The DOI matches its Crossref record; 34 of the 35 references it cites were found in a registry or an index.
Effect of Aspirin on Disability-free Survival in the Healthy Elderly
Open accessAbstract
BACKGROUND: Information on the use of aspirin to increase healthy independent life span in older persons is limited. Whether 5 years of daily low-dose aspirin therapy would extend disability-free life in healthy seniors is unclear. METHODS: From 2010 through 2014, we enrolled community-dwelling persons in Australia and the United States who were 70 years of age or older (or ≥65 years of age among blacks and Hispanics in the United States) and did not have cardiovascular disease, dementia, or physical disability. Participants were randomly assigned to receive 100 mg per day of enteric-coated aspirin or placebo orally. The primary end point was a composite of death, dementia, or persistent physical disability. Secondary end points reported in this article included the individual components of the primary end point and major hemorrhage. RESULTS: A total of 19,114 persons with a median age of 74 years were enrolled, of whom 9525 were randomly assigned to receive aspirin and 9589 to receive placebo. A total of 56.4% of the participants were women, 8.7% were nonwhite, and 11.0% reported previous regular aspirin use. The trial was terminated at a median of 4.7 years of follow-up after a determination was made that there would be no benefit with continued aspirin use with regard to the primary end point. The rate of the composite of death, dementia, or persistent physical disability was 21.5 events per 1000 person-years in the aspirin group and 21.2 per 1000 person-years in the placebo group (hazard ratio, 1.01; 95% confidence interval [CI], 0.92 to 1.11; P=0.79). The rate of adherence to the assigned intervention was 62.1% in the aspirin group and 64.1% in the placebo group in the final year of trial participation. Differences between the aspirin group and the placebo group were not substantial with regard to the secondary individual end points of death from any cause (12.7 events per 1000 person-years in the aspirin group and 11.1 events per 1000 person-years in the placebo group), dementia, or persistent physical disability. The rate of major hemorrhage was higher in the aspirin group than in the placebo group (3.8% vs. 2.8%; hazard ratio, 1.38; 95% CI, 1.18 to 1.62; P<0.001). CONCLUSIONS: Aspirin use in healthy elderly persons did not prolong disability-free survival over a period of 5 years but led to a higher rate of major hemorrhage than placebo. (Funded by the National Institute on Aging and others; ASPREE ClinicalTrials.gov number, NCT01038583 .).
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“One RCT found 100 mg aspirin versus placebo in 19 114 healthy adults older than 65 years did not reduce dementia (HR 1·0, 95% CI 0·8–1·2), death, physical disability, or cardiovascular disease over a period of 4·7 years.”
From Dementia prevention, intervention, and care: 2020 report of the Lancet Commission (2020) · cites this paper as [87]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Zhang, Q., Wang, C., Zheng, M., Li, Y., Li, J., Zhang, L., Shang, X., & Yan, C. (2014) · Cerebrovascular Diseases · doi:10.1159/000369778 · Cited by 11,609
Collaboration, A. T. (2002) · BMJ · doi:10.1136/bmj.324.7329.71 · Cited by 6,943
Hansson, L., Zanchetti, A., Carruthers, S. G., Dahlöf, B., Elmfeldt, D., Julius, S., Ménard, J., Rahn, K. H., Wedel, H., & Westerling, S. (1998) · The Lancet · doi:10.1016/s0140-6736(98)04311-6 · Cited by 5,728
Katz, S. (1983) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1983.tb03391.x · Cited by 2,734
(1987) · PubMed · Cited by 2,657
Final Report on the Aspirin Component of the Ongoing Physicians' Health Study
Steering Committee of the Physicians' Health Study Research Group (1989) · New England Journal of Medicine · doi:10.1056/nejm198907203210301 · Cited by 2,267
A Randomized Trial of Low-Dose Aspirin in the Primary Prevention of Cardiovascular Disease in Women
Ridker, P. M., Cook, N. R., Lee, I.-M., Gordon, D., Gaziano, J. M., Manson, J. E., Hennekens, C. H., & Buring, J. E. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa050613 · Cited by 1,945
Randomised trial of prophylactic daily aspirin in British male doctors
Peto, R., Gray, R. G., Collins, R., Wheatley, K., Hennekens, C. H., Jamrozik, K. D., Warlow, C., Hafner, B., Thompson, E., Norton, S., et al. (1988) · BMJ · doi:10.1136/bmj.296.6618.313 · Cited by 1,164
Carnethon, M. R., Pu, J., Howard, G., Albert, M. A., Anderson, C. A. M., Bertoni, A. G., Mujahid, M. S., Palaniappan, L., Taylor, H. A., Willis, M., et al. (2017) · Circulation · doi:10.1161/cir.0000000000000534 · Cited by 1,147
Flagged first, then by citations
1 of the 35 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- Whitlock EP Williams SB Burda BU Feightner A Beil T. Aspirin use in adults: cancer all-cause mortality and harms: a systematic evidence review for the U.S. Preventive Services Task Force. Evidence syntheses no. 132. Rockville MD: Agency for Healthcare Research and Quality 2015 (https://www.ncbi.nlm.nih.gov/books/NBK321643/).
- Diagnostic and statistical manual of mental disorders, 4th ed.: DSM IV. Washington, DC: American Psychiatric Association, 1994.
Cited by
Sorted by citations
Items 201–300 of 590
GFR Variability, Survival, and Cardiovascular Events in Older Adults
Fravel, M. A., Ernst, M. E., Webb, K. L., Wetmore, J. B., Wolfe, R. S., Woods, R. L., Reid, C. M., Chowdhury, E., Murray, A. M., & Polkinghorne, K. R. (2022) · Kidney Medicine · doi:10.1016/j.xkme.2022.100583 · Cited by 12
Self-citationLow-Dose Aspirin and Progression of Age-Related Hearing Loss
Clark, D. P., Zhou, Z., Hussain, S. M., Tran, C., Britt, C. J., Storey, E., Lowthian, J. A., Shah, R. C., Dillon, H., Wolfe, R. S., et al. (2024) · JAMA Network Open · doi:10.1001/jamanetworkopen.2024.24373 · Cited by 12
Self-citationAssociations Between MASLD, Ultra-Processed Food and a Mediterranean Dietary Pattern in Older Adults
Commins, I., Clayton‐Chubb, D., Fitzpatrick, J. A., George, E. S., Schneider, H. G., Phyo, A. Z. Z., Majeed, A., Janko, N., Vaughan, N. V., Woods, R. L., et al. (2025) · Nutrients · doi:10.3390/nu17091415 · Cited by 14
Self-citationPrevalence and disease predisposition of p.A91V perforin in an aged population of European ancestry
Voskoboinik, I., Lacaze, P. A., Jang, H. S., Flinsenberg, T. W. H., Fernando, S. L., Kerridge, I., Riaz, M., Sebra, R., Thia, K. Y. T., Noori, T., et al. (2020) · Blood · doi:10.1182/blood.2019003487 · Cited by 13
Self-citationCancer history and risk factors in healthy older people enrolling in the ASPREE clinical trial
Orchard, S. G., Lockery, J. E., Gibbs, P., Polekhina, G., Wolfe, R. S., Zalcberg, J. R., Haydon, A. M., McNeil, J. J., Nelson, M. R., Reid, C. M., et al. (2020) · Contemporary Clinical Trials · doi:10.1016/j.cct.2020.106095 · Cited by 12
Self-citationAspirin for primary prevention: Is this the end of the road?
Singal, A. K., & Karthikeyan, G. (2019) · Indian Heart Journal · doi:10.1016/j.ihj.2019.04.001 · Cited by 13
Aspirin Efficacy in Primary Prevention: A Meta-analysis of Randomized Controlled Trials
Barbarawi, M., Kheiri, B., Zayed, Y., Gakhal, I., Al‐Abdouh, A., Barbarawi, O., Rashdan, L., Rizk, F., Bachuwa, G. I., & Alkotob, M. L. (2019) · High Blood Pressure & Cardiovascular Prevention · doi:10.1007/s40292-019-00325-5 · Cited by 12
Xie, W., Luo, Y., Liang, X., Lin, Z., Wang, Z., & Liu, M. (2019) · Therapeutics and Clinical Risk Management · doi:10.2147/tcrm.s198403 · Cited by 12
A comparison of contemporary versus older studies of aspirin for primary prevention
Moriarty, F., & Ebell, M. H. (2019) · Family Practice · doi:10.1093/fampra/cmz080 · Cited by 12
Gilmartin‐Thomas, J., Cicuttini, F., Owen, A. J., Wolfe, R. S., Ernst, M. E., Nelson, M. R., Lockery, J. E., Woods, R. L., Britt, C. J., Liew, D., et al. (2020) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2020.104231 · Cited by 12
Self-citationKhan, S. U., Lone, A. N., Kleiman, N. S., Arshad, A., Jain, V., Rifai, M. A., Arshad, H. B., Dani, S. S., Khera, A., Morris, P. B., et al. (2023) · JACC Advances · doi:10.1016/j.jacadv.2022.100197 · Cited by 15
Aspirin for Primary Prevention
Gaziano, J. M. (2019) · JAMA · doi:10.1001/jama.2018.20577 · Cited by 13
Davoodian, N., Forbes, M., Berk, M., Clayton‐Chubb, D., Huxley, R., Lee, C., Lotfaliany, M., McNeil, J. J., Pasco, J. A., Polkinghorne, K. R., et al. (2025) · EClinicalMedicine · doi:10.1016/j.eclinm.2025.103182 · Cited by 11
Self-citationLoss of Y Chromosome and Major Cardiovascular Events in a Prospective Study of Older Men
Hussain, M., Bjurling, J., Yu, C., Tonkin, A. M., Reid, C. M., Tran, C., Fransquet, P., Halvardson, J., Curtis, D. J., McQuilten, Z., et al. (2026) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2025.10.069 · Cited by 11
Self-citationLong-term blood pressure variability and frailty risk in older adults
Fravel, M. A., Ernst, M. E., Woods, R. L., Beilin, L. J., Zhou, Z., Orchard, S. G., Chowdhury, E., Reid, C. M., Ekram, A. S., Espinoza, S. E., et al. (2023) · Journal of Hypertension · doi:10.1097/hjh.0000000000003599 · Cited by 11
Self-citationSymptoms of depression and risk of emergency department visits among people aged 70 years and over
Dwyer, R., Jachno, K., Tran, T. D., Owen, A. J., Layton, N. A., Collyer, T. A., Kirkman, M., Lowthian, J. A., Hammarberg, K., McNeil, J. J., et al. (2024) · BMC Public Health · doi:10.1186/s12889-024-17794-6 · Cited by 11
Self-citationNational Asthma Education and Prevention Program 2020 Guidelines: What’s Important for Primary Care
Murphy, M. (2021) · The Journal of Family Practice · doi:10.12788/jfp.0219 · Cited by 14
Bell, S. P., & Rich, M. W. (2021) · Springer eBooks · doi:10.1007/978-3-030-76271-1_19 · Cited by 11
Yan, M. K., Orchard, S. G., Adler, N. R., Wolfe, R., McLean, C., Rodriguez, L. M., Woods, R. L., Gibbs, P., Chan, A. T., Haydon, A., et al. (2022) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-21-0244 · Cited by 11
Self-citationCraig, H., Gašević, D., Ryan, J. L., Owen, A. J., McNeil, J. J., Woods, R. L., Britt, C. J., Ward, S. A., & Freak‐Poli, R. (2023) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20043259 · Cited by 14
Self-citationZhang, K., Yang, W., Zhang, M., Sun, Y., Zhang, T., Liu, J., & Zhang, J. (2019) · Cardiology Journal · doi:10.5603/cj.a2019.0051 · Cited by 11
Chemoprevention: A new concept for cancer prevention in primary care
Emery, J. D., Nguyen, P., Minshall, J., Cummings, K.-L., & Walker, J. (2018) · Australian Journal of General Practice · doi:10.31128/ajgp-07-18-4644 · Cited by 11
Aspirin for primary prevention of atherosclerotic cardiovascular events
Schenone, A. L., & Lincoff, A. M. (2020) · Cleveland Clinic Journal of Medicine · doi:10.3949/ccjm.87a.19045 · Cited by 11
Bakshi, A., Cao, Y., Orchard, S. G., Carr, P. R., Joshi, A. D., Manning, A. K., Buchanan, D. D., Umar, A., Winship, I., Gibbs, P., et al. (2022) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-22-0011 · Cited by 12
Self-citationUpper Gastrointestinal Bleeding
Costable, N. J., & Greenwald, D. A. (2021) · Springer eBooks · doi:10.1007/978-3-030-30192-7_47 · Cited by 11
Severe low back or lower limb pain is associated with recurrent falls among older Australians
Tse, A. W. W., Ward, S. A., McNeil, J. J., Barker, A. L., Cicuttini, F., Fitzgibbon, B. M., Hussain, S. M., Owen, A. J., Wang, Y., Wolfe, R. S., et al. (2022) · European Journal of Pain · doi:10.1002/ejp.2013 · Cited by 11
Self-citationBranzoli, S., Guarracini, F., Marini, M., D’Onghia, G., Catanzariti, D., Merola, E., Annicchiarico, L., Casagranda, G., Stegagno, C., Fantinel, M., et al. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11216492 · Cited by 10
Effect of Low-Dose Aspirin on the Course of Age-Related Macular Degeneration
Robman, L. D., Wolfe, R. S., Woods, R. L., Thảo, L. T. P., Makeyeva, G. A., Hodgson, L., Le-Pham, Y.-A., Jachno, K., Phung, J., Maguire, E., et al. (2024) · JAMA Ophthalmology · doi:10.1001/jamaophthalmol.2024.1584 · Cited by 10
Self-citationDeprescribing Cardiovascular Medications in Older Adults Living with Frailty
Ho, K., Mallery, L. H., Trenaman, S. C., Searle, S. D., & Bata, I. R. (2024) · CJC Open · doi:10.1016/j.cjco.2024.09.008 · Cited by 13
Long-Term Aspirin Use and Self-Reported Walking Speed in Older Men: The Physicians' Health Study
Orkaby, A. R., Dufour, A. B., Yang, L., Sesso, H. D., Gaziano, J. M., Djoussé, L., Driver, J. A., & Travison, T. G. (2021) · The Journal of Frailty & Aging · doi:10.14283/jfa.2021.36 · Cited by 10
Roth, L., Rombouts, M., Schrijvers, D. M., Veseli, B. E., Martinet, W., & Meyer, G. R. Y. D. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010404 · Cited by 11
The Relationship between Long-Term Blood Pressure Variability and Cortical Thickness in Older Adults
Gutteridge, D. S., Segal, A., McNeil, J. J., Beilin, L. J., Brodtmann, A. G., Chowdhury, E., Egan, G. F., Ernst, M. E., Hussain, S. M., Reid, C. M., et al. (2023) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2023.05.011 · Cited by 10
Self-citationAspirin and the metabolic hallmark of cancer: novel therapeutic opportunities for colorectal cancer
Hoskin, A. J., Holt, A. K., Legge, D., Collard, T. J., Williams, A. C., & Vincent, E. E. (2023) · Exploration of Targeted Anti-tumor Therapy · doi:10.37349/etat.2023.00155 · Cited by 10
Medication Use Quality and Safety in Older Adults: 2018 Update
Ailabouni, N. J., Marcum, Z. A., Schmader, K. E., & Gray, S. L. (2019) · Journal of the American Geriatrics Society · doi:10.1111/jgs.16243 · Cited by 11
Milton, S., McIntosh, J., Macrae, F., Chondros, P., Trevena, L., Jenkins, M., Walter, F., Taylor, N., Boyd, L., Saya, S., et al. (2021) · Trials · doi:10.1186/s13063-021-05365-8 · Cited by 8
Heart Team for Left Atrial Appendage Occlusion: A Patient-Tailored Approach
Branzoli, S., Guarracini, F., Marini, M., D’Onghia, G., Penzo, D., Piffer, S., Peterlana, D., Graffigna, A., Gulizia, M. M., Gelsomino, S., et al. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm11010176 · Cited by 10
Aspirin for Primary Stroke Prevention; Evidence for a Differential Effect in Men and Women
Gdovinová, Z., Kremer, C., Lorenzano, S., Dawson, J., Lal, A., & Caso, V. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.856239 · Cited by 13
Aspirin Interacts with Cholesterol-Containing Membranes in a pH-Dependent Manner
Krmic, M., Perez, E., Scollan, P., Ivanchenko, K., Hernandez, A. G., Giancaspro, J., Rosario, J., Ceja-Vega, J., Gudyka, J., Porteus, R., et al. (2023) · Langmuir · doi:10.1021/acs.langmuir.3c02242 · Cited by 9
Age-Related Hearing Loss: A Cross-Sectional Study of Healthy Older Australians
Britt, C. J., Storey, E., Woods, R. L., Stocks, N. P., Nelson, M. R., Murray, A. M., Ryan, J. L., Rance, G., McNeil, J. J., & the ASPREE Investigators (2024) · Gerontology · doi:10.1159/000541895 · Cited by 12
Self-citationPlayford, D. A., Hamilton-Craig, C. R., Dwivedi, G., & Figtree, G. A. (2021) · Heart Lung and Circulation · doi:10.1016/j.hlc.2021.04.026 · Cited by 9
Ball, J., Neumann, F., Tonkin, A. M., Kirchhof, P. F., Freedman, B., Brodtmann, A. G., Reid, C. M., Nelson, M. R., Beilin, L. J., Fitzgerald, S. M., et al. (2023) · European Heart Journal - Cardiovascular Pharmacotherapy · doi:10.1093/ehjcvp/pvad082 · Cited by 9
Self-citationCoronary and Extra-coronary Subclinical Atherosclerosis to Guide Lipid-Lowering Therapy
Grant, J. K., & Orringer, C. E. (2023) · Current Atherosclerosis Reports · doi:10.1007/s11883-023-01161-8 · Cited by 9
Zhao, Y., Jeyaraman, K., Burgess, P., Connors, C. M., Guthridge, S. L., Maple-Brown, L. J., & Falhammar, H. (2020) · BMJ Open · doi:10.1136/bmjopen-2019-030034 · Cited by 10
Cainzos‐Achirica, M., Anugula, D., Mszar, R., Grandhi, G. R., Patel, K. V., Bittencourt, M. S., Blankstein, R., Blaha, M. J., Blumenthal, R. S., Ray, K. K., et al. (2021) · American Heart Journal · doi:10.1016/j.ahj.2021.09.006 · Cited by 8
Calderone, D., Ingala, S., Mauro, M. S., Angiolillo, D. J., & Capodanno, D. (2021) · Expert Review of Cardiovascular Therapy · doi:10.1080/14779072.2021.2020100 · Cited by 9
Muhandiramge, J., Warner, E. T., Zalcberg, J. R., Haydon, A. M., Polekhina, G., Londen, G. J. V., Gibbs, P., Bernstein, W. B., Tie, J., Millar, J. L., et al. (2023) · Cancers · doi:10.3390/cancers15041017 · Cited by 10
Self-citationLi, X., Shi, Z., Zhao, D., & Yin, D. (2020) · Chinese Medical Journal · doi:10.1097/cm9.0000000000000762 · Cited by 9
The ASPREE Trial: An Unanticipated Stimulus for Greater Precision in Prevention?
Hawk, E. T., & Maresso, K. C. (2020) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djaa115 · Cited by 10
Hu, Y., Carr, P. R., Liew, D., Broder, J. C., Callander, E. J., & McNeil, J. J. (2022) · BMC Health Services Research · doi:10.1186/s12913-022-08017-y · Cited by 8
Self-citationThe Spectrum of Cerebral Small Vessel Disease
Muir, R. T., & Smith, E. E. (2024) · Neurologic Clinics · doi:10.1016/j.ncl.2024.03.003 · Cited by 8
Short- and long-term impact of aspirin cessation in older adults: a target trial emulation
Zhou, Z., Webb, K. L., Nelson, M. R., Woods, R. L., Ernst, M. E., Murray, A. M., Chan, A. T., Tonkin, A. M., Reid, C. M., Orchard, S. G., et al. (2024) · BMC Medicine · doi:10.1186/s12916-024-03507-8 · Cited by 9
Self-citationSteatotic Liver Disease in Older Adults: Clinical Implications and Unmet Needs
Clayton‐Chubb, D., Kemp, W. W., Majeed, A., Lange, P. W., Fitzpatrick, J. A., Vaz, K., Lubel, J. S., Hodge, A. D., Ryan, J. L., McNeil, J. J., et al. (2025) · Nutrients · doi:10.3390/nu17132189 · Cited by 12
Self-citationSciahbasi, A., Minardi, S., Salvi, N., Infusino, F., & Granatelli, A. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14207340 · Cited by 8
Zhou, A., Britt, C. J., Woods, R. L., Orchard, S. G., Murray, A. M., Shah, R. C., Rajan, R., McNeil, J. J., Chong, T. T. ‐., Storey, E., et al. (2023) · Journal of Alzheimer s Disease Reports · doi:10.3233/adr-230089 · Cited by 8
Self-citationCardiovascular Health and Healthy Aging
Reynolds, I. J., Page, R. L., II, & Boxer, R. S. (2019) · Springer eBooks · doi:10.1007/978-3-030-06200-2_5 · Cited by 10
Role of Aspirin for Primary Prevention in Persons with Diabetes Mellitus and in the Elderly
Patel, N., & Baliga, R. R. (2020) · Current Cardiology Reports · doi:10.1007/s11886-020-01296-z · Cited by 7
Antihypertensive medication use and blood pressure control among treated older adults
Ernst, M. E., Chowdhury, E., Nelson, M. R., Reid, C. M., Margolis, K. L., Beilin, L. J., Stocks, N. P., Murray, A. M., Wolfe, R. S., Lockery, J. E., et al. (2020) · Journal of Clinical Hypertension · doi:10.1111/jch.13934 · Cited by 7
Self-citationZhou, B., Wang, Q., Zhao, Z., & Feng, X. (2020) · Therapeutic Innovation & Regulatory Science · doi:10.1007/s43441-020-00156-w · Cited by 9
Gilmartin‐Thomas, J., Ernst, M. E., Nelson, M. R., Lockery, J. E., Ward, S. A., Woods, R. L., Britt, C. J., Murray, A. M., Workman, B., McNeil, J. J., et al. (2020) · Journal of Aging and Health · doi:10.1177/0898264320952914 · Cited by 8
Self-citationCorrelates of Meal Skipping in Community Dwelling Older Adults: A Cross-Sectional Study
Wild, H., Gašević, D., Woods, R. L., Ryan, J. L., Berk, M., Wolfe, R. S., McNeil, J. J., & Owen, A. J. (2023) · The journal of nutrition health & aging · doi:10.1007/s12603-023-1884-2 · Cited by 8
Self-citationAspirin for primary prevention of cardiovascular disease: What do the current USPSTF guidelines say?
Mallick, S., Shroff, G. R., & Linzer, M. (2023) · Cleveland Clinic Journal of Medicine · doi:10.3949/ccjm.90a.22087 · Cited by 8
Compliance-Adjusted Estimates of Aspirin Effects Among Older Persons in the ASPREE Randomized Trial
Smith, C. L., Kasza, J., Woods, R. L., Lockery, J. E., Kirpach, B., Reid, C. M., Storey, E., Nelson, M. R., Shah, R. C., Orchard, S. G., et al. (2023) · American Journal of Epidemiology · doi:10.1093/aje/kwad168 · Cited by 8
Self-citationCaterina, R. D., Aimo, A., & Ridker, P. M. (2019) · Thrombosis and Haemostasis · doi:10.1055/s-0039-3400294 · Cited by 8
Fras, Z., Sahebkar, A., & Banach, M. (2020) · American Journal of Cardiovascular Drugs · doi:10.1007/s40256-020-00424-y · Cited by 9
Genomic Risk Prediction for Breast Cancer in Older Women
Lacaze, P. A., Bakshi, A., Riaz, M., Orchard, S. G., Tiller, J. M., Neumann, F., Carr, P. R., Joshi, A. D., Cao, Y., Warner, E. T., et al. (2021) · Cancers · doi:10.3390/cancers13143533 · Cited by 8
Self-citationPatrono, C. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813456-6.00050-3 · Cited by 10
Antiplatelet and Anticoagulant Therapy in Regenerative Medicine
Manchikanti, L., Sanapati, M. R., Kaye, A. D., & Kaye, A. M. (2024) · Springer eBooks · doi:10.1007/978-3-031-50357-3_15 · Cited by 7
Scores to predict steatotic liver disease – correlates and outcomes in older adults
Clayton‐Chubb, D., Commins, I., Roberts, S. K., Majeed, A., Woods, R. L., Ryan, J. L., Schneider, H. G., Lubel, J. S., Hodge, A. D., McNeil, J. J., et al. (2025) · npj gut and liver. · doi:10.1038/s44355-025-00021-3 · Cited by 7
Self-citationForbes, M., Mohebbi, M., Woods, R. L., Lotfaliany, M., Reynolds, C. F., O'Neil, A. E., McNeil, J. J., & Berk, M. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.05.014 · Cited by 7
Self-citationLow-Dose Aspirin for Individualized Cancer Prevention in Older Adults
Thảo, L. T. P., Nguyen, T., Singh, J., Byars, S., Bick, A. G., Ford, L. G., Gibbs, P., McNeil, J. J., Murray, A. M., Orchard, S. G., et al. (2025) · JAMA Oncology · doi:10.1001/jamaoncol.2025.3593 · Cited by 7
Self-citationClonal Hematopoiesis and Cardiovascular Disease and Bleeding Risk and the Effectiveness of Aspirin
McQuilten, Z., Thảo, L. T. P., Bick, A. G., Byars, S., Chan, A. T., Ford, L., Leichter, A., McNeil, J. J., Murray, A. M., Murphy, A. J., et al. (2025) · JAMA Cardiology · doi:10.1001/jamacardio.2025.3756 · Cited by 8
Self-citationAntiplatelet therapy for coronary artery disease in 2023: current status and future prospects
Chandiramani, R., Spirito, A., Johnson, J. W., Mehta, A., Vogel, B., FAILLACE, R. T., & Mehran, R. (2023) · Expert Review of Cardiovascular Therapy · doi:10.1080/14779072.2023.2201437 · Cited by 8
Aspirin: latest evidence and developments
Nelson, M. R., & Black, J. A. (2024) · Heart · doi:10.1136/heartjnl-2024-323948 · Cited by 7
Self-citationPredictive Model of Internal Bleeding in Elderly Aspirin Users Using XGBoost Machine Learning
Chen, T., Lei, W., & Maofeng, W. (2024) · Risk Management and Healthcare Policy · doi:10.2147/rmhp.s478826 · Cited by 7
Aspirin for Primary Prevention of Cardiovascular Disease
Kim, J. H., Shim, M. J., Lee, S., Oh, J., & Kim, S. H. (2019) · Journal of Lipid and Atherosclerosis · doi:10.12997/jla.2019.8.2.162 · Cited by 8
Tan, J. W. C., Sim, D., Ako, J., Almahmeed, W. A., Cooper, M. E., Dalal, J. J., Deerochanawong, C., Huang, D. W. C., Johar, S., Kaul, U., et al. (2021) · European Cardiology Review · doi:10.15420/ecr.2020.52 · Cited by 8
Primary Prevention of CVD with Aspirin: Benefits vs Risks
Weisman (2021) · The Journal of Family Practice · doi:10.12788/jfp.0222 · Cited by 7
Craig, H., Ryan, J. L., Freak‐Poli, R., Owen, A. J., McNeil, J. J., Woods, R. L., Britt, C. J., Tonkin, A. M., & Gašević, D. (2022) · Journal of Aging and Health · doi:10.1177/08982643221083118 · Cited by 8
Self-citationAspirin for Primary Prevention of Cardiovascular Diseases: “WALTZ” with the Evidence
Dimitriadis, K. S., Lazarou, E., Tsioufis, P., Σουλαϊδόπουλος, Σ., & Tsioufis, K. P. (2022) · Current Cardiology Reports · doi:10.1007/s11886-022-01740-2 · Cited by 11
Marquis‐Gravel, G., Modrow, M. F., Merritt, G., Farrehi, P. M., Zemon, N., Robertson, H. R., Jones, W. S., & Kraschnewski, J. L. (2022) · Clinical Trials · doi:10.1177/17407745221118559 · Cited by 11
Universal health coverage and chronic conditions
Niessen, L. W., & Squire, S. B. (2019) · The Lancet Global Health · doi:10.1016/s2214-109x(19)30366-3 · Cited by 7
Antiplatelet Therapy or Not for Asymptomatic/Incidental Lacunar Infarction
Bilski, A. E., Aparicio, H. J., Gutierrez, J., de Leeuw, F., & Hilkens, N. A. (2023) · Stroke · doi:10.1161/strokeaha.122.040444 · Cited by 6
Antiplatelet therapy for treatment of coronary artery disease in older patients
Fischer, Q., Pham, V., Seret, G., Brami, P., Picard, F. A., & Varenne, O. (2024) · Archives of cardiovascular diseases · doi:10.1016/j.acvd.2024.02.008 · Cited by 8
Ward, S. A., Storey, E., Naughton, M. T., Wolfe, R. S., Hamilton, G. S., Law, M., Kawasaki, R., Abhayaratna, W. P., Webb, K. L., O’Donoghue, F. J., et al. (2024) · SLEEP · doi:10.1093/sleep/zsae204 · Cited by 6
Self-citationYu, C., Bakshi, A., Agustini, B., Walker, A., Lin, T., Lotfaliany, M., Williams, L. J., McNeil, J. J., Wray, N. R., Berk, M., et al. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03145-3 · Cited by 6
Self-citationExamining evidence of time-dependent treatment effects: an illustration using regression methods
Jachno, K., Heritier, S. R., Woods, R. L., Mahady, S. E., Chan, A. T., Tonkin, A. M., Murray, A. M., McNeil, J. J., & Wolfe, R. S. (2022) · Trials · doi:10.1186/s13063-022-06803-x · Cited by 7
Self-citationHussain, S. M., Tonkin, A. M., Watts, G. F., Lacaze, P. A., Yu, C., Beilin, L. J., Zhou, Z., Newman, A. B., Neumann, F., Tran, C., et al. (2023) · GeroScience · doi:10.1007/s11357-023-00904-4 · Cited by 6
Self-citationWild, H., Nurgozhina, M., Gašević, D., Coates, A. M., Woods, R. L., Ryan, J. L., Beilin, L. J., Govindaraju, T., McNeil, J. J., & Owen, A. J. (2024) · Age and Ageing · doi:10.1093/ageing/afae239 · Cited by 8
Self-citationChowdhury, E., Ernst, M. E., Nelson, M. R., Beilin, L. J., Neumann, F., Tonkin, A., Woods, R. L., Stocks, N. P., Lacaze, P. A., Orchard, S. G., et al. (2025) · European Journal of Preventive Cardiology · doi:10.1093/eurjpc/zwaf329 · Cited by 7
Self-citationEgan, R. A., Arnold, A. C., Lee, A. G., & Stavern, G. P. V. (2020) · Journal of Neuro-Ophthalmology · doi:10.1097/wno.0000000000000930 · Cited by 6
Radiation-Induced Cardiotoxicity
Zorn, S. J., Rayan, D., Brown, S.-A. N., & Bergom, C. R. (2021) · Advances in Oncology · doi:10.1016/j.yao.2021.02.001 · Cited by 6
Dispositional Optimism and All-Cause Mortality in Older Adults: A Cohort Study
Craig, H., Ryan, J. L., Freak‐Poli, R., Owen, A. J., McNeil, J. J., Woods, R. L., Ward, S. A., Britt, C. J., & Gašević, D. (2021) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000989 · Cited by 6
Self-citationZakko, A., Zakko, L., Grimshaw, A. A., & Laine, L. (2021) · Digestive Diseases and Sciences · doi:10.1007/s10620-021-07302-w · Cited by 6
Polkinghorne, K. R., Wetmore, J. B., Thảo, L. T. P., Wolfe, R. S., Woods, R. L., Ernst, M. E., Nelson, M. R., Reid, C. M., Shah, R. C., McNeil, J. J., et al. (2022) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2022.02.019 · Cited by 6
Self-citationAntiplatelet Therapy in Coronary Artery Disease: Now and Then
Tscharre, M., & Gremmel, T. (2022) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-0042-1758821 · Cited by 5
Functional outcomes following knee replacement in community-dwelling older adults
Wang, Y., Owen, A. J., Franks, A., Ackerman, I. N., Fitzgerald, S. M., Liew, S. M., Woods, R. L., Wluka, A. E., McNeil, J. J., & Cicuttini, F. (2023) · BMC Geriatrics · doi:10.1186/s12877-023-03925-y · Cited by 6
Self-citationUpadhaya, S., Madala, S., Baniya, R., Saginala, K., & Khan, J. (2018) · European Journal of Preventive Cardiology · doi:10.1177/2047487318816387 · Cited by 7
Polypharmacy and Rational Prescribing: Changing the Culture of Medicine One Patient at a Time
Yoon, S. K., Okyere, B., & Strasser, D. C. (2019) · Current Physical Medicine and Rehabilitation Reports · doi:10.1007/s40141-019-00220-z · Cited by 6
Effects of Colorectal Cancer Risk Factors on the Association Between Aspirin and Colorectal Cancer
Seaton, M. E., Peters, U., Johnson, K., Kooperberg, C. L., Bafford, A. C., & Zubair, N. (2019) · Anticancer Research · doi:10.21873/anticanres.13673 · Cited by 6
Aspirin for the Primary Prevention of Cardiovascular Disease
Cicci, J. D., Iyer, P. S., Clarke, M. M., & Mazzella, A. J. (2019) · Cardiology in Review · doi:10.1097/crd.0000000000000297 · Cited by 5
Metadata
- Authors
- McNeil, J. J., Woods, R. L., Nelson, M. R., Reid, C. M., Kirpach, B., Wolfe, R., Storey, E., Shah, R. C., Lockery, J. E., Tonkin, A. M., Newman, A. B., Williamson, J. D., Margolis, K. L., Ernst, M. E., Abhayaratna, W. P., Stocks, N., Fitzgerald, S. M., Orchard, S. G., Trevaks, R. E., Beilin, L. J., Donnan, G. A., Gibbs, P., Johnston, C. I., Ryan, J., Radziszewska, B., Grimm, R., & Murray, A. M.
- Affiliations
- Baker Heart and Diabetes Institute (AU)
- University of Tasmania (AU)
- Rush University Medical Center (US)
- University of Iowa (US)
- Australian National University (AU)
- National Institutes of Health (US)
- University of Minnesota (US)
- ORCID
- McNeil, John J.
- Woods, Robyn L.
- Nelson, Mark R.
- Reid, Christopher M.
- Kirpach, Brenda
- Wolfe, Rory
- Storey, Elsdon
- Shah, Raj C.
- Lockery, Jessica E.
- Tonkin, Andrew M.
- Newman, Anne B.
- Williamson, Jeff D.
- Margolis, Karen L.
- Ernst, Michael E.
- Abhayaratna, Walter P.
- Stocks, Nigel
- Fitzgerald, Sharyn M.
- Orchard, Suzanne G.
- Trevaks, Ruth E.
- Beilin, Lawrence J.
- Donnan, Geoffrey A.
- Gibbs, Peter
- Ryan, Joanne
- Murray, Anne M.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2018-10-18
- Volume
- 379
- Issue
- 16
- Pages
- 1499-1508
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- PMC
- PMC6426126
- OpenAlex
- W2891412296
- Cited by
- 590
- References
- 35
- Citations by year
- 2026: 44 · 2025: 69 · 2024: 64 · 2023: 85 · 2022: 67 · 2021: 91 · 2020: 72 · 2019: 79 · 2018: 19
- FWCI
- 49.37
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- UWA Profiles and Research Repository (UWA) (publishedVersion, other-oa)
- PubMed (publishedVersion)
- UTAS Research Repository (acceptedVersion)
- PubMed Central (acceptedVersion)
- Digital Commons-TMC (Texas Medical Center) (submittedVersion)
- eCite Digital Repository (University of Tasmania) (submittedVersion)
- eSpace (Curtin University) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- ANU Open Research (Australian National University) (submittedVersion)
- Funders
- Victorian Cancer Agency, Australia
- National Health and Medical Research Council of Australia (334047, 1127060)
- Monash University, Australia
- National Institutes of Health (U01AG029824)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Antiplatelet Therapy and Cardiovascular Diseases
- Health Sciences › Medicine › Pharmacology (medical) › Inflammatory mediators and NSAID effects
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Aging, Health, and Disability
- Keywords
- aspirin, healthy older adults, disability-free survival, dementia, physical disability, mortality, major bleeding, bleeding risk, community-dwelling older adults, trial termination, medication adherence, enteric-coated aspirin, cardiovascular disease prevention, cognitive function
- MeSH terms
- Administration, Oral, Aged, Aged, 80 and over, Aspirin, Australia, Dementia, Double-Blind Method, Female, Follow-Up Studies, Persons with Disabilities, Disabled Persons, Hemorrhage, Humans, Male, Mortality, Platelet Aggregation Inhibitors, United States, Incidence, Treatment Failure, Disease-Free Survival, Independent Living
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
