The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Restrictive or Liberal Transfusion Strategy in Myocardial Infarction and Anemia
Open accessAbstract
BACKGROUND: A strategy of administering a transfusion only when the hemoglobin level falls below 7 or 8 g per deciliter has been widely adopted. However, patients with acute myocardial infarction may benefit from a higher hemoglobin level. METHODS: In this phase 3, interventional trial, we randomly assigned patients with myocardial infarction and a hemoglobin level of less than 10 g per deciliter to a restrictive transfusion strategy (hemoglobin cutoff for transfusion, 7 or 8 g per deciliter) or a liberal transfusion strategy (hemoglobin cutoff, <10 g per deciliter). The primary outcome was a composite of myocardial infarction or death at 30 days. RESULTS: A total of 3504 patients were included in the primary analysis. The mean (±SD) number of red-cell units that were transfused was 0.7±1.6 in the restrictive-strategy group and 2.5±2.3 in the liberal-strategy group. The mean hemoglobin level was 1.3 to 1.6 g per deciliter lower in the restrictive-strategy group than in the liberal-strategy group on days 1 to 3 after randomization. A primary-outcome event occurred in 295 of 1749 patients (16.9%) in the restrictive-strategy group and in 255 of 1755 patients (14.5%) in the liberal-strategy group (risk ratio modeled with multiple imputation for incomplete follow-up, 1.15; 95% confidence interval [CI], 0.99 to 1.34; P = 0.07). Death occurred in 9.9% of the patients with the restrictive strategy and in 8.3% of the patients with the liberal strategy (risk ratio, 1.19; 95% CI, 0.96 to 1.47); myocardial infarction occurred in 8.5% and 7.2% of the patients, respectively (risk ratio, 1.19; 95% CI, 0.94 to 1.49). CONCLUSIONS: In patients with acute myocardial infarction and anemia, a liberal transfusion strategy did not significantly reduce the risk of recurrent myocardial infarction or death at 30 days. However, potential harms of a restrictive transfusion strategy cannot be excluded. (Funded by the National Heart, Lung, and Blood Institute and others; MINT ClinicalTrials.gov number, NCT02981407.).
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Third Universal Definition of Myocardial Infarction
Thygesen, K., Alpert, J. S., Jaffe, A. S., Simoons, M. L., Chaitman, B. R., & White, H. D. (2012) · Circulation · doi:10.1161/cir.0b013e31826e1058 · Cited by 2,985
Self-citationThird universal definition of myocardial infarction
the Writing Group on behalf of the Joint ESC/ACCF/AHA/WHF Task Force for the Universal Definition of Myocardial Infarction, Thygesen, K., Alpert, J. S., Jaffe, A. S., Simoons, M. L., Chaitman, B. R., & White, H. D. (2012) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2012.122 · Cited by 2,053
Self-citationLiberal or Restrictive Transfusion after Cardiac Surgery
Murphy, G. J., Pike, K., Rogers, C. A., Wordsworth, S., Stokes, E. A., Angelini, G. D., & Reeves, B. C. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1403612 · Cited by 787
Restrictive or Liberal Red-Cell Transfusion for Cardiac Surgery
Mazer, C. D., Whitlock, R. P., Fergusson, D. A., Hall, J., Belley-Cote, E., Connolly, K., Khanykin, B., Gregory, A. J., de Médicis, É., McGuinness, S., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1711818 · Cited by 764
Self-citationAssociation of Hemoglobin Levels With Clinical Outcomes in Acute Coronary Syndromes
Sabatine, M. S., Morrow, D. A., Giugliano, R. P., Burton, P. B. J., Murphy, S. A., McCabe, C. H., Gibson, C. M., & Braunwald, E. (2005) · Circulation · doi:10.1161/01.cir.0000162477.70955.5f · Cited by 745
Patient Blood Management: Recommendations From the 2018 Frankfurt Consensus Conference
Mueller, M. M., Van Remoortel, H., Meybohm, P., Aranko, K., Aubron, C., Burger, R., Carson, J. L., Cichutek, K., De Buck, E., Devine, D., et al. (2019) · JAMA · doi:10.1001/jama.2019.0554 · Cited by 632
Self-citationRed Blood Cell Transfusion: 2023 AABB International Guidelines
Carson, J. L., Stanworth, S. J., Guyatt, G., Valentine, S., Dennis, J., Bakhtary, S., Cohn, C. S., Dubon, A., Grossman, B. J., Gupta, G. K., et al. (2023) · JAMA · doi:10.1001/jama.2023.12914 · Cited by 435
Self-citationCarson, J. L., Brooks, M. M., Abbott, J. D., Chaitman, B., Kelsey, S. F., Triulzi, D. J., Srinivas, V., Menegus, M. A., Marroquin, O. C., Rao, S. V., et al. (2013) · American Heart Journal · doi:10.1016/j.ahj.2013.03.001 · Cited by 381
Self-citationTransfusion thresholds for guiding red blood cell transfusion
Carson, J. L., Stanworth, S. J., Dennis, J. A., Trivella, M., Roubinian, N., Fergusson, D. A., Triulzi, D., Dorée, C., & Hébert, P. C. (2021) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002042.pub5 · Cited by 322
Self-citationDucrocq, G., Gonzalez-Juanatey, J. R., Puymirat, E., Lemesle, G., Cachanado, M., Durand-Zaleski, I., Arnaiz, J. A., Martínez-Sellés, M., Silvain, J., Ariza-Solé, A., et al. (2021) · JAMA · doi:10.1001/jama.2021.0135 · Cited by 290
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Cited by
Rao, S. V., O’Donoghue, M. L., Ruel, M., Rab, T., Tamis-Holland, J. E., Alexander, J. H., Baber, U., Baker, H., Cohen, M. G., Cruz-Ruiz, M., et al. (2025) · Circulation · doi:10.1161/cir.0000000000001309 · Cited by 625
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Metadata
- Authors
- Carson, J. L., Brooks, M. M., Hébert, P. C., Goodman, S. G., Bertolet, M., Glynn, S. A., Chaitman, B. R., Simon, T., Lopes, R. D., Goldsweig, A. M., DeFilippis, A. P., Abbott, J. D., Potter, B. J., Carrier, F. M., Rao, S. V., Cooper, H. A., Ghafghazi, S., Fergusson, D. A., Kostis, W. J., Noveck, H., Kim, S., Tessalee, M., Ducrocq, G., de Barros e Silva, P. G. M., Triulzi, D. J., Alsweiler, C., Menegus, M. A., Neary, J. D., Uhl, L., Strom, J. B., Fordyce, C. B., Ferrari, E., Silvain, J., Wood, F. O., Daneault, B., Polonsky, T. S., Senaratne, M., Puymirat, E., Bouleti, C., Lattuca, B., White, H. D., Kelsey, S. F., Steg, P. G., & Alexander, J. H.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2023-12-28
- Volume
- 389
- Issue
- 26
- Pages
- 2446-2456
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W4388591663
- Cited by
- 270
- References
- 14
- FWCI
- 26.44
- Type
- journal article
- Language
- en
- Open access
- green
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- Carson, J. L., Brooks, M. M., Hébert, P. C., Goodman, S. G., Bertolet, M., Glynn, S. A., Chaitman, B. R., Simon, T., Lopes, R. D., Goldsweig, A. M., DeFilippis, A. P., Abbott, J. D., Potter, B. J., Carrier, F. M., Rao, S. V., Cooper, H. A., Ghafghazi, S., Fergusson, D. A., Kostis, W. J., . . . Alexander, J. H. (2023). Restrictive or Liberal Transfusion Strategy in Myocardial Infarction and Anemia. New England Journal of Medicine. https://doi.org/10.1056/nejmoa2307983
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
