Cited by 1,621Asthma and respiratory diseasesAir Quality and Health ImpactsOccupational exposure and asthma

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The Asthma Epidemic

Eder, Waltraud, Ege, Markus J., von Mutius, Erika·2006·New England Journal of Medicine

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Abstract

This review surveys the data on the increase in the prevalence of asthma in recent decades and finds evidence of a plateau in many Western countries. The authors examine the evidence of possible causal relations to factors such as air pollution, obesity, diet, and exposure to infections, antibiotics, and allergens, including exposures at very young ages. The most strongly supported preventive measure is the avoidance of passive and active exposure to smoke.

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Crossref · 10.1056/nejmra054308

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Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multicountry cross-sectional surveys
Asher, M. I., Montefort, S., Björkstén, B., Lai, C. K., Strachan, D. P., Weiland, S. K., & Williams, H. (2006) · The Lancet · doi:10.1016/s0140-6736(06)69283-0 · Cited by 4,223
Occupational Asthma
O’Hollaren, M. T., Bardana, E. J., & Montanaro, A. J. (1991) · Cited by 1,360
Prevalence of Asthma and Atopy in Two Areas of West and East Germany
von Mutius, E., Martinez, F. D., Fritzsch, C., Nicolai, T., Roell, G., & Hh, T. (1994) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.149.2.8306030 · Cited by 897
Changes in asthma prevalence: two surveys 15 years apart.
Burr, M. L., Butland, B. K., King, S., & Vaughan‐Williams, E. (1989) · Archives of Disease in Childhood · doi:10.1136/adc.64.10.1452 · Cited by 859
Perennial allergen sensitisation early in life and chronic asthma in children: a birth cohort study
Illi, S., von Mutius, E., Lau, S., Niggemann, B., Grüber, C., & Wahn, U. (2006) · The Lancet · doi:10.1016/s0140-6736(06)69286-6 · Cited by 720
Early exposure to house-dust mite and cat allergens and development of childhood asthma: a cohort study
Lau, S., Illi, S., Sommerfeld, C., Niggemann, B., Bergmann, R. L., von Mutius, E., & Wahn, U. (2000) · The Lancet · doi:10.1016/s0140-6736(00)02842-7 · Cited by 701
Incidence and prognosis of asthma and wheezing illness from early childhood to age 33 in a national British cohort
Strachan, D. P., Butland, B. K., & ANDERSON, H. R. (1996) · BMJ · doi:10.1136/bmj.312.7040.1195 · Cited by 654
Parental smoking and childhood asthma: longitudinal and case-control studies
Strachan, D. P., & Cook, D. G. (1998) · Thorax · doi:10.1136/thx.53.3.204 · Cited by 597
Increasing prevalence of hay fever and atopy among children in Leipzig, East Germany
von Mutius, E., Weiland, S. K., Fritzsch, C., Duhme, H., & Keil, U. (1998) · The Lancet · doi:10.1016/s0140-6736(97)10100-3 · Cited by 572
Frequency, severity, and duration of rhinovirus infections in asthmatic and non-asthmatic individuals: a longitudinal cohort study
Corne, J. M., Marshall, C., Smith, S. H., Schreiber, J., Sanderson, G., Holgate, S. T., & Johnston, S. L. (2002) · The Lancet · doi:10.1016/s0140-6736(02)07953-9 · Cited by 571

Show all 99 references

Research works printed but not linked: 2

Emeryk A, 2004, Ann Agric Environ Med, 11, 63
Frank PI, 2005, Br J Gen Pract, 55, 596

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Interaction effect of prenatal and postnatal exposure to ambient air pollution and temperature on childhood asthma
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Consequences ofHelicobacter pyloriinfection in children
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Authors: Eder, W., Ege, M. J., & von Mutius, E.
Affiliations: Ludwig-Maximilians-Universität München (DE)
ORCID: Ege, Markus J.
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 2006-11-23
Volume: 355
Issue: 21
Pages: 2226-2235
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejmra054308
OpenAlex: W2081375496
Cited by: 1,621
References: 99
Citations by year: 2026: 13 · 2025: 29 · 2024: 35 · 2023: 59 · 2022: 57 · 2021: 83 · 2020: 61 · 2019: 69 · 2018: 85 · 2017: 82 · 2016: 93 · 2015: 119 · 2014: 122 · 2013: 118 · 2012: 129
FWCI: 10.23
Type: journal article
Language: en
Open access: closed
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Occupational exposure and asthma
Keywords: asthma, asthma prevalence, asthma epidemic, air pollution, obesity, diet, infection exposure, antibiotic exposure, allergen exposure, early life exposure, passive smoking, active smoking, asthma prevention
MeSH terms: Air Pollution, Allergens, Asthma, Bacteria, Diet, Humans, Hypersensitivity, Immediate, Infections, Tobacco Smoke Pollution, Causality, Prevalence, Bronchial Hyperreactivity

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