Traffic-related air pollution exposure over a 5-year period is associated with increased risk of asthma and poor lung function in middle age
Open accessAbstract
Current evidence concerning the impact of exposure to traffic-related air pollution (TRAP) on adult respiratory morbidity mainly comes from cross-sectional studies. We sought to establish more robust measures of this association and potential gene–environment interactions using longitudinal data from an established cohort study. Associations between measures of TRAP (nitrogen dioxide (NO2) and distance to major roads) and wheeze, asthma prevalence and lung function were investigated in participants of the Tasmanian Longitudinal Health Study at 45- and 50-year follow-ups. Generalised estimating equations were used to quantify associations and the potential modifying effect of glutathioneS-transferase gene variants. Living <200 m from a major road was associated with increased prevalence of current asthma and wheeze, and lower lung function. The association between living <200 m from a major road and current asthma and wheeze was more marked for carriers of theGSTT1null andGSTP1 val/valorile/valgenotypes. Over the 5-year period, higher NO2exposures were associated with increased current asthma prevalence. Higher NO2exposure was associated with lower forced vital capacity for carriers of theGSTT1null genotype. TRAP exposures were associated with increased risk of asthma, wheeze and lower lung function in middle-aged adults. The interaction with theGSTT1genotype suggests that deficient antioxidant mechanisms may play a role in these adverse health effects.
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Residential markers of traffic-related air pollution, including NO2 exposure and distance to major roads, are associated with increased risk for new-onset asthma, persistence of asthma and current asthma in a middle-aged, asthma-enriched, population-based cohort.
“Residential markers of traffic-related air pollution, including nitrogen dioxide (NO2) exposure and distance to major roads, have been associated with increased risk for new-onset asthma, persistence of asthma and current asthma in a middle-aged, asthma-enriched, population-based cohort (125).”
From Epidemiology of Asthma in Children and Adults (2019) · cites this paper as [125]
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Indoor and Outdoor Pollution as Risk Factor for Allergic Diseases of the Skin and Lungs
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Household dust as a reservoir for environmentally persistent free radicals: a longitudinal study
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Early-Life Exposure to Oral Antibiotics and Lung Function Into Early Adulthood
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Auswirkungen der Luftschadstoffbelastung
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- Authors
- Bowatte, G., Erbas, B., Lodge, C. J., Knibbs, L. D., Gurrin, L. C., Marks, G. B., Thomas, P. S., Johns, D. P., Giles, G. G., Hui, J., Dennekamp, M., Perret, J. L., Abramson, M. J., Walters, E. H., Matheson, M. C., & Dharmage, S. C.
- Affiliations
- The University of Melbourne (AU)
- La Trobe University (AU)
- The University of Queensland (AU)
- The University of Sydney (AU)
- UNSW Sydney (AU)
- University of Tasmania (AU)
- The University of Western Australia (AU)
- University of Limerick (IE)
- Monash University (AU)
- ORCID
- Venue
- European Respiratory Journal
- Publisher
- European Respiratory Society (ERS)
- Published
- 2017-10
- Volume
- 50
- Issue
- 4
- Pages
- 1602357
- ISSN
- 0903-1936 (ISSN-L)
- 1399-3003
- OpenAlex
- W2765204948
- Cited by
- 111
- References
- 40
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 15 · 2023: 11 · 2022: 17 · 2021: 13 · 2020: 20 · 2019: 15 · 2018: 9
- FWCI
- 6.51
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- European Respiratory Journal (publishedVersion)
- PubMed (publishedVersion)
- eCite Digital Repository (University of Tasmania) (submittedVersion)
- UTAS Research Repository (submittedVersion)
- Monash University Research Portal (Monash University) (submittedVersion, other-oa)
- UWA Profiles and Research Repository (UWA) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- Funders
- Medical Research Council
- National Health and Medical Research Council
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Indoor Air Quality and Microbial Exposure
- Keywords
- traffic-related air pollution, asthma, wheezing, lung function, nitrogen dioxide, gene-environment interaction, glutathione S-transferase, GSTT1, GSTP1, antioxidant defense, middle-aged adults, Tasmanian Longitudinal Health Study
- MeSH terms
- Air Pollution, Asthma, Australia, Cross-Sectional Studies, Environmental Exposure, Female, Glutathione Transferase, Heterozygote, Humans, Longitudinal Studies, Lung, Male, Middle Aged, Nitrogen Dioxide, Respiratory Sounds, Severity of Illness Index, Vital Capacity, Multivariate Analysis, Logistic Models, Risk Assessment, Gene-Environment Interaction
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