Physiological integration of taste and metabolism

Projected U.S. State-Level Prevalence of Adult Obesity and Severe Obesity

Ward, Z. J., Bleich, S. N., Cradock, A. L., Barrett, J. L., Giles, C. M., Flax, C., Long, M. W., & Gortmaker, S. L. (2019) · New England Journal of Medicine · doi:10.1056/nejmsa1909301 · Cited by 2,009 · see citing works

Glucagon-like peptide 1 (GLP-1)

Müller, T. D., Finan, B., Bloom, S. R., D'Alessio, D., Drucker, D. J., Flatt, P. R., Fritsche, A., Gribble, F., Grill, H. J., Habener, J. F., et al. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.09.010 · Cited by 1,868 · see citing works

Mechanisms, Pathophysiology, and Management of Obesity

Heymsfield, S. B., & Wadden, T. A. (2017) · New England Journal of Medicine · doi:10.1056/nejmra1514009 · Cited by 1,867 · see citing works

The Receptors for Mammalian Sweet and Umami Taste

Zhao, G. Q., Zhang, Y., Hoon, M. A., Chandrashekar, J. V., Erlenbach, I., Ryba, N. J. P., & Zuker, C. S. (2003) · Cell · doi:10.1016/s0092-8674(03)00844-4 · Cited by 1,343 · see citing works

The Molecular Receptive Ranges of Human TAS2R Bitter Taste Receptors

Meyerhof, W., Batram, C., Kühn, C., Brockhoff, A., Chudoba, E., Bufe, B., Appendino, G., & Behrens, M. (2009) · Chemical Senses · doi:10.1093/chemse/bjp092 · Cited by 1,146 · see citing works

Consumption of sugar sweetened beverages, artificially sweetened beverages, and fruit juice and incidence of type 2 diabetes: systematic review, meta-analysis, and estimation of population attributable fraction

Imamura, F., O’Connor, L., Ye, Z., Mursu, J., Hayashino, Y., Bhupathiraju, S. N., & Forouhi, N. G. (2015) · BMJ · doi:10.1136/bmj.h3576 · Cited by 977 · see citing works

Added sugar intake and cardiovascular diseases mortality among US adults

Yang, Q., Zhang, Z., Gregg, E. W., Flanders, W. D., Merritt, R., & Hu, F. B. (2014) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2013.13563 · Cited by 947 · see citing works

T1R3 and gustducin in gut sense sugars to regulate expression of Na ⁺ -glucose cotransporter 1

Margolskee, R. F., Dyer, J., Kokrashvili, Z., Salmon, K. S. H., Ilegems, E., Daly, K., Maillet, E. L., Ninomiya, Y., Mosinger, B., & Shirazi-Beechey, S. P. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706678104 · Cited by 882 · see citing works

A Neural Circuit for Gut-Induced Reward

Han, W., Téllez, L. A., Perkins, M. H., Pérez-Martínez, I. O., Qu, T., Ferreira, J. G. P., Ferreira, T. L., Quinn, D., Liu, Z.-W., Gao, X., et al. (2018) · Cell · doi:10.1016/j.cell.2018.08.049 · Cited by 739 · see citing works

The cells and peripheral representation of sodium taste in mice

Chandrashekar, J. V., Kühn, C., Oka, Y., Yarmolinsky, D. A., Hümmler, E., Ryba, N. J. P., & Zuker, C. S. (2010) · Nature · doi:10.1038/nature08783 · Cited by 694 · see citing works

Sugar-Sweetened Beverages and Genetic Risk of Obesity

Qi, Q., Chu, A. Y., Kang, J., Jensen, M. K., Curhan, G. C., Pasquale, L. R., Ridker, P. M., Hunter, D. J., Willett, W. C., Rimm, E. B., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1203039 · Cited by 599 · see citing works

Sweet taste receptors in rat small intestine stimulate glucose absorption through apical GLUT2

Mace, O. J., Affleck, J. A., Patel, N., & Kellett, G. L. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.130906 · Cited by 455 · see citing works

Personalized microbiome-driven effects of non-nutritive sweeteners on human glucose tolerance

Suez, J., Cohen, Y., Valdés‐Mas, R., Mor, U., Dori-Bachash, M., Federici, S., Zmora, N., Leshem, A., Heinemann, M., Linevsky, R., et al. (2022) · Cell · doi:10.1016/j.cell.2022.07.016 · Cited by 431 · see citing works

The effect of semaglutide 2.4 mg once weekly on energy intake, appetite, control of eating, and gastric emptying in adults with obesity

Friedrichsen, M., Breitschaft, A., Tadayon, S., Wizert, A., & Skovgaard, D. (2021) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.14280 · Cited by 427 · see citing works

The sweetness and bitterness of childhood: Insights from basic research on taste preferences

Mennella, J. A., & Bobowski, N. K. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.05.015 · Cited by 403 · see citing works

Decoding Neural Circuits that Control Compulsive Sucrose Seeking

Nieh, E. H., Matthews, G. A., Allsop, S. A., Presbrey, K. N., Leppla, C. A., Wichmann, R., Neve, R., Wildes, C. P., & Tye, K. M. (2015) · Cell · doi:10.1016/j.cell.2015.01.003 · Cited by 402 · see citing works

A Gustotopic Map of Taste Qualities in the Mammalian Brain

Chen, X., Gabitto, M., Peng, Y., Ryba, N. J. P., & Zuker, C. S. (2011) · Science · doi:10.1126/science.1204076 · Cited by 379 · see citing works

Psychophysics of sweet and fat perception in obesity: problems, solutions and new perspectives

Bartoshuk, L. M., Duffy, V. B., Hayes, J. E., MOSKOWITZ, H. R., & Snyder, D. J. (2006) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2006.1853 · Cited by 378 · see citing works

The Taste of Carbonation

Chandrashekar, J. V., Yarmolinsky, D. A., von Buchholtz, L. J., Oka, Y., Sly, W. S., Ryba, N. J. P., & Zuker, C. S. (2009) · Science · doi:10.1126/science.1174601 · Cited by 377 · see citing works

The gut–brain axis mediates sugar preference

Tan, H.-E., Sisti, A. C., Jin, H., Vignovich, M., Villavicencio, M., Tsang, K. S., Goffer, Y., & Zuker, C. S. (2020) · Nature · doi:10.1038/s41586-020-2199-7 · Cited by 317 · see citing works

Modulation of taste sensitivity by GLP‐1 signaling

Shin, Y., Martin, B., Golden, E. J., Dotson, C. D., Maudsley, S. R., Kim, W., Jang, H.-J., Mattson, M. P., Drucker, D. J., Egan, J. M., et al. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05397.x · Cited by 287 · see citing works

Consumption of Low-Calorie Sweeteners among Children and Adults in the United States

Sylvetsky, A. C., Jin, Y., Clark, E. J., Welsh, J. A., Rother, K. I., & Talegawkar, S. A. (2017) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2016.11.004 · Cited by 282 · see citing works

Bitter, Sweet, Salty, Sour and Umami Taste Perception Decreases with Age: Sex-Specific Analysis, Modulation by Genetic Variants and Taste-Preference Associations in 18 to 80 Year-Old Subjects

Barragán, R., Coltell, Ó., Portolés, O., Asensio, E. M., Sorlí, J. V., Ortega‐Azorín, C., González, J. I., Sáiz, C., Fernández-Carrión, R., Ordovás, J. M., et al. (2018) · Nutrients · doi:10.3390/nu10101539 · Cited by 261 · see citing works

Sweet and bitter taste in the brain of awake behaving animals

Peng, Y., Gillis-Smith, S., Jin, H., Tränkner, D., Ryba, N. J. P., & Zuker, C. S. (2015) · Nature · doi:10.1038/nature15763 · Cited by 246 · see citing works

G Protein-Coupled Receptors in Taste Physiology and Pharmacology

Ahmad, R., & Dalziel, J. E. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.587664 · Cited by 241 · see citing works

The artificial sweetener erythritol and cardiovascular event risk

Witkowski, M., Nemet, I., Alamri, H. S., Wilcox, J. D., Gupta, N., Nimer, N. A., Haghikia, A., Li, X. S., Wu, Y., Saha, P. P., et al. (2023) · Nature Medicine · doi:10.1038/s41591-023-02223-9 · Cited by 238 · see citing works

Separate circuitries encode the hedonic and nutritional values of sugar

Téllez, L. A., Han, W., Zhang, X., Ferreira, T. L., Pérez-Martínez, I. O., Shammah‐Lagnado, S. J., van den Pol, A. N., & de Araújo, I. E. (2016) · Nature Neuroscience · doi:10.1038/nn.4224 · Cited by 215 · see citing works

The preference for sugar over sweetener depends on a gut sensor cell

Buchanan, K. L., Rupprecht, L. E., Kaelberer, M. M., Sahasrabudhe, A., Klein, M. E., Villalobos, J. A., Liu, W. W., Yang, A., Gelman, J., Park, S., et al. (2022) · Nature Neuroscience · doi:10.1038/s41593-021-00982-7 · Cited by 202 · see citing works

An inter-organ neural circuit for appetite suppression

Zhang, T., Perkins, M. H., Chang, H., Han, W., & de Araujo, I. E. (2022) · Cell · doi:10.1016/j.cell.2022.05.007 · Cited by 192 · see citing works

Taste preferences and body weight changes in an obesity-prone population.

Salbe, A. D., DelParigi, A., Pratley, R. E., Drewnowski, A., & Tataranni, P. A. (2004) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.3.372 · Cited by 188 · see citing works

GLP-1 Analog Modulates Appetite, Taste Preference, Gut Hormones, and Regional Body Fat Stores in Adults with Obesity

Kadouh, H., Chedid, V., Halawi, H., Burton, D. D., Clark, M. M., Khemani, D., Vella, A., Acosta, A., & Camilleri, M. (2020) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgz140 · Cited by 166 · see citing works

Inflammation arising from obesity reduces taste bud abundance and inhibits renewal

Kaufman, A., Choo, E., Koh, A., & Dando, R. (2018) · PLoS Biology · doi:10.1371/journal.pbio.2001959 · Cited by 164 · see citing works

Short-Term Consumption of Sucralose with, but Not without, Carbohydrate Impairs Neural and Metabolic Sensitivity to Sugar in Humans

Dalenberg, J. R., Patel, B. P., Denis, R., Veldhuizen, M. G., Nakamura, Y., Vinke, P. C., Luquet, S. H., & Small, D. M. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.01.014 · Cited by 163 · see citing works

All-Electrical Ca2+-Independent Signal Transduction Mediates Attractive Sodium Taste in Taste Buds

Nomura, K., Nakanishi, M., Ishidate, F., Iwata, K., & Taruno, A. (2020) · Neuron · doi:10.1016/j.neuron.2020.03.006 · Cited by 163 · see citing works

Mechanism of fat taste perception: Association with diet and obesity

Liu, D., Archer, N., Duesing, K., Hannan, G. N., & Keast, R. (2016) · Progress in Lipid Research · doi:10.1016/j.plipres.2016.03.002 · Cited by 151 · see citing works

The gustatory cortex and multisensory integration

de Araujo, I. E., & Simon, S. A. (2009) · International Journal of Obesity · doi:10.1038/ijo.2009.70 · Cited by 150 · see citing works

The endocrinology of taste receptors

Calvo, S. S.-C., & Egan, J. M. (2015) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.7 · Cited by 142 · see citing works

Sugar Addiction: From Evolution to Revolution

Wiss, D. A., Avena, N. M., & Rada, P. V. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00545 · Cited by 138 · see citing works

Food Intake Recruits Orosensory and Post-ingestive Dopaminergic Circuits to Affect Eating Desire in Humans

Thanarajah, S. E., Backes, H., DiFeliceantonio, A. G., Albus, K., Cremer, A. L., Hanßen, R., Lippert, R. N., Cornely, O. A., Small, D. M., Brüning, J. C., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.12.006 · Cited by 128 · see citing works

The cellular mechanism for water detection in the mammalian taste system

Zocchi, D., Wennemuth, G., & Oka, Y. (2017) · Nature Neuroscience · doi:10.1038/nn.4575 · Cited by 127 · see citing works

Factors Related to Fungiform Papillae Density: The Beaver Dam Offspring Study

Fischer, M., Cruickshanks, K. J., Schubert, C. R., Pinto, A., Klein, R., Pankratz, N., Pankow, J. S., & Huang, G.-H. (2013) · Chemical Senses · doi:10.1093/chemse/bjt033 · Cited by 122 · see citing works

Low-calorie sweetener use and energy balance: Results from experimental studies in animals, and large-scale prospective studies in humans

Fowler, S. P. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.04.047 · Cited by 117 · see citing works

The dietary sweetener sucralose is a negative modulator of T cell-mediated responses

Zani, F., Blagih, J., Gruber, T., Buck, M. D., Jones, N., Hennequart, M., Newell, C. L., Pilley, S. E., Soro-Barrio, P., Kelly, G. P., et al. (2023) · Nature · doi:10.1038/s41586-023-05801-6 · Cited by 116 · see citing works

The Effect of Artificial Sweeteners Use on Sweet Taste Perception and Weight Loss Efficacy: A Review

Wilk, K., Korytek, W., Pelczyńska, M., Moszak, M., & Bogdański, P. (2022) · Nutrients · doi:10.3390/nu14061261 · Cited by 105 · see citing works

Artificial Sweeteners Disrupt Tight Junctions and Barrier Function in the Intestinal Epithelium through Activation of the Sweet Taste Receptor, T1R3

Shil, A., Olusanya, O., Ghufoor, Z., Forson, B., Marks, J., & Chichger, H. (2020) · Nutrients · doi:10.3390/nu12061862 · Cited by 103 · see citing works

Human Type II Taste Cells Express Angiotensin-Converting Enzyme 2 and Are Infected by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)

Doyle, M. E., Appleton, A., Liu, Q., Yao, Q., Mazucanti, C. H., & Egan, J. M. (2021) · American Journal Of Pathology · doi:10.1016/j.ajpath.2021.05.010 · Cited by 96 · see citing works

Effects of Sugar‐Sweetened, Artificially Sweetened, and Unsweetened Beverages on Cardiometabolic Risk Factors, Body Composition, and Sweet Taste Preference: A Randomized Controlled Trial

Ebbeling, C. B., Feldman, H. A., Steltz, S. K., Quinn, N. L., Robinson, L. M., & Ludwig, D. S. (2020) · Journal of the American Heart Association · doi:10.1161/jaha.119.015668 · Cited by 95 · see citing works

Physiology of the tongue with emphasis on taste transduction

Doyle, M. E., Premathilake, H., Yao, Q., Mazucanti, C. H., & Egan, J. M. (2022) · Physiological Reviews · doi:10.1152/physrev.00012.2022 · Cited by 88 · see citing works

An application of Pavlovian principles to the problems of obesity and cognitive decline

Davidson, T. L., Sample, C. H., & Swithers, S. E. (2013) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.07.014 · Cited by 86 · see citing works

Chronic Low-Calorie Sweetener Use and Risk of Abdominal Obesity among Older Adults: A Cohort Study

Chia, C. W., Shardell, M. D., Tanaka, T., Liu, D. D., Gravenstein, K. S., Simonsick, E. M., Egan, J. M., & Ferrucci, L. (2016) · PLoS ONE · doi:10.1371/journal.pone.0167241 · Cited by 81 · see citing works

Dietary sugar inhibits satiation by decreasing the central processing of sweet taste

May, C. E., Rosander, J., Gottfried, J., Dennis, E., & Dus, M. (2020) · eLife · doi:10.7554/elife.54530 · Cited by 72 · see citing works

Genetic loss or pharmacological blockade of testes-expressed taste genes causes male sterility

Mosinger, B. J., Redding, K., Parker, M. R., Yevshayeva, V., Yee, K. K., Dyomina, K., Li, Y., & Margolskee, R. F. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1302827110 · Cited by 69 · see citing works

Taste loss with obesity in mice and men

Kaufman, A., Kim, J., Noel, C. A., & Dando, R. (2019) · International Journal of Obesity · doi:10.1038/s41366-019-0429-6 · Cited by 67 · see citing works

The neural basis of sugar preference

Liu, W. W., & Bohórquez, D. V. (2022) · Nature reviews. Neuroscience · doi:10.1038/s41583-022-00613-5 · Cited by 63 · see citing works

Effect of sucralose and aspartame on glucose metabolism and gut hormones

Ahmad, S. Y., Friel, J. K., & MacKay, D. (2019) · Nutrition Reviews · doi:10.1093/nutrit/nuz099 · Cited by 61 · see citing works

Obesity is associated with altered gene expression in human tastebuds

Archer, N., Shaw, J. M., Cochet-Broch, M. O., Bunch, R. J., Poelman, A. A. M., Barendse, W., & Duesing, K. (2019) · International Journal of Obesity · doi:10.1038/s41366-018-0303-y · Cited by 59 · see citing works

Glucose promotes its own metabolism by acting on the cell-surface glucose-sensing receptor T1R3

Nakagawa, Y. S., Ohtsu, Y., Nagasawa, M., Shibata, H., & Kojima, I. (2013) · Endocrine Journal · doi:10.1507/endocrj.ej13-0431 · Cited by 57 · see citing works

Dietary sugars and non-caloric sweeteners elicit different homeostatic and hedonic responses in the brain

van Opstal, A. M., Kaal, I., van den Berg‐Huysmans, A. A., Hoeksma, M. R., Blonk, C., Pijl, H., Rombouts, S. A. R. B., & van der Grond, J. (2018) · Nutrition · doi:10.1016/j.nut.2018.09.004 · Cited by 57 · see citing works

A subset of broadly responsive Type III taste cells contribute to the detection of bitter, sweet and umami stimuli

Banik, D. D., Benfey, E. D., Martin, L. E., Kay, K. E., Loney, G. C., Nelson, A. R., Ahart, Z. C., Kemp, B. T., Kemp, B. R., Torregrossa, A., et al. (2020) · PLoS Genetics · doi:10.1371/journal.pgen.1008925 · Cited by 57 · see citing works

Obese Subjects With Specific Gustatory Papillae Microbiota and Salivary Cues Display an Impairment to Sense Lipids

Besnard, P., Christensen, J. E., Brignot, H., Bernard, A., Passilly‐Degrace, P., Nicklaus, S., de Barros, J.-P. P., Collet, X., Lelouvier, B., Servant, F., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-24619-1 · Cited by 55 · see citing works

Taste Intensity in the Beaver Dam Offspring Study

Fischer, M., Cruickshanks, K., Schubert, C., Pinto, A., Klein, B. E. K., Klein, R., Nieto, F., Pankow, J. S., Huang, G.-H., & Snyder, D. J. (2013) · The Laryngoscope · doi:10.1002/lary.23894 · Cited by 52 · see citing works

The proton channel OTOP1 is a sensor for the taste of ammonium chloride

Liang, Z., Wilson, C., Teng, B., Kinnamon, S. C., & Liman, E. R. (2023) · Nature Communications · doi:10.1038/s41467-023-41637-4 · Cited by 52 · see citing works

The evolution of sour taste

Frank, H. E. R., Amato, K., Trautwein, M., Maia, P. D., Liman, E. R., Nichols, L. M., Schwenk, K., Breslin, P. A. S., & Dunn, R. R. (2022) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2021.1918 · Cited by 48 · see citing works

Differences in taste detection thresholds between normal-weight and obese young adults

Park, D. C., Yeo, J. H., Ryu, I. Y., Kim, S. H., Jung, J., & Yeo, S. G. (2015) · Acta Oto-Laryngologica · doi:10.3109/00016489.2014.975370 · Cited by 47 · see citing works

Effects of amiloride on salt taste in humans

Desor, J. A., & Finn, J. P. (1989) · Chemical Senses · doi:10.1093/chemse/14.6.793 · Cited by 47 · see citing works

Evidence that human oral glucose detection involves a sweet taste pathway and a glucose transporter pathway

Breslin, P. A. S., Izumi, A., Tharp, A., Ohkuri, T., Yokoo, Y., Flammer, L. J., Rawson, N. E., & Margolskee, R. F. (2021) · PLoS ONE · doi:10.1371/journal.pone.0256989 · Cited by 46 · see citing works

Sweet Taste Receptor Activation in the Gut Is of Limited Importance for Glucose-Stimulated GLP-1 and GIP Secretion

Saltiel, M. Y., Kuhre, R. E., Christiansen, C. B., Eliasen, R., Conde‐Frieboes, K. W., ROSENKILDE, M. M., & Holst, J. J. (2017) · Nutrients · doi:10.3390/nu9040418 · Cited by 43 · see citing works

Long-Term Dysfunction of Taste Papillae in SARS-CoV-2

Yao, Q., Doyle, M. E., Liu, Q., Appleton, A., O’Connell, J. F., Weng, N., & Egan, J. M. (2023) · NEJM Evidence · doi:10.1056/evidoa2300046 · Cited by 43 · see citing works

Trends in added sugars intake and sources among U.S. adults using the National Health and Nutrition Examination Survey (NHANES) 2001–2018

DiFrancesco, L., Fulgoni, V. L. I., Gaine, P. C., Scott, M. O., & Ricciuto, L. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.897952 · Cited by 40 · see citing works

Activation of the sweet taste receptor, T1R3, by the artificial sweetener sucralose regulates the pulmonary endothelium

Harrington, E. O., Vang, A., Braza, J., Shil, A., & Chichger, H. (2017) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00490.2016 · Cited by 39 · see citing works

Persistent symptoms are associated with long term effects of COVID-19 among children and young people: Results from a systematic review and meta-analysis of controlled studies

Behnood, S. A., Newlands, F., O’Mahoney, L. L., Ghahfarokhi, M. H., Muhid, M. Z., Dudley, J., Stephenson, T. J., Ladhani, S. N., Bennett, S. D., Viner, R., et al. (2023) · PLoS ONE · doi:10.1371/journal.pone.0293600 · Cited by 35 · see citing works

Genetic determinants of liking and intake of coffee and other bitter foods and beverages

Cornelis, M. C., & van Dam, R. M. (2021) · Scientific Reports · doi:10.1038/s41598-021-03153-7 · Cited by 34 · see citing works

Chloride ions evoke taste sensations by binding to the extracellular ligand-binding domain of sweet/umami taste receptors

Atsumi, N., Yasumatsu, K., Takashina, Y., Ito, C., Yasui, N., Margolskee, R. F., & Yamashita, A. (2023) · eLife · doi:10.7554/elife.84291 · Cited by 30 · see citing works

Sweet Taste Receptor Expression and Its Activation by Sucralose to Regulate Glucose Absorption in Mouse Duodenum

Shi, Q., Zhu, X., & Deng, S. (2019) · Journal of Food Science · doi:10.1111/1750-3841.14586 · Cited by 25 · see citing works

Offspring of obese mice display enhanced intake and sensitivity for palatable stimuli, with altered expression of taste signaling elements

Choo, E., Wong, L., Chau, P., Bushnell, J., & Dando, R. (2020) · Scientific Reports · doi:10.1038/s41598-020-68216-7 · Cited by 22 · see citing works

Age-related taste cell generation in circumvallate papillae organoids via regulation of multiple signaling pathways

Ren, W., Liu, Q., Zhang, X., & Yu, Y. (2020) · Experimental Cell Research · doi:10.1016/j.yexcr.2020.112150 · Cited by 19 · see citing works

Encoding Taste: From Receptors to Perception

Roper, S. D. (2021) · Handbook of experimental pharmacology · doi:10.1007/164_2021_559 · Cited by 18 · see citing works

Longitudinal trajectories and determinants of human fungiform papillae density

Karikkineth, A. C., Tang, E. Y., Kuo, P., Ferrucci, L., Egan, J. M., & Chia, C. W. (2021) · Aging · doi:10.18632/aging.203741 · Cited by 16 · see citing works

Associations between Taste Perception Profiles and Empirically Derived Dietary Patterns: An Exploratory Analysis among Older Adults with Metabolic Syndrome

Gervis, J. E., Fernández-Carrión, R., Chui, K. K. H., Ma, J., Coltell, Ó., Sorlí, J. V., Asensio, E. M., Ortega‐Azorín, C., Fidalgo, J. A. P., Portolés, O., et al. (2021) · Nutrients · doi:10.3390/nu14010142 · Cited by 13 · see citing works

The Influence of Common Noncommunicable Diseases on Chemosensory Perception and Clinical Implications in Children and Adolescents

Cattaneo, C., Mameli, C., D’Auria, E., Zuccotti, G., & Pagliarini, E. (2021) · Advances in Nutrition · doi:10.1093/advances/nmab100 · Cited by 12 · see citing works

Western Diet Induced Remodelling of the Tongue Proteome

Dutt, M., Ng, Y., Molendijk, J., Karimkhanloo, H., Liao, L., Blazev, R., Montgomery, M. K., Watt, M. J., & Parker, B. L. (2021) · Proteomes · doi:10.3390/proteomes9020022 · Cited by 10 · see citing works

Endocrinology of Taste with Aging

Chia, C. W., Yeager, S. M., & Egan, J. M. (2023) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2022.10.002 · Cited by 10 · see citing works

GLP-1 single, dual, and triple receptor agonists for treating type 2 diabetes and obesity: a narrative review

Alfaris, N., Waldrop, S., Johnson, V., Boaventura, B., Kendrick, K., & Stanford, F. C. (2024) · EClinicalMedicine · doi:10.1016/j.eclinm.2024.102782 · Cited by 224 · see citing works

A menu for microbes: unraveling appetite regulation and weight dynamics through the microbiota-brain connection across the lifespan

Ribeiro, G., Schellekens, H., Cuesta‐Marti, C., Maneschy, I. R., Ismael, S., Cuevas‐Sierra, A., Martínez, J. A., Silvestre, M. P., Marques, C., Moreira-Rosário, A., et al. (2025) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00227.2024 · Cited by 12 · see citing works

Effect of a Novel Food Rich in Miraculin on the Oral Microbiome of Malnourished Oncologic Patients with Dysgeusia

Plaza‐Díaz, J., Ruiz‐Ojeda, F. J., Plaza, B. L., Brandimonte‐Hernández, M., Álvarez‐Mercado, A. I., Arcos-Castellanos, L., Feliú, J., Hummel, T. R., Milla, S. P., & Gil, Á. (2024) · Cancers · doi:10.3390/cancers16193414 · Cited by 8 · see citing works

The multiorgan crosstalk network of the liver-brain axis: From molecular mechanisms to emerging therapeutic targets

Wang, W., Xin, Y.-Y., Niu, J.-Q., & Jin, W.-L. (2026) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2026.101460 · Cited by 8 · see citing works

Differences in Perceived Versus Actual Sensory Perception in Avoidant/Restrictive Food Intake Disorder

Gydus, J. E., Holman, K., Harshman, S. G., Stull, M. R., Kuhnle, M. C., Wons, O. B., Asanza, E., Hauser, K., Stern, C. M., Becker, K. R., et al. (2025) · International Journal of Eating Disorders · doi:10.1002/eat.24358 · Cited by 6 · see citing works

From Liking to Following: The Role of Food Preferences, Taste Perception, and Lifestyle Factors in Adherence to the Mediterranean Diet Among Young Individuals

Sorlí, J. V., Sahuquillo, E. D. L. C., Arráez, J. I. G., Portolés, O., Gimenez-Alba, I. M., Fernández-Carrión, R., Coltell, Ó., Gonzalez-Monje, I., Sáiz, C., Pascual, E. C., et al. (2025) · Nutrients · doi:10.3390/nu17030600 · Cited by 6 · see citing works

Psychological and behavioral effects of GLP-1 and GIP agonists in weight loss: a comprehensive review

Ameer, F., Villacres, N. Y., Bustos, D., Shah, P., Appah, N., Luzaya, G. N., Corradi, F., Bakare, I. S., Trujillo, J. V., Mylavarapu, M., et al. (2025) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-025-01770-x · Cited by 5 · see citing works

Biased histamine signaling selectively gates fat preference

Zheng, Y., Liao, J., Fang, Z., Tang, X., Zhou, Z., Zhao, X., Li, M., Liu, M., Xu, S., Chen, J., et al. (2025) · Neuron · doi:10.1016/j.neuron.2025.10.035 · Cited by 4 · see citing works

Enteroendocrine hormonal response after the ingestion of cola beverages with sucrose and non-nutritive sweeteners in healthy adults: A randomized crossover trial

Galicia-Ayala, C., Klünder‐Klünder, M., Vilchis-Ordóñez, A., López-Martı́nez, B., & Miranda‐Lora, A. L. (2025) · Nutrition · doi:10.1016/j.nut.2025.112938 · Cited by 3 · see citing works

Debittering and Masking Soy Peptides for Oral Consumption and Immune‐Boosting Function

Li, W., Wen, C., Olatunji, O. J., Lee, C. C., & Ashaolu, T. J. (2026) · Journal of Food Biochemistry · doi:10.1155/jfbc/5596045 · Cited by 3 · see citing works

The structure and function of taste G protein-coupled receptors and their implications in diseases

Zhai, R., Yong, X., Jiang, P., Tizzano, M., Shao, Z., Yan, W., & Zheng, X. M. (2026) · International Journal of Oral Science · doi:10.1038/s41368-026-00436-5 · Cited by 3 · see citing works

Ultra-processed foods and cardiometabolic risk: from evidence to policy

O’Neill, H. M. (2026) · npj Metabolic Health and Disease · doi:10.1038/s44324-026-00116-2 · Cited by 3 · see citing works

Hunger and the transition from parenteral nutrition in hospitalized adults: A descriptive cohort study

Loss, S. H., Alves, K. M., Nunes, A. C., Stefani, J., Loureiro, G. P., Píscopo, A., & Viana, L. V. (2024) · Journal of Parenteral and Enteral Nutrition · doi:10.1002/jpen.2710 · Cited by 3 · see citing works

Head and neck complications of cancer therapies: taste and smell

Barasch, A., Epstein, J. B., & Doty, R. L. (2024) · Oral Diseases · doi:10.1111/odi.15074 · Cited by 3 · see citing works

Ibuprofen inhibits human sweet taste and glucose detection implicating an additional mechanism of metabolic disease risk reduction

Hanselman, E. C., Harmon, C. P., Deng, D., Sywanycz, S. M., Caronia, L., Jiang, P., & Breslin, P. A. S. (2025) · British Journal of Pharmacology · doi:10.1111/bph.70004 · Cited by 3 · see citing works

Nil by mouth in intensive care – A qualitative, multiformat survey exploring the impact of mandatory oral restriction, from the health care providers perspective

Nunn, L., Allison, M., McEntee, J., Mooney, L., Green, L., Brown, A., Lewis, R., Karpasiti, T., Nurek, M., Meechan, C., et al. (2025) · Intensive and Critical Care Nursing · doi:10.1016/j.iccn.2024.103931 · Cited by 2 · see citing works

Functional variants in the TAS2R38 bitter taste receptor associate with postprandial glycemiaPreprint

Gervis, J. E., Westerman, K. E., Cole, J. B., Merino, J., CROMER, S. J., & Udler, M. S. (2025) · medRxiv · doi:10.1101/2025.05.23.25328232 · Cited by 2 · see citing works

Olfactory and gustatory perception in Brazilian PKU patients: A cross‐sectional study

Tonon, T., Martinez, C. C., Nalin, T., Poloni, S., Piltcher, O. B., Maillot, F., Franceschetto, B. F., & Schwartz, I. V. D. (2024) · JIMD Reports · doi:10.1002/jmd2.12445 · Cited by 1 · see citing works

Taste in ICU: An unmet need

Nunn, L., McEntee, J., & Singh, S. (2024) · Intensive and Critical Care Nursing · doi:10.1016/j.iccn.2024.103855 · Cited by 1 · see citing works

Weight loss injections for the obese and unemployed in the UK: is wellbeing the missing link?

Madan, V. (2025) · Discover Social Science and Health · doi:10.1007/s44155-025-00213-5

Sour taste sensation as a neuroimmune modulator in liver injury

Dutta, R. K., Oben, J. A., & Diehl, A. M. (2025) · Journal of Hepatology · doi:10.1016/j.jhep.2025.06.003

17β-estradiol enhances sucrose chemosensory signaling via estrogen receptor-dependent genomic regulation in STC-1 cells

Gao, L., Mao, Y., Li, C., Zhu, Y., Liu, Y., Xu, Q., Chen, M., & Zhang, G. (2025) · Food Bioscience · doi:10.1016/j.fbio.2025.107499

Postoral receptors and alimentary taste: implications for energy intake and appetite

Pennaneach, C., Costanzo, A., Dinnella, C., Spinelli, S., Monteleone, E., & Keast, R. (2025) · Chemical Senses · doi:10.1093/chemse/bjaf039

XVI Jesús Culebras Lecture. Development of eating habits in children: sense and sensitivity

Villares, J. M. M. (2025) · Nutrición Hospitalaria · doi:10.20960/nh.06231

Taste disorders in cancer patients and current therapeutic approaches: a narrative review of an understudied topic in supportive care

Barasch, A., & Epstein, J. B. (2025) · Supportive Care in Cancer · doi:10.1007/s00520-025-10078-8

Ultra-Processed Foods and Cardiometabolic Risk: From Evidence to PolicyPreprint

O’Neill, H. M. (2026) · Research Square · doi:10.21203/rs.3.rs-8430013/v1

Targeting the brain-gut-taste axis: The role of GLP-1-mediated SGLT-1 signaling in metabolic diseases

Heng, Y., & Qiuming, Y. (2026) · Nutrition Clinique et Métabolisme · doi:10.1016/j.nupar.2026.103032

Targeting sweet taste receptor T1R2/T1R3: a new strategy for metabolic disease regulation and intervention of multiple organ diseases

Zhang, J., Zhu, L., Lu, T., & Zhan, L. (2026) · Food Chemistry Molecular Sciences · doi:10.1016/j.fochms.2026.100394

The use (and misuse) of nonnutritive sweeteners in studies of sugar appetite and reward in rodents

Sclafani, A. J., Ackroff, K., & Glendinning, J. I. (2026) · Physiology & Behavior · doi:10.1016/j.physbeh.2026.115332

Can Reprogramming Taste Modulate Excess Food Intake?

Rohde‐Zimmermann, K., & Blüher, M. (2026) · Obesity · doi:10.1002/oby.70199

Ligand recognition mechanism and structure-activity relationship of TAS2R1 revealed by a CMK-3/AuNPs sensor and computational modeling

Shi, Z., Lu, D., Xu, W., Geng, L., & Lai, C. (2026) · Microchemical Journal · doi:10.1016/j.microc.2026.118969

Interactions between taste and oral microbiome: mechanisms and implications for oral and systemic diseases

Xi, M., Li, S., Tang, Y., Zhu, J., & Deng, S. (2026) · Journal of Oral Microbiology · doi:10.1080/20002297.2026.2699527

Genetic variations underlying bitter and sweet taste perception are associated with food and beverage intake habits and taste-modifying behaviors among Dutch adults with a prior myocardial infarction

Gervis, J. E., Mars, M., Pertiwi, K., Heerkens, L., Lichtenstein, A. H., & Geleijnse, J. M. (2026) · Genes & Nutrition · doi:10.1186/s12263-026-00814-y

Generation of Human Taste Bud Organoids as a Human-Mimetic Platform for Modeling Taste PerceptionPreprint

Chae, J., Kwon, S. S., Kim, J., Moon, H., Do, V. Q., Zehentner, S., Cho, H., Bhin, J., Moon, S. J., & Kim, C. H. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.08.09.743674

Ultra-Processed Diets and Pediatric Acne: Insulin–mTOR Activation and Its Potential Role in Cutaneous Inflammation

Magharehabed, Y., Ibrahim, Z., Shiekhtholth, H., & Yusuf, N. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27167123

How the Sea Salt Chocolate Cookie Became a Thing: The Role of Flavor Pairing in Obesity

Ayyad, M., & Kim, E. (2026) · Obesity · doi:10.1002/oby.70285

Umami-Enhancing Effects of Kokumi Peptides Associated with CaSR-Related Cellular Responses in STC-1 Cells

Deng, P., Yang, C., Shen, X., Chen, Q., Wang, Z., He, Z., Chen, J., & Zeng, M. (2026) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.6c11250

Establishment of a Three-Dimensional In Vitro Model of Taste Bud Cells for Fat Taste Investigation

Saidou-Diabé, S., Khan, A. S., Khan, N. A., & Hichami, A. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27198545

DmcFlavor: Compound–informed prediction and interpretation of integrated multi–flavor profiles in foods and herbs

Xu, T., Zhao, K., Li, H., Lin, N., Zhang, Y., Ma, Z., Li, W., Guo, W., Wang, L., Chen, J., et al. (2026) · Food Chemistry · doi:10.1016/j.foodchem.2026.151386

Neuroimaging insights into the effects of non-nutritive sweeteners on appetite regulation: A systematic review

Bierenstiel, A., Choi, S., Park, Y., Sandforth, L., Preissl, H. T., Kullmann, S., & Lee, I. (2026) · Appetite · doi:10.1016/j.appet.2026.108803

Taste and its relevance to obesity and metabolic diseases.

Jaime-Lara, R. B., Agarwal, K., & Joseph, P. V. (2024) · Appetite · doi:10.1016/j.appet.2024.107246

Commentary: Is obesity associated with taste alterations? a systematic review

Alessandrini, M., Vezzoli, A., Mrakic‐Sposta, S., Malacrida, S., & Micarelli, A. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1282276 · Cited by 3 · see citing works

The interplay between obesity, taste, and the microbiome

Goodman, J. R. (2021) · eCommons (Cornell University) · doi:10.7298/3j87-8262

The Plasticity of Taste Function Links the Appetitive Taste of Fats with Obesity

Dando, R. (2015) · Chemosensory Perception · doi:10.1007/s12078-015-9187-6 · Cited by 8 · see citing works

Obesity-induced taste dysfunction, and its implications for dietary intake

Harnischfeger, F., & Dando, R. (2021) · International Journal of Obesity · doi:10.1038/s41366-021-00855-w · Cited by 44 · see citing works