JAKs and STATs in Immunity, Immunodeficiency, and Cancer

STATs in cancer inflammation and immunity: a leading role for STAT3

Yu, H., Pardoll, D., & Jove, R. (2009) · Nature reviews. Cancer · doi:10.1038/nrc2734 · Cited by 4,383

Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders

Baxter, E. J., Scott, L. M., Campbell, P. J., East, C., Fourouclas, N., Swanton, S., Vassiliou, G. S., Bench, A. J., Boyd, E. M., Curtin, N., et al. (2005) · The Lancet · doi:10.1016/s0140-6736(05)71142-9 · Cited by 3,548

A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera

James, C., Ugo, V., Couedic, J. P. L., Staerk, J., Delhommeau, F., Lacout, C., Garçon, L., Raslová, H., Berger, R., Griscelli, A. B., et al. (2005) · Nature · doi:10.1038/nature03546 · Cited by 3,542

A Gain-of-Function Mutation of JAK2 in Myeloproliferative Disorders

Kralovics, R., Passamonti, F., Buser, A. S., Teo, S.-S., Tiedt, R., Passweg, J. R., Tichelli, A., Cazzola, M., & Skoda, R. C. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa051113 · Cited by 3,470

A Genome-Wide Association Study Identifies IL23R as an Inflammatory Bowel Disease Gene

Duerr, R. H., Taylor, K. D., Brant, S. R., Rioux, J. D., Silverberg, M. S., Daly, M. J., Steinhart, A. H., Abraham, C., Regueiro, M., Griffiths, A., et al. (2006) · Science · doi:10.1126/science.1135245 · Cited by 3,039

Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis

Levine, R. L., Wadleigh, M., Cools, J., Ebert, B. L., Wernig, G., Huntly, B. J. P., Boggon, T. J., Wlodarska, I., Clark, J. J., Moore, S., et al. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.03.023 · Cited by 2,993

A double-blind, placebo-controlled trial of ruxolitinib for myelofibrosis

Verstovsek, S., Mesa, R. A., Gotlib, J., Levy, R. S., Gupta, V., DiPersio, J. F., Catalano, J. V., Deininger, M., Miller, C., Silver, R. T., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1110557 · Cited by 2,103

JAKS AND STATS: Biological Implications

Leonard, W. J., & O’Shea, J. J. (1998) · Annual Review of Immunology · doi:10.1146/annurev.immunol.16.1.293 · Cited by 1,826

JAK inhibition with ruxolitinib versus best available therapy for myelofibrosis

Harrison, C., Kiladjian, J.-J., Al-Ali, H. K., Gisslinger, H., Waltzman, R., Stalbovskaya, V., McQuitty, M., Hunter, D. S., Levy, R., Knoops, L., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1110556 · Cited by 1,825

The genetic basis of early T-cell precursor acute lymphoblastic leukaemia

Zhang, J., Ding, L., Holmfeldt, L., Wu, G., Heatley, S. L., Payne-Turner, D., Easton, J., Chen, X., Wang, J., Rusch, M., et al. (2012) · Nature · doi:10.1038/nature10725 · Cited by 1,596

Down-Regulation of Long Non-Coding RNA TINCR Induces Cell Dedifferentiation and Predicts Progression in Oral Squamous Cell Carcinoma

Zhuang, Z., Huang, J., Wang, W., Wang, C., Yu, P., Hu, J. R., Liu, H., Yin, H., Hou, J., & Liu, X. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2020.624752 · Cited by 20

Targeting micro-environmental pathways by PROTACs as a therapeutic strategy

Liu, J., Peng, Y., Inuzuka, H., & Wei, W. (2022) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2022.07.001 · Cited by 20

Case report: A STAT1 gain-of-function mutation causes a syndrome of combined immunodeficiency, autoimmunity and pure red cell aplasia

Xie, Y., Shao, F., Lei, J., Huang, N., Fan, Z., & Yu, H. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.928213 · Cited by 20

ARID2 mitigates hepatic steatosis via promoting the ubiquitination of JAK2

Cao, H., Jiang, H., Ding, K., Qiu, X., Ma, N., Zhang, F.-K., Wang, Y., Zheng, Q., Xia, J., Ni, Q., et al. (2022) · Cell Death and Differentiation · doi:10.1038/s41418-022-01090-0 · Cited by 20

Uncovering the Underworld of Axial Spondyloarthritis

Vescovo, S. D., Venerito, V., Iannone, C., & Lopalco, G. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076463 · Cited by 21

The Molecular Biology of Prostate Cancer Stem Cells: From the Past to the Future

Zhou, Y., Li, T., Jia, M., Dai, R., & Wang, R. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087482 · Cited by 22

JAK Inhibition in Juvenile Idiopathic Arthritis (JIA): Better Understanding of a Promising Therapy for Refractory Cases

Melki, I., & Frémond, M. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12144695 · Cited by 20

Scope of JAK Inhibitors in Children: Recent Evidence and Way Forward

Bagri, N. K., Chew, C., & Ramanan, A. V. (2023) · Pediatric Drugs · doi:10.1007/s40272-023-00594-7 · Cited by 20

Pyrrole-3-carboxamides as potent and selective JAK2 inhibitors

Brasca, M. G., Nesi, M., Avanzi, N. R., Ballinari, D., Bandiera, T., Bertrand, J. A., Bindi, S., Canevari, G., Carenzi, D., Casero, D., et al. (2014) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2014.06.025 · Cited by 20

Mycobacteria Manipulate G-Protein-Coupled Receptors to Increase Mucosal Rac1 Expression in the Lungs

Alaridah, N., Lutay, N., Tenland, E., Rönnholm, A., Hällgren, O., Puthia, M., Westergren‐Thorsson, G., & Godaly, G. (2016) · Journal of Innate Immunity · doi:10.1159/000453454 · Cited by 20

An Essential Role for Perforin-2 in Type I IFN Signaling

McCormack, R., Hunte, R., Podack, E. R., Plano, G. V., & Shembade, N. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.1901013 · Cited by 20

Biologic and advanced immunomodulating therapeutic options for sarcoidosis: a clinical update

Obi, O. N., Lower, E. E., & Baughman, R. P. (2021) · Expert Review of Clinical Pharmacology · doi:10.1080/17512433.2021.1878024 · Cited by 20

Recent advances in the design of small molecular drugs with acrylamides covalent warheads

Liang, L., Zhang, Z., You, Q., & Guo, X. (2024) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2024.117902 · Cited by 20

Interrelation of Natural Polyphenol and Fibrosis in Diabetic Nephropathy

Ma, Y., Wang, J., Fan, J., Jia, H., & Li, J. (2024) · Molecules · doi:10.3390/molecules30010020 · Cited by 19

Ganoderic acid A: an in-depth review of pharmacological effects and molecular docking analysis

Sui, Q., Zhu, C., Shi, S., Xu, J., Zhang, J., Wang, A., Chen, P., Liang, G., & Zhang, Y. (2025) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2025.119868 · Cited by 21

Affecting the effectors: JAK inhibitors modulation of immune cell numbers and functions in patients with rheumatoid arthritis

Garufi, C., Maclean, M., Gadina, M., & Spinelli, F. R. (2022) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2022.2042254 · Cited by 19

Janus Kinase Inhibitors for the Management of Patients With Inflammatory Bowel Disease.

Sedaño, R., Ma, C., Jairath, V., & Feagan, B. G. (2022) · PubMed Central · Cited by 19

Atopic Dermatitis-like Genodermatosis: Disease Diagnosis and Management

Pan, C., Zhao, A., & Li, M. (2022) · Diagnostics · doi:10.3390/diagnostics12092177 · Cited by 19

Update on the systemic management of noninfectious uveitis in children and adolescents

Leal, I., Steeples, L. R., Wong, S. W., Giuffré, C., Počkar, S., Sharma, V., Green, E. K. Y., Payne, J., Jones, N. P., Chieng, A., et al. (2023) · Survey of Ophthalmology · doi:10.1016/j.survophthal.2023.01.002 · Cited by 19

Design, synthesis and biological evaluation of purine-based derivatives as novel JAK2/BRD4(BD2) dual target inhibitors

Guo, Y. C., Zou, Y., Chen, Y. X., Deng, D., Zhang, Z., Liu, K., Tang, M., Yang, T., Fu, S., Zhang, C., et al. (2023) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2023.106386 · Cited by 19

Update on the role of upadacitinib in the treatment of adults with moderately to severely active ulcerative colitis

Ernest-Suárez, K., & Panaccione, R. (2023) · Therapeutic Advances in Gastroenterology · doi:10.1177/17562848231158235 · Cited by 19

Association of Notch pathway down-regulation with Triple Negative/Basal-like breast carcinomas and high tumor-infiltrating FOXP3 + Tregs

Ortiz-Martínez, F., Gutiérrez-Aviñó, F. J., Sanmartín, E., Pomares-Navarro, E., Villalba-Riquelme, C., García‐Martínez, A., Lerma, E., & Peiró, G. (2016) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2016.04.006 · Cited by 19

Is HBV prophylaxis required during CLL treatment with ibrutinib?

Tedeschi, A., Frustaci, A. M., Mazzucchelli, M., Cairoli, R., & Montillo, M. (2017) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.1080/10428194.2017.1317094 · Cited by 19

Suppression of PTBP1 signaling is responsible for mesenchymal stem cell induced invasion of low malignancy cancer cells

Fu, X., Xie, F., Gong, F., Yang, Z., Lv, X., Li, X., Jiao, H., Wang, Q., Liu, X., Li, Y., et al. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2018.08.002 · Cited by 19

Perfluorocarbon Nanoemulsions for Combined Pulmonary siRNA Treatment of Lung Metastatic Osteosarcoma

Li, Z., Shen, Y., Wang, Y., Zhu, L., Zhu, C., Qian, C., Sun, M., & Oupický, D. (2019) · Advanced Therapeutics · doi:10.1002/adtp.201900039 · Cited by 19

Current Status in the Discovery of Covalent Janus Kinase 3 (JAK3) Inhibitors

Dai, J., Yang, L., & Addison, G. (2019) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557519666190617152011 · Cited by 19

Development of Oxadiazole-Based ODZ10117 as a Small-Molecule Inhibitor of STAT3 for Targeted Cancer Therapy

Kim, B., Lee, H., Song, Y., Park, J.-S., Gadhe, C. G., Choi, J., Lee, C.-G., Pae, A. N., Kim, S., & Ye, S. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8111847 · Cited by 21

RIPK3 Suppresses the Progression of Spontaneous Intestinal Tumorigenesis

Zhao, Q., Guo, J., Cheng, X., Liao, Y., Bi, Y., Gong, Y., Zhang, X., Guo, Y., Wang, X., Yu, W., et al. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.664927 · Cited by 19

Insight into the role of multiple signaling pathways in regulating cancer stem cells of gynecologic cancers

Song, Y., Pan, S., Li, K., Chen, X., Wang, Z. P., & Zhu, X. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.06.001 · Cited by 21

Inactivation of DAP12 in PMN Inhibits TREM1-Mediated Activation in Rheumatoid Arthritis

Chen, X., Eksioglu, E. A., Carter, J. D., Fortenbery, N. R., Donatelli, S. S., Zhou, J., Liu, J., Yang, L., Gilvary, D. L., Djeu, J. Y., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0115116 · Cited by 20

Coptis Chinensis affects the function of glioma cells through the down-regulation of phosphorylation of STAT3 by reducing HDAC3

Li, J., Ni, L., Li, B., Wang, M., Ding, Z., Xiong, C., & Lu, X. (2017) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-017-2029-0 · Cited by 19

Discovery of the Potent and Selective Inhaled Janus Kinase 1 Inhibitor AZD4604 and Its Preclinical Characterization

Nilsson, M., Berggren, K., Berglund, S., Cerboni, S., Collins, M., Dahl, G., Elmqvist, D., Grimster, N. P., Hendrickx, R., Johansson, J. R., et al. (2023) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.3c00554 · Cited by 18

Phospho-flow detection of constitutive and cytokine-induced pSTAT3/5, pAKT and pERK expression highlights novel prognostic biomarkers for patients with multiple myeloma

Brown, R. D., Yang, S. S., Weatherburn, C., Gibson, J., Ho, P. J., Suen, H., Hart, D. N. J., & Joshua, D. E. (2014) · Leukemia · doi:10.1038/leu.2014.204 · Cited by 18

Cytokine-mediated STAT-dependent pathways underpinning human B-cell differentiation and function

Tangye, S. G., Pathmanandavel, K., & Ma, C. S. (2023) · Current Opinion in Immunology · doi:10.1016/j.coi.2023.102286 · Cited by 20

OASL knockdown inhibits the progression of stomach adenocarcinoma by regulating the mTORC1 signaling pathway

Zhao, W., Yang, H., Liu, L., Qu, X., Ding, J., Yu, H., Xu, B., Zhao, S., Xi, G., Xing, L., et al. (2023) · The FASEB Journal · doi:10.1096/fj.202201582r · Cited by 20

Venetoclax durable response in adult relapsed/refractory Philadelphia-negative acute lymphoblastic leukemia with JAK/STAT pathway alterations

Ferrari, A., Cangini, D., di Rorà, A. G. L., Condorelli, A., Pugliese, M., Schininà, G., Cosentino, S., Fonzi, E., Domizio, C., Simonetti, G., et al. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1165308 · Cited by 18

Midazolam Inhibits the Apoptosis of Astrocytes Induced by Oxygen Glucose Deprivation via Targeting JAK2-STAT3 Signaling Pathway

Liu, L., You, Q., Tu, Y., Li, Q., Zheng, L., Li, X., Gu, J., & Wang, G. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000369681 · Cited by 18

Development and validation of a rapid and sensitive UPLC–MS/MS assay for the quantification of tofacitinib in human plasma

Bharwad, K. D., Shah, P. A., Shrivastav, P. S., & Singhal, P. (2018) · Biomedical Chromatography · doi:10.1002/bmc.4458 · Cited by 18

The Giants (biologicals) against the Pigmies (small molecules), pros and cons of two different approaches to the disease modifying treatment in rheumatoid arthritis

Favalli, E. G., Matucci‐Cerinic, M., & Szekanecz, Z. (2019) · Autoimmunity Reviews · doi:10.1016/j.autrev.2019.102421 · Cited by 18

Transcriptome analysis reveals seven key immune pathways of Japanese flounder (Paralichthys olivaceus) involved in megalocytivirus infection

Wu, Q., Ning, X., Jiang, S., & Sun, L. (2020) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2020.05.011 · Cited by 18

Megalocytivirus Induces Complicated Fish Immune Response at Multiple RNA Levels Involving mRNA, miRNA, and circRNA

Wu, Q., Ning, X., & Sun, L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22063156 · Cited by 18

Multiple Environmental Signaling Pathways Control the Differentiation of RORγt-Expressing Regulatory T Cells

Hussein, H., Denanglaire, S., Gool, F. V., Azouz, A., Ajouaou, Y., El-Khatib, H., Oldenhove, G., Léo, O., & Andris, F. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2019.03007 · Cited by 20

Infections associated with the new ‘nibs and mabs’ and cellular therapies

Maus, M. V., & Lionakis, M. S. (2020) · Current Opinion in Infectious Diseases · doi:10.1097/qco.0000000000000656 · Cited by 19

The Biology of Ocular Adnexal Marginal Zone Lymphomas

Johansson, P., Eckstein, A. K., & Küppers, R. (2022) · Cancers · doi:10.3390/cancers14051264 · Cited by 18

P38γ modulates the lipid metabolism in non‐alcoholic fatty liver disease by regulating the JAK–STAT signaling pathway

Yao, Y., Luo, Z., Li, H., Wang, S., Wu, Y., Hu, Y., Hu, S., Yang, C., Yang, J., Wang, J., et al. (2022) · The FASEB Journal · doi:10.1096/fj.202200939rr · Cited by 18

An Open-Label, Uncontrolled, Single-Arm Clinical Trial of Tofacitinib, an Oral JAK1 and JAK3 Kinase Inhibitor, in Chinese Patients with Keloid

Chen, J., Feng, Q., Pan, H.-H., Zhu, D., He, R., Deng, C., & Yang, B. (2023) · Dermatology · doi:10.1159/000532064 · Cited by 17

Medicinal chemistry perspective of JAK inhibitors: synthesis, biological profile, selectivity, and structure activity relationship

Maji, L., Sengupta, S., Matada, G. S. P., Teli, G., Biswas, G., Das, P. K., & Mudgal, M. P. (2024) · Molecular Diversity · doi:10.1007/s11030-023-10794-5 · Cited by 18

L-Leucine Promotes STAT1 and ISGs Expression in TGEV-Infected IPEC-J2 Cells via mTOR Activation

Du, J., Chen, D., Yu, B., He, J., Yu, J., Mao, X., Luo, Y., Zheng, P., & Luo, J. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.656573 · Cited by 17

The Evolving View of IL-17-Mediated Immunity in Defense Against Mucocutaneous Candidiasis in Humans

Soltész, B., Tóth, B., Sarkadi, A. K., Erdös, M., & Maródi, L. (2015) · International Reviews of Immunology · doi:10.3109/08830185.2015.1049345 · Cited by 18

Small-molecule inhibitors for autoimmune arthritis: Success, failure and the future

Ho, L., & Lai, J. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.08.031 · Cited by 17

STAT3 Expression and Activity are Up-Regulated in Diffuse Large B Cell Lymphoma of Dogs

Assumpção, A. L. F. V., Jark, P. C., Hong, C. C., Lu, Z., Ruetten, H. M., Heaton, C. M., Pinkerton, M. E., & Pan, X. (2017) · Journal of Veterinary Internal Medicine · doi:10.1111/jvim.14860 · Cited by 17

Safety of Baricitinib in Adults with Severe Alopecia Areata from Two Phase III Trials Over a Median of 2.3 Years and Up to 4 Years of Treatment

King, B., Mostaghimi, A., Shimomura, Y., Piraccini, B. M., Blume‐Peytavi, U., Sontag, A., Dutronc, Y., Denning, K., Kolodsick, J., Lu, X., et al. (2025) · American Journal of Clinical Dermatology · doi:10.1007/s40257-025-00932-0 · Cited by 16

Expression of JAK3, STAT2, STAT4, and STAT6 in pemphigus vulgaris

Juczyńska, K., Woźniacka, A. J., Waszczykowska, E., Danilewicz, M., Wągrowska‐Danilewicz, M., & Żebrowska, A. (2020) · Immunologic Research · doi:10.1007/s12026-020-09122-y · Cited by 16

Progress on the Pharmacological Targeting of Janus Pseudokinases

Henry, S. P., & Jorgensen, W. L. (2023) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.3c00926 · Cited by 16

Dual‐Barb Microneedle with JAK/STAT Inhibitor‐Loaded Nanovesicles Encapsulation for Tendinopathy

Chen, M., Zou, F., Wang, P., Hu, W., Shen, P., Wu, X., Xu, H., Rui, Y., Wang, X., & Wang, Y. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202401512 · Cited by 17

Loss of Suppressors of Cytokine Signaling 3 Promotes Aggressiveness in Hepatocellular Carcinoma

Wu, W., Kim, H., Zhang, C., Meng, X.-L., & Wu, Z. (2014) · Journal of Investigative Surgery · doi:10.3109/08941939.2013.873098 · Cited by 17

A mix of S and ΔS variants of STAT3 enable survival of activated B-cell-like diffuse large B-cell lymphoma cells in culture

Zheng, M., Turton, K. B., Zhu, F., Li, Y., Grindle, K. M., Annis, D. S., Lü, L., Drennan, A. C., Tweardy, D. J., Bharadwaj, U., et al. (2016) · Oncogenesis · doi:10.1038/oncsis.2015.44 · Cited by 15

B cells gone rogue: the intersection of diffuse large B cell lymphoma and autoimmune disease

Koff, J. L., & Flowers, C. R. (2016) · Expert Review of Hematology · doi:10.1080/17474086.2016.1180972 · Cited by 16

Genomics of LGL leukemia and select other rare leukemia/lymphomas

Moosic, K. B., Paila, U., Olson, K. C., Dziewulska, K. H., Wang, T. T., Xing, J. C., Ratan, A., Feith, D. J., Loughran, T. P., & Olson, T. L. (2019) · Best Practice & Research Clinical Haematology · doi:10.1016/j.beha.2019.06.003 · Cited by 16

Temporary interruption of baricitinib: characterization of interruptions and effect on clinical outcomes in patients with rheumatoid arthritis

Emery, P., Tanaka, Y., Cardillo, T. E., Schlichting, D. E., Rooney, T. P., Beattie, S. D., Helt, C. C., & Smolen, J. S. (2020) · Arthritis Research & Therapy · doi:10.1186/s13075-020-02199-8 · Cited by 16

Leukemic Diffuse Large B-Cell Lymphoma in a Patient With Myeloproliferative Disorder

Bhatt, V. R., Bociek, R. G., Yuan, J., Fu, K., Greiner, T. C., Davé, B. J., Rajan, S. K., & Armitage, J. O. (2015) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2015.0039 · Cited by 16

Identification of 4-(2-furanyl)pyrimidin-2-amines as Janus kinase 2 inhibitors

Wang, Y., Huang, W., Xin, M., Chen, P., Gui, L., Zhao, X., Tang, F. S., Wang, J., & Liu, F. (2016) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2016.10.011 · Cited by 16

Janus Kinase 3 Activity Is Necessary for Phosphorylation of Cytosolic Phospholipase A2 and Prostaglandin E2 Synthesis by Macrophages Infected with Francisella tularensis Live Vaccine Strain

Brummett, A. M., Navratil, A. R., Bryan, J. D., & Woolard, M. D. (2013) · Infection and Immunity · doi:10.1128/iai.01461-13 · Cited by 16

pH Dependent Drug Release of Silibinin, a Polyphenol Conjugated with Magnetic Nanoparticle Against the Human Colon Cancer Cell

Ramya, S., Saranya, T., Kavithaa, K., Preethi, S., Babu, H. W. S., Balachander, V., Paulpandi, M., & Narayanasamy, A. (2020) · Journal of Cluster Science · doi:10.1007/s10876-020-01789-5 · Cited by 15

Annona squamosa Fruit Extract Ameliorates Lead Acetate-Induced Testicular Injury by Modulating JAK-1/STAT-3/SOCS-1 Signaling in Male Rats

Mobasher, M. A., Alsirhani, A. M., Alwaili, M. A., Baakdah, F. M., Eid, T. M., Alshanbari, F. A., Alzahri, R. Y., Alkhodair, S. A., & El-Said, K. S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25105562 · Cited by 18

The genetics of hyper IgE syndromes

AlYafie, R. S., Velayutham, D., van Panhuys, N., & Jithesh, P. V. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1516068 · Cited by 16

Beyond calcineurin inhibitors

Safa, K., Riella, L. V., & Chandraker, A. K. (2013) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0b013e328365b3e6 · Cited by 15

Epstein-Barr virus gastric ulcer associated with ruxolitinib

Kusano, Y., Terui, Y., Ueda, K., & Hatake, K. (2016) · Annals of Hematology · doi:10.1007/s00277-016-2748-1 · Cited by 15

Nuclear Import of JAK1 Is Mediated by a Classical NLS and Is Required for Survival of Diffuse Large B-cell Lymphoma

Zhu, F., Hwang, B., Miyamoto, S., & Rui, L. (2016) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-16-0344 · Cited by 15

Risk of Inflammatory Bowel Disease in Patients with Chronic Myeloproliferative Neoplasms: A Danish Nationwide Cohort Study

Bak, M., Jess, T., Flachs, E. M., Zwisler, A., Juel, K., & Frederiksen, H. (2020) · Cancers · doi:10.3390/cancers12092700 · Cited by 16

Conjugated bilirubin affects cytokine profiles in hepatitis A virus infection by modulating function of signal transducer and activator of transcription factors

Castro-García, F. P., Corral‐Jara, K. F., Escobedo-Meléndez, G., Sandoval-Hernández, M. A., Rosenstein, Y., Román, S., Panduro, A., & Fierro, N. A. (2014) · Immunology · doi:10.1111/imm.12336 · Cited by 16

The off-label uses profile of tofacitinib in systemic rheumatic diseases

Zhao, Z., Ye, C., & Dong, L. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.106480 · Cited by 14

Targeting the Cyclophilin Domain of Ran-binding Protein 2 (Ranbp2) with Novel Small Molecules to Control the Proteostasis of STAT3, hnRNPA2B1 and M-Opsin

Cho, K., Orry, A. J. W., Park, S. E., & Ferreira, P. A. (2015) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.5b00134 · Cited by 15

CCM111, the water extract of Antrodia cinnamomea, regulates immune-related activity through STAT3 and NF-κB pathways

Lin, I.-Y., Pan, M., Lai, C., Lin, T.-T., Chen, C.-T., Chung, T.-S., Chen, C.-L., Lin, C.-H., Chuang, W., Lee, M.-C., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-05072-y · Cited by 14

Primary Immune Regulatory Disorders and Targeted Therapies

Kolukısa, B., & Barış, S. (2021) · Turkish Journal of Hematology · doi:10.4274/tjh.galenos.2021.2020.0724 · Cited by 14

Oral Janus Kinase Inhibitor for the Treatment of Rheumatoid Arthritis: Tofacitinib

Ni, H., Moe, S., Myint, K. T., & Htet, A. (2013) · ISRN Rheumatology · doi:10.1155/2013/357904 · Cited by 14

Discovery of potent and efficacious pyrrolopyridazines as dual JAK1/3 inhibitors

Hynes, J. J., Wu, H., Kempson, J., Duan, J. J. ‐., Lu, Z., Jiang, B., Stachura, S., Tokarski, J. S., Sack, J. S., Khan, J., et al. (2017) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2017.05.043 · Cited by 14

Development of selective inhibitors for the treatment of rheumatoid arthritis: (R)-3-(3-(Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)pyrrolidin-1-yl)-3-oxopropanenitrile as a JAK1-selective inhibitor

Chough, C., Joung, M., Lee, S., Lee, J., Kim, J. H., & Kim, B. M. (2018) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2018.01.021 · Cited by 14

Phosphorylated STAT 3 expression predicts better prognosis in smoldering type of adult T‐cell leukemia/lymphoma

Morichika, K., Karube, K., Kayo, H., Uchino, S., Nishi, Y., Nakachi, S., Okamoto, S., Morishima, S., Ohshiro, K., Nakazato, I., et al. (2019) · Cancer Science · doi:10.1111/cas.14114 · Cited by 14

MiR‐4282 inhibits tumor progression through down‐regulation of ZBTB2 by targeting LIN28B in oral squamous cell carcinoma

Zhang, Y., Zhang, Z., Huang, W., & Jinbiao, Z. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.29458 · Cited by 14

Live Cell Imaging Demonstrates Multiple Routes Toward a STAT1 Gain-of-Function Phenotype

Giovannozzi, S., Lemmens, V., Hendrix, J., Gijsbers, R., & Schrijvers, R. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01114 · Cited by 14

Development of JAK inhibitors for the treatment of immune-mediated diseases: kinase-targeted inhibitors and pseudokinase-targeted inhibitors

Kim, H.-O. (2020) · Archives of Pharmacal Research · doi:10.1007/s12272-020-01282-7 · Cited by 14

STAT3 promotes CD1d‐mediated lipid antigen presentation by regulating a critical gene in glycosphingolipid biosynthesis

Iyer, A. K., Liu, J., Gallo, R. M., Kaplan, M. H., & Brutkiewicz, R. R. (2015) · Immunology · doi:10.1111/imm.12521 · Cited by 14

Baricitinib for systemic lupus erythematosus

Yuan, K., Huang, G., Sang, X., & Xu, A. (2019) · The Lancet · doi:10.1016/s0140-6736(18)32763-6 · Cited by 14

The STAT Signaling Pathway in HIV-1 Infection: Roles and Dysregulation

Tolomeo, M., & Cascio, A. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26189123 · Cited by 15

JAK/STAT in human diseases: a common axis in immunodeficiencies and hematological disorders

Djidjik, R., Mahammed, L. L., Berkani, L. M., Allam, I., Benmoussa, A. H., Gharnaout, M., & Belaid, B. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1669688 · Cited by 25

Microglia Signaling Pathway Reporters Unveiled Manganese Activation of the Interferon/STAT1 Pathway and Its Mitigation by Flavonoids

Mossine, V. V., Waters, J. K., Sun, G. Y., Gu, Z., & Mawhinney, T. P. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03369-w · Cited by 13

Janus kinase inhibitors: efficacy and safety

Cohen, S. B., & Reddy, V. (2023) · Current Opinion in Rheumatology · doi:10.1097/bor.0000000000000972 · Cited by 13

Antioxidant mechanisms of mesenchymal stem cells and their therapeutic potential in vitiligo

Yang, R., Chen, S., Fu, S.-P., Zhao, D., Wan, W.-H., Yang, K., Lei, W., Yang, Y. C., Zhang, Q., & Zhang, T. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1293101 · Cited by 14

EBV + B cell-derived exosomes promote EBV-associated T/NK-cell lymphoproliferative disease immune evasion by STAT3/IL-10/PD-L1 pathway

Chen, W., Xie, Y., Li, D., Wen, P., & Wang, L. (2024) · Immunologic Research · doi:10.1007/s12026-024-09531-3 · Cited by 13

Anti‐angiogenic activity of thienopyridine derivative LCB 03‐0110 by targeting VEGFR ‐2 and JAK / STAT 3 Signalling

Kim, B., Lee, Y., Yoo, H., Cui, M., Lee, S., Kim, S. Y., Cho, J. U., Lee, H., Yang, B., Kwon, Y., et al. (2015) · Experimental Dermatology · doi:10.1111/exd.12698 · Cited by 13

Acceleration of Bcr-Abl+ leukemia induced by deletion of JAK2

Grundschober, E., Hoelbl‐Kovacic, A., Bhagwat, N., Kovačic, B., Scheicher, R., Eckelhart, E., Kollmann, K., Keller, M., Grebien, F., Wagner, K.-U., et al. (2014) · Leukemia · doi:10.1038/leu.2014.152 · Cited by 13

CXCR7 silencing inhibits the migration and invasion of human tumor endothelial cells derived from hepatocellular carcinoma by suppressing STAT3

Wu, Y., Tian, L., Xu, Y., Zhang, M., Xiang, S., Zhao, J., & Wang, Z. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.9114 · Cited by 13

Influence of single nucleotide polymorphisms in pri-miR-124-1 and STAT3 genes on gastric cancer susceptibility

Mirnoori, S., Shahangian, S. S., Salehi, Z., Mashayekhi, F., Sasani, S. T., & Saedi, H. (2018) · British Journal of Biomedical Science · doi:10.1080/09674845.2018.1492206 · Cited by 13

Therapeutic Advances in Hematology

Kolibaba, K. S., Sterchele, J. A., Joshi, A. D., Forsyth, M., Alwon, E., Beygi, H., & Kennealey, G. T. (2013) · Cited by 13

Persistent Large Granular Lymphocyte Clonal Expansions: “The Root of Many Evils”—And of Some Goodness

Bravo‐Pérez, C., Carrillo‐Tornel, S., Torralba, E. G., & Jerez, A. (2022) · Cancers · doi:10.3390/cancers14051340 · Cited by 13

Modulatory properties of curcumin in cancer: A narrative review on the role of interferons

Chamani, S., Moossavi, M., Naghizadeh, A., Abbasifard, M., Kesharwani, P., Sathyapalan, T., & Sahebkar, A. (2023) · Phytotherapy Research · doi:10.1002/ptr.7734 · Cited by 13

Recent progress on tyrosine kinase 2 JH2 inhibitors

Deng, L., Wan, L., Liao, T., Wang, L., Wang, J., Wu, X., & Shi, J. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110434 · Cited by 13

Exploring conformation changes of Janus kinase 2 pseudokinase mediated by mutations through Gaussian accelerated molecular dynamics and principal component analysis

Bao, H., He, W., & Chen, J. (2023) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2023.2260486 · Cited by 13

JAKs—STATs信号传导——疾病治疗新领域

Ping, Z. X. (2001) · 国外医学（免疫学分册）

004 JAKs-STATs信号传导--疾病治疗新领域

Ping, Z. X., & 吴慧君 (2001) · 国外医学（免疫学分册） · doi:10.3760/cma.j.issn.1673-4394.2001.01.004

Evolving cognition of the JAK-STAT signaling pathway: autoimmune disorders and cancer

Chen, X., Yao, Q., Gu, X., Shi, Q., Yuan, X., Chu, Q., Bao, Z., Lu, J., & Li, L. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01468-7 · Cited by 797

JAKs and STATs from a Clinical Perspective: Loss-of-Function Mutations, Gain-of-Function Mutations, and Their Multidimensional Consequences

Ott, N., Faletti, L. E., Heeg, M., Andreani, V., & Grimbacher, B. (2023) · Journal of Clinical Immunology · doi:10.1007/s10875-023-01483-x · Cited by 87

Immunodeficiency: Consequences of Mutations in JAK-STAT Signaling

Silberger, D. J., & Pham, D. (2020) · CRC Press eBooks · doi:10.1201/9781351042468-13 · Cited by 1