ARID1A Mutations in Endometriosis-Associated Ovarian Carcinomas
Open accessAbstract
BACKGROUND: Ovarian clear-cell and endometrioid carcinomas may arise from endometriosis, but the molecular events involved in this transformation have not been described. METHODS: We sequenced the whole transcriptomes of 18 ovarian clear-cell carcinomas and 1 ovarian clear-cell carcinoma cell line and found somatic mutations in ARID1A (the AT-rich interactive domain 1A [SWI-like] gene) in 6 of the samples. ARID1A encodes BAF250a, a key component of the SWI–SNF chromatin remodeling complex. We sequenced ARID1A in an additional 210 ovarian carcinomas and a second ovarian clear-cell carcinoma cell line and measured BAF250a expression by means of immunohistochemical analysis in an additional 455 ovarian carcinomas. RESULTS: ARID1A mutations were seen in 55 of 119 ovarian clear-cell carcinomas (46%), 10 of 33 endometrioid carcinomas (30%), and none of the 76 high-grade serous ovarian carcinomas. Seventeen carcinomas had two somatic mutations each. Loss of the BAF250a protein correlated strongly with the ovarian clear-cell carcinoma and endometrioid carcinoma subtypes and the presence of ARID1A mutations. In two patients, ARID1A mutations and loss of BAF250a expression were evident in the tumor and contiguous atypical endometriosis but not in distant endometriotic lesions. CONCLUSIONS: These data implicate ARID1A as a tumor-suppressor gene frequently disrupted in ovarian clear-cell and endometrioid carcinomas. Since ARID1A mutation and loss of BAF250a can be seen in the preneoplastic lesions, we speculate that this is an early event in the transformation of endometriosis into cancer. (Funded by the British Columbia Cancer Foundation and the Vancouver General Hospital–University of British Columbia Hospital Foundation.).
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Detection of PTEN, PIK3CA, and ARID1A mutations in benign or atypical endometriotic lesions, which have also been reported in ovarian clear cell carcinoma and endometrioid carcinoma, supports the possibility of malignant transformation of endometriosis.
“Recently, the detection of PTEN, PIK3CA, and ARID1A mutations in benign or atypical endometriotic lesions [15][16][17], which have been also reported in ovarian clear cell carcinoma and endometrioid carcinoma, supports the possibility of malignant transformation of endometriosis.”
From Malignancies Associated with Extraovarian Endometriosis: A Literature Review (2021) · cites this paper as [16]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Jemal, A., Siegel, R., Xu, J., & Ward, E. (2010) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.20073 · Cited by 12,596 · see citing works
Pathology and Genetics of Tumours of the Breast and Female Genital Organs
Tavassoli, F. A., & Devilee, P. (2003) · International Agency for Research on Cancer eBooks · Cited by 2,818 · see citing works
The Nonsense-Mediated Decay RNA Surveillance Pathway
Chang, Y.-F., Imam, J. S., & Wilkinson, M. (2007) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.76.050106.093909 · Cited by 1,283 · see citing works
Ovarian Carcinoma Subtypes Are Different Diseases: Implications for Biomarker Studies
Köbel, M., Kalloger, S. E., Boyd, N., McKinney, S., Mehl, E., Palmer, C., Leung, S., Bowen, N. J., Ionescu, D. N., Rajput, A., et al. (2008) · PLoS Medicine · doi:10.1371/journal.pmed.0050232 · Cited by 814 · see citing works
Self-citationDriver mutations in TP53 are ubiquitous in high grade serous carcinoma of the ovary
Ahmed, A. A., Etemadmoghadam, D., Temple, J., Lynch, A. G., Riad, M., Sharma, R. N., Stewart, C. J. R., Fereday, S., Caldas, C., DeFazio, A., et al. (2010) · The Journal of Pathology · doi:10.1002/path.2696 · Cited by 786 · see citing works
Self-citationMutation of FOXL2 in Granulosa-Cell Tumors of the Ovary
Shah, S. P., Köbel, M., Senz, J., Morin, R. D., Clarke, B. A., Wiegand, K. C., Leung, G., Zayed, A., Mehl, E., Kalloger, S. E., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0902542 · Cited by 770 · see citing works
Self-citationA breakpoint map of recurrent chromosomal rearrangements in human neoplasia
Mitelman, F., Mertens, F., & Johansson, B. (1997) · Nature Genetics · doi:10.1038/ng0497supp-417 · Cited by 708 · see citing works
Diversity and specialization of mammalian SWI/SNF complexes.Preprint
Wang, W., Xue, Y., Zhou, S., Kuo, A. C., Cairns, B. R., & Crabtree, G. R. (1996) · Genes & Development · doi:10.1101/gad.10.17.2117 · Cited by 707 · see citing works
Expression of hypoxia-inducible factor 1? in brain tumors
Zagzag, D., Zhong, H., Scalzitti, J. M., Laughner, E., Simons, J. W., & Semenza, G. L. (2000) · Cancer · doi:10.1002/1097-0142(20000601)88:11 · Cited by 603 · see citing works
Dinulescu, D. M., Ince, T. A., Quade, B. J., Shafer, S. A., Crowley, D. G., & Jacks, T. (2004) · Nature Medicine · doi:10.1038/nm1173 · Cited by 601 · see citing works
The SWI/SNF complex and cancer
Reisman, D., Glaros, S., & Thompson, E. A. (2009) · Oncogene · doi:10.1038/onc.2009.4 · Cited by 567 · see citing works
Frequent Activating Mutations of PIK3CA in Ovarian Clear Cell Carcinoma
Kuo, K., Mao, T., Jones, S., Veras, E. F. T., Ayhan, A., Wang, T., Glas, R., Slamon, D. J., Velculescu, V. E., Kuman, R. J., et al. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.081000 · Cited by 487 · see citing works
Self-citationSato, N., Tsunoda, H., Nishida, M., Morishita, Y., Takimoto, Y., Kubo, T., & Noguchi, M. (2000) · PubMed · Cited by 451 · see citing works
Differences in Tumor Type in Low-stage Versus High-stage Ovarian Carcinomas
Köbel, M., Kalloger, S. E., Huntsman, D. D., Santos, J. L., Swenerton, K. D., Seidman, J. D., & Gilks, C. B. (2010) · International Journal of Gynecological Pathology · doi:10.1097/pgp.0b013e3181c042b6 · Cited by 398 · see citing works
Self-citationGoff, B. A., de la Cuesta, R. S., Muntz, H. G., et al. (1996) · Gynecologic Oncology · doi:10.1006/gyno.1996.0065 · Cited by 357 · see citing works
Gao, X., Tate, P. H., Hu, P., Tjian, R., Skarnes, W. C., & Wang, Z. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801802105 · Cited by 336 · see citing works
Ovarian carcinomas with genetic and epigenetic BRCA1 loss have distinct molecular abnormalities
Press, J. Z., Luca, A. D., Boyd, N., Young, S. S., Troussard, A. A., Ridge, Y., Kaurah, P., Kalloger, S. E., Blood, K. A., Smith, M. J., et al. (2008) · BMC Cancer · doi:10.1186/1471-2407-8-17 · Cited by 287 · see citing works
Self-citationPurification and characterization of mSin3A-containing Brg1 and hBrm chromatin remodeling complexesPreprint
Sif, S., Saurin, A. J., Imbalzano, A. N., & Kingston, R. E. (2001) · Genes & Development · doi:10.1101/gad.872801 · Cited by 283 · see citing works
Mechanisms of chemoresistance and poor prognosis in ovarian clear cell carcinoma
Itamochi, H., Kigawa, J., & Terakawa, N. (2008) · Cancer Science · doi:10.1111/j.1349-7006.2008.00747.x · Cited by 237 · see citing works
Köbel, M., Kalloger, S. E., Carrick, J., Huntsman, D. D., Haider, A. A., Oliva, E., Ewanowich, C. A., Soslow, R. A., & Gilks, C. B. (2008) · The American Journal of Surgical Pathology · doi:10.1097/pas.0b013e3181788546 · Cited by 230 · see citing works
Self-citationEndometriosis and ovarian cancer: Thoughts on shared pathophysiology
Ness, R. B. (2003) · American Journal of Obstetrics and Gynecology · doi:10.1067/mob.2003.408 · Cited by 227 · see citing works
SNVMix: predicting single nucleotide variants from next-generation sequencing of tumors
Goya, R., Sun, M., Morin, R. D., Leung, G., Ha, G., Wiegand, K. C., Senz, J., Crisan, A., Marra, M. A., Hirst, M., et al. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq040 · Cited by 210 · see citing works
Self-citationCristofaro, M. F. D., Betz, B. L., Rorie, C. J., Reisman, D., Wang, W., & Weissman, B. E. (2001) · Journal of Cellular Physiology · doi:10.1002/1097-4652(200101)186:1 · Cited by 161 · see citing works
Lack of effective systemic therapy for recurrent clear cell carcinoma of the ovary
Crotzer, D. R., Sun, C. C., Coleman, R. L., et al. (2007) · Gynecologic Oncology · doi:10.1016/j.ygyno.2006.12.024 · Cited by 150 · see citing works
Clinical significance of cytogenetic findings in solid tumors
Mitelman, F., Johansson, B., Mandahl, N., & Mertens, F. (1997) · Cancer Genetics and Cytogenetics · doi:10.1016/s0165-4608(96)00252-x · Cited by 138 · see citing works
Dagan, T., Talmor, Y., & Graur, D. (2002) · Molecular Biology and Evolution · doi:10.1093/oxfordjournals.molbev.a004161 · Cited by 118 · see citing works
Viganò, P., Somigliana, E., Chiodo, I., Abbiati, A., & Vercellini, P. (2005) · Human Reproduction Update · doi:10.1093/humupd/dmi037 · Cited by 112 · see citing works
Lau, D. H., Lewis, A. D., Ehsan, M. N., & Sikic, B. I. (1991) · PubMed · Cited by 97 · see citing works
Expression of p270 (ARID1A), a component of human SWI/SNF complexes, in human tumors
Wang, X., Nagl, N. G., Flowers, S. J., Zweitzig, D. R., Dallas, P. B., & Morán, E. (2004) · International Journal of Cancer · doi:10.1002/ijc.20450 · Cited by 93 · see citing works
Genomic and functional evidence for an ARID1A tumor suppressor role
Huang, J., Zhao, Y., Li, Y., Fletcher, J. A., & Xiao, S. (2007) · Genes Chromosomes and Cancer · doi:10.1002/gcc.20459 · Cited by 79 · see citing works
Self-citationSuehiro, Y., Sakamoto, M., Umayahara, K., et al. (2000) · Oncology · doi:10.1159/000012137 · Cited by 77 · see citing works
Molecular Abnormalities in Ovarian Cancer Subtypes Other than High-Grade Serous Carcinoma
Gilks, C. B. (2009) · Journal of Oncology · doi:10.1155/2010/740968 · Cited by 64 · see citing works
Dent, J., Hall, G. D., Wilkinson, N. S., et al. (2003) · British Journal of Cancer · doi:10.1038/sj.bjc.6600896 · Cited by 40 · see citing works
Kozmík, Z., Machoň, O., Králová, J., et al. (2001) · Genomics · doi:10.1006/geno.2001.6477 · Cited by 23 · see citing works
AGED GARLIC EXTRACT SUPPRESSES LIPID PEROXIDATION INDUCED BY β-AMYLOID IN PC12 CELLS
Griffin, B., Selassie, M., & Gwebu, E. T. (2000) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1290/1071-2690(2000)036 · Cited by 8 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The Somatic Genomic Landscape of Glioblastoma
Brennan, C. W., Verhaak, R. G. W., McKenna, A., Campos, B., Noushmehr, H., Salama, S. R., Zheng, S., Chakravarty, D., Sanborn, J. Z., Berman, S. H., et al. (2013) · Cell · doi:10.1016/j.cell.2013.09.034 · Cited by 5,016 · see citing works
“A role for chromatin organization in GBM pathology, which has been described for cancer types such as ovarian carcinoma (Wiegand et al., 2010) and renal carcinoma (Varela et al.”
BackgroundSelf-citationA decade of exploring the cancer epigenome—biological and translational implications
Baylin, S. B., & Jones, P. A. (2011) · Nature Reviews Cancer · doi:10.1038/nrc3130 · Cited by 2,871 · see citing works
Zondervan, K. T., Becker, C. M., & Missmer, S. A. (2020) · New England Journal of Medicine · doi:10.1056/nejmra1810764 · Cited by 2,249 · see citing works
Endometriosis: pathogenesis and treatment
Vercellini, P., Viganò, P., Somigliana, E., & Fedele, L. (2014) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2013.255 · Cited by 1,940 · see citing works
Mutational analysis reveals the origin and therapy-driven evolution of recurrent glioma
Johnson, B. E., Mazor, T., Hong, C., Barnes, M., Aihara, K., McLean, C. Y., Fouse, S. D., Yamamoto, S., Ueda, H., Tatsuno, K., et al. (2014) · Science · doi:10.1126/science.1239947 · Cited by 1,362 · see citing works
Self-citationZondervan, K. T., Becker, C. M., Koga, K., Missmer, S. A., Taylor, R. N., & Viganò, P. (2018) · Nature Reviews Disease Primers · doi:10.1038/s41572-018-0008-5 · Cited by 1,257 · see citing works
Pearce, C. L., Templeman, C., Rossing, M. A., Lee, A., Near, A. M., Webb, P. M., Nagle, C. M., Doherty, J. A., Cushing-Haugen, K. L., Wicklund, K. G., et al. (2012) · The Lancet Oncology · doi:10.1016/s1470-2045(11)70404-1 · Cited by 939 · see citing works
Self-citationVitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells
Blaschke, K., Ebata, K. T., Karimi, M. M., Zepeda-Martínez, J. A., Goyal, P., Mahapatra, S., Tam, A., Laird, D. J., Hirst, M., Rao, A., et al. (2013) · Nature · doi:10.1038/nature12362 · Cited by 865 · see citing works
Self-citationBulun, S. E., Yilmaz, B. D., Sison, C., Miyazaki, K., Bernardi, L., Liu, S., Kohlmeier, A., Yin, P., Milad, M., & Wei, J. (2019) · Endocrine Reviews · doi:10.1210/er.2018-00242 · Cited by 844 · see citing works
Epigenetic reprogramming in cancer
Suvà, M. L., Riggi, N., & Bernstein, B. E. (2013) · Science · doi:10.1126/science.1230184 · Cited by 706 · see citing works
Cancer-associated mutations in endometriosis without cancer
Anglesio, M. S., Papadopoulos, N., Ayhan, A., Nazeran, T. M., Noë, M., Horlings, H. M., Lum, A., Jones, S., Senz, J., Seckin, T., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1614814 · Cited by 628 · see citing works
Self-citationdeFuse: An Algorithm for Gene Fusion Discovery in Tumor RNA-Seq Data
McPherson, A., Hormozdiari, F., Zayed, A., Giuliany, R., Ha, G., Sun, M. G. F., Griffith, M., Heravi Moussavi, A., Senz, J., Melnyk, N., et al. (2011) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1001138 · Cited by 557 · see citing works
Self-citationFrom neural development to cognition: unexpected roles for chromatin
Ronan, J. L., Wu, W., & Crabtree, G. R. (2013) · Nature Reviews Genetics · doi:10.1038/nrg3413 · Cited by 544 · see citing works
Suda, K., Nakaoka, H., Yoshihara, K., Ishiguro, T., Tamura, R., Mori, Y., Yamawaki, K., Adachi, S., Takahashi, T., Kase, H., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.07.037 · Cited by 414 · see citing works
Hoffman, G. R., Rahal, R., Buxton, F., Xiang, K., McAllister, G., Frias, E., Bagdasarian, L., Huber, J., Lindeman, A., Chen, D., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1316793111 · Cited by 421 · see citing works
Thompson, L. H. (2012) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2012.06.002 · Cited by 357 · see citing works
Marked for death: Targeting epigenetic changes in cancer
Pfister, S. X., & Ashworth, A. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.256 · Cited by 288 · see citing works
Vangamudi, B., Paul, T. A., Shah, P. K., Kost-Alimova, M., Nottebaum, L., Shi, X., Zhan, Y., Leo, E., Mahadeshwar, H. S., Protopopov, A., et al. (2015) · Cancer Research · doi:10.1158/0008-5472.can-14-3798 · Cited by 281 · see citing works
Rahmioglu, N., Fassbender, A., Vitonis, A. F., Tworoger, S. S., Hummelshoj, L., D'Hooghe, T. M., Adamson, G. D., Giudice, L. C., Becker, C. M., Zondervan, K. T., et al. (2014) · Fertility and Sterility · doi:10.1016/j.fertnstert.2014.07.1208 · Cited by 227 · see citing works
Coffin-Siris Syndrome and the BAF Complex: Genotype-Phenotype Study in 63 Patients
Santen, G. W. E., Aten, E., Vulto-van Silfhout, A. T., Pottinger, C., van Bon, B. W. M., van Minderhout, I. J. H. M., Snowdowne, R., van der Lans, C. A. C., Boogaard, M., Linssen, M. M. L., et al. (2013) · Human Mutation · doi:10.1002/humu.22394 · Cited by 221 · see citing works
Plasma MicroRNAs as Novel Biomarkers for Endometriosis and Endometriosis-Associated Ovarian Cancer
Suryawanshi, S., Vlad, A. M., Lin, H.-M., Mantia-Smaldone, G., Laskey, R., Lee, M., Lin, Y., Donnellan, N., Klein-Patel, M., Lee, T., et al. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-2726 · Cited by 197 · see citing works
von Figura, G., Fukuda, A., Roy, N., Liku, M. E., Morris IV, J. P., Kim, G. E., Russ, H. A., Firpo, M. A., Mulvihill, S. J., Dawson, D. W., et al. (2014) · Nature Cell Biology · doi:10.1038/ncb2916 · Cited by 190 · see citing works
Endometriosis: where are we and where are we going?
Greene, A. D., Lang, S. A., Kendziorski, J. A., Sroga-Rios, J. M., Herzog, T. J., & Burns, K. A. (2016) · Reproduction · doi:10.1530/rep-16-0052 · Cited by 187 · see citing works
Yamamoto, S., Tsuda, H., Takano, M., Iwaya, K., Tamai, S., & Matsubara, O. (2011) · The Journal of Pathology · doi:10.1002/path.2940 · Cited by 152 · see citing works
Genome profiling of pancreatic adenocarcinoma
Birnbaum, D. J., Adélaïde, J., Mamessier, E., Finetti, P., Lagarde, A., Monges, G., Viret, F., Gonçalvès, A., Turrini, O., Delpero, J., et al. (2011) · Genes, Chromosomes and Cancer · doi:10.1002/gcc.20870 · Cited by 122 · see citing works
Endometriosis-associated Malignancy
Krawczyk, N., Banys-Paluchowski, M., Schmidt, D., Ulrich, U., & Fehm, T. (2016) · Geburtshilfe und Frauenheilkunde · doi:10.1055/s-0035-1558239 · Cited by 107 · see citing works
Dawson, A., Llauradó Fernandez, M., Anglesio, M., Yong, P. J., & Carey, M. S. (2018) · ecancermedicalscience · doi:10.3332/ecancer.2018.803 · Cited by 106 · see citing works
Self-citationIatrogenic endometriosis harbors somatic cancer-driver mutations
Lac, V, Verhoef, L., Aguirre-Hernandez, R., Nazeran, T. M., Tessier-Cloutier, B., Praetorius, T., Orr, N. L., Noga, H., Lum, A., Khattra, J., et al. (2019) · Human Reproduction · doi:10.1093/humrep/dey332 · Cited by 99 · see citing works
Self-citationCancer-associated mutations in endometriosis: shedding light on the pathogenesis and pathophysiology
Guo, S.-W. (2020) · Human Reproduction Update · doi:10.1093/humupd/dmz047 · Cited by 96 · see citing works
Treating ARID1A mutated cancers by harnessing synthetic lethality and DNA damage response
Mandal, J., Mandal, P., Wang, T.-L., & Shih, I.-M. (2022) · Journal of Biomedical Science · doi:10.1186/s12929-022-00856-5 · Cited by 84 · see citing works
Self-citationSen, M., Wang, X., Hamdan, F. H., Rapp, J., Eggert, J., Kosinsky, R. L., Wegwitz, F., Kutschat, A. P., Younesi, F. S., Gaedcke, J., et al. (2019) · Clinical Epigenetics · doi:10.1186/s13148-019-0690-5 · Cited by 61 · see citing works
The Link Between Endometriosis and Ovarian Cancer
Nezhat, F. R., Pejovic, T., Reis, F. M., & Guo, S.-W. (2014) · International Journal of Gynecological Cancer · doi:10.1097/igc.0000000000000100 · Cited by 58 · see citing works
The Endometriotic Tumor Microenvironment in Ovarian Cancer
Wendel, J. R. H., Wang, X., & Hawkins, S. M. (2018) · Cancers · doi:10.3390/cancers10080261 · Cited by 51 · see citing works
Praetorius, T. H., Leonova, A., Lac, V., Senz, J., Tessier-Cloutier, B., Nazeran, T. M., Köbel, M., Grube, M., Kraemer, B., Yong, P. J., et al. (2022) · Fertility and Sterility · doi:10.1016/j.fertnstert.2022.05.030 · Cited by 43 · see citing works
Self-citationJohnson, R. M., Qu, X., Lin, C.-F., Huw, L.-Y., Venkatanarayan, A., Sokol, E., Ou, F.-S., Ihuegbu, N., Zill, O. A., Kabbarah, O., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-33172-5 · Cited by 42 · see citing works
Li, Q., Sun, Y., Zhang, X., Wang, L., Wu, W., Wu, M., Meng, C., & Liu, G. (2019) · Cancer Biology & Therapy · doi:10.1080/15384047.2019.1595278 · Cited by 30 · see citing works
Structure of the yeast Swi/Snf complex in a nucleosome free state
Wang, C., Guo, Z., Zhan, X., Yang, F., Wu, M., & Zhang, X. (2020) · Nature Communications · doi:10.1038/s41467-020-17229-x · Cited by 25 · see citing works
Funingana, I.-G., Reinius, M. A. V., Petrillo, A., Ang, J. E., & Brenton, J. D. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.02.008 · Cited by 23 · see citing works
Integrated genomic analyses of ovarian carcinoma
The Cancer Genome Atlas Research Network (2011) · Nature · doi:10.1038/nature10166 · Cited by 129 · see citing works
Role of SWI/SNF chromatin remodeling genes in lung cancer development
Monterde, B., & Varela, I. (2022) · Biochemical Society Transactions · doi:10.1042/bst20211084 · Cited by 13 · see citing works
Malignancies Associated with Extraovarian Endometriosis: A Literature Review
Inoue, N., Hirakawa, T., Mitsushita, J., Kitahara, Y., & Iwase, A. (2021) · Endocrines · doi:10.3390/endocrines2030024 · Cited by 7 · see citing works
- Authors
- Wiegand, K. C., Shah, S. P., Al-Agha, O. M., Zhao, Y., Tse, K., Zeng, T., Senz, J., McConechy, M. K., Anglesio, M. S., Kalloger, S. E., Yang, W., Heravi-Moussavi, A., Giuliany, R., Chow, C., Fee, J., Zayed, A., Prentice, L., Melnyk, N., Turashvili, G., Delaney, A. D., Madore, J., Yip, S., McPherson, A. W., Ha, G., Bell, L., Fereday, S., Tam, A., Galletta, L., Tonin, P. N., Provencher, D., Miller, D., Jones, S. J. M., Moore, R. A., Morin, G. B., Oloumi, A., Boyd, N., Aparicio, S. A., Shih, I.-M., Mes-Masson, A.-M., Bowtell, D. D., Hirst, M., Gilks, B., Marra, M. A., & Huntsman, D. G.
- Affiliations
- BC Cancer Agency (CA)
- Hôpital Notre-Dame (CA)
- Peter MacCallum Cancer Centre (AU)
- Research Institute of the McGill University Health Centre (CA)
- University of British Columbia (CA)
- Johns Hopkins University (US)
- The University of Melbourne (AU)
- ORCID
- Shah, Sohrab P.
- Zhao, Yongjun
- Senz, Janine
- McConechy, Melissa K.
- Anglesio, Michael S.
- Kalloger, Steve E.
- Yang, Winnie
- Chow, Christine
- Prentice, Leah
- Turashvili, Gulisa
- Madore, Jason
- Yip, Stephen
- McPherson, Andrew W.
- Ha, Gavin
- Tam, Angela
- Tonin, Patricia N.
- Provencher, Diane
- Miller, Dianne
- Jones, Steven J.M.
- Moore, Richard A.
- Morin, Gregg B.
- Boyd, Niki
- Aparicio, Samuel A.
- Shih, Ie-Ming
- Bowtell, David D.
- Hirst, Martin
- Marra, Marco A.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2010-10-14
- Volume
- 363
- Issue
- 16
- Pages
- 1532-1543
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- PMC
- PMC2976679
- OpenAlex
- W2034852369
- Cited by
- 1,712
- References
- 35
- Citations by year
- 2026: 73 · 2025: 74 · 2024: 84 · 2023: 109 · 2022: 79 · 2021: 106 · 2020: 118 · 2019: 105 · 2018: 106 · 2017: 111 · 2016: 103 · 2015: 137 · 2014: 122 · 2013: 143 · 2012: 131
- FWCI
- 49.54
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Sanofi
- Genome Canada
- Canada's Michael Smith Genome Sciences Centre
- Ovarian Cancer Canada
- Michael Smith Health Research BC
- University of British Columbia
- National Institutes of Health (RO1CA129080)
- Canadian Institutes of Health Research (STP53912)
- Medical Research Council
- National Health and Medical Research Council
- Cancer Council Tasmania
- National Cancer Institute (R01CA103937, RO1CA129080, RO1CA103937, R01CA129080)
- Medical Research and Materiel Command (DAMD17-O1-1-0729)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Health Sciences › Medicine › Reproductive Medicine › Ovarian cancer diagnosis and treatment
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Keywords
- ARID1A mutation, endometriosis-associated ovarian cancer, ovarian clear cell carcinoma, endometrioid carcinoma, ARID1A, SWI/SNF complex, tumor suppressor, somatic mutations, precancerous lesions, transcriptome sequencing
- MeSH terms
- DNA-Binding Proteins, Endometriosis, Female, Humans, Mutation, Nuclear Proteins, Ovarian Neoplasms, Transcription Factors, Gene Expression, Genes, Tumor Suppressor, Sequence Analysis, RNA, Adenocarcinoma, Clear Cell, Carcinoma, Endometrioid, Gene Expression Profiling, Cell Line, Tumor
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
