JAKs and STATs in Immunity, Immunodeficiency, and Cancer

STATs in cancer inflammation and immunity: a leading role for STAT3

Yu, H., Pardoll, D., & Jove, R. (2009) · Nature reviews. Cancer · doi:10.1038/nrc2734 · Cited by 4,383

Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders

Baxter, E. J., Scott, L. M., Campbell, P. J., East, C., Fourouclas, N., Swanton, S., Vassiliou, G. S., Bench, A. J., Boyd, E. M., Curtin, N., et al. (2005) · The Lancet · doi:10.1016/s0140-6736(05)71142-9 · Cited by 3,548

A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera

James, C., Ugo, V., Couedic, J. P. L., Staerk, J., Delhommeau, F., Lacout, C., Garçon, L., Raslová, H., Berger, R., Griscelli, A. B., et al. (2005) · Nature · doi:10.1038/nature03546 · Cited by 3,542

A Gain-of-Function Mutation of JAK2 in Myeloproliferative Disorders

Kralovics, R., Passamonti, F., Buser, A. S., Teo, S.-S., Tiedt, R., Passweg, J. R., Tichelli, A., Cazzola, M., & Skoda, R. C. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa051113 · Cited by 3,470

A Genome-Wide Association Study Identifies IL23R as an Inflammatory Bowel Disease Gene

Duerr, R. H., Taylor, K. D., Brant, S. R., Rioux, J. D., Silverberg, M. S., Daly, M. J., Steinhart, A. H., Abraham, C., Regueiro, M., Griffiths, A., et al. (2006) · Science · doi:10.1126/science.1135245 · Cited by 3,039

Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis

Levine, R. L., Wadleigh, M., Cools, J., Ebert, B. L., Wernig, G., Huntly, B. J. P., Boggon, T. J., Wlodarska, I., Clark, J. J., Moore, S., et al. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.03.023 · Cited by 2,993

A double-blind, placebo-controlled trial of ruxolitinib for myelofibrosis

Verstovsek, S., Mesa, R. A., Gotlib, J., Levy, R. S., Gupta, V., DiPersio, J. F., Catalano, J. V., Deininger, M., Miller, C., Silver, R. T., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1110557 · Cited by 2,103

JAKS AND STATS: Biological Implications

Leonard, W. J., & O’Shea, J. J. (1998) · Annual Review of Immunology · doi:10.1146/annurev.immunol.16.1.293 · Cited by 1,826

JAK inhibition with ruxolitinib versus best available therapy for myelofibrosis

Harrison, C., Kiladjian, J.-J., Al-Ali, H. K., Gisslinger, H., Waltzman, R., Stalbovskaya, V., McQuitty, M., Hunter, D. S., Levy, R., Knoops, L., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1110556 · Cited by 1,825

The genetic basis of early T-cell precursor acute lymphoblastic leukaemia

Zhang, J., Ding, L., Holmfeldt, L., Wu, G., Heatley, S. L., Payne-Turner, D., Easton, J., Chen, X., Wang, J., Rusch, M., et al. (2012) · Nature · doi:10.1038/nature10725 · Cited by 1,596

Predictors for clinical effectiveness of baricitinib in rheumatoid arthritis patients in routine clinical practice: data from a Japanese multicenter registry

Takahashi, N., Asai, S., Kobayakawa, T., Kaneko, A., Watanabe, T., Kato, T., Nishiume, T., Ishikawa, H., Yoshioka, Y., Kanayama, Y., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-78925-8 · Cited by 33

KRAS-Mutant Lung Cancer: Targeting Molecular and Immunologic Pathways, Therapeutic Advantages and Restrictions

Karimi, N., & Moghaddam, S. J. (2023) · Cells · doi:10.3390/cells12050749 · Cited by 37

Small-molecule therapeutics in rheumatoid arthritis: Scientific rationale, efficacy and safety

Meier, F. M. P., & McInnes, I. B. (2014) · Best Practice & Research Clinical Rheumatology · doi:10.1016/j.berh.2014.10.017 · Cited by 32

HIF-3α1 promotes colorectal tumor cell growth by activation of JAK-STAT3 signaling

Xue, X., Jungles, K. N., Onder, G., Samhoun, J., Győrffy, B., & Hardiman, K. M. (2016) · Oncotarget · doi:10.18632/oncotarget.7272 · Cited by 33

Efficacy and Safety of Long‐Term Baricitinib With and Without Methotrexate for the Treatment of Rheumatoid Arthritis: Experience With Baricitinib Monotherapy Continuation or After Switching From Methotrexate Monotherapy or Baricitinib Plus Methotrexate

Fleischmann, R., Takeuchi, T., Schiff, M. H., Schlichting, D. E., Xie, L., Issa, M., Stoykov, I., LISSE, J. R., Martínez-Osuna, P., Rooney, T. P., et al. (2019) · Arthritis Care & Research · doi:10.1002/acr.24007 · Cited by 32

Magnolol exerts anti-asthmatic effects by regulating Janus kinase-signal transduction and activation of transcription and Notch signaling pathways and modulating Th1/Th2/Th17 cytokines in ovalbumin-sensitized asthmatic mice

Huang, Q., Han, L., Lv, R., & Ling, L. (2019) · Korean Journal of Physiology and Pharmacology · doi:10.4196/kjpp.2019.23.4.251 · Cited by 32

[Research Advances of JAK/STAT Signaling Pathway in Lung Cancer].

Yang, X., Tang, Z., Zhang, P., & Zhang, L. (2019) · Europe PMC (PubMed Central) · doi:10.3779/j.issn.1009-3419.2019.01.09 · Cited by 32

Targets of Vitamin C With Therapeutic Potential for Cardiovascular Disease and Underlying Mechanisms: A Study of Network Pharmacology

Zhu, N., Huang, B., & Jiang, W. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.591337 · Cited by 32

TYK2 in Cancer Metastases: Genomic and Proteomic Discovery

Borcherding, D. C., He, K., Amin, N. V., & Hirbe, A. C. (2021) · Cancers · doi:10.3390/cancers13164171 · Cited by 31

Noncanonical Wnt5a signaling regulates tendon stem/progenitor cells senescence

Chen, M., Li, Y., Xiao, L., Dai, G.-C., Lu, P., & Rui, Y. (2021) · Stem Cell Research & Therapy · doi:10.1186/s13287-021-02605-1 · Cited by 32

Cryptococcal meningoencephalitis associated with the long-term use of ruxolitinib

Chen, C., Chen, Y., & Huang, C. (2015) · Annals of Hematology · doi:10.1007/s00277-015-2532-7 · Cited by 32

African swine fever virus MGF-360-10L is a novel and crucial virulence factor that mediates ubiquitination and degradation of JAK1 by recruiting the E3 ubiquitin ligase HERC5

Li, D., Peng, J., Wu, J., Yi, J., Wu, P., Qi, X., Ren, J., Peng, G., Duan, X., Ru, Y., et al. (2023) · mBio · doi:10.1128/mbio.00606-23 · Cited by 31

Human growth disorders associated with impaired GH action: Defects in STAT5B and JAK2

Hwa, V. (2020) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2020.111063 · Cited by 32

Development of a prognostic signature for esophageal cancer based on nine immune related genes

Zhang, Z., Chen, C., Fang, Y., Li, S., Wang, X., Sun, L., Zhou, G., & Ye, J. (2021) · BMC Cancer · doi:10.1186/s12885-021-07813-9 · Cited by 31

Developing a JAK Inhibitor for Targeted Local Delivery: Ruxolitinib Cream

Smith, P. A., Yao, W., Shepard, S., Covington, M. B., Lee, J., Lofland, J. H., Naim, A. B., Sheth, T., Parikh, B., & Yeleswaram, S. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13071044 · Cited by 31

Mesenchymal Stem Cell-Derived Exosomes as a Novel Strategy for the Treatment of Intervertebral Disc Degeneration

Lu, L., Xu, A., Gao, F., Tian, C., Wang, H., Zhang, J., Xie, Y., Liu, P., Liu, S., Cao, Y., et al. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.770510 · Cited by 30

Dose/Exposure‐Response Modeling to Support Dosing Recommendation for Phase III Development of Baricitinib in Patients with Rheumatoid Arthritis

Zhang, X., Chua, L., Ernest, C. S., Macias, W. L., Rooney, T. P., & Tham, L. S. (2017) · CPT Pharmacometrics & Systems Pharmacology · doi:10.1002/psp4.12251 · Cited by 30

SATB1 Defines a Subtype of Cutaneous CD30+ Lymphoproliferative Disorders Associated with a T-Helper 17 Cytokine Profile

Sun, J., Yi, S., Qiu, L., Fu, W., Wang, A., Liu, F., Wang, L., Wang, T., Chen, H., Wang, L., et al. (2018) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2018.02.028 · Cited by 30

Analysis of clinical significance and prospective molecular mechanism of main elements of the JAK/STAT pathway in hepatocellular carcinoma

Wang, X., Liao, X., Yu, T., Gong, Y., Zhang, L., Huang, J., Yang, C., Han, C., Yu, L., Zhu, G., et al. (2019) · International Journal of Oncology · doi:10.3892/ijo.2019.4862 · Cited by 31

A Novel Complete Autosomal-Recessive STAT1 LOF Variant Causes Immunodeficiency with Hemophagocytic Lymphohistiocytosis–Like Hyperinflammation

Boehmer, D. F. R., Köhler, L.-M., Magg, T., Metzger, P., Rohlfs, M., Ahlfeld, J., Rack-Hoch, A., Reiter, K., Albert, M. H., Endres, S., et al. (2020) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2020.06.034 · Cited by 30

Untwining Anti-Tumor and Immunosuppressive Effects of JAK Inhibitors—A Strategy for Hematological Malignancies?

Klein, K., Stoiber, D., Sexl, V., & Witalisz‐Siepracka, A. (2021) · Cancers · doi:10.3390/cancers13112611 · Cited by 30

3B, a novel photosensitizer, inhibits glycolysis and inflammation via miR-155-5p and breaks the JAK/STAT3/SOCS1 feedback loop in human breast cancer cells

Lei, K., Du, W., Lin, S., Yang, L., Xu, Y., Gao, Y., Xu, B., Tan, S., Xu, Y. F., Qian, X. H., et al. (2016) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2016.04.049 · Cited by 30

Replicated, replicable and relevant–target engagement and pharmacological experimentation in the 21st century

Kenakin, T., Bylund, D. B., Toews, M. L., Mullane, K., Winquist, R. J., & Williams, M. J. (2013) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.10.024 · Cited by 28

Rapid and precise diagnosis of T. marneffei pulmonary infection in a HIV-negative patient with autosomal-dominant STAT3 mutation: a case report

Zhang, W., Ye, J., Qiu, C., Wang, L., Jin, W., Jiang, C., Xu, L., Xu, J., Li, Y., Wang, L., et al. (2020) · Therapeutic Advances in Respiratory Disease · doi:10.1177/1753466620929225 · Cited by 29

Identification of possible pathogenic pathways in Behçet’s disease using genome-wide association study data from two different populations

Bakır-Güngör, B., Remmers, E. F., Meguro, A., Mizuki, N., Kastner, D. L., Gül, A., & Sezerman, O. U. (2014) · European Journal of Human Genetics · doi:10.1038/ejhg.2014.158 · Cited by 28

Emerging therapeutic paradigms to target the dysregulated Janus kinase/signal transducer and activator of transcription pathway in hematological malignancies

Mughal, T. I., Girnius, S. K., Rosen, S. T., Kumar, S. K., Wiestner, A. U., Abdel-Wahab, O. I., Kiladjian, J., Wilson, W. H., & Etten, R. A. V. (2013) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.3109/10428194.2013.863307 · Cited by 29

The Use of Janus Kinase Inhibitors in Alopecia Areata: A Review of the Literature

Crowley, E. L., Fine, S. C., Katipunan, K. K., & Gooderham, M. (2019) · Journal of Cutaneous Medicine and Surgery · doi:10.1177/1203475418824079 · Cited by 29

Selenium‐Containing Nanocomplexes Achieve Dual Immune Checkpoint Blockade for NK Cell Reinvigoration

Xianyu, B., Pan, S., Gao, S., Xu, H., & Li, T. (2023) · Small · doi:10.1002/smll.202306225 · Cited by 28

Janus Kinase 3 (JAK3): A Critical Conserved Node in Immunity Disrupted in Immune Cell Cancer and Immunodeficiency

Liongue, C., Ratnayake, T., Basheer, F., & Ward, A. C. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25052977 · Cited by 28

Brief Report: Blockade of TANK‐Binding Kinase 1/IKKɛ Inhibits Mutant Stimulator of Interferon Genes (STING)–Mediated Inflammatory Responses in Human Peripheral Blood Mononuclear Cells

Frémond, M., Uggenti, C., Eyck, L. V., Melki, I., Bondet, V., Kitabayashi, N., Hertel, C. B., Hayday, A., Neven, B., Rose, Y., et al. (2017) · Arthritis & Rheumatology · doi:10.1002/art.40122 · Cited by 28

Future Research Priorities in Fungal Resistance

McCarthy, M. W., Denning, D. W., & Walsh, T. J. (2017) · The Journal of Infectious Diseases · doi:10.1093/infdis/jix103 · Cited by 28

JAK/STAT pathway modulation: Does it work in dermatology?

Gündüz, Ö. (2019) · Dermatologic Therapy · doi:10.1111/dth.12903 · Cited by 28

Tyrosine kinases in the pathogenesis of tissue fibrosis in systemic sclerosis and potential therapeutic role of their inhibition

Mendoza, F. A., Piera-Velázquez, S., & Jiménez, S. A. (2021) · Translational research · doi:10.1016/j.trsl.2021.01.001 · Cited by 27

Lessons From the Success and Failure of Targeted Drugs for Rheumatoid Arthritis: Perspectives for Effective Basic and Translational Research

Kim, M., Choe, Y., & Lee, S. (2022) · Immune Network · doi:10.4110/in.2022.22.e8 · Cited by 30

A multitask GNN-based interpretable model for discovery of selective JAK inhibitors

Wang, Y., Gu, Y., Lou, C., Gong, Y., Wu, Z., Li, W., Tang, Y., & Liu, G. (2022) · Journal of Cheminformatics · doi:10.1186/s13321-022-00593-9 · Cited by 27

Combined Immunodeficiency Evolving into Predominant CD4+ Lymphopenia Caused by Somatic Chimerism in JAK3

Ban, S. A., Salzer, E., Eibl, M. M., Linder, A., Geier, C. B., Santos-Valente, E., Garncarz, W., Lion, T., Ott, R., Seelbach, C., et al. (2014) · Journal of Clinical Immunology · doi:10.1007/s10875-014-0088-2 · Cited by 28

miR-634 Decreases the Radioresistance of Human Breast Cancer Cells by Targeting STAT3

Yang, B., Kuai, F., Chen, Z., Fu, D., Liu, J., Wu, Y., & Zhong, J. (2020) · Cancer Biotherapy and Radiopharmaceuticals · doi:10.1089/cbr.2019.3220 · Cited by 28

Selective Janus Kinase 2 (JAK2) Pseudokinase Ligands with a Diaminotriazole Core

Liosi, M.-E., Krimmer, S. G., Newton, A. S., Dawson, T. K., Puleo, D. E., Cutrona, K. J., Suzuki, Y., Schlessinger, J., & Jorgensen, W. L. (2020) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.0c00192 · Cited by 28

Therapeutic potential of anticancer activity of nitrogen-containing heterocyclic scaffolds as Janus kinase (JAK) inhibitor: Biological activity, selectivity, and structure–activity relationship

Pal, R., Matada, G. S. P., Teli, G., Saha, M., & Patel, R. (2024) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2024.107696 · Cited by 27

Metadynamics as a Postprocessing Method for Virtual Screening with Application to the Pseudokinase Domain of JAK2

Cutrona, K. J., Newton, A. S., Krimmer, S. G., Tirado‐Rives, J., & Jorgensen, W. L. (2020) · Journal of Chemical Information and Modeling · doi:10.1021/acs.jcim.0c00276 · Cited by 28

Pantoprazole blocks the JAK2/STAT3 pathway to alleviate skeletal muscle wasting in cancer cachexia by inhibiting inflammatory response

Guo, D., Wang, C., Wang, Q., Qiao, Z., & Tang, H. (2017) · Oncotarget · doi:10.18632/oncotarget.17387 · Cited by 27

Role of the JAK‐STAT Signalling Pathway in Cancer

Dutta, P., & Li, W. X. (2013) · Wiley eBooks · doi:10.1002/9780470015902.a0025214 · Cited by 29

Application of JAK inhibitors in paradoxical reaction through immune-related dermatoses

Zhang, Y., & Jiang, G. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1341632 · Cited by 27

Comparative risk of incident malignancies in rheumatoid arthritis patients treated with Janus kinase inhibitors or bDMARDs: observational data from the German RABBIT register

Schäfer, M. K.-H., Purschke, A., Zietemann, V., Rudi, T., Meißner, Y., Richter, A., Berger, S., Rockwitz, K., Krüger, K., Schneider, K. M., et al. (2025) · Annals of the Rheumatic Diseases · doi:10.1016/j.ard.2025.05.014 · Cited by 26

STAT5 acetylation

Kosan, C., Ginter, T., Heinzel, T., & Krämer, O. H. (2013) · JAK-STAT · doi:10.4161/jkst.26102 · Cited by 26

Tyrosine kinase 2 promotes sepsis-associated lethality by facilitating production of interleukin-27

Bosmann, M., Strobl, B., Kichler, N., Rigler, D., Grailer, J. J., Pache, F. C., Murray, P. J., Müller, M. M., & Ward, P. A. (2014) · Journal of Leukocyte Biology · doi:10.1189/jlb.3a1013-541r · Cited by 25

Novel approaches for preventing acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation

Servais, S., Beguin, Y. P., Delens, L., Ehx, G., Fransolet, G., Hannon, M., Willems, É., Humblet‐Baron, S., Belle, L., & Baron, F. (2016) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2016.1182498 · Cited by 26

Small molecule therapeutics for inflammation-associated chronic musculoskeletal degenerative diseases: Past, present and future

Chen, Y., Huang, J., Tang, C., Chen, X., Yin, Z., Heng, B. C., Chen, W., & Shen, W. (2017) · Experimental Cell Research · doi:10.1016/j.yexcr.2017.07.027 · Cited by 26

Genetic causes of growth hormone insensitivity beyond GHR

Hwa, V., Fujimoto, M., Zhu, G., Gao, W., Foley, C. L., Kumbaji, M., & Rosenfeld, R. G. (2020) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-020-09603-3 · Cited by 26

Exploring a novel triptolide derivative possess anti-colitis effect via regulating T cell differentiation

Fu, J., Zang, Y., Zhou, Y. J., Chen, C., Shao, S., Shi, G., Wu, L., Zhu, G., Sun, T., Zhang, D., et al. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.107472 · Cited by 26

Insights on JAK2 Modulation by Potent, Selective, and Cell-Permeable Pseudokinase-Domain Ligands

Liosi, M.-E., Ippolito, J. A., Henry, S. P., Krimmer, S. G., Newton, A. S., Cutrona, K. J., Olivarez, R. A., Mohanty, J., Schlessinger, J., & Jorgensen, W. L. (2022) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.2c00283 · Cited by 28

Redox regulation of Janus kinase

Duhé, R. J. (2013) · JAK-STAT · doi:10.4161/jkst.26141 · Cited by 26

Pulmonary tuberculosis reactivation following ruxolitinib treatment in a patient with primary myelofibrosis

Chen, Y., Lee, C., & Pei, S. (2014) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.3109/10428194.2014.963082 · Cited by 26

Fatal ruxolitinib-related JC virus meningitis

Ballesta, B., González, H., Martín, V., & Ballesta, J. J. (2017) · Journal of NeuroVirology · doi:10.1007/s13365-017-0558-4 · Cited by 26

Profile of Tofacitinib in the Treatment of Ulcerative Colitis: An Evidence-Based Review of Recent Data

Varyani, F., Argyriou, K., Phillips, F. M., Tsakiridou, E., & Moran, G. W. (2019) · Drug Design Development and Therapy · doi:10.2147/dddt.s182891 · Cited by 26

JAK / STAT defects and immune dysregulation, and guiding therapeutic choices

Chaimowitz, N. S., Smith, M. R., & Satter, L. F. (2024) · Immunological Reviews · doi:10.1111/imr.13312 · Cited by 27

Low rates of radiographic progression of structural joint damage over 2 years of baricitinib treatment in patients with rheumatoid arthritis

van der Heijde, D. M. F. M., Schiff, M. H., Tanaka, Y., Xie, L., Meszaros, G., Ishii, T., Casillas, M., Ortmann, R., & Emery, P. (2019) · RMD Open · doi:10.1136/rmdopen-2019-000898 · Cited by 25

The Study on the Regulation of Th Cells by Mesenchymal Stem Cells Through the JAK-STAT Signaling Pathway to Protect Naturally Aged Sepsis Model Rats

Wang, L., Deng, Z., Sun, Y. K., Zhao, Y., Li, Y., Yang, M., Yuan, R., Liu, Y., Qian, Z., Zhou, F., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.820685 · Cited by 25

Sequential treatment with AT-101 enhances cisplatin chemosensitivity in human non-small cell lung cancer cells through inhibition of apurinic/apyrimidinic endonuclease 1-activated IL-6/STAT3 signaling pathway

Ren, T., Shan, J., Qing, Y., Qian, C., Qing, Y., Guoshou, L., Li, M., Li, C., Peng, Y., Luo, H., et al. (2014) · Drug Design Development and Therapy · doi:10.2147/dddt.s71432 · Cited by 25

Elevation of the Hepatitis B Virus DNA during the Treatment of Polycythemia Vera with the JAK Kinase Inhibitor Ruxolitinib

Kirito, K., Sakamoto, M., & Enomoto, N. (2016) · Internal Medicine · doi:10.2169/internalmedicine.55.5529 · Cited by 25

Clinical outcomes in patients switched from adalimumab to baricitinib due to non-response and/or study design: phase III data in patients with rheumatoid arthritis

Tanaka, Y., Fautrel, B., Keystone, E. C., Ortmann, R., Xie, L., Zhu, B., Issa, M., Patel, H. J., Gaich, C. L., de Bono, S., et al. (2019) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2018-214529 · Cited by 25

Discovery of a Gut-Restricted JAK Inhibitor for the Treatment of Inflammatory Bowel Disease

Leonard, K. A., Madge, L. A., Krawczuk, P. J., Wang, A., Kreutter, K. D., Bacani, G. M., Chai, W., Smith, R. C., Tichenor, M. S., Harris, M. C., et al. (2020) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.9b01439 · Cited by 25

Large Granular Lymphocytic Leukemia: From Immunopathogenesis to Treatment of Refractory Disease

Zawit, M., Bahaj, W., Gurnari, C., & Maciejewski, J. P. (2021) · Cancers · doi:10.3390/cancers13174418 · Cited by 25

Transcriptional Profiling of STAT1 Gain-of-Function Reveals Common and Mutation-Specific Fingerprints

Giovannozzi, S., Demeulemeester, J., Schrijvers, R., & Gijsbers, R. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.632997 · Cited by 26

Fatal cytokine release syndrome by an aberrant FLIP/STAT3 axis

Musiu, C., Caligola, S., Fiore, A., Lamolinara, A., Frusteri, C., Pizzo, F. D. D., Sanctis, F. D., Canè, S., Adamo, A., Hofer, F., et al. (2021) · Cell Death and Differentiation · doi:10.1038/s41418-021-00866-0 · Cited by 23

An update on novel therapeutic intervention in Rheumatoid arthritis

Shah, P., Siddique, A., Thakkar, A. P., Gharat, S., Godad, A. P., Kale, P. P., & Doshi, G. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.108794 · Cited by 24

Immunotherapy for Melanoma: The Significance of Immune Checkpoint Inhibitors for the Treatment of Advanced Melanoma

Fujimura, T., Muto, Y., & Asano, Y. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232415720 · Cited by 26

A review of Janus kinase inhibitors for the treatment of Covid-19 pneumonia

Tanaka, Y. (2023) · Inflammation and Regeneration · doi:10.1186/s41232-022-00253-3 · Cited by 26

NEW APPROACHES TO PHARMACOTHERAPY OF RHEUMATOID ARTHRITIS: TOFACITINIB

Nasonov, E. L. (2014) · Rheumatology Science and Practice · doi:10.14412/1995-4484-2014-209-221 · Cited by 24

Janus kinase/signal transducer and activator of transcription pathways in spondyloarthritis

Raychaudhuri, S. K., & Raychaudhuri, S. P. (2017) · Current Opinion in Rheumatology · doi:10.1097/bor.0000000000000399 · Cited by 24

14-3-3ζ Regulates Immune Response through Stat3 Signaling in Oral Squamous Cell Carcinoma

Han, X., Han, Y., Jiao, H., & Jie, Y. (2014) · Molecules and Cells · doi:10.14348/molcells.2015.02101 · Cited by 24

A heterozygous germline CD100 mutation in a family with primary sclerosing cholangitis

Jiang, X., Bergquist, A. M., Löscher, B.-S., Venkatesh, G., Mold, J. E., Holm, K., Laerdahl, J. K., Skånland, S. S., Maleki, K. T., Cornillet, M., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abb0036 · Cited by 24

Transcriptome analysis of grass carp (Ctenopharyngodon idella) and Holland's spinibarbel (Spinibarbus hollandi) infected with Ichthyophthirius multifiliis

Shen, M., Jiang, Z., Zhang, K., Li, C., Liu, F., Hu, Y., Zheng, S., & Zheng, R. (2022) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2022.01.008 · Cited by 23

Development and Therapeutic Implications of Tyrosine Kinase 2 Inhibitors

Zhang, K., Ye, K., Tang, H. Q., Qi, Z., Wang, T., Mao, J., Zhang, X., & Jiang, S. (2023) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.2c01800 · Cited by 23

A trivial role of STAT4 variant in chronic hepatitis B induced hepatocellular carcinoma

Clark, A., Gerlach, F., Tong, H. V., Hoan, N. X., Song, L. H., Toàn, N. L., Bock, C. –., Kremsner, P. G., & Velavan, T. P. (2013) · Infection Genetics and Evolution · doi:10.1016/j.meegid.2013.05.025 · Cited by 24

IFN Signaling: How a Non-Canonical Model Led to the Development of IFN Mimetics

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