Cited by 590Antiplatelet Therapy and Cardiovascular DiseasesInflammatory mediators and NSAID effectsAging, Health, and Disability

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Effect of Aspirin on Disability-free Survival in the Healthy Elderly

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McNeil, John J., Woods, Robyn L., Nelson, Mark R., Reid, Christopher M., Kirpach, Brenda, Wolfe, Rory, Storey, Elsdon, Shah, Raj C., Lockery, Jessica E., Tonkin, Andrew M., Newman, Anne B., Williamson, Jeff D., Margolis, Karen L., Ernst, Michael E., Abhayaratna, Walter P., Stocks, Nigel, Fitzgerald, Sharyn M., Orchard, Suzanne G., Trevaks, Ruth E., Beilin, Lawrence J., Donnan, Geoffrey A., Gibbs, Peter, Johnston, Colin I., Ryan, Joanne, Radziszewska, Barbara, Grimm, Richard, Murray, Anne M.·2018·New England Journal of Medicine

DOI 10.1056/nejmoa1800722PMC PMC6426126

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Abstract

BACKGROUND: Information on the use of aspirin to increase healthy independent life span in older persons is limited. Whether 5 years of daily low-dose aspirin therapy would extend disability-free life in healthy seniors is unclear. METHODS: From 2010 through 2014, we enrolled community-dwelling persons in Australia and the United States who were 70 years of age or older (or ≥65 years of age among blacks and Hispanics in the United States) and did not have cardiovascular disease, dementia, or physical disability. Participants were randomly assigned to receive 100 mg per day of enteric-coated aspirin or placebo orally. The primary end point was a composite of death, dementia, or persistent physical disability. Secondary end points reported in this article included the individual components of the primary end point and major hemorrhage. RESULTS: A total of 19,114 persons with a median age of 74 years were enrolled, of whom 9525 were randomly assigned to receive aspirin and 9589 to receive placebo. A total of 56.4% of the participants were women, 8.7% were nonwhite, and 11.0% reported previous regular aspirin use. The trial was terminated at a median of 4.7 years of follow-up after a determination was made that there would be no benefit with continued aspirin use with regard to the primary end point. The rate of the composite of death, dementia, or persistent physical disability was 21.5 events per 1000 person-years in the aspirin group and 21.2 per 1000 person-years in the placebo group (hazard ratio, 1.01; 95% confidence interval [CI], 0.92 to 1.11; P=0.79). The rate of adherence to the assigned intervention was 62.1% in the aspirin group and 64.1% in the placebo group in the final year of trial participation. Differences between the aspirin group and the placebo group were not substantial with regard to the secondary individual end points of death from any cause (12.7 events per 1000 person-years in the aspirin group and 11.1 events per 1000 person-years in the placebo group), dementia, or persistent physical disability. The rate of major hemorrhage was higher in the aspirin group than in the placebo group (3.8% vs. 2.8%; hazard ratio, 1.38; 95% CI, 1.18 to 1.62; P<0.001). CONCLUSIONS: Aspirin use in healthy elderly persons did not prolong disability-free survival over a period of 5 years but led to a higher rate of major hemorrhage than placebo. (Funded by the National Institute on Aging and others; ASPREE ClinicalTrials.gov number, NCT01038583 .).

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Authors: McNeil, J. J., Woods, R. L., Nelson, M. R., Reid, C. M., Kirpach, B., Wolfe, R., Storey, E., Shah, R. C., Lockery, J. E., Tonkin, A. M., Newman, A. B., Williamson, J. D., Margolis, K. L., Ernst, M. E., Abhayaratna, W. P., Stocks, N., Fitzgerald, S. M., Orchard, S. G., Trevaks, R. E., Beilin, L. J., Donnan, G. A., Gibbs, P., Johnston, C. I., Ryan, J., Radziszewska, B., Grimm, R., & Murray, A. M.
Affiliations: Baker Heart and Diabetes Institute (AU)
University of Tasmania (AU)
Rush University Medical Center (US)
University of Iowa (US)
Australian National University (AU)
National Institutes of Health (US)
University of Minnesota (US)
ORCID: McNeil, John J.
Woods, Robyn L.
Nelson, Mark R.
Reid, Christopher M.
Kirpach, Brenda
Wolfe, Rory
Storey, Elsdon
Shah, Raj C.
Lockery, Jessica E.
Tonkin, Andrew M.
Newman, Anne B.
Williamson, Jeff D.
Margolis, Karen L.
Ernst, Michael E.
Abhayaratna, Walter P.
Stocks, Nigel
Fitzgerald, Sharyn M.
Orchard, Suzanne G.
Trevaks, Ruth E.
Beilin, Lawrence J.
Donnan, Geoffrey A.
Gibbs, Peter
Ryan, Joanne
Murray, Anne M.
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 2018-10-18
Volume: 379
Issue: 16
Pages: 1499-1508
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejmoa1800722
PMC: PMC6426126
OpenAlex: W2891412296
Cited by: 590
References: 35
Citations by year: 2026: 44 · 2025: 69 · 2024: 64 · 2023: 85 · 2022: 67 · 2021: 91 · 2020: 72 · 2019: 79 · 2018: 19
FWCI: 49.37
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.nejmgroup.org/legal/terms-of-use.htm (vor)
Locations: New England Journal of Medicine (publishedVersion)
UWA Profiles and Research Repository (UWA) (publishedVersion, other-oa)
PubMed (publishedVersion)
UTAS Research Repository (acceptedVersion)
PubMed Central (acceptedVersion)
Digital Commons-TMC (Texas Medical Center) (submittedVersion)
eCite Digital Repository (University of Tasmania) (submittedVersion)
eSpace (Curtin University) (submittedVersion)
Figshare (submittedVersion, cc-by)
ANU Open Research (Australian National University) (submittedVersion)
Funders: Victorian Cancer Agency, Australia
National Health and Medical Research Council of Australia (334047, 1127060)
Monash University, Australia
National Institutes of Health (U01AG029824)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Antiplatelet Therapy and Cardiovascular Diseases
Health Sciences › Medicine › Pharmacology (medical) › Inflammatory mediators and NSAID effects
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Aging, Health, and Disability
Keywords: aspirin, healthy older adults, disability-free survival, dementia, physical disability, mortality, major bleeding, bleeding risk, community-dwelling older adults, trial termination, medication adherence, enteric-coated aspirin, cardiovascular disease prevention, cognitive function
MeSH terms: Administration, Oral, Aged, Aged, 80 and over, Aspirin, Australia, Dementia, Double-Blind Method, Female, Follow-Up Studies, Persons with Disabilities, Disabled Persons, Hemorrhage, Humans, Male, Mortality, Platelet Aggregation Inhibitors, United States, Incidence, Treatment Failure, Disease-Free Survival, Independent Living

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Effect of Aspirin on Disability-free Survival in the Healthy Elderly

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