment-related adverse events. RESULTS: A total of 762 patients underwent randomization (378 assigned to cryoballoon ablation and 384 assigned to radiofrequency ablation). The mean duration of follow-up was 1.5 years. The primary efficacy end point occurred in 138 patients in the cryoballoon group and in 143 in the radiofrequency group (1-year Kaplan-Meier event rate estimates, 34.6% and 35.9%, respectively; hazard ratio, 0.96; 95% confidence interval [CI], 0.76 to 1.22; P<0.001 for noninferiority). The primary safety end point occurred in 40 patients in the cryoballoon group and in 51 patients in the radiofrequency group (1-year Kaplan-Meier event rate estimates, 10.2% and 12.8%, respectively; hazard ratio, 0.78; 95% CI, 0.52 to 1.18; P=0.24). CONCLUSIONS: In this randomized trial, cryoballoon ablation was noninferior to radiofrequency ablation with respect to efficacy for the treatment of patients with drug-refractory paroxysmal atrial fibrillation, and there was no significant difference between the two methods with regard to overall safety. (Funded by Medtronic; FIRE AND ICE ClinicalTrials.gov number, NCT01490814.).

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1056/nejmoa1602014

Cites

22 of 22 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Spontaneous initiation of atrial fibrillation by ectopic beats originating in the pulmonary veins.
Haïssaguerre, M., Jaïs, P., Shah, D. C., Takahashi, A., Hocini, M., Quiniou, G., Garrigue, S., Mouroux, A. L., Métayer, P. L., & Clémenty, J. (1998) · New England Journal of Medicine · doi:10.1056/nejm199809033391003 · Cited by 8,040
Approaches to catheter ablation for persistent atrial fibrillation
Verma, A., Jiang, C.-Y., Betts, T. R., Chen, J., Deisenhofer, I., Mantovan, R., Macle, L., Morillo, C. A., Haverkamp, W., Weerasooriya, R., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1408288 · Cited by 2,339
Self-citation
2012 HRS/EHRA/ECAS expert consensus statement on catheter and surgical ablation of atrial fibrillation: recommendations for patient selection, procedural techniques, patient management and follow-up, definitions, endpoints, and research trial design
Calkins, H. G., Kück, K., Cappato, R., Brugada, J., Camm, A. J., Chen, S., Crijns, H. J. G. M., Damiano, R. J., Davies, D. W., Dimarco, J., et al. (2012) · Journal of Interventional Cardiac Electrophysiology · doi:10.1007/s10840-012-9672-7 · Cited by 1,685
Self-citation
2012 HRS/EHRA/ECAS expert consensus statement on catheter and surgical ablation of atrial fibrillation: Recommendations for patient selection, procedural techniques, patient management and follow-up, definitions, endpoints, and research trial design
Calkins, H., Kuck, K. H., Cappato, R., Brugada, J., Camm, A. J., Chen, S.-A., Crijns, H. J. G., Damiano, R. J., Davies, D. W., DiMarco, J., et al. (2012) · Heart Rhythm · doi:10.1016/j.hrthm.2011.12.016 · Cited by 1,456
Self-citation
Comparison of Antiarrhythmic Drug Therapy and Radiofrequency Catheter Ablation in Patients With Paroxysmal Atrial Fibrillation: A Randomized Controlled Trial
Wilber, D. J., Pappone, C., Neuzil, P., De Paola, A., Marchlinski, F., Natale, A., Macle, L., Daoud, E. G., Calkins, H., Hall, B., et al. (2010) · JAMA · doi:10.1001/jama.2009.2029 · Cited by 1,170
Cryoballoon Ablation of Pulmonary Veins for Paroxysmal Atrial Fibrillation
Packer, D. L., Kowal, R. C., Wheelan, K. R., Irwin, J. M., Champagne, J., Guerra, P. G., Dubuc, M., Reddy, V. Y., Nelson, L., Holcomb, R. G., et al. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.11.064 · Cited by 919
Paroxysmal AF Catheter Ablation With a Contact Force Sensing Catheter
Natale, A., Reddy, V. Y., Monir, G., Wilber, D. J., Lindsay, B. D., McElderry, H. T., Kantipudi, C., MANSOUR, M. C., Melby, D. P., Packer, D. L., et al. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.04.072 · Cited by 476
EFFICAS II: optimization of catheter contact force improves outcome of pulmonary vein isolation for paroxysmal atrial fibrillation
Kautzner, J., Neužil, P., Lambert, H., Peichl, P., Petrů, J., Cihak, R. J., Skoda, J., Wichterle, D., Wißner, E., Yulzari, A., et al. (2015) · EP Europace · doi:10.1093/europace/euv057 · Cited by 374
Cryoballoon Versus Open Irrigated Radiofrequency Ablation in Patients With Paroxysmal Atrial Fibrillation: The Prospective, Randomized, Controlled, Noninferiority FreezeAF Study
Luik, A., Radzewitz, A., Kieser, M., Walter, M., Bramlage, P., Hörmann, P., Schmidt, K., Horn, N., Brinkmeier-Theofanopoulou, M., Kunzmann, K., et al. (2015) · Circulation · doi:10.1161/circulationaha.115.016871 · Cited by 275
Impact of Complete Versus Incomplete Circumferential Lines Around the Pulmonary Veins During Catheter Ablation of Paroxysmal Atrial Fibrillation: Results From the Gap-Atrial Fibrillation–German Atrial Fibrillation Competence Network 1 Trial
Kuck, K.-H., Hoffmann, B. A., Ernst, S., Wegscheider, K., Treszl, A., Metzner, A., Eckardt, L., Lewalter, T., Breithardt, G., & Willems, S. (2016) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.115.003337 · Cited by 261
Self-citation

Flagged first, then by citations

Show all 22 references

Sorted by citations

Items 901–1,000 of 1,000

Catheter ablation for atrial fibrillation: Results from a European survey
Sousa, P. A., Heeger, C.-H. H., Barra, S., Luther, V., Steinfurt, J., Fernández‐Armenta, J., & Silberbauer, J. (2025) · Heart Rhythm · doi:10.1016/j.hrthm.2025.05.028 · Cited by 6
Cost effectiveness of focal impulse and rotor modulation guided ablation added to pulmonary vein isolation for atrial fibrillation
Baykaner, T., Duff, S., Hasegawa, J. T., Mafilios, M. S., & Turakhia, M. P. (2018) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.13449 · Cited by 6
Efficacy of temperature-guided cryoballoon ablation without using real-time recordings – 12-Month follow-up
Prochnau, D., von Knorre, K., Figulla, H., Schulze, P. C., & Surber, R. (2018) · IJC Heart & Vasculature · doi:10.1016/j.ijcha.2018.09.009 · Cited by 6
Ablation versus Anti-Arrhythmic Therapy for Reducing All Hospital Episodes from Recurrent Atrial Fibrillation (AVATAR-AF): Design and rationale
Mann, I., Sasikaran, T., Sandler, B. C., Babalis, D. S., Johnson, N. A., Falaschetti, E., Copley, A., Tayebjee, M. H., TODD, D. M., Shepherd, E., et al. (2019) · American Heart Journal · doi:10.1016/j.ahj.2019.04.015 · Cited by 6
The Coagulation and Atrial Fibrillation Ablation Cascades
Asirvatham, S. J., & van Zyl, M. (2019) · JACC. Clinical electrophysiology · doi:10.1016/j.jacep.2019.09.009 · Cited by 6
Catheter Ablation in the Treatment of Atrial Fibrillation
HESSELSON, A. B. (2020) · International Journal of Angiology · doi:10.1055/s-0040-1708476 · Cited by 6
[Success rate of one-stop procedure for atrial fibrillation ablation and its impact on cardiac function: a propensity-matched study].
Zhu, S., Zheng, M., Yan, R., Tan, Z., Zhao, H., Zhang, J., & Peng, J. (2020) · PubMed Central · doi:10.12122/j.issn.1673-4254.2020.10.06 · Cited by 6
Current Management Strategies in Patients with Heart Failure and Atrial Fibrillation: A Review of the Literature
Parker, A. M., Vilaro, J. R., Ahmed, M. M., & Aranda, J. M. (2020) · Cardiovascular Innovations and Applications · doi:10.15212/cvia.2019.0595 · Cited by 6
Interpretation of clinical studies in electrophysiology: statistical considerations for the clinician
Chieng, D., Finch, S. J., Sugumar, H., Taylor, A. J., Reid, C. M., Kalman, J. M., & Kistler, P. M. (2020) · EP Europace · doi:10.1093/europace/euaa308 · Cited by 6
Clinical outcomes following rhythm control for atrial fibrillation: is early better?
Kotalczyk, A., Ding, W. Y., Gupta, D., Wright, D. J., & Lip, G. Y. H. (2021) · Expert Review of Cardiovascular Therapy · doi:10.1080/14779072.2021.1902307 · Cited by 6
Prevalence of gastric hypomotility after additional cryoballoon ablation of the left atrial roof
Shigeta, T., Yamauchi, Y., Oda, A., Tachibana, S., Hirao, T., Nakamura, R. A., Yoshida, H., Okishige, K., Goya, M., & Sasano, T. (2021) · Pacing and Clinical Electrophysiology · doi:10.1111/pace.14387 · Cited by 6
Cryoballoon Ablation for Treatment of Atrial Fibrillation in a Chinese Population: Five-Year Outcomes and Predictors of Recurrence After a Single Procedure
Chen, D., Xia, Y., Lin, Y., Li, X., Wang, C., Chen, Y., Fang, P., & Liu, J. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.836392 · Cited by 6
Pulmonary vein isolation for atrial fibrillation using true high-power short-duration vs. cryoballoon ablation
Wörmann, J., Lüker, J., van den Bruck, J., Filipovic, K., Erlhöfer, S., Scheurlen, C., Dittrich, S., Schipper, J., Steven, D., & Sultan, A. (2023) · Clinical Research in Cardiology · doi:10.1007/s00392-023-02188-2 · Cited by 6
Prognostic implication of early recurrence after cryoballoon ablation in patients with atrial fibrillation
Park, C. S., Kim, H., Lee, S., Lee, J. H., Cho, Y., Choi, E., Oh, I., & Oh, S. (2023) · Journal of Interventional Cardiac Electrophysiology · doi:10.1007/s10840-023-01555-3 · Cited by 6
Atrial fibrillation recurrences during the blanking period after catheter ablation with the laser balloon technique
Schiavone, M., Gasperetti, A., Martignani, C., Montemerlo, E., Ciconte, G., Ziacchi, M., Arosio, R., Piazzi, E., Spadotto, A., Ruggiero, D., et al. (2023) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.16087 · Cited by 6
The impact of early cryoballoon ablation on clinical outcome in patients with atrial fibrillation: From the Korean cryoballoon ablation registry
Kwon, C. H., Choi, J., Oh, I., Lee, S., Kim, J. Y., Lee, S. H., Park, J., Kim, K., Yang, P., Kim, J., et al. (2023) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.16122 · Cited by 6
Characteristics of two different cryoballoon systems for treatment of paroxysmal atrial fibrillation: study protocol for a multicenter randomized controlled trial (CONTRAST-CRYO Trial)
Ikenouchi, T., Miyazaki, S., Nitta, J., Sekiguchi, Y., Kobori, A., Nakamura, K., Inamura, Y., Murakami, M., Sagawa, Y., Sasaki, Y., et al. (2023) · Journal of Interventional Cardiac Electrophysiology · doi:10.1007/s10840-023-01718-2 · Cited by 6
Catheter Ablation for Atrial Fibrillation—Influence of Modifiable Risk Factors and Ablation Modality on Procedural Efficacy and Safety
Sargent, S. R., Mladenovic, J., Liaw, J. J. T., Siller, J., Russell, P. L., Tung, M., & Holland, D. J. (2024) · Heart Lung and Circulation · doi:10.1016/j.hlc.2024.02.009 · Cited by 6
Use of three-dimensional computed tomography overlay for real-time cryoballoon ablation in atrial fibrillation reduces radiation dose and contrast dye
Velthuis, B. O., Molenaar, M. M. D., Dorman, H. G. R., Stevenhagen, J., SCHOLTEN, M. F., van der Palen, J. A. M., & van Opstal, J. M. (2017) · Netherlands Heart Journal · doi:10.1007/s12471-017-0962-7 · Cited by 6
Advances in Clinical Cardiology 2016: A Summary of the Key Clinical Trials
Gray, A. P., McQuillan, C., & Menown, I. B. A. (2017) · Advances in Therapy · doi:10.1007/s12325-017-0560-5 · Cited by 6
Efficacy of second-generation cryoballoon ablation in paroxysmal and persistent atrial fibrillation patients
Curnis, A., Salghetti, F., Cerini, M., Vassanelli, F., Inama, L., Villa, C., Giacopelli, D., Raweh, A., & Bontempi, L. (2017) · Journal of Cardiovascular Medicine · doi:10.2459/jcm.0000000000000542 · Cited by 6
Atrial Fibrillation Catheter Ablation: Overcoming Complications and Improving Success
Mathew, S. T., & Po, S. S. (2017) · Journal of Innovations in Cardiac Rhythm Management · doi:10.19102/icrm.2017.081004 · Cited by 6
Long-term outcome of cryoballoon ablation versus radiofrequency ablation for focal atrial tachycardias originating from the pulmonary veins
Wei, H., Guo, X., Zhou, G., Sun, Q., Liu, X., Luo, B., Yang, J., Zhang, S., & Ma, J. (2019) · Journal of Interventional Cardiac Electrophysiology · doi:10.1007/s10840-019-00507-0 · Cited by 6
New mapping tools to assess lesion in atrial fibrillation
García‐Bolao, I., Ramos, P., Ballesteros, G., & Vives, E. (2019) · EP Europace · doi:10.1093/europace/euz110 · Cited by 6
Prevention of left atrium esophagus fistula: Appraisal of existing technologies and strategies
Jiang, R., Zei, P. C., & Jiang, C. (2020) · Pacing and Clinical Electrophysiology · doi:10.1111/pace.13939 · Cited by 6
Stroke and left atrial thrombi after cryoballoon ablation of atrial fibrillation: incidence and predictors. Results from a long-term follow-up
Santoro, F., Brunetti, N. D., Rillig, A., Reißmann, B., Lemeš, C., Maurer, T., Fink, T., Hashiguchi, N., Leopizzi, A., Mallardi, A., et al. (2020) · Journal of Thrombosis and Thrombolysis · doi:10.1007/s11239-020-02148-x · Cited by 6
Self-citation
Learning curves in atrial fibrillation ablation – A comparison between second generation cryoballoon and contact force sensing radiofrequency catheters
Velagić, V., Prepolec, I., Pašara, V., Puljević, M., Puljević, D., Planinc, I., Samardžić, J., & Miličić, D. (2020) · Indian Pacing and Electrophysiology Journal · doi:10.1016/j.ipej.2020.09.003 · Cited by 6
The procedural efficiency, efficacy and safety of high power and short duration ablation in patients with atrial fibrillation: A systemic review and meta-analysis
Sun, X., Qi, P., Yang, B., Li, Z., Bie, Z., & Li, X. (2020) · International Journal of Cardiology · doi:10.1016/j.ijcard.2020.10.030 · Cited by 6
A modified fluoroscopy protocol to minimize radiation exposure during pulmonary vein isolation with second‐generation cryoballoon
Wieczorek, M., & Hoeltgen, R. (2020) · Pacing and Clinical Electrophysiology · doi:10.1111/pace.14102 · Cited by 6
Personalized Evaluation of Atrial Complexity of Patients Undergoing Atrial Fibrillation Ablation: A Clinical Computational Study
Nava, A., Mansilla, A. G., González‐Torrecilla, E., Ávila, P., Datino, T., Bermejo, J., Arenal, Á., Fernández‐Avilés, F., & Atienza, F. (2021) · Biology · doi:10.3390/biology10090838 · Cited by 6
The future of long‐term monitoring after catheter and surgical ablation for atrial fibrillation
Baman, J. R., & PASSMAN, R. S. (2022) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.15375 · Cited by 7
Single ring isolation for atrial fibrillation ablation: Impact of the learning curve
Thiyagarajah, A., Mahajan, R., Iwai, S., Gupta, A. K., Linz, D., Chim, I., Emami, M., Kadhim, K., O’Shea, C., Middeldorp, M. E., et al. (2022) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.15387 · Cited by 6
The impact of hospital case volume on the outcomes after catheter ablation for atrial fibrillation according to the ablation technology
Kanaoka, K., Nishida, T., Nishioka, Y., Myojin, T., Kubo, S., Soeda, T., Okada, K., Noda, T., Iwanaga, Y., Miyamoto, Y., et al. (2022) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.15495 · Cited by 6
Long-Term prognosis of radiofrequency catheter ablation for atrial fibrillation with different subtypes of heart failure in the era of ablation index guidance
Qiao, Y., Zhao, Z., Cai, X., Guo, Y., Fu, M., Liu, K., Guo, J., Guo, T., & Niu, G. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.922910 · Cited by 6
A Simplified Trans-Septal Puncture Technique using a Needle Free Approach for Cryoablation of Atrial Fibrillation
Honarbakhsh, S., O’Brien, B., & SCHILLING, R. J. (2017) · Journal of Atrial Fibrillation · doi:10.4022/jafib.1628 · Cited by 6
A case of successful cryoballoon ablation of paroxysmal atrial fibrillation originating from a persistent left superior vena cava
Fujino, T., Yuzawa, H., Kinoshita, T., Shinohara, M., Okishige, K., & Ikeda, T. (2019) · Journal of Cardiology Cases · doi:10.1016/j.jccase.2019.04.005 · Cited by 6
Evaluation of a novel esophageal retractor utilizing vacuum suction and mechanical force for deviating the esophagus
Houmsse, M., Daoud, E. G., Joseph, M., Weiss, R., & Essandoh, M. K. (2020) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.14529 · Cited by 6
Cryoballoon pulmonary vein isolation-mediated rise of sinus rate in patients with paroxysmal atrial fibrillation
Wagner, L., Darche, F. F., Thomas, D., Lugenbiel, P., Xynogalos, P., Seide, S., Scholz, E., Katus, H. A., & Schweizer, P. A. (2020) · Clinical Research in Cardiology · doi:10.1007/s00392-020-01659-0 · Cited by 6
Systematic review and network meta‐analysis of atrial fibrillation percutaneous catheter ablation technologies using randomized controlled trials
Kukendrarajah, K., Παπαγεωργίου, Ν., Jewell, P. D., Hunter, R. J., Ang, R., SCHILLING, R. J., & Providencia, R. A. (2020) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.14598 · Cited by 6
Basket Catheter-Guided Ultra-High-Density Mapping of Cardiac Arrhythmias: A Systematic Review and Meta-Analysis
Alken, F., Chen, S., Masjedi, M., Pürerfellner, H., Maury, P., Martin, C., Sacher, F., Jaı̈s, P., & Meyer, C. G. (2020) · Future Cardiology · doi:10.2217/fca-2020-0032 · Cited by 6
Comparative efficacy and safety of catheter ablation interventions for atrial fibrillation: comprehensive network meta-analysis of randomized controlled trials
Zhou, X., Dai, J. M., Xu, X., Lian, M., Lou, Y., Lv, Z., Wang, Z., & Mao, W. (2020) · Journal of Interventional Cardiac Electrophysiology · doi:10.1007/s10840-020-00878-9 · Cited by 6
Factors Influencing Diaphragmatic Compound Motor Action Potentials During Cryoballoon Ablation for Atrial Fibrillation
Sharma, P. S., Padala, S. K., THOMPSON, J. J., Gunda, S., Koneru, J. N., & Ellenbogen, K. A. (2016) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.13082 · Cited by 6
Circulatory Dynamics During Pulmonary Vein Isolation Using the Second‐Generation Cryoballoon
Kajiyama, T., Miyazaki, S., Watanabe, T., Yamao, K., Kusa, S., Igarashi, M., Nakamura, H., Hachiya, H., & Iesaka, Y. (2017) · Journal of the American Heart Association · doi:10.1161/jaha.117.006559 · Cited by 6
When It Comes to Defining the Outcomes of Catheter Ablation of Atrial Fibrillation, an Implantable Monitor Is a Great Place to Start
Calkins, H. G. (2019) · Circulation · doi:10.1161/circulationaha.119.043155 · Cited by 6
Comparative Studies of Different Ablation Techniques for Atrial Fibrillation
Keževičiūtė, M., Marinskis, G., Sudavičienė, D., Barysienė, J., Bileišienė, N., Radauskaitė, G., Aidietis, A., & Račkauskas, G. (2025) · Reviews in Cardiovascular Medicine · doi:10.31083/rcm33490 · Cited by 6
Arrhythmia-Induced Cardiomyopathy in Atrial Fibrillation: Pathogenesis, Diagnosis, and Treatment
Karakasis, P., Theofilis, P., Vlachakis, P. K., Apostolos, A., Ktenopoulos, N., Grigoriou, K., Patoulias, D., Antoniadis, A. P., & Fragakis, N. (2025) · Life · doi:10.3390/life15111675 · Cited by 8
Hemolysis and renal safety of pulsed-field vs thermal ablation for atrial fibrillation: A systematic review and meta-analysis
Kılıç, M. E., Arayıcı, M. E., Yılancıoglu, R. Y., Turan, O. E., & Özcan, E. E. (2026) · Heart Rhythm · doi:10.1016/j.hrthm.2026.01.026 · Cited by 5
First clinical experience using the DiamondTemp catheter and a novel omnipolar high-resolution mapping system for atrial fibrillation ablation
Sohns, C., Fink, T., Bergau, L., BRAUN, M. U., Hamriti, M. E., Sciacca, V., Guckel, D., Khalaph, M., Imnadze, G., & Sommer, P. (2023) · Cardiology Journal · doi:10.5603/cj.a2022.0122 · Cited by 5
How the new technologies and tools will change the electrophysiology of the future
Tondo, C. (2023) · European Heart Journal Supplements · doi:10.1093/eurheartjsupp/suad024 · Cited by 5
Self-citation
How to perform effective cryoballooon ablation of the left atrial roof: Considerations after experiencing more than 1000 cases
Shigeta, T., Okishige, K., Murata, K., Oda, A., Arai, H., Sagawa, Y., Kurabayashi, M., Goya, M., Sasano, T., & Yamauchi, Y. (2023) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.16082 · Cited by 5
Comparison of pulmonary vein isolation using cryoballoon, high-power short-duration, and conventional radiofrequency ablation for atrial fibrillation: a propensity score-weighted study
Park, H., Park, J., Kim, D., Yu, H. T., Kim, T., Uhm, J., Joung, B., Lee, M., Hwang, C., & Pak, H. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1238363 · Cited by 5
Implementation of the multielectrode radiofrequency-balloon in real-world clinical practice—operator learning curve and procedural outcome at a high-volume center
Zylla, M. M., Starrach, L., Rahm, A., Thomas, D., Frey, N., & Lugenbiel, P. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1208250 · Cited by 5
Association of Preablation Plasma Corin Levels With Atrial Fibrillation Recurrence After Catheter Ablation: A Prospective Observational Study
Zhao, Y., Yuan, X., Xie, Y., Yin, X., Liu, Y., Sun, Y., Gong, Y., Liu, J., & Chen, F. (2024) · Journal of the American Heart Association · doi:10.1161/jaha.123.031928 · Cited by 5
Comparison of Cryoballoon vs. Pulsed Field Ablation in Patients with Symptomatic Paroxysmal Atrial Fibrillation (SINGLE SHOT CHAMPION): Study protocol for a randomized controlled trial
Maurhofer, J., Kueffer, T., Knecht, S., Thalmann, G., Badertscher, P., Kozhuharov, N., Krisai, P., Jufer, C., Iqbal, S. U. R., Heg, D., et al. (2024) · Heart Rhythm O2 · doi:10.1016/j.hroo.2024.05.008 · Cited by 5
Novel cryoballoon technology for atrial fibrillation ablation: Impact of pulmonary vein variant anatomy, cooling characteristics, and 1-year outcome from the CHARISMA registry
Schiavone, M., Bianchi, S., Malacrida, M., Fassini, G. M., Ricciolino, R., Pecora, D., Pelargonio, G., Iacopino, S., Ducceschi, V., Maggio, R., et al. (2024) · Heart Rhythm · doi:10.1016/j.hrthm.2024.08.040 · Cited by 5
Self-citation
Comparison of Therapeutic Effects Between Pulsed Field Ablation and Cryoballoon Ablation in the Treatment of Atrial Fibrillation: A Systematic Review and Meta-analysis
Wan, Y., Zeng, S., Liu, F., Gao, X., Li, W., Liu, K., He, J., Ji, J., & Luo, J. (2024) · Cardiology in Review · doi:10.1097/crd.0000000000000808 · Cited by 5
Global Research Progress on Radiofrequency Ablation in Cardiology
Elendu, C., Ogwu, N. P., Okatta, A. U., Omeludike, E., Ogelle, E. C., Obidigbo, B. T., Joseph, M. C., Osamuyi, E. I., Ogidan, A. O., Jingwa, K. A., et al. (2024) · Annals of Medicine and Surgery · doi:10.1097/ms9.0000000000002858 · Cited by 5
Impact of Routine Postoperative Care Versus Nurse-Led Lifestyle Interventions on Patient Outcomes After Radiofrequency Ablation: A Randomized Controlled Trial
Yang, F., & Wu, Y. Y. (2025) · The Journal of Cardiovascular Nursing · doi:10.1097/jcn.0000000000001219 · Cited by 5
Comparison of Extended Cryoballoon, Standard Cryoballoon, and Radiofrequency Catheter Ablation in Patients With Persistent AF
Cho, M. S., Lee, J. H., Oh, I.-Y., Lee, J.-B., Kim, M., Choi, K., Cho, Y., Nam, G., Nam, G.-B., Cho, Y., et al. (2025) · JACC. Clinical electrophysiology · doi:10.1016/j.jacep.2025.08.003 · Cited by 5
ARENA – Projekt Vorhofflimmern in der Rhein-Neckar-Region
Baumann, S., Grau, A., Senges, J., Schneider, S., Alonso, Á., Katus, H. A., Thomas, D., Waldecker, B., Haass, M., Zahn, R., et al. (2019) · Herz · doi:10.1007/s00059-018-4772-5 · Cited by 5
Pulmonary vein volume and myocardial sleeve extension estimated by 3D computed tomography and voltage mapping predict arrhythmogenic triggers of paroxysmal atrial fibrillation
Chen, J., Wu, H. I., & Chang, K. (2020) · Journal of Interventional Cardiac Electrophysiology · doi:10.1007/s10840-020-00892-x · Cited by 5
Katheterablation
Yahsaly, L., Siebermair, J., & Wakili, R. (2022) · Herzschrittmachertherapie + Elektrophysiologie · doi:10.1007/s00399-022-00843-1 · Cited by 5
Catheter ablation of atrial fibrillation using 2nd-generation cryoballoon in congenital heart disease patients — significance of RF ablation of additional atrial macro-reentrant tachycardia
Krause, U., Müller, M. J., Schneider, H. E., & Paul, T. (2022) · Journal of Interventional Cardiac Electrophysiology · doi:10.1007/s10840-022-01213-0 · Cited by 5
Long‐term outcomes of a time to isolation – based strategy for cryoballoon ablation compared to radiofrequency ablation in patients with symptomatic paroxysmal atrial fibrillation
Wei, Y., Chen, L., Cao, J., Liu, S., Ling, T., Huang, X., Zhou, G., Lin, C., Xie, Y., Bao, Y., et al. (2022) · Pacing and Clinical Electrophysiology · doi:10.1111/pace.14556 · Cited by 5
Impact of BMI and Type of Ablation Procedure on Atrial Fibrillation Recurrence in Japanese Patients
Takami, A., Miake, J., Kato, M., Ogura, K., Okamura, A., Tomomori, T., Tsujimoto, D., Kawatani, S., Kato, M., & Yamamoto, K. (2022) · Journal of Asian Pacific Society of Cardiology · doi:10.15420/japsc.2021.27 · Cited by 5
Effectiveness and safety of a time to isolation strategy of cryoballoon ablation of atrial fibrillation: A systematic review and meta‐analysis
Tsiachris, D., Doundoulakis, I., Antoniou, C. K., Pagkalidou, E., Zafeiropoulos, S., Kordalis, A., Gatzoulis, K. A., Chierchia, G., de Asmundis, C., Tsioufis, K. P., et al. (2022) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.15697 · Cited by 5
Using the pre-freezing technique results in a wider area of antral isolation during cryoballoon pulmonary vein isolation in patients with atrial fibrillation
Tokuda, M., Yamashita, S., Sato, H., Oseto, H., Yokoyama, M., Tokutake, K., Yokoyama, K., Kato, M., Narui, R., Tanigawa, S., et al. (2022) · Heart and Vessels · doi:10.1007/s00380-022-02179-9 · Cited by 5
Comparison of phrenic nerve injury and its effect on the extrapulmonary vein structures with cryoballoon and hot-balloon ablation systems: considering the lesion created on the superior vena cava as a surrogate marker
Hori, Y., Nakahara, S., Aoki, H., Sato, H., Fukuda, R., Hua, Z., Koshikawa, Y., Mizutani, Y., Nakamura, H., Hisauchi, I., et al. (2022) · Heart and Vessels · doi:10.1007/s00380-022-02210-z · Cited by 5
Indirect Comparison of Cryoablation and Radiofrequency Ablation as Initial Therapy for Symptomatic Paroxysmal Atrial Fibrillation: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials
Mao, Y., Ai, L.-J., Cai, Y.-H., Huang, Q., Yu, F., Chen, J., Huang, P., & Wang, H. (2023) · Cardiology · doi:10.1159/000528758 · Cited by 5
Structural characteristics of patients with superior vena cava foci initiating atrial fibrillation: Analysis with electrocardiogram‐triggered computed tomography
Oka, S., Yamagata, K., Nishii, T., Tonegawa‐Kuji, R., Shimamoto, K., Inoue, Y. Y., Miyamoto, K., Nagase, S., Aiba, T., & KUSANO, K. F. (2023) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.15825 · Cited by 5
Elevated thrombin generation levels in the left atrial appendage in patients with atrial fibrillation
Elias, A., Khoury, Y., Shehadeh, F., Ron, G., Boulos, M., Nashashibi, J., Zukermann, R., Elias, M. S., Gepstein, L., & Suleiman, M. A. (2023) · Research and Practice in Thrombosis and Haemostasis · doi:10.1016/j.rpth.2023.100127 · Cited by 5
Numerical simulations of temperature inside the heart tissues to evaluate the performances of cryoablative probe
Potenza, M., Pisano, C., Coppa, P., Bovesecchi, G., Corasaniti, S., & Barbero, F. (2023) · International Communications in Heat and Mass Transfer · doi:10.1016/j.icheatmasstransfer.2023.106877 · Cited by 5
Pulsed field ablation of superior vena cava in paroxysmal atrial fibrillation: a case report
Tao, Y., Zhou, Y., Sun, X., Liao, W., Wang, Y., Shi, L., & Liu, X. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1211674 · Cited by 5
Mechanisms that affect reimbursement prices for medical devices in Japan, the world’s third largest medical device market: A scoping review
Hashimoto, S., Motozawa, Y., & Mano, T. (2023) · International Journal of Healthcare Management · doi:10.1080/20479700.2023.2250612 · Cited by 5
Percutaneous Neuromodulation for Atrial Fibrillation
Zuhair, M., Keene, D., Kanagaratnam, P., & Lim, P. B. (2023) · Cardiac Electrophysiology Clinics · doi:10.1016/j.ccep.2023.09.001 · Cited by 5
Treatment of atrial fibrillation with second-generation cryoballoon followed by contact-sensing radiofrequency catheter ablation for arrhythmia recurrences—results of a 5-year follow-up
Nekić, A., Prepolec, I., Pašara, V., Bogdanic, J. E., Posavec, J. P., Kardum, D., Katić, Z., Štajduhar, A., Pezo-Nikolić, B., Puljević, D., et al. (2024) · Journal of Interventional Cardiac Electrophysiology · doi:10.1007/s10840-024-01752-8 · Cited by 5
Multidisciplinary management strategies for atrial fibrillation
Yue, X., Zhou, L., Li, Y., & Zhao, C. (2024) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2024.102514 · Cited by 5
Diaphragm movement sensor for phrenic nerve monitoring during cryoballoon procedures: the first clinical evaluation
Schemoul, E., Tovmassian, L., Mancini, J., Koutbi, L., Biermé, C., Deharo, J., Franceschi, F., & Maille, B. (2024) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2024.1361761 · Cited by 5
Impact of wall thickness on the tissue cooling effect of cryoballoon ablation
Masuda, M., Matsuda, Y., Uematsu, H., Nishijima, M., Okamoto, S., Ishihara, T., Nanto, K., Tsujimura, T., Hata, Y., & Mano, T. (2024) · EP Europace · doi:10.1093/europace/euae135 · Cited by 5
Evaluation of microembolic signals on carotid ultrasound during pulmonary vein isolation with high‐power short‐duration and cryoballoon ablations: When and where do bubble and solid emboli arise?
Mizutani, Y., Yanagisawa, S., Ichikawa, M., Nishio, K., Sakai, H., Nonokawa, D., Makino, Y., Suzuki, H., Ichimiya, H., Uchida, Y., et al. (2024) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.16337 · Cited by 5
Efficacy and safety of catheter ablation for atrial fibrillation in patients with heart failure with preserved ejection fraction: a systematic review and meta-analysis
Chen, X., Zhang, X., Fang, X. M., & Feng, S. (2024) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2024.1423147 · Cited by 5
Comprehensive analysis of recurrence factors in cryoballoon AF ablation: integrating clinical, biomarkers, and echocardiographic parameters
Soysal, A. U., Gulfidan, A., Raimoglou, D., Atıcı, A., Yalman, H., Kücür, M., Onder, S. E., Durmaz, E., İkitimur, B., & Yalın, K. (2024) · The International Journal of Cardiovascular Imaging · doi:10.1007/s10554-024-03218-4 · Cited by 5
Insights into the prospects of nanobiomaterials in the treatment of cardiac arrhythmia
Lu, D., & Fan, X. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02805-w · Cited by 5
Prospective evaluation of antral lesion size of the 31-mm size of a novel size-adjustable cryoballoon: Results of the BETTER-FIT study
van Boven, N., Bhagwandien, R. E., Wijchers, S. A., Hoogendijk, M. G., Mahmoodi, B. K., & Yap, S. (2025) · Heart Rhythm O2 · doi:10.1016/j.hroo.2025.01.013 · Cited by 5
Cryoablation in persistent atrial fibrillation – a critical appraisal
Tzeis, S. E., Pastromas, S. C., Sikiotis, A., & Andrikopoulos, G. K. (2016) · Netherlands Heart Journal · doi:10.1007/s12471-016-0858-y · Cited by 5
Loop Recorder Detected High Rate of Atrial Fibrillation Recurrence after a Single Balloon- or Basket-Based Ablation of Paroxysmal Atrial Fibrillation: Results of the MACPAF Study
Schirdewan, A., Herm, J., Roser, M., Landmesser, U., Endres, M., Koch, L., & Hæusler, K. G. (2017) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2017.00004 · Cited by 5
Pulmonary vein isolation using multi-electrode radiofrequency vs conventional point-by-point radiofrequency ablation: A meta-analysis of randomized and non-randomized studies
Aras, D., Topaloğlu, S., Çay, S., Özeke, Ö., Özcan, F., & Cagirci, G. (2017) · Indian Pacing and Electrophysiology Journal · doi:10.1016/j.ipej.2017.02.004 · Cited by 5
Comparison of Cryoablation and Radiofrequency Ablation Areas Demarcated by Postprocedural Electroanatomic Mapping in Patients with Atrial Fibrillation Treated by Pulmonary Vein Isolation
Takahashi, K., Watanabe, I., Okumura, Y., Nagashima, K., Kogawa, R., Iso, K., Watanabe, R., Arai, M., Ohkubo, K., Nakai, T., et al. (2018) · Journal of Nihon University Medical Association · doi:10.4264/numa.77.1_7 · Cited by 5
“Crosstalk” technique: A comparison between two generations of cryoballoon catheter
Yang, J., Sun, Q., Guo, X., Zhou, G., Liu, X., Luo, B., Wei, H., Liang, J. J., & Ma, J. (2018) · Pacing and Clinical Electrophysiology · doi:10.1111/pace.13336 · Cited by 5
Management of arrhythmia recurrence in patients with pulmonary vein stenosis following atrial fibrillation ablation
Fink, T., Tilz, R. R., Heeger, C.-H. H., Schlüter, M., Feickert, S., Rottner, L., Reißmann, B., Lemeš, C., Alessandrini, H., Maurer, T., et al. (2019) · EP Europace · doi:10.1093/europace/euz187 · Cited by 5
Self-citation
Ablation therapy in atrial fibrillation
Bhatti, A., Oakeshott, P., Dhinoja, M., & Grapsa, J. (2019) · BMJ · doi:10.1136/bmj.l6428 · Cited by 5
Recurrent Atrial Fibrillation After Cryoballoon Ablation
Aryana, A., Chierchia, G., & de Asmundis, C. (2020) · Cardiac Electrophysiology Clinics · doi:10.1016/j.ccep.2020.02.002 · Cited by 5
Contemporary analysis of phrenic nerve injuries following cryoballoon-based pulmonary vein isolation: A single-centre experience with the systematic use of compound motor action potential monitoring
Anwar, O., Gunawardene, M., Dickow, J., Scherschel, K., Jungen, C., Münkler, P., Eickholt, C., Willems, S., Geßler, N., & Meyer, C. G. (2020) · PLoS ONE · doi:10.1371/journal.pone.0235132 · Cited by 5
Lesion durability after antral pulmonary vein isolation using a radiofrequency hot balloon catheter
Yamasaki, H., Aonuma, K., Shinoda, Y., Komatsu, Y., Watanabe, H., Kimata, A., Aita, S., Hattori, M., Machino, T., Igarashi, M., et al. (2020) · Journal of Interventional Cardiac Electrophysiology · doi:10.1007/s10840-020-00857-0 · Cited by 5
Atrial appendages’ mechanics assessed by 3D transoesophageal echocardiography as predictors of atrial fibrillation recurrence after pulmonary vein isolation
Zeljković, I., Bulj, N., Kordić, K., Pavlović, N., Radeljić, V., Benko, I., Kordić, I. Z., Đula, K., Kos, N., Delić-Brkljačić, D., et al. (2020) · IJC Heart & Vasculature · doi:10.1016/j.ijcha.2020.100642 · Cited by 5
Association of the H2FPEF Risk Score with Recurrence of Atrial Fibrillation Following Pulmonary Vein Isolation
Lakkireddy, D. (2020) · Journal of Atrial Fibrillation · doi:10.4022/jafib.2295 · Cited by 5
Ablation versus medication as initial therapy for paroxysmal atrial fibrillation: An updated meta‐analysis of randomized controlled trials
Kewcharoen, J., Prasitlumkum, N., Chokesuwattanaskul, R., Yi, R., Jongnarangsin, K., Bunch, T. J., Ranjan, R., & Navaravong, L. (2021) · Journal of Arrhythmia · doi:10.1002/joa3.12641 · Cited by 4
Localized Atrial Tachycardia and Dispersion Regions in Atrial Fibrillation: Evidence of Spatial Concordance
Gitenay, E., Bars, C., Bremondy, M., Ayari, A., Maillot, N., Baptiste, F., Taormina, A., Fofana, A., Siame, S., Kalifa, J., et al. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10143170 · Cited by 5
Meta‐analysis of cryoballoon ablation versus antiarrhythmic drugs as initial therapy for symptomatic atrial fibrillation
Mao, Y., Feng, W., Huang, Q., Yu, F., Chen, J., & Wang, H. (2021) · Clinical Cardiology · doi:10.1002/clc.23695 · Cited by 5
How Close Are We toward an Optimal Balance in Safety and Efficacy in Catheter Ablation of Atrial Fibrillation? Lessons from the CLOSE Protocol
Lycke, M., O’Neill, L., Gillis, K., Wielandts, J., de Waroux, J. L. P., Tavernier, R., Knecht, S., & Duytschaever, M. F. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10184268 · Cited by 5

Authors: Kuck, K.-H., Brugada, J., Fürnkranz, A., Metzner, A., Ouyang, F., Chun, K. R. J., Elvan, A., Arentz, T., Bestehorn, K., Pocock, S. J., Albenque, J.-P., & Tondo, C.
Affiliations: University of Milan (IT)
ORCID: Metzner, Andreas
Ouyang, Feifan
Chun, K.R. Julian
Elvan, Arif
Arentz, Thomas
Bestehorn, Kurt
Pocock, Stuart J.
Albenque, Jean-Paul
Tondo, Claudio
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 2016-06-09
Volume: 374
Issue: 23
Pages: 2235-2245
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejmoa1602014
OpenAlex: W2333001326
Cited by: 1,950
References: 22
Citations by year: 2026: 127 · 2025: 182 · 2024: 184 · 2023: 194 · 2022: 201 · 2021: 218 · 2020: 223 · 2019: 196 · 2018: 176 · 2017: 179 · 2016: 67
FWCI: 169.93
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
LSHTM Research Online (London School of Hygiene and Tropical Medicine) (acceptedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac pacing and defibrillation studies
Keywords: paroxysmal atrial fibrillation, cryoballoon ablation, radiofrequency ablation, pulmonary vein isolation, catheter ablation, non-inferiority, drug-refractory atrial fibrillation, atrial flutter, atrial tachycardia, antiarrhythmic drug use, repeat ablation, treatment-related adverse events, mortality, cerebrovascular events
MeSH terms: Aged, Atrial Fibrillation, Cryosurgery, Female, Follow-Up Studies, Humans, Male, Middle Aged, Postoperative Complications, Recurrence, Reoperation, Single-Blind Method, Catheter Ablation, Disease-Free Survival, Kaplan-Meier Estimate

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Cryoballoon or Radiofrequency Ablation for Paroxysmal Atrial Fibrillation

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks