JAKs and STATs in Immunity, Immunodeficiency, and Cancer

STATs in cancer inflammation and immunity: a leading role for STAT3

Yu, H., Pardoll, D., & Jove, R. (2009) · Nature reviews. Cancer · doi:10.1038/nrc2734 · Cited by 4,383

Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders

Baxter, E. J., Scott, L. M., Campbell, P. J., East, C., Fourouclas, N., Swanton, S., Vassiliou, G. S., Bench, A. J., Boyd, E. M., Curtin, N., et al. (2005) · The Lancet · doi:10.1016/s0140-6736(05)71142-9 · Cited by 3,548

A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera

James, C., Ugo, V., Couedic, J. P. L., Staerk, J., Delhommeau, F., Lacout, C., Garçon, L., Raslová, H., Berger, R., Griscelli, A. B., et al. (2005) · Nature · doi:10.1038/nature03546 · Cited by 3,542

A Gain-of-Function Mutation of JAK2 in Myeloproliferative Disorders

Kralovics, R., Passamonti, F., Buser, A. S., Teo, S.-S., Tiedt, R., Passweg, J. R., Tichelli, A., Cazzola, M., & Skoda, R. C. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa051113 · Cited by 3,470

A Genome-Wide Association Study Identifies IL23R as an Inflammatory Bowel Disease Gene

Duerr, R. H., Taylor, K. D., Brant, S. R., Rioux, J. D., Silverberg, M. S., Daly, M. J., Steinhart, A. H., Abraham, C., Regueiro, M., Griffiths, A., et al. (2006) · Science · doi:10.1126/science.1135245 · Cited by 3,039

Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis

Levine, R. L., Wadleigh, M., Cools, J., Ebert, B. L., Wernig, G., Huntly, B. J. P., Boggon, T. J., Wlodarska, I., Clark, J. J., Moore, S., et al. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.03.023 · Cited by 2,993

A double-blind, placebo-controlled trial of ruxolitinib for myelofibrosis

Verstovsek, S., Mesa, R. A., Gotlib, J., Levy, R. S., Gupta, V., DiPersio, J. F., Catalano, J. V., Deininger, M., Miller, C., Silver, R. T., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1110557 · Cited by 2,103

JAKS AND STATS: Biological Implications

Leonard, W. J., & O’Shea, J. J. (1998) · Annual Review of Immunology · doi:10.1146/annurev.immunol.16.1.293 · Cited by 1,826

JAK inhibition with ruxolitinib versus best available therapy for myelofibrosis

Harrison, C., Kiladjian, J.-J., Al-Ali, H. K., Gisslinger, H., Waltzman, R., Stalbovskaya, V., McQuitty, M., Hunter, D. S., Levy, R., Knoops, L., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1110556 · Cited by 1,825

The genetic basis of early T-cell precursor acute lymphoblastic leukaemia

Zhang, J., Ding, L., Holmfeldt, L., Wu, G., Heatley, S. L., Payne-Turner, D., Easton, J., Chen, X., Wang, J., Rusch, M., et al. (2012) · Nature · doi:10.1038/nature10725 · Cited by 1,596

Fungal Infections in the Era of Biologic Therapies

Gundacker, N. D., & Baddley, J. W. (2015) · Current Clinical Microbiology Reports · doi:10.1007/s40588-015-0018-y · Cited by 13

Noncanonical IFN Signaling: Mechanistic Linkage of Genetic and Epigenetic Events

Johnson, H. M., & Ahmed, C. M. I. (2016) · Mediators of Inflammation · doi:10.1155/2016/9564814 · Cited by 13

Lack of Association betweenJAK3Gene Polymorphisms and Cardiovascular Disease in Spanish Patients with Rheumatoid Arthritis

García-Bermúdez, M., López‐Mejías, R., Genre, F., Castañeda, S., Corrales, A., Llorca, J., González‐Juanatey, C., Ubilla, B., Miranda-Filloy, J. A., Pina, T., et al. (2015) · BioMed Research International · doi:10.1155/2015/318364 · Cited by 13

Single Nucleotide Polymorphisms in STAT3 and STAT4 and Risk of Hepatocellular Carcinoma in Thai Patients with Chronic Hepatitis B

Chanthra, N., Payungporn, S., Chuaypen, N., Piratanantatavorn, K., Pinjaroen, N., Poovorawan, Y., & Tangkijvanich, P. (2016) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2015.16.18.8405 · Cited by 13

Nitazoxanide alleviates CFA-induced rheumatoid arthritis in Wistar rats by modulating the STAT-3 and NF-κB pathways

Prajapati, P. S., & Doshi, G. (2025) · Rheumatology and Immunology Research · doi:10.1515/rir-2025-0004 · Cited by 12

Risk of Dyslipidemia Associated With Oral Janus Kinase Inhibitors: A Systematic Review and Meta‐Analysis of Randomized Placebo‐Controlled Trials

Isufi, D., Javanmardi, N., Jensen, M. B., Loft, N., Skov, L., Elberling, J., Thomsen, S. F., & Alinaghi, F. (2025) · International Journal of Dermatology · doi:10.1111/ijd.70122 · Cited by 12

Conversion of a False Virtual Screen Hit into Selective JAK2 JH2 Domain Binders Using Convergent Design Strategies

Henry, S. P., Liosi, M.-E., Ippolito, J. A., Cutrona, K. J., Krimmer, S. G., Newton, A. S., Schlessinger, J., & Jorgensen, W. L. (2022) · ACS Medicinal Chemistry Letters · doi:10.1021/acsmedchemlett.2c00051 · Cited by 12

B cell receptor-induced IL-10 production from neonatal mouse CD19+CD43- cells depends on STAT5-mediated IL-6 secretion

Sakai, J., Yang, J., Chou, C., Wu, W. W., & Akkoyunlu, M. (2023) · eLife · doi:10.7554/elife.83561 · Cited by 11

Cardiovascular and thromboembolic risks of JAK inhibitors in atopic dermatitis: A global cohort study

Kridin, K., Kridin, S., Mayer, E., Sawaed, W., & Ludwig, R. J. (2025) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.20864 · Cited by 12

A novel mechanism of skin tumor promotion involving interferon‐gamma (IFNγ)/signal transducer and activator of transcription‐1 (Stat1) signaling

Bozeman, R., Abel, E. L., Macias, E., Cheng, T., Beltrán, L., & DiGiovanni, J. (2014) · Molecular Carcinogenesis · doi:10.1002/mc.22132 · Cited by 12

Accessing Expert‐Curated Pharmacological Data in the IUPHAR/BPS Guide to PHARMACOLOGY

Sharman, J. L., Harding, S. D., Southan, C., Faccenda, E., Pawson, A. J., Davies, J. A., & NC‐IUPHAR (2018) · Current Protocols in Bioinformatics · doi:10.1002/cpbi.46 · Cited by 12

Promoter methylation of Bax and Bcl2 genes and their expression in patients with Behcet’s disease

Asadi, S., Khabbazi, A., Alipour, S., Abolhasani, S., Haji, J., Amjadi, H., & Sakhinia, E. (2020) · International Journal of Immunogenetics · doi:10.1111/iji.12473 · Cited by 12

Transcription Factor STAT1 Promotes the Proliferation, Migration and Invasion of Nasopharyngeal Carcinoma Cells by Upregulating LINC01160

Ai, J., Tan, G., Wang, T., Li, W., Gao, R., Song, Y., Xiong, S., & Qing, X. (2020) · Future Oncology · doi:10.2217/fon-2020-0618 · Cited by 12

Pathological relevance and treatment perspective of JAK targeting in systemic lupus erythematosus

Nakayamada, S., & Tanaka, Y. (2022) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2022.2040988 · Cited by 12

Janus kinase inhibitors in immunoinflammatory diseases: 10 years of clinical practice in rheumatology

Nasonov, E. L., & Korotaeva, T. V. (2022) · Rheumatology Science and Practice · doi:10.47360/1995-4484-2022-131-148 · Cited by 12

Synthetic Heterodimers of Type III Interferon Receptors Require TYK2 for STAT Activation

Mesev, E. V., Guare, E. G., Ploß, A., & Toettcher, J. E. (2023) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2023.0039 · Cited by 12

A Case Report of Majocchi's Granuloma Associated with Combined Therapy of Topical Steroids and Adalimumab

Chou, W., & Hsu, C.-J. (2016) · Medicine · doi:10.1097/md.0000000000002245 · Cited by 13

STAT5a promotes the transcription of mature mmu-miR-135a in 3T3-L1 cells by binding to both miR-135a-1 and miR-135a-2 promoter elements

Wei, X., Cheng, X., Peng, Y., Zheng, R., Chai, J., & Jiang, S. (2016) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2016.06.003 · Cited by 12

Experimental and Clinical Pharmacology:Janus kinase inhibitors: Mechanisms of action

Kubler, P. A. (2014) · Australian Prescriber · doi:10.18773/austprescr.2014.061 · Cited by 12

JAK Inhibition as a Therapeutic Strategy for Inflammatory Bowel Disease

Macaluso, F. S., & Rodríguez–Lago, I. (2020) · Current Drug Metabolism · doi:10.2174/1389200221666200310111409 · Cited by 12

Baricitinib relieves DSS-induced ulcerative colitis in mice by suppressing the NF-κB and JAK2/STAT3 signalling pathways

Wu, Q., Liu, Y., Liang, J., Dai, A., Du, B., Xi, X., Jin, L., & Guo, Y. (2024) · Inflammopharmacology · doi:10.1007/s10787-023-01396-6 · Cited by 11

Analysis of publicly available adverse events reported for pediatric patients treated with Janus kinase inhibitors

Talasila, S., Lee, E., Teichner, E. M., Siegfried, E. C., & Jackson, S. R. (2024) · Pediatric Dermatology · doi:10.1111/pde.15721 · Cited by 11

A distinct immune landscape in anti-synthetase syndrome profiled by a single-cell genomic study

Ding, J., Li, Y., Wang, Z., Han, F., Chen, M., Du, J., Yang, T., Zhang, M., Wang, Y., Xu, J., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1436114 · Cited by 11

JAK/STAT3 signaling promotes pain and depression-like behaviors in rats with bone cancer pain by regulating Th17 cell differentiation

Wu, S., Jiang, J., Wang, D., Lin, D., Lin, M., Chen, P., Chen, J., Zhang, H., Wang, Y., Chen, X., et al. (2025) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2025.111218 · Cited by 12

The Dual-Edged Sword: Risks and Benefits of JAK Inhibitors in Infections

Jarneborn, A., Kopparapu, P. K., & Jin, T. (2025) · Pathogens · doi:10.3390/pathogens14040324 · Cited by 14

Inhibiting Interferon Pathways in Dermatomyositis: Rationale and Preliminary Evidence

Casal-Domínguez, M., Pinal‐Fernandez, I., & Mammen, A. L. (2021) · Current Treatment Options in Rheumatology · doi:10.1007/s40674-021-00182-1 · Cited by 11

Interplay between epigenetic and genetic alterations in inborn errors of immunity

Rodríguez‐Ubreva, J., Calvillo, C. L., Satter, L. F., & Ballestar, E. (2023) · Trends in Immunology · doi:10.1016/j.it.2023.09.005 · Cited by 11

Replication the association of 2q32.2–q32.3 and 14q32.11 with hepatocellular carcinoma

Chen, W., Wang, M., Zhang, Z., Tang, H., Zuo, X., Meng, X.-L., Xiong, M., Zhou, F., Liang, B., Dai, F., et al. (2015) · Gene · doi:10.1016/j.gene.2015.02.006 · Cited by 11

Adaptor Protein STAP-2 Modulates Cellular Signaling in Immune Systems

Sekine, Y. (2014) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b13-00421 · Cited by 12

Nav1.6 promotes the progression of human follicular thyroid carcinoma cells via JAK-STAT signaling pathway

Li, H., Liu, J., Fan, N., Wang, H., Thomas, A. M., Yan, Q., Li, S., & Qin, H. (2022) · Pathology - Research and Practice · doi:10.1016/j.prp.2022.153984 · Cited by 11

mi RNA in mycosis fungoides and skin inflammation

Persson, J. L. (2013) · Apmis · doi:10.1111/apm.12186 · Cited by 11

T-cell receptor-mediated characteristic signaling pathway of peripheral blood T cells in dermatomyositis and polymyositis

Shimojima, Y., Matsuda, M., Ishii, W., Kishida, D., & Sekijima, Y. (2017) · Autoimmunity · doi:10.1080/08916934.2017.1405942 · Cited by 11

Dysregulated STAT1 gain-of-function: Pathogen-free autoimmunity and fungal infection

Guo, L., Lian, D., Gu, Y., Lu, X., Zhang, Y., Li, X., Khrustaleva, T. A., Lan, J., Liang, Y., Khrustalev, V. V., et al. (2024) · hLife · doi:10.1016/j.hlife.2024.03.002 · Cited by 10

JAK Inhibitors and Risk of Cancer in IBD Patients

Bernardi, F., Faggiani, I., Parigi, T. L., Zilli, A., Allocca, M., Furfaro, F., Peyrin‐Biroulet, L., Danese, S., & D’Amico, F. (2025) · Cancers · doi:10.3390/cancers17111795 · Cited by 10

Global burden of alopecia areata from 1990 to 2019 and emerging treatment trends analyzed through GBD 2019 and bibliometric data

Ding, H., Yu, Z., Yao, H., Xu, X., Liu, Y., & Chen, M. (2025) · Scientific Reports · doi:10.1038/s41598-025-07224-x · Cited by 10

Discovery and optimization of 2-aminopyridine derivatives as novel and selective JAK2 inhibitors

Ma, X., Diao, Y., Ge, H., Xu, F., Zhu, L., Zhao, Z., & Li, H. (2020) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2020.127048 · Cited by 10

Experience With the Use of Baricitinib and Tocilizumab Monotherapy or Combined, in Patients With Interstitial Pneumonia Secondary to Coronavirus COVID19: A Real-World Study

Rosas, J., Liaño, F. P., Llombart, M., Barea, J. M. C., Beser, A. R., Rabasa, J. T. A., Martínez-Adsuar, F., Auli, B. V., López, I. F., Sainz, A. M. G., et al. (2022) · Reumatología Clínica (English Edition) · doi:10.1016/j.reumae.2020.10.006 · Cited by 10

Synchrotron Fourier Transform Infrared Microscopy Spectra in Cellular Effects of Janus Kinase Inhibitors on Myelofibrosis Cancer Cells

Siriwaseree, J., Sanachai, K., Aiebchun, T., Tabtimmai, L., Kuaprasert, B., & Choowongkomon, K. (2022) · ACS Omega · doi:10.1021/acsomega.2c02404 · Cited by 10

DisseminatedTalaromyces marneffeiInfection With STAT3-Hyper-IgE Syndrome: A Case Series and Literature Review

Li, Z., Yang, J.-L., Qiu, Y., Yang, F. J., Tang, M., Li, S., Zhan, Y., Li, Y., Tang, S., Jing, C., et al. (2023) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofac614 · Cited by 10

Clinical manifestations associated with novel mutations in the coiled-coil domain of STAT1

Nahum, A., & Dalal, I. (2014) · LymphoSign Journal · doi:10.14785/lpsn-2014-0021 · Cited by 10

Kinase Inhibitors in Cancer

Mortlock, A. A., Foote, K. M., Kettle, J. G., & Aquila, B. M. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-409547-2.11033-9 · Cited by 13

Exploitable Signaling Pathways for the Treatment of Inflammatory Bowel Disease

Tiwari, A., Jain, A., Verma, A., & Jain, S. (2017) · Current Signal Transduction Therapy · doi:10.2174/1574362412666170330145342 · Cited by 10

Primary immunodeficiency‐related genes in neonatal intensive care unit patients with various genetic immune abnormalities: a multicentre study in China

Zhu, T., Gong, X., Bei, F., Ma, L., Sun, J., Wang, J., Qiu, G., Sun, J., Sun, Y., & Zhang, Y. (2021) · Clinical & Translational Immunology · doi:10.1002/cti2.1266 · Cited by 10

N6-Substituted adenosine analogues, a novel class of JAK2 inhibitors, potently block STAT3 signaling in human cancer cells

Liu, P., Zhao, L., Xu, X., Liu, F., Zhang, W., Zhou, C., Chen, J., Pan, Y., Du, Y., Yang, J., et al. (2014) · Cancer Letters · doi:10.1016/j.canlet.2014.07.043 · Cited by 10

Discovery of potent anti-inflammatory 4-(4,5,6,7-tetrahydrofuro[3,2-c]pyridin-2-yl) pyrimidin-2-amines for use as Janus kinase inhibitors

Wang, Y., Huang, W., Xin, M., Chen, P., Gui, L., Zhao, X., Zhu, X., Luo, H., Cong, X., Wang, J., et al. (2019) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2019.03.048 · Cited by 10

Ion channel gene GJB2 influences the intercellular communication by Up-regulating the SPP1 signaling pathway identified by the single-cell RNA sequencing in lung adenocarcinoma

Zuo, L., Xiao, Z., Wang, X., Zhang, L., & Zhang, Z. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1146976 · Cited by 9

The Glycosyltransferase XYLT1 Activates NF-κB Signaling to Promote Metastasis of Early-Stage Lung Adenocarcinoma

Han, J., Du, J., Li, X., Zhou, Q., Zeng, J., Lin, J., Zhou, W., Cai, J., Ye, Y., Yang, B., et al. (2025) · Cancer Research · doi:10.1158/0008-5472.can-24-1893 · Cited by 9

STAT3 phosphorylation in the rheumatoid arthritis immunological synapse

Novak‐Kotzer, H., Capera, J., Jainarayanan, A., Elanchezhian, M., Valvo, S., Mayya, V., Zanin‐Zhorov, A., Macdonald, J., Taylor, P. C., & Dustin, M. L. (2025) · Journal of Autoimmunity · doi:10.1016/j.jaut.2025.103456 · Cited by 13

In Silico Evaluation of a Promising Key Intermediate Thieno [2,3-d] Pyrimidine Derivative with Expected JAK2 Kinase Inhibitory Activity

Elmongy, E. I., & Henidi, H. A. (2022) · Molbank · doi:10.3390/m1352 · Cited by 9

Therapeutic Effects of Tofacitinib on Pristane-Induced Murine Lupus

Lin, J., ZHANG, Y., Wang, M., Yang, Z., Pin, L., Cao, Y., & Yang, X. (2022) · Archives of Rheumatology · doi:10.46497/archrheumatol.2022.8252 · Cited by 9

PAQR5 inhibits the growth and metastasis of clear cell renal cell carcinoma by suppressing the JAK/STAT3 signaling pathway

Wang, L., Yue, Y., Zhang, L., Jing, M., Ma, M., Liu, C., Li, Y., Xu, S., Wang, K., Wang, X., et al. (2023) · Cellular Oncology · doi:10.1007/s13402-023-00813-w · Cited by 9

Increased STAT3 phosphorylation on CD27 + B-cells from common variable immunodeficiency disease patients

Clemente, A., Pons, J., Lanio, N., Cunill, V., Frontera, G., Crespı́, C., Matamoros, N., & Ferrer, J. M. (2015) · Clinical Immunology · doi:10.1016/j.clim.2015.09.004 · Cited by 9

Novel treatment options for ulcerative colitis

Vaughn, B. P., & Moss, A. C. (2013) · Clinical Investigation · doi:10.4155/cli.13.97 · Cited by 9

A Novel STAT3 Mutation in a Qatari Patient With Hyper-IgE Syndrome

Chaimowitz, N. S., Branch, J., Reyes, A., Vargas‐Hernández, A., Orange, J. S., Forbes, L. R., Ehlayel, M. S., Purayil, S. C., Al‐Nesf, M. A., & Vogel, T. P. (2019) · Frontiers in Pediatrics · doi:10.3389/fped.2019.00130 · Cited by 9

Identification of immune checkpoint inhibitors and biomarkers among STAT family in stomach adenocarcinoma.

Guo, L., Fang, T., Jiang, Y., & Liu, D. (2020) · PubMed Central · Cited by 9

Pulmonary Histopathology Findings in Patients With STAT3 Gain of Function Syndrome

Cortes‐Santiago, N., Forbes, L. R., Vogel, T. P., Silva‐Carmona, M., Hicks, J. M., Guillerman, R. P., Thatayatikom, A., & Patel, K. R. (2021) · Pediatric and Developmental Pathology · doi:10.1177/1093526620980615 · Cited by 9

Targeting STAT3 Signaling Facilitates Responsiveness of Pancreatic Cancer Cells to Chemoradiotherapy

Flebbe, H., Spitzner, M., Marquet, P. E., Gaedcke, J., Ghadimi, Β. M., Rieken, S., Schneider, G., König, A. O., & Grade, M. (2022) · Cancers · doi:10.3390/cancers14051301 · Cited by 10

Attenuating Janus Kinases (JAK) by Tofacitinib Effectively Prevented Psoriasis Pathology in Various Mouse Skin Inflammation Models

Fish, H.-L. M. S. (2013) · Journal of Clinical & Cellular Immunology · doi:10.4172/2155-9899.1000176 · Cited by 9

A Phenotypic Screening Approach to Identify Anticancer Compounds Derived from Marine Fungi

Ellinger, B., Silber, J., Prashar, A., Landskron, J., Weber, J., Rehermann, S., Müller, F.-J., Smith, S., Wrigley, S. K., Taskén, K., et al. (2014) · Assay and Drug Development Technologies · doi:10.1089/adt.2013.564 · Cited by 10

Recipient and donor JAK2 46/1 haplotypes are associated with acute graft-versus-host disease following allogeneic hematopoietic stem cell transplantation

Balassa, K., Krähling, T., Reményi, P., Bátai, Á., Bors, A., Kiss, K. P., Torbágyi, É., Gopcsa, L., Lengyel, L., Barta, A., et al. (2016) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.1080/10428194.2016.1198956 · Cited by 9

Filgotinib, a JAK1 Inhibitor, Has No Effect on QT Interval in Healthy Subjects

Anderson, K., Xin, Y., Zheng, H. W., Yun, C., Kwan, E., Qin, A., Namour, F., Kearney, B. P., & Mathias, A. A. (2019) · Clinical Pharmacology in Drug Development · doi:10.1002/cpdd.755 · Cited by 9

Novel STAT3 Inhibitor Exerts Anti-breast Cancer Effects Both In vitro and In vivo

Liu, Z., Sun, Y., Yu, M., Huang, Y., Ma, L., & Kong, L. (2023) · Letters in Drug Design & Discovery · doi:10.2174/1570180820666230116153822 · Cited by 8

LPS and type I and II interferons have opposing effects on epigenetic regulation of LAIR1 expression in mouse and human macrophages

Dorando, H. K., Mutic, E. C., Li, J. Y., Perrin, E. P., Wurtz, M., Quinn, C. C., & Payton, J. E. (2023) · Journal of Leukocyte Biology · doi:10.1093/jleuko/qiad148 · Cited by 8

Covalent Modification of the JH2 Domain of Janus Kinase 2

Henry, S. P., Liosi, M.-E., Ippolito, J. A., Menges, F., Newton, A. S., Schlessinger, J., & Jorgensen, W. L. (2022) · ACS Medicinal Chemistry Letters · doi:10.1021/acsmedchemlett.2c00414 · Cited by 8

Glycosaminoglycans: Participants in Microvascular Coagulation of Sepsis

Li, N., Hao, R., Ren, P., Wang, J., Dong, J., Ye, T., Zhao, D., Qiao, X., Meng, Z., Gan, H. K., et al. (2024) · Thrombosis and Haemostasis · doi:10.1055/a-2250-3166 · Cited by 8

“Model T” Cells: A Time-Tested Vehicle for Gene Therapy

Kerkar, S. P. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00304 · Cited by 8

The effects of STAT1 dysfunction on the gut

Thoeni, C. E., Hamilton, E. A., Elkadri, A. A., Murchie, R., Fiedler, K. B., Ovadia, A., Sharfe, N., Ngan, B., Cutz, E., Nahum, A., et al. (2015) · LymphoSign Journal · doi:10.14785/lpsn-2015-0012 · Cited by 8

Klebsiella pneumoniae primary liver abscess associated with ruxolitinib

Kusano, Y., Terui, Y., Ueda, K., & Hatake, K. (2016) · Annals of Hematology · doi:10.1007/s00277-016-2718-7 · Cited by 8

Investigation of JAKs/STAT-3 in lipopolysaccharide-induced intestinal epithelial cells

Fu, L., Wei, L.-W., Zhao, M.-D., Zhu, J.-L., Chen, S.-Y., Jia, X.-B., & Lai, S.-J. (2016) · Clinical & Experimental Immunology · doi:10.1111/cei.12835 · Cited by 8

Debio 0617B Inhibits Growth of STAT3-Driven Solid Tumors through Combined Inhibition of JAK, SRC, and Class III/V Receptor Tyrosine Kinases

Murone, M., Chessex, A. V., Attinger, A., Ramachandra, R. K., Shetty, S. J., Daginakatte, G., Sengupta, S., Marappan, S., Dhodheri, S., Rigotti, S., et al. (2016) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-15-0974 · Cited by 8

Influenza virus non-structural protein 1 inhibits the production of interferon β of alveolar epithelial cells upon the infection of influenza A H1N1

Jiang, H., Shen, S.-M., Yin, J., Zhang, P., & Shi, Y. P. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.7138 · Cited by 8

Pulmonary granulomatosis of genetic origin

Bode, S. F. N., Rohr, J., Quernheim, J. M., Seidl, M., Speckmann, C., & Heinzmann, A. (2021) · European Respiratory Review · doi:10.1183/16000617.0152-2020 · Cited by 8

One arrow for two targets: potential co-treatment regimens for lymphoma and HIV

Chen, X., Jia, L., Zhang, X., Zhang, T., & Zhang, Y. (2022) · Blood Reviews · doi:10.1016/j.blre.2022.100965 · Cited by 8

Regulation of mesenchymal stem cell differentiation by key cell signaling pathways

Dhinekaran, A., Lakshmi, M. B. S., Graceline, H., Dey, A. K., Adhikari, S., Ramalingam, S., Ramachandran, I., Bişgin, A., Boğa, İ., Pathak, S., et al. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-18800-8.00007-1 · Cited by 8

A sensitive bioanalytical method development and validation of cabozantinib in human plasma by LC-ESI-MS/MS

Inturi, S., & Avula, P. R. (2018) · Brazilian Journal of Pharmaceutical Sciences · doi:10.1590/s2175-97902018000217163 · Cited by 8

Infections in the Era of Targeted Therapies: Mapping the Road Ahead

Calabrese, L. H., Calabrese, C. M., Lenfant, T., Kirchner, E., & Strand, V. (2020) · Frontiers in Medicine · doi:10.3389/fmed.2020.00336 · Cited by 8

Turning the Tide against Herpes Zoster in Rheumatoid Arthritis Patients Treated with JAK Inhibitors

Cito, A., Fornaro, M., Carenza, A., Anelli, M. G., Scioscia, C., Iannone, F., & Lopalco, G. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13154423 · Cited by 7

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The treatment efficacy of dupilumab in autosomal dominant hyper-immunoglobulin E syndrome with severe atopic dermatitis

Li, W., Qi, Q., Wang, W., & Dong-qin, L. (2023) · Asia Pacific Allergy · doi:10.5415/apallergy.0000000000000121 · Cited by 7

Regulation of STAT1 and STAT4 Expression by Growth Factor and Interferon Supplementation in Sjögren’s Syndrome Cell Culture Models

Mougeot, J.-L., Thornburg, T. E., Noll, B. D., Brennan, M. T., & Mougeot, F. B. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25063166 · Cited by 7

Tumor antigen presentation and the associated signal transduction during carcinogenesis

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Rheumatoid arthritis synovial fluid induces JAK-dependent intracellular activation of human sensory neurons

Li, Y., Gray, E., Ross, R., Zebochin, I., Lock, A., Fedele, L., Kamajaya, L. J., Marrow, R. J., Ryan, S. E., Röderer, P., et al. (2025) · JCI Insight · doi:10.1172/jci.insight.186646 · Cited by 13

Systematic Review and Meta-Analysis on the Association between Polymorphisms in Genes of IL-12 Signaling Pathway and Hepatocellular Carcinoma Risk

Xiao, Y., Liu, G., & Gong, L. (2018) · Journal of Cancer · doi:10.7150/jca.26419 · Cited by 7

Tuberculosis Peritonitis During Treatment of Polycythemia Vera with Ruxolitinib

Sakiyama, E., Chinen, Y., Tsukamoto, T., Takimoto‐Shimomura, T., Kuwahara‐Ota, S., Matsumura‐Kimoto, Y., Shimura, Y., Kobayashi, T., Horiike, S., & Kuroda, J. (2020) · Infection and Drug Resistance · doi:10.2147/idr.s249030 · Cited by 7

Identification and Validation of STAT6 as a Prognostic and Predictive Biomarker in Acute Myeloid Leukemia

Liu, W., Zhu, F., Yan, J., Liu, Y., Chen, C., Zhang, K., Zhao, X., & Chen, J. (2020) · OncoTargets and Therapy · doi:10.2147/ott.s272757 · Cited by 7

Exploring the oncogenic and therapeutic target potential of the MYB-TYK2 fusion gene in B-cell acute lymphoblastic leukemia

Shirazi, P. T., Eadie, L. N., Heatley, S. L., Page, E. C., François, M., Hughes, T. P., Yeung, D., & White, D. L. (2022) · Cancer Gene Therapy · doi:10.1038/s41417-021-00421-6 · Cited by 7

Stat5b inhibition blocks proliferation and tumorigenicity of glioblastoma stem cells derived from a de novo murine brain cancer model.

Moyama, C., Fujita, M., Ando, S., Taniguchi, K., Ii, H., Tanigawa, S., Hashimoto, N., & Nakata, S. (2022) · PubMed Central · Cited by 7

Mechanism Investigation of Wuwei Shexiang Pills on Gouty Arthritis via Network Pharmacology, Molecule Docking, and Pharmacological Verification

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Discovery of novel dual Bruton’s tyrosine kinase (BTK) and Janus kinase 3 (JAK3) inhibitors as a promising strategy for rheumatoid arthritis

Liang, T., Cen, L., Wang, J., Cheng, M., Guo, W., Wang, W., Yu, C., Zhang, H., Wang, Y., Hao, Z., et al. (2023) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2023.117354 · Cited by 7

Trastuzumab-induced human cardiomyocyte damage through the Notch2/JAK2/STAT3 pathway

Su, Z., Liu, S., Zou, Y., Shan, L., Yu, M., Xie, S., Li, X., & Jin, Y. (2023) · Clinics · doi:10.1016/j.clinsp.2023.100268 · Cited by 7

Th17/1 and ex-Th17 cells are detected in patients with polyarticular juvenile arthritis and increase following treatment

Wood, S., Branch, J., Vasquez, P., DeGuzman, M., Brown, A. L., Sagcal‐Gironella, A. C. P., Singla, S., Ramirez, A. A., & Vogel, T. P. (2024) · Pediatric Rheumatology · doi:10.1186/s12969-024-00965-5 · Cited by 7

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Speth, F., Wellinghausen, N., & Haas, J. (2013) · Zeitschrift für Rheumatologie · doi:10.1007/s00393-013-1203-0 · Cited by 7

Investigation of JAK1 and STAT3 polymorphisms and their gene–gene interactions in nonspecific digestive disorder of rabbits

Fu, L., Yang, Z.-J., Chen, S., Wang, J., & Lai, S. (2014) · Gene · doi:10.1016/j.gene.2014.04.017 · Cited by 7

STAT1 inhibitor alleviates spinal cord injury by decreasing apoptosis

Wu, Y., Gao, C., Fan, K.-L., Yang, L. M., & Mei, X. (2016) · Genetics and Molecular Research · doi:10.4238/gmr.15017271 · Cited by 7

Phospho-STAT5B Expression Is a Prognostic Marker for Merkel Cell Carcinoma

Fujimura, T., Furudate, S., KAMBAYAHSI, Y., Kakizaki, A., Yamamoto, Y., Okuhira, H., Fujimoto, N., & Aiba, S. (2017) · Anticancer Research · doi:10.21873/anticanres.11571 · Cited by 7

Muscular proteomic profiling of deep pressure ulcers reveals myoprotective role of JAK2 in ischemia and reperfusion injury.

Liu, Z., Ren, L., Cui, X., Guo, L., Jiang, B., Zhou, J., Liang, P., Zeng, J., He, Z., & Zhang, P. (2018) · Europe PMC (PubMed Central) · Cited by 7

Differential STAT gene expressions of Penaeus monodon and Macrobrachium rosenbergii in response to white spot syndrome virus (WSSV) and bacterial infections: Additional insight into genetic variations and transcriptomic highlights

Soo, T. C. C., & Bhassu, S. (2021) · PLoS ONE · doi:10.1371/journal.pone.0258655 · Cited by 7

JAKs—STATs信号传导——疾病治疗新领域

Ping, Z. X. (2001) · 国外医学（免疫学分册）

004 JAKs-STATs信号传导--疾病治疗新领域

Ping, Z. X., & 吴慧君 (2001) · 国外医学（免疫学分册） · doi:10.3760/cma.j.issn.1673-4394.2001.01.004

Evolving cognition of the JAK-STAT signaling pathway: autoimmune disorders and cancer

Chen, X., Yao, Q., Gu, X., Shi, Q., Yuan, X., Chu, Q., Bao, Z., Lu, J., & Li, L. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01468-7 · Cited by 797

JAKs and STATs from a Clinical Perspective: Loss-of-Function Mutations, Gain-of-Function Mutations, and Their Multidimensional Consequences

Ott, N., Faletti, L. E., Heeg, M., Andreani, V., & Grimbacher, B. (2023) · Journal of Clinical Immunology · doi:10.1007/s10875-023-01483-x · Cited by 87

Immunodeficiency: Consequences of Mutations in JAK-STAT Signaling

Silberger, D. J., & Pham, D. (2020) · CRC Press eBooks · doi:10.1201/9781351042468-13 · Cited by 1