The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Hypothermic Machine Perfusion in Liver Transplantation — A Randomized Trial
Open accessAbstract
BACKGROUND: Transplantation of livers obtained from donors after circulatory death is associated with an increased risk of nonanastomotic biliary strictures. Hypothermic oxygenated machine perfusion of livers may reduce the incidence of biliary complications, but data from prospective, controlled studies are limited. METHODS: In this multicenter, controlled trial, we randomly assigned patients who were undergoing transplantation of a liver obtained from a donor after circulatory death to receive that liver either after hypothermic oxygenated machine perfusion (machine-perfusion group) or after conventional static cold storage alone (control group). The primary end point was the incidence of nonanastomotic biliary strictures within 6 months after transplantation. Secondary end points included other graft-related and general complications. RESULTS: A total of 160 patients were enrolled, of whom 78 received a machine-perfused liver and 78 received a liver after static cold storage only (4 patients did not receive a liver in this trial). Nonanastomotic biliary strictures occurred in 6% of the patients in the machine-perfusion group and in 18% of those in the control group (risk ratio, 0.36; 95% confidence interval [CI], 0.14 to 0.94; P = 0.03). Postreperfusion syndrome occurred in 12% of the recipients of a machine-perfused liver and in 27% of those in the control group (risk ratio, 0.43; 95% CI, 0.20 to 0.91). Early allograft dysfunction occurred in 26% of the machine-perfused livers, as compared with 40% of control livers (risk ratio, 0.61; 95% CI, 0.39 to 0.96). The cumulative number of treatments for nonanastomotic biliary strictures was lower by a factor of almost 4 after machine perfusion, as compared with control. The incidence of adverse events was similar in the two groups. CONCLUSIONS: Hypothermic oxygenated machine perfusion led to a lower risk of nonanastomotic biliary strictures following the transplantation of livers obtained from donors after circulatory death than conventional static cold storage. (Funded by Fonds NutsOhra; DHOPE-DCD ClinicalTrials.gov number, NCT02584283.).
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Cites
Characteristics Associated with Liver Graft Failure: The Concept of a Donor Risk Index
Feng, S., Goodrich, N. P., Bragg-Gresham, J. L., Dykstra, D. M., Punch, J. D., DebRoy, M. A., Greenstein, S. M., & Merion, R. M. (2006) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2006.01242.x · Cited by 1,958
Olthoff, K. M., Kulik, L., Samstein, B., Kaminski, M., Abecassis, M., Emond, J., Shaked, A., & Christie, J. D. (2010) · Liver Transplantation · doi:10.1002/lt.22091 · Cited by 1,256
A randomized trial of normothermic preservation in liver transplantation
for the Consortium for Organ Preservation in Europe, Nasralla, D., Coussios, C. C., Mergental, H., Akhtar, M. Z., Butler, A. J., Ceresa, C. D. L., Chiocchia, V., Dutton, S. J., García-Valdecasas, J. C., et al. (2018) · Nature · doi:10.1038/s41586-018-0047-9 · Cited by 1,199
Self-citationHypothermic Machine Preservation in Human Liver Transplantation: The First Clinical Series
Guarrera, J. V., Henry, S. D., Samstein, B., Odeh-Ramadan, R., Kinkhabwala, M., Goldstein, M. J., Ratner, L. E., Renz, J. F., Lee, H. T., Brown, R. S., et al. (2010) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2009.02932.x · Cited by 555
Guidelines for the Content of Statistical Analysis Plans in Clinical Trials
Gamble, C., Krishan, A., Stocken, D., Lewis, S., Juszczak, E., Doré, C., Williamson, P. R., Altman, D. G., Montgomery, A., Lim, P., et al. (2017) · JAMA · doi:10.1001/jama.2017.18556 · Cited by 536
Foley, D. P., Fernandez, L. A., Leverson, G., Anderson, M., Mezrich, J., Sollinger, H. W., & D'Alessandro, A. (2011) · Annals of Surgery · doi:10.1097/sla.0b013e3182104784 · Cited by 400
HOPE for human liver grafts obtained from donors after cardiac death
Dutkowski, P., Schlegel, A., de Oliveira, M., Müllhaupt, B., Neff, F., & Clavien, P.-A. (2014) · Journal of Hepatology · doi:10.1016/j.jhep.2013.11.023 · Cited by 333
van Leeuwen, O. B., de Vries, Y., Fujiyoshi, M., Nijsten, M. W., Ubbink, R., Pelgrim, G. J., Werner, M. J. M., Reyntjens, K. M. E. M., van den Berg, A. P., de Boer, M. T., et al. (2019) · Annals of Surgery · doi:10.1097/sla.0000000000003540 · Cited by 258
Self-citationHilmi, I., Horton, C. N., Planinsic, R. M., Sakai, T., Nicolau-Raducu, R., Damian, D., Gligor, S., & Marcos, A. (2008) · Liver Transplantation · doi:10.1002/lt.21381 · Cited by 249
Buis, C. I., Verdonk, R. C., Van der Jagt, E. J., van der Hilst, C. S., Slooff, M. J. H., Haagsma, E. B., & Porte, R. J. (2007) · Liver Transplantation · doi:10.1002/lt.21166 · Cited by 228
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Lucey, M. R., Furuya, K. N., & Foley, D. P. (2023) · New England Journal of Medicine · doi:10.1056/nejmra2200923 · Cited by 182
Cryopreservation of Whole Rat Livers by Vitrification and Nanowarming
Sharma, A., Lee, C. Y., Namsrai, B.-E., Han, Z., Tobolt, D., Rao, J. S., Gao, Z., Etheridge, M. L., Garwood, M., Clemens, M. G., et al. (2023) · Annals of Biomedical Engineering · doi:10.1007/s10439-022-03064-2 · Cited by 62
Metadata
- Authors
- van Rijn, R., Schurink, I. J., de Vries, Y., van den Berg, A. P., Cortes Cerisuelo, M., Darwish Murad, S., Erdmann, J. I., Gilbo, N., de Haas, R. J., Heaton, N., van Hoek, B., Huurman, V. A. L., Jochmans, I., van Leeuwen, O. B., de Meijer, V. E., Monbaliu, D., Polak, W. G., Slangen, J. J. G., Troisi, R. I., Vanlander, A., de Jonge, J., & Porte, R. J.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2021-04-15
- Volume
- 384
- Issue
- 15
- Pages
- 1391-1401
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W3129886283
- Cited by
- 649
- References
- 23
- FWCI
- 88.12
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- van Rijn, R., Schurink, I. J., de Vries, Y., van den Berg, A. P., Cortes Cerisuelo, M., Darwish Murad, S., Erdmann, J. I., Gilbo, N., de Haas, R. J., Heaton, N., van Hoek, B., Huurman, V. A. L., Jochmans, I., van Leeuwen, O. B., de Meijer, V. E., Monbaliu, D., Polak, W. G., Slangen, J. J. G., Troisi, R. I., . . . Porte, R. J. (2021). Hypothermic Machine Perfusion in Liver Transplantation — A Randomized Trial. New England Journal of Medicine. https://doi.org/10.1056/nejmoa2031532
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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