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Thyroiditis
Abstract
This article summarizes the current understanding of the mechanisms of destruction in autoimmune thyroid disease. The authors explain the approach to the diagnosis and treatment of the most common types of thyroiditis, including Hashimoto's thyroiditis, painless postpartum thyroiditis, and painless sporadic thyroiditis. Thyroid dysfunction can also develop from treatment with medications such as amiodarone, lithium, interferon alfa, and interleukin-2.
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“Painless or silent thyroiditis classically presents with the same triphasic course described for subacute thyroiditis, but with no prodrome, neck pain, or elevated ESR, WBC count, or C-reactive protein (625).”
From 2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis (2016) · cites this paper as [625]
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Metadata
- Authors
- Pearce, E. N., Farwell, A. P., & Braverman, L. E.
- Affiliations
- Boston University (US)
- University of Massachusetts Chan Medical School (US)
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2003-06-26
- Volume
- 348
- Issue
- 26
- Pages
- 2646-2655
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W4250376568
- Cited by
- 878
- References
- 68
- Citations by year
- 2026: 25 · 2025: 31 · 2024: 62 · 2023: 59 · 2022: 71 · 2021: 56 · 2020: 52 · 2019: 40 · 2018: 44 · 2017: 36 · 2016: 41 · 2015: 54 · 2014: 43 · 2013: 40 · 2012: 43
- FWCI
- 3.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
- Health Sciences › Medicine › Ophthalmology › Ophthalmology and Eye Disorders
- Keywords
- thyroiditis, autoimmune thyroid disease, Hashimoto's thyroiditis, postpartum thyroiditis, thyroid dysfunction, drug-induced thyroid dysfunction, amiodarone, lithium, interferon-alpha, interleukin-2, pathogenesis
- MeSH terms
- Female, Humans, Hypothyroidism, Male, Puerperal Disorders, Thyroid Gland, Thyroiditis, Thyrotoxicosis, Age of Onset
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