Risk factors of new-onset asthma in adults: a population-based international cohort study
Abstract
BACKGROUND: The occurrence of new-onset asthma during adulthood is common, but there is insufficient understanding of its determinants including the role of atopy. OBJECTIVE: To assess the risk factors for the development of new-onset asthma in middle-aged adults and to compare them according to atopy. METHODS: A longitudinal analysis of 9175 young adults who participated in two surveys of the European Community Respiratory Health Survey (ECRHS) conducted 9 years apart. FINDINGS: We observed 179 cases of new-onset asthma among 4588 participants who were free of asthma and reported at the beginning of the follow-up that they had never had asthma (4.5 per 1000 person-years). In a logistic regression, the following risk factors were found to increase the risk of new-onset asthma: female gender (OR: 1.97; 95% confidence interval (CI): 1.38, 2.81), bronchial hyperresponsiveness (3.25; 2.19, 4.83), atopy (1.55; 1.08, 2.21), FEV(1) < 100 % predicted (1.87; 1.34, 2.62), nasal allergy (1.98;1.39,2.84) and maternal asthma (1.91; 1.13; 3.21). Obesity, respiratory infections in early life and high-risk occupations increased the risk of new-onset asthma although we had limited power to confirm their role. Among the atopics, total IgE and sensitization to cat were independently related to the risk of new-onset asthma. The proportion of new-onset asthma attributable to atopy varied from 12% to 21%. CONCLUSION: Adults reporting that they had never had asthma were at a substantial risk of new-onset asthma as a result of multiple independent risk factors including lung function. Atopy explains a small proportion of new-onset adult asthma.
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Adults who developed new-onset asthma had reduced lung function at baseline.
“It has been suggested that adults who developed new-onset asthma had reduced lung function at baseline (172, 173), but it is unknown whether lower lung function before early adulthood, in the absence of childhood asthma, predisposes to “true” adult onset asthma.”
From Epidemiology of Asthma in Children and Adults (2019) · cites this paper as [173]
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Epidemiology of Asthma in Children and Adults
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- Authors
- Antó, J. M., Sunyer, J., Basagaña, X., Garcia‐Esteban, R., Cerveri, I., De Marco, R., Heinrich, J., Janson, C., Jarvis, D., Kogevinas, M., Kuenzli, N., Leynaert, B., Svanes, C., Wjst, M., Gislason, T., & Burney, P.
- Affiliations
- Universitat Pompeu Fabra (ES)
- Center for Research in Environmental Epidemiology (ES)
- University of Pavia (IT)
- Helmholtz Munich (DE)
- Uppsala University (SE)
- Imperial College London (GB)
- University of Bergen (NO)
- Eurac Research (IT)
- Corresponding author
- Antó, J. M.
- ORCID
- Venue
- Allergy
- Publisher
- Wiley
- Published
- 2010-07
- Volume
- 65
- Issue
- 8
- Pages
- 1021-1030
- ISSN
- 0105-4538 (ISSN-L)
- 1398-9995
- OpenAlex
- W1697433908
- Cited by
- 122
- References
- 44
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 7 · 2022: 5 · 2021: 12 · 2020: 4 · 2019: 10 · 2018: 6 · 2017: 5 · 2016: 6 · 2015: 16 · 2014: 8 · 2013: 13 · 2012: 9
- FWCI
- 8.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Allergy (publishedVersion)
- PubMed (publishedVersion)
- edoc (University of Basel) (submittedVersion)
- Site cant be reached (submittedVersion)
- Hirsla (Landspítali University Hospital) (submittedVersion)
- Funders
- European Commission
- National Institutes of Health (2s07rr005521-29)
- National Center for Research Resources (2 S07RR05521-28)
- Topics
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Occupational exposure and asthma
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Keywords
- new-onset asthma, adult asthma, risk factors, atopy, airway hyperresponsiveness, nasal allergy, maternal asthma, total IgE, lung function, obesity, respiratory infections, occupational risk, sex differences, European Community Respiratory Health Survey
- MeSH terms
- Adult, Animals, Asthma, Cats, Europe, Female, Health Surveys, Humans, Hypersensitivity, Immediate, Longitudinal Studies, Male, Population Surveillance, Respiratory Function Tests, Respiratory Tract Infections, Risk Factors, Cohort Studies, Incidence, Bronchial Hyperreactivity, Age of Onset, Young Adult
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