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Cancer-Associated Mutations in Endometriosis without Cancer
Open accessAbstract
BACKGROUND: Endometriosis, defined as the presence of ectopic endometrial stroma and epithelium, affects approximately 10% of reproductive-age women and can cause pelvic pain and infertility. Endometriotic lesions are considered to be benign inflammatory lesions but have cancerlike features such as local invasion and resistance to apoptosis. METHODS: We analyzed deeply infiltrating endometriotic lesions from 27 patients by means of exomewide sequencing (24 patients) or cancer-driver targeted sequencing (3 patients). Mutations were validated with the use of digital genomic methods in microdissected epithelium and stroma. Epithelial and stromal components of lesions from an additional 12 patients were analyzed by means of a droplet digital polymerase-chain-reaction (PCR) assay for recurrent activating KRAS mutations. RESULTS: Exome sequencing revealed somatic mutations in 19 of 24 patients (79%). Five patients harbored known cancer driver mutations in ARID1A, PIK3CA, KRAS, or PPP2R1A, which were validated by Safe-Sequencing System or immunohistochemical analysis. The likelihood of driver genes being affected at this rate in the absence of selection was estimated at P=0.001 (binomial test). Targeted sequencing and a droplet digital PCR assay identified KRAS mutations in 2 of 3 patients and 3 of 12 patients, respectively, with mutations in the epithelium but not the stroma. One patient harbored two different KRAS mutations, c.35G→T and c.35G→C, and another carried identical KRAS c.35G→A mutations in three distinct lesions. CONCLUSIONS: We found that lesions in deep infiltrating endometriosis, which are associated with virtually no risk of malignant transformation, harbor somatic cancer driver mutations. Ten of 39 deep infiltrating lesions (26%) carried driver mutations; all the tested somatic mutations appeared to be confined to the epithelial compartment of endometriotic lesions.
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In the citing paper
“While nucleotide variants or mutations were noted sporadically in the epithelial component of ovarian endometriomas or deep-infiltrating endometriosis, stromal cells consistently lack any somatic mutations (Anglesio et al., 2017).”
From Endometriosis and nuclear receptors (2019) · cites this paper as Anglesio et al., 2017
Experimental — accuracy not yet measuredIn the citing paper
“Recently, molecular biology techniques using a next‐generation sequencing have also provided clues to the origin of endometriosis and pathogenesis that cannot be elucidated by epidemiological investigations alone.”
From Extra-pelvic endometriosis: a review. (2020) · cites this paper as [104]
In the citing paper
“Cancer genomic mutations have also been reported for extraovarian endometriosis in recent years, and mutations in cancer-associated genes, such as PIK3CA, KRAS, and ARID1A, have been identified [106].”
From Malignancies Associated with Extraovarian Endometriosis: A Literature Review (2021) · cites this paper as [106]
In the citing paper
“Cancer genomic mutations have also been reported for extraovarian endometriosis in recent years, and mutations in cancer-associated genes, such as PIK3CA, KRAS, and ARID1A, have been identified [106].”
From Malignancies Associated with Extraovarian Endometriosis: A Literature Review (2021) · cites this paper as [106]
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Cites
Stratton, M. R., Campbell, P. J., & Futreal, P. A. (2009) · Nature · doi:10.1038/nature07943 · Cited by 3,625
Sampson, J. A. (1927) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(15)30003-x · Cited by 2,334
COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer
Forbes, S. A., Bindal, N., Bamford, S., Cole, C., Kok, C. Y., Beare, D., Jia, M., Shepherd, R., Leung, K., Menzies, A., et al. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkq929 · Cited by 2,278
Giudice, L. C. (2010) · New England Journal of Medicine · doi:10.1056/nejmcp1000274 · Cited by 1,924
Bulun, S. E. (2009) · New England Journal of Medicine · doi:10.1056/nejmra0804690 · Cited by 1,772
High burden and pervasive positive selection of somatic mutations in normal human skin
Martincorena, I., Roshan, A., Gerstung, M., Ellis, P., Van Loo, P., McLaren, S., Wedge, D. C., Fullam, A., Alexandrov, L. B., Tubio, J. M., et al. (2015) · Science · doi:10.1126/science.aaa6806 · Cited by 1,770
ARID1A Mutations in Endometriosis-Associated Ovarian Carcinomas
Wiegand, K. C., Shah, S. P., Al-Agha, O. M., Zhao, Y., Tse, K., Zeng, T., Senz, J., McConechy, M. K., Anglesio, M. S., Kalloger, S. E., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa1008433 · Cited by 1,712
Self-citationDetection and quantification of rare mutations with massively parallel sequencing
Kinde, I., Wu, J., Papadopoulos, N., Kinzler, K. W., & Vogelstein, B. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1105422108 · Cited by 1,144
Self-citationSimoens, S., Dunselman, G., Dirksen, C., Hummelshoj, L., Bokor, A., Brandes, I., Brodszky, V., Canis, M., Colombo, G. L., DeLeire, T., et al. (2012) · Human Reproduction · doi:10.1093/humrep/des073 · Cited by 1,070
(1927) · PubMed Central · Cited by 1,008
Flagged first, then by citations
Research works printed but not linked: 4
- Ferguson BR, 1969, Obstet Gynecol, 33, 617
- Sampson JA, 1927, Am J Pathol, 3, 93
- Sato N, 2000, Cancer Res, 60, 7052
- Cullen TS. Adenoma-myoma uteri diffusum benignum. Johns Hopkins Hosp Bull 1896;6:133-7.
Cited by
Sorted by citations
Items 401–500 of 629
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Marquardt, R. M., Ahn, S. H., Reske, J. J., Chandler, R. L., Petroff, M. G., Kim, T. H., & Jeong, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23116067 · Cited by 5
Chao, A., Wu, R., Lin, C., Lee, L.-Y., Tsai, C.-L., Lee, Y., & Wang, C. (2023) · Journal of Obstetrics and Gynaecology · doi:10.1080/01443615.2022.2161352 · Cited by 5
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Chagani, S., de Macêdo, M. P., Carapeto, F. C. L., Wang, F., Marzese, D. M., Wani, K., Haydu, L. E., Peng, W., Ong, G. T., Warren, S. E., et al. (2023) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2023.01.034 · Cited by 5
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Minamikawa, T., Yachida, N., Takahashi, K., Saito, K., Sekizuka, T., Akashi, H., Suzuki, M. M., Mori, Y., Yamawaki, K., Suda, K., et al. (2023) · Cancers · doi:10.3390/cancers15235635 · Cited by 5
Riaz, M. A., Mecha, E. O., Omwandho, C. O. A., Zeppernick, F. A., Meinhold-Heerlein, I. M., & Konrad, L. (2024) · Biomedicines · doi:10.3390/biomedicines12061276 · Cited by 5
Panir, K., Hull, M. L., & Greaves, E. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-820661-4.00019-4 · Cited by 5
Genetics and Genomics of Endometriosis
Giudice, L. C., Burney, R. O., Becker, C. M., Missmer, S. A., Montgomery, G. W., Rahmioğlu, N., Rogers, P. A. W., & Zondervan, K. T. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-813570-9.00018-8 · Cited by 5
Gottlieb, B., Babrzadeh, F., Oros, K. K., Alvarado, C., Wang, C., Gharizadeh, B., Basik, M., Greenwood, C. M. T., Beitel, L. K., & Trifiro, M. A. (2018) · Journal of Cancer Metastasis and Treatment · doi:10.20517/2394-4722.2018.26 · Cited by 5
Nonneoplastic Disorders of the Ovary
Watkins, J. C., & Young, R. H. (2023) · Essentials of Diagnostic Gynecological Pathology. · doi:10.1007/978-3-031-39659-5_2 · Cited by 5
Kyei-Barffour, I., Montgomery, G. W., & McKinnon, B. D. (2026) · Journal of Endometriosis and Uterine Disorders · doi:10.1016/j.jeud.2026.100152 · Cited by 4
Chen, P., Wei, X. C., Li, X., Zhou, Y., Liu, Q., & Ouyang, L. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1371498 · Cited by 5
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Goh, K. Y., Tham, S. C., Cheng, T. Y. D., Nadarajah, R., Goh, R. C. H., Wong, S. L., Ho, T. H., Chew, G. K., Tan, A. W. K., Rajesh, H., et al. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26051822 · Cited by 4
Stewart, K. A., Cope, A. G., Burnett, T. L., & Green, I. C. (2025) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/gco.0000000000001036 · Cited by 4
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Guo, Q., Chen, X., Bi, R., Li, H., Liu, M., Ju, X., Feng, Z., Zhu, J., Li, Y., Wang, X., et al. (2025) · Communications Biology · doi:10.1038/s42003-025-08617-4 · Cited by 4
Therapeutic targeting of interleukin-17C signaling in carcinogenesis of endometriosis
Yao, B., Zheng, R., Yang, Y., Zhao, Z., Lash, G. E., Guo, B., Pan, J., Shuai, H., Zhou, H. K., Wang, M., et al. (2025) · Cell Reports Medicine · doi:10.1016/j.xcrm.2025.102464 · Cited by 5
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Chan, W. Y., da Silva, I. P., Long, G. V., & Rizos, H. (2026) · The Lancet · doi:10.1016/s0140-6736(26)00199-6 · Cited by 5
Lessey, B. A., Dong, A. C., Deaton, J. L., Angress, D., Savaris, R. F., & Walker, S. J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25136852 · Cited by 6
Absence of KRAS hotspot mutations in endometriosis of Korean patients
Kim, M. S., Yoo, N. J., Hwang, H., Kim, M., & Lee, S. H. (2018) · Histopathology · doi:10.1111/his.13524 · Cited by 4
Endometriosis and cancerogenesis of the ovaries (a review)
Adamyan, L. V., Martirosyan, Y. O., & Asaturova, A. V. (2018) · Russian Journal of Human Reproduction · doi:10.17116/repro2018240417 · Cited by 4
Role of GLI1 in Hypoxia-Driven Endometrial Stromal Cell Migration and Invasion in Endometriosis
Wang, L., Liang, J., Bi, S., Li, Y., Zhang, W., Wang, X., Liu, Y., & Liu, H. (2022) · Computational and Mathematical Methods in Medicine · doi:10.1155/2022/6890790 · Cited by 4
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Meinhold-Heerlein, I. M., Zeppernick, M. M., Wölfler, M. M., Janschek, E., Bornemann, S., Holtmann, L., Oehmke, F., Salehin, D., Scheible, C. M., Brandes, I., et al. (2023) · Geburtshilfe und Frauenheilkunde · doi:10.1055/a-2061-6845 · Cited by 4
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Marongiu, F., Cheri, S., & Laconi, E. (2023) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2023.151340 · Cited by 4
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Steffensen, L. B., Kavan, S., Jensen, P., Møller‐Larsen, S., Larsen, M. L., Dembić, M., Andersen, L., Lindholt, J. S., Houlind, K. C., Thomassen, M., et al. (2022) · medRxiv · doi:10.1101/2022.05.16.22275001 · Cited by 4
Cheng, A. P., Rusinek, I., Sossin, A., Widman, A. J., Meiri, E., Krieger, G., Hirschberg, O., Tov, D. S., Gilad, S., Jaimovich, A., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.08.11.669689 · Cited by 7
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Kyriacou, I., Vaidakis, D., & Constantinou, C. (2025) · Oncology Research and Treatment · doi:10.1159/000548022 · Cited by 3
Güzelbağ, B., Güngör‐Ordueri, N. E., Karahan, H., Maghsoudi, A., & Oral, E. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27073034 · Cited by 3
Maggiore, U. L. R., Vignali, M., Kvaskoff, M., Chiappa, V., Somigliana, E., Vercellini, P., Raspagliesi, F., & Viganò, P. (2026) · Human Reproduction Update · doi:10.1093/humupd/dmag011 · Cited by 4
Kiyokawa, T. (2022) · Surgical pathology clinics · doi:10.1016/j.path.2022.02.005 · Cited by 3
Kanno, K., Nakayama, K., Razia, S., Sohel, H. I., Zahan, U. F., Sonia, S. B., Yamashita, H., Ishikawa, M., Ishibashi, T., Imamura, K., et al. (2024) · Current Issues in Molecular Biology · doi:10.3390/cimb46040224 · Cited by 3
Alejandre, C., Calle-Espinosa, J., & Iranzo, J. (2024) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1012081 · Cited by 3
KRAS oncogenic mutations in benign tumors: adenomatoid odontogenic tumor as a model
Coura, B. P., Guimarães, L. M., Gomez, R. S., & Gomes, C. C. (2025) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2025.108552 · Cited by 3
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Akatsuka, H., Kashikawa, T., Masuhara, K., Tokusanai, M., Li, C., Iida, Y., Okada-Yamaguchi, C., Okada, Y., Tanaka, M., Suzuki, T., et al. (2025) · iScience · doi:10.1016/j.isci.2025.113054 · Cited by 3
Koninckx, P. R., Ussia, A., Adamyan, L. V., Wattiez, A., & Viganò, P. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14207196 · Cited by 3
Praetorius, T., Lac, V., Tessier‐Cloutier, B., Nazeran, T. M., Köebel, M., Mason, M., Senz, J., Grube, M. P., Krämer, B., Brucker, S. Y., et al. (2020) · Geburtshilfe und Frauenheilkunde · doi:10.1055/s-0040-1718045 · Cited by 3
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Koninckx, P. R., Ussia, A., Adamyan, L. V., Keckstein, J., Wattiez, A., Gomel, V., & Martin, D. C. (2020) · Springer eBooks · doi:10.1007/978-3-030-52984-0_6 · Cited by 3
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Mijatovic, V. (2020) · Human Reproduction · doi:10.1093/humrep/deaa265 · Cited by 3
The etiology of clonal mosaicism in human aging and disease
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Malignant endometriosis-associated ovarian and extraovarian neoplasia (review of literature)
Котив, Х. Б., Городнова, Т. В., Lavrinovich, O., & Берлев, И. В. (2022) · Tumors of female reproductive system · doi:10.17650/1994-4098-2022-18-4-127-137 · Cited by 3
Miyama, Y., Ogasawara, A., Hasegawa, K., & Yasuda, M. (2024) · International Journal of Gynecological Pathology · doi:10.1097/pgp.0000000000001002 · Cited by 3
Amanda, C. R., Fadilah, F., Hestiantoro, A., Muharam, R., Suryandari, D. A., Tulandi, T., & Asmarinah, A. (2024) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2024.09.026 · Cited by 3
Vu, T. H., Nakamura, K., Shigeyasu, K., Kashino, C., Okamoto, K., Kubo, K., Kamada, Y., & Masuyama, H. (2024) · Scientific Reports · doi:10.1038/s41598-024-76589-2 · Cited by 3
Cancer-causing somatic mutations: they are neither necessary nor sufficient
Sonnenschein, C., & Soto, A. M. (2018) · Organisms. Journal of Biological Sciences · doi:10.13133/2532-5876_3.12 · Cited by 3
Iafolla, M. A. J., Picardo, S. L., Aung, K. L., & Hansen, A. R. (2020) · JNCI Cancer Spectrum · doi:10.1093/jncics/pkaa050 · Cited by 3
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Chalela, R., González-García, J. G., Khilzi, K., Curull, V., Sánchez‐Font, A., Longarón, R., Rodrigo‐Calvo, M. T., Martín‐Ontiyuelo, C., Gea, J., & Bellosillo, B. (2021) · Pathology & Oncology Research · doi:10.3389/pore.2021.598292 · Cited by 3
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Ponomarenko, I., Валерьевич, П. А., Николаевна, В. И., Николаевна, С. И., Orlova, V. S., & Churnosov, M. I. (2019) · Voprosy ginekologii akušerstva i perinatologii · doi:10.20953/1726-1678-2019-3-15-20 · Cited by 3
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Yong, P. J. (2020) · Wiley eBooks · doi:10.1002/9781119482598.ch33 · Cited by 3
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David, C. J., & Vanharanta, S. (2024) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-060524-105603 · Cited by 2
Management of early-stage ovarian cancer: Open questions and debated issues
Salutari, Giudice, E., Rapisarda, E., Pavone, M., Ghizzoni, V., Perri, M. T., Boccia, S. M., Lardino, S., Gallotta, V., Fagotti, A., et al. (2025) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2025.104704 · Cited by 2
Kobayashi, R., & Hatada, I. (2025) · Epigenomics · doi:10.1080/17501911.2025.2491298 · Cited by 3
Eto, C., Hiraki, T., Kawata, T., Takahashi, N., & Hirashima, Y. (2025) · International Journal of Surgical Pathology · doi:10.1177/10668969251333437 · Cited by 2
Systemic comorbidities in patients with adenomyosis
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NEZHAT, C. R., Najmi, Z., Monfared, V., Nezhat, A., NEZHAT, C. H., & Nezhat, F. R. (2026) · Journal of Clinical Medicine · doi:10.3390/jcm15082871 · Cited by 2
Beck, M. H., Kordowitzki, P., Roser, E., Trelinska-Finger, A., Schoof, E., Chinczewski, L., Mechsner, S., & Sehouli, J. (2026) · BMC Cancer · doi:10.1186/s12885-026-15980-w · Cited by 2
Yao, R., Wu, P., Sung, C. J., Lamson, J. A., & Zhang, C. (2022) · International Journal of Surgical Pathology · doi:10.1177/10668969221105618 · Cited by 2
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Liu, C., Chen, P., Yang, Z., Zhang, K., Chen, F., Zhu, Y., Liu, J., Liu, L., Wang, D., & Wang, D. (2024) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2024.104326 · Cited by 2
Gristina, V., Pepe, F., Genova, C., Russo, T. D. B., Gottardo, A., Russo, G., Incorvaia, L., Galvano, A., Badalamenti, G., Bazan, V., et al. (2024) · Expert Review of Molecular Diagnostics · doi:10.1080/14737159.2024.2403081 · Cited by 4
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Ukrainets, R. V., Korneva, Y. S., & Ae, D. (2020) · Russian Journal of Archive of Pathology · doi:10.17116/patol20208202157 · Cited by 2
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Saavalainen, L., Lassus, H. J., But, A., Gissler, M., Heikinheimo, O., & Pukkala, . (2021) · PLoS ONE · doi:10.1371/journal.pone.0253270 · Cited by 2
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Noor, S., Muhammad, T., Rehman, M.-U., Sayyed, B., Noor, S., Ubaidullah, J., Maqbool, T., & Shams, R. M. A. A. (2022) · Pak-Euro Journal of Medical and Life Sciences · doi:10.31580/pjmls.v5i2.2523 · Cited by 3
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Mallinder, H., Nesbitt‐Hawes, E. M., Scheck, S. M., Wynn‐Williams, M., Yazdani, A., Rombauts, L. J. F., & Abbott, J. A. (2024) · Australian and New Zealand Journal of Obstetrics and Gynaecology · doi:10.1111/ajo.13882 · Cited by 2
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Ólafsson, S., Arnthorsson, A. O., Kübler, K., Sigurðsson, Á., Gunnarsdottir, H. S., Jónsson, H., Ásbjörnsdóttir, B., le Roux, L., Saemundsdottir, J., Steinthórsdóttir, V., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.02.25.708037 · Cited by 3
Castiglia, M., Incorvaia, L., Gristina, V., Malapelle, U., Bazan, V., Rolfo, C. D., & Russo, A. D. (2021) · UNIPA Springer series · doi:10.1007/978-3-030-56051-5_6 · Cited by 1
Thoracic endometriosis and catamenial pneumothorax
Bobbio, A., Pauw, V. D., Lefqih, I., Sion, A., & Alifano, M. (2023) · European Respiratory Society eBooks · doi:10.1183/2312508x.10019322 · Cited by 1
ARID1a Gene as a Potential Early Marker to Tackle Endometriosis-Associated Ovarian Cancer
Kordowitzki, P., Mechsner, S., & Sehouli, J. (2023) · Aging and Disease · doi:10.14336/ad.2023.1109 · Cited by 1
Immune сheckpoints in the context of external genital endometriosis
Belevich, A. S., Yarmolinskaya, M. I., Selkov, S. А., & Соколов, Д. И. (2024) · Medical Immunology (Russia) · doi:10.15789/1563-0625-ici-2923 · Cited by 1
How to bridge the gap between evidence-based and clinical management of endometriosis
Koninckx, P. R., Ussia, A., Miller, C. E., Guo, S., Lesaffre, E. M. E. H., Wattiez, A., & Adamyan, L. V. (2025) · Journal of Endometriosis and Uterine Disorders · doi:10.1016/j.jeud.2025.100123 · Cited by 1
Klymenko, Y., Kersey, J. L., Quigley, H. D., & Hawkins, S. M. (2025) · Biology of Reproduction · doi:10.1093/biolre/ioaf255 · Cited by 1
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Olcha, P., Paja, W., Kępski, M., Pancerz, K., Klębowski, B., Nowakowski, Ł., Gałczyński, K., & Depciuch, J. (2025) · Journal of Biophotonics · doi:10.1002/jbio.202500511 · Cited by 1
Diagnostic value of MiRNAs in endometriosis: a systematic review and meta-analysis
Wei, N., Liu, H., Zhang, Y., Yang, X., Wu, G., Dong, Z., Li, X., Yue, L., & Zhao, R. (2026) · BMC Women s Health · doi:10.1186/s12905-026-04281-w · Cited by 1
Gerede, A., Oikonomou, E., Gkaitatzi, F., Danavasi, M., Papasozomenou, P., Potiris, A., Stavros, S., Kourti, V., Domali, E., Koutlaki, N., et al. (2026) · Biomolecules · doi:10.3390/biom16030402 · Cited by 1
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Bogani, G., Moore, K. N., Ray-Coquard, I. L., Ceccaroni, M., Coleman, R. L., Fotopoulou, C., Mabrouk, M., Taylor, H. S., Roman, H., Ferrari, F. A., et al. (2026) · Gynecologic Oncology · doi:10.1016/j.ygyno.2026.05.004 · Cited by 1
Солопова, А. Г., Shatilina, A. Y., Martirosyan, N., Khadanovich, M. R., & Grigoreva, K. N. (2026) · Obstetrics Gynecology and Reproduction · doi:10.17749/2313-7347/ob.gyn.rep.2026.763 · Cited by 1
Moberg, L., Li, X., Herbst, F., Jansåker, F., Dobilas, A., Sundquist, K., & Borgfeldt, C. (2026) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.1111/aogs.70223 · Cited by 1
World Ovarian Cancer Day: unravelling the molecular anatomy of a silent killer
Kanneganti, A., Low, J. J. H., Huang, R. Y., & Choolani, M. (2026) · Singapore Medical Journal · doi:10.4103/singaporemedj.smj-2026-255 · Cited by 1
The Role of Molecular Characterization in Precision Medicine in Endometriosis
Niles, I. T., Scialabba, M., Lacouline-Boulanger, R., Akiki, G., Diwan, S.-S., Leung, S. O. A., Zakhari, A., Tessier‐Cloutier, B., & Nguyen, D. B. (2026) · Obstetrics and Gynecology · doi:10.1097/aog.0000000000006352 · Cited by 1
Self-citationMetabolic remodeling of endometriosis microenvironment: Energy stress and immune evasion
Yang, P., Wang, T., Liu, W., Miao, Y., Zhu, Y., & Sun, J. (2026) · iScience · doi:10.1016/j.isci.2026.116592 · Cited by 1
Self-citationWang, J., Li, W., Feng, J., & Wang, Z. H. (2026) · Stem Cells International · doi:10.1155/sci/7134066 · Cited by 1
Kordowitzki, P., Ying, K., Beck, M. H., Velho, R. V., Engelbrecht, C., Sehouli, J., & Mechsner, S. (2026) · BMC Medicine · doi:10.1186/s12916-026-05101-6 · Cited by 1
Santhamma, B., Chacon, J. A., Deemer, E. M., Stary, D., Hernandez, S. A., Subramani, R., Lakshmanaswamy, R., Nickisch, K. J., Batra, S., & Nair, H. B. B. (2026) · Cancer Letters · doi:10.1016/j.canlet.2026.218845 · Cited by 1
Soslow, R. A. (2020) · Elsevier eBooks · doi:10.1016/b978-0-323-35909-2.00018-7 · Cited by 1
The Role of the Microenvironment in Endometriosis: Parallels and Distinctions to Cancer
Rogers, M. S. (2022) · Springer eBooks · doi:10.1007/978-3-030-98950-7_28 · Cited by 1
Pathogenesis of Endometriosis: Role of Platelets in Endometriosis
Guo, S. (2022) · Springer eBooks · doi:10.1007/978-3-030-97236-3_4 · Cited by 1
Manning‐Geist, B. L., Gordhandas, S., Ramalingam, P., & Zivanovic, O. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-82938-0.00004-5 · Cited by 1
Yoshihara, K. (2023) · Journal of obstetrics and gynaecology research · doi:10.1111/jog.15680 · Cited by 2
Inggriani, R. C., Chang, C., & Yang, W. V. (2023) · doi:10.3390/iecc2023-14214 · Cited by 1
Metadata
- Authors
- Anglesio, M. S., Papadopoulos, N., Ayhan, A., Nazeran, T. M., Noë, M., Horlings, H. M., Lum, A., Jones, S., Senz, J., Seckin, T., Ho, J., Wu, R.-C., Lac, V., Ogawa, H., Tessier-Cloutier, B., Alhassan, R., Wang, A., Wang, Y., Cohen, J. D., Wong, F., Hasanovic, A., Orr, N., Zhang, M., Popoli, M., McMahon, W., Wood, L. D., Mattox, A., Allaire, C., Segars, J., Williams, C., Tomasetti, C., Boyd, N., Kinzler, K. W., Gilks, C. B., Diaz, L., Wang, T.-L., Vogelstein, B., Yong, P. J., Huntsman, D. G., & Shih, I.-M.
- Affiliations
- University of British Columbia (CA)
- Hiroshima University (JP)
- BC Cancer Agency (CA)
- Howard Hughes Medical Institute (US)
- ORCID
- Anglesio, Michael S.
- Papadopoulos, Nickolas
- Ayhan, Ayse
- Noë, Michaël
- Horlings, Hugo M.
- Lum, Amy
- Jones, Siân
- Senz, Janine
- Seckin, Tamer
- Wu, Ren-Chin
- Lac, Vivian
- Ogawa, Hiroshi
- Wang, Yuxuan
- Cohen, Joshua D.
- Orr, Natasha
- Zhang, Ming
- Popoli, Maria
- Wood, Laura D.
- Mattox, Austin
- Allaire, Catherine
- Segars, James
- Tomasetti, Cristian
- Boyd, Niki
- Kinzler, Kenneth W.
- Gilks, C. Blake
- Diaz, Luis
- Wang, Tian-Li
- Vogelstein, Bert
- Yong, Paul J.
- Shih, Ie-Ming
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2017-05-11
- Volume
- 376
- Issue
- 19
- Pages
- 1835-1848
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- PMC
- PMC5555376
- OpenAlex
- W2612851374
- Cited by
- 628
- References
- 50
- Citations by year
- 2026: 57 · 2025: 62 · 2024: 51 · 2023: 75 · 2022: 72 · 2021: 75 · 2020: 80 · 2019: 68 · 2018: 69 · 2017: 19
- FWCI
- 74.93
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (R01CA215483, U01CA200469, R01CA057345, T32CA009243, P50CA062924, R37CA057345, P30CA006973)
- National Institute of General Medical Sciences (T32GM007309, T32GM007184)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Keywords
- endometriosis, deep infiltrating endometriosis, somatic mutations, cancer driver mutations, KRAS mutation, ARID1A, PIK3CA, PPP2R1A, malignant transformation risk, droplet digital PCR
- MeSH terms
- Adult, Cell Transformation, Neoplastic, DNA Mutational Analysis, DNA-Binding Proteins, Endometriosis, Endometrium, Female, Humans, Middle Aged, Mutation, Nuclear Proteins, Transcription Factors, Polymerase Chain Reaction, Proto-Oncogene Proteins p21(ras), Phosphatidylinositol 3-Kinases, Protein Phosphatase 2, Class I Phosphatidylinositol 3-Kinases, Exome
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