Post-Hospital Syndrome — An Acquired, Transient Condition of Generalized Risk
Open accessAbstract
Interview with Dr. Harlan Krumholz on a condition of generalized risk after patients are discharged from the hospital. (17:28)Download Patients who were recently hospitalized experience a period of generalized risk for myriad adverse health events. Their condition may be characterized as a post-hospital syndrome, an acquired condition of vulnerability not necessarily linked to the original illness.
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Poor nutritional status contributes to post hospital syndrome, leading to higher morbidity and an increased rate of unplanned readmissions.
“Poor nutritional status is acknowledged to contribute to the recently described post hospital syndrome that represents a 30-day “generalized transient vulnerability following hospital discharge” leading to higher morbidity and an increased rate of unplanned readmissions”
From ESPEN guideline on nutritional support for polymorbid medical inpatients (2023) · cites this paper as [112]
Near-total inactivity during acute hospitalisation contributes to posthospital syndrome, a vulnerable 30-day post-discharge phase marked by deconditioning.
“Exposure to acute periods of almost total inactivity during hospitalisation plays a role in causing a condition known as posthospital syndrome, 3 a critical 30-day post-discharge period associated with a general deconditioning.”
Without management, this increasingly vulnerable period can result in readmission, disability, nursing-home admission, morbidity, and death.
“If not managed, this period of increasing vulnerability may lead to hospital readmission, disability, nursing home placement, morbidity and mortality.3”
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- Authors
- Krumholz, H. M.
- Affiliations
- Yale New Haven Hospital (US)
- Corresponding author
- Krumholz, Harlan M.
- ORCID
- Krumholz, Harlan M.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2013-01-10
- Volume
- 368
- Issue
- 2
- Pages
- 100-102
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- PMC
- PMC3688067
- OpenAlex
- W2087178869
- Cited by
- 1,218
- References
- 3
- Citations by year
- 2026: 66 · 2025: 60 · 2024: 108 · 2023: 83 · 2022: 93 · 2021: 125 · 2020: 91 · 2019: 133 · 2018: 87 · 2017: 92 · 2016: 83 · 2015: 93 · 2014: 67 · 2013: 36
- FWCI
- 91.41
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (U01HL105270)
- Topics
- Health Sciences › Medicine › Emergency Medicine › Hospital Admissions and Outcomes
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Intensive Care Unit Cognitive Disorders
- Health Sciences › Health Professions › Emergency Medical Services › Patient Safety and Medication Errors
- Keywords
- hospital discharge, post-discharge care, adverse health events, patient vulnerability
- MeSH terms
- Hospitalization, Humans, Inpatients, Patient Readmission, Risk, Stress Disorders, Post-Traumatic
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