An inter-organ neural circuit for appetite suppression
Open accessAbstract
Glucagon-like peptide-1 (GLP-1) is a signal peptide released from enteroendocrine cells of the lower intestine. GLP-1 exerts anorectic and antimotility actions that protect the body against nutrient malabsorption. However, little is known about how intestinal GLP-1 affects distant organs despite rapid enzymatic inactivation. We show that intestinal GLP-1 inhibits gastric emptying and eating via intestinofugal neurons, a subclass of myenteric neurons that project to abdominal sympathetic ganglia. Remarkably, cell-specific ablation of intestinofugal neurons eliminated intestinal GLP-1 effects, and their chemical activation functioned as a GLP-1 mimetic. GLP-1 sensing by intestinofugal neurons then engaged a sympatho-gastro-spinal-reticular-hypothalamic pathway that links abnormal stomach distension to craniofacial programs for food rejection. Within this pathway, cell-specific activation of discrete neuronal populations caused systemic GLP-1-like effects. These molecularly identified, delimited enteric circuits may be targeted to ameliorate the abdominal bloating and loss of appetite typical of gastric motility disorders.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
GLP-1's action in the brain reduces appetite and may influence energy expenditure.
“And GLP-1’s action in the brain reduces appetite and may influence energy expenditure.176,210,211”
From Glucagon-like peptide-1 receptor: mechanisms and advances in therapy (2024) · cites this paper as [176]
The Results section reports that intracerebroventricular GLP-1 inhibited eating in mice, supporting the brain-action and appetite portion of the claim. The paper does not report an effect on energy expenditure; its experiments on intestinal GLP-1 instead identify local ileal receptors as necessary for those appetite-suppressing effects. No page numbers are available in our copy. (LLM, conf=0.88)
Experimental — accuracy not yet measuredGLP-1 initiates signaling by binding to its receptor, GLP-1R, which is a G-protein-coupled receptor.
“GLP-1 initiates signaling by binding to its receptor, GLP-1R, which is a G-protein-coupled receptor.176,177”
From Glucagon-like peptide-1 receptor: mechanisms and advances in therapy (2024) · cites this paper as [176]
The Introduction identifies GLP-1R as the receptor for GLP-1 analogs, and the Results show that ileal GLP-1 effects depend on GLP-1R signaling. Our copy does not state that GLP-1R is a G-protein-coupled receptor or describe GLP-1 binding to it as the initiating step. (LLM, conf=0.84)
Experimental — accuracy not yet measuredIleal GLP-1-evoked gastric distension suppressed eating via a spinal afferent pathway to the parasubthalamic nucleus and a brainstem premotor circuit controlling orofacial food rejection behavior, rather than via the canonical mechanosensory vagal afferent pathway.
“Interestingly, rather than acting via the canonical mechanosensory VAN pathway (23), ileal GLP-1-evoked gastric distension suppressed eating via a spinal afferent pathway to the parasubthalamic nucleus and a brainstem premotor circuit controlling orofacial food rejection behavior.”
From GLP-1 and the Neurobiology of Eating Control: Recent Advances (2025) · cites this paper as [44]
The intestinofugal pathway connects GLP-1R-expressing enteric neurons to stomach-innervating sympathetic neurons which inhibit gastric emptying and eating by a nitric oxide neuron-mediated increase in gastric distension.
“This intestinofugal pathway connects GLP-1R-expressing enteric neurons to stomach-innervating sympathetic neurons which inhibit gastric emptying and eating by a potent nitric oxide neuron-mediated increase in gastric distension.”
From GLP-1 and the Neurobiology of Eating Control: Recent Advances (2025) · cites this paper as [44]
Zhang et al. mapped a GLP-1-dependent inter-organ circuit from ileal L-cells to the brain that underlies the ileal brake.
“A recent study by Zhang et al (44) elegantly delineated the neural circuit basis for this ileal brake, mapping a GLP-1-dependent inter-organ circuit from ileal L-cells to the brain.”
From GLP-1 and the Neurobiology of Eating Control: Recent Advances (2025) · cites this paper as [44]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
How do you feel? Interoception: The sense of the physiological condition of the body
Craig, A. D. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn894 · Cited by 6,006 · see citing works
Cellpose: a generalist algorithm for cellular segmentation
Stringer, C., Wang, T., Michaelos, M., & Pachitariu, M. (2021) · Nature Methods · doi:10.1038/s41592-020-01018-x · Cited by 4,369 · see citing works
The Physiology of Glucagon-like Peptide 1
Holst, J. J. (2007) · Physiological Reviews · doi:10.1152/physrev.00034.2006 · Cited by 3,371 · see citing works
Functional Gastroduodenal Disorders
Tack, J., Talley, N. J., Camilleri, M., Holtmann, G., Hu, P., Malagelada, J.-R., & Stanghellini, V. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.11.059 · Cited by 2,418 · see citing works
Mechanisms of Action and Therapeutic Application of Glucagon-like Peptide-1
Drucker, D. J. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.03.001 · Cited by 2,170 · see citing works
Glucagon-like peptide 1 (GLP-1)
Müller, T. D., Finan, B., Bloom, S. R., D'Alessio, D., Drucker, D. J., Flatt, P. R., Fritsche, A., Gribble, F., Grill, H. J., Habener, J. F., et al. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.09.010 · Cited by 1,868 · see citing works
iDISCO: A Simple, Rapid Method to Immunolabel Large Tissue Samples for Volume Imaging
Renier, N., Wu, Z., Simon, D. J., Yang, J. H., Ariel, P., & Tessier‐Lavigne, M. (2014) · Cell · doi:10.1016/j.cell.2014.10.010 · Cited by 1,838 · see citing works
Jares-Erijman, E. A., & Jovin, T. M. (2003) · Nature Biotechnology · doi:10.1038/nbt896 · Cited by 1,830 · see citing works
NoRMCorre: An online algorithm for piecewise rigid motion correction of calcium imaging data
Pnevmatikakis, E. A., & Giovannucci, A. (2017) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2017.07.031 · Cited by 1,038 · see citing works
Simultaneous Denoising, Deconvolution, and Demixing of Calcium Imaging Data
Pnevmatikakis, E. A., Soudry, D., Gao, Y., Machado, T. A., Merel, J., Pfau, D., Reardon, T. R., Mu, Y., Lacefield, C., Yang, W., et al. (2016) · Neuron · doi:10.1016/j.neuron.2015.11.037 · Cited by 1,035 · see citing works
Vilsbøll, T., Krarup, T., Deacon, C. F., Madsbad, S., & Holst, J. J. (2001) · Diabetes · doi:10.2337/diabetes.50.3.609 · Cited by 876 · see citing works
The enteric nervous system and gastrointestinal innervation: integrated local and central control
Furness, J. B., Callaghan, B. P., Rivera, L. R., & Cho, H.-J. (2014) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4939-0897-4_3 · Cited by 827 · see citing works
CaImAn an open source tool for scalable calcium imaging data analysis
Giovannucci, A., Friedrich, J., Gunn, P., Kalfon, J., Brown, B. L., Koay, S. A., Taxidis, J., Najafi, F., Gauthier, J., Zhou, P., et al. (2019) · eLife · doi:10.7554/elife.38173 · Cited by 827 · see citing works
Nauck, M. A., Niedereichholz, U., Ettler, R., Holst, J. J., Ørskov, C., Ritzel, R. A., & Schmiegel, W. (1997) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1997.273.5.e981 · Cited by 822 · see citing works
A Neural Circuit for Gut-Induced Reward
Han, W., Téllez, L. A., Perkins, M. H., Pérez-Martínez, I. O., Qu, T., Ferreira, J. G. P., Ferreira, T. L., Quinn, D., Liu, Z.-W., Gao, X., et al. (2018) · Cell · doi:10.1016/j.cell.2018.08.049 · Cited by 739 · see citing works
Self-citationGlucagon‐like peptide‐1 cells in the gastrointestinal tract and pancreas of rat, pig and man
EISSELE, R., GÖKE, R., WILLEMER, S., HARTHUS, H. ‐., VERMEER, H., ARNOLD, R., & GÖKE, B. (1992) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.1992.tb01464.x · Cited by 654 · see citing works
Sensory neurons that detect stretch and nutrients in the digestive system
Williams, E. K., Chang, R. B., Strochlic, D. E., Umans, B. D., Lowell, B. B., & Liberles, S. D. (2016) · Cell · doi:10.1016/j.cell.2016.05.011 · Cited by 645 · see citing works
Hansen, L., Deacon, C. F., Ørskov, C., & Holst, J. J. (1999) · Endocrinology · doi:10.1210/endo.140.11.7143 · Cited by 595 · see citing works
Tension receptors in the stomach and the urinary bladder
Iggo, A. (1955) · The Journal of Physiology · doi:10.1113/jphysiol.1955.sp005327 · Cited by 515 · see citing works
Chemogenetic Tools to Interrogate Brain Functions
Sternson, S. M., & Roth, B. L. (2014) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-071013-014048 · Cited by 506 · see citing works
Genetic identification of vagal sensory neurons that control feeding
Bai, L., Mesgarzadeh, S., Ramesh, K. S., Huey, E. L., Liu, Y., Gray, L. A., Aitken, T. J., Chen, Y., Beutler, L. R., Ahn, J. S., et al. (2019) · Cell · doi:10.1016/j.cell.2019.10.031 · Cited by 494 · see citing works
Microbiota modulate sympathetic neurons via a gut–brain circuit
Muller, P. A., Schneeberger, M., Matheis, F., Wang, P., Kerner, Z. J., Ilanges, A., Pellegrino, K., del Mármol, J. I., Castro, T. B. R., Furuichi, M., et al. (2020) · Nature · doi:10.1038/s41586-020-2474-7 · Cited by 449 · see citing works
Self-citationCamilleri, M., Chedid, V., Ford, A. C., Haruma, K., Horowitz, M., Jones, K. L., Low, P. A., Park, S.-Y., Parkman, H. P., & Stanghellini, V. (2018) · Nature Reviews Disease Primers · doi:10.1038/s41572-018-0038-z · Cited by 411 · see citing works
Read, N. W., McFarlane, A. S., Kinsman, R., Bates, T. E., Blackhall, N. W., Farrar, G. B. J., Hall, J., Moss, G. J., Morris, A. P., O'Neill, B., et al. (1984) · Gastroenterology · doi:10.1016/0016-5085(84)90411-6 · Cited by 329 · see citing works
Facial expressions of emotion states and their neuronal correlates in mice
Dolensek, N., Gehrlach, D. A., Klein, A. S., & Gogolla, N. (2020) · Science · doi:10.1126/science.aaz9468 · Cited by 327 · see citing works
Schmidt, W. E., Siegel, E. G., & Creutzfeldt, W. (1985) · Diabetologia · doi:10.1007/bf00291980 · Cited by 318 · see citing works
Vahl, T. P., Tauchi, M., Durler, T. S., Elfers, E. E., Fernandes, T. M., Bitner, R. D., Ellis, K. S., Woods, S. C., Seeley, R. J., Herman, J. P., et al. (2007) · Endocrinology · doi:10.1210/en.2006-0153 · Cited by 318 · see citing works
Integrated Control of Predatory Hunting by the Central Nucleus of the Amygdala
Han, W., Téllez, L. A., Rangel, M. J., Motta, S. C., Zhang, X., Pérez-Martínez, I. O., Canteras, N. S., Shammah‐Lagnado, S. J., van den Pol, A. N., & de Araújo, I. E. (2017) · Cell · doi:10.1016/j.cell.2016.12.027 · Cited by 292 · see citing works
Self-citationGLP-1 and weight loss: unraveling the diverse neural circuitry
Kanoski, S. E., Hayes, M. R., & Skibicka, K. P. (2016) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00520.2015 · Cited by 290 · see citing works
Berthoud, H., & Powley, T. L. (1992) · The Journal of Comparative Neurology · doi:10.1002/cne.903190206 · Cited by 287 · see citing works
Sensory transmission in the gastrointestinal tract
Blackshaw, L. A., Brookes, S. J., Grundy, D., & Schemann, M. (2007) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2006.00871.x · Cited by 285 · see citing works
Grasset, E., Puel, A., Charpentier, J., Collet, X., Christensen, J. E., Tercé, F., & Burcelin, R. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.04.013 · Cited by 280 · see citing works
Neuroanatomy of extrinsic afferents supplying the gastrointestinal tract
Berthoud, H. R., Blackshaw, L. A., Brookes, S. J. H., & Grundy, D. (2004) · Neurogastroenterology & Motility · doi:10.1111/j.1743-3150.2004.00471.x · Cited by 274 · see citing works
Central and peripheral GLP-1 systems independently suppress eating
Brierley, D. I., Holt, M. K., Singh, A., de Araujo, A., McDougle, M., Vergara, M., Afaghani, M. H., Lee, S. J., Scott, K., Maske, C., et al. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00344-4 · Cited by 265 · see citing works
Area postrema cell types that mediate nausea-associated behaviors
Zhang, C., Kaye, J. A., Cai, Z., Wang, Y., Prescott, S. L., & Liberles, S. D. (2021) · Neuron · doi:10.1016/j.neuron.2020.11.010 · Cited by 263 · see citing works
Rüttimann, E. B., Arnold, M., Hillebrand, J. J., Geary, N., & Langhans, W. (2008) · Endocrinology · doi:10.1210/en.2008-1221 · Cited by 258 · see citing works
Lo, L., & Anderson, D. J. (2011) · Neuron · doi:10.1016/j.neuron.2011.12.002 · Cited by 251 · see citing works
What do we know about the secretion and degradation of incretin hormones?
Deacon, C. F. (2005) · Regulatory Peptides · doi:10.1016/j.regpep.2004.06.007 · Cited by 243 · see citing works
The Role of Pancreatic Preproglucagon in Glucose Homeostasis in Mice
Chambers, A. P., Sorrell, J. E., Haller, A. M., Roelofs, K. J., Hutch, C. R., Kim, K., Gutiérrez‐Aguilar, R., Li, B., Drucker, D. J., D’Alessio, D. A., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.02.008 · Cited by 242 · see citing works
Enteroendocrine L Cells Sense LPS after Gut Barrier Injury to Enhance GLP-1 Secretion
Lebrun, L. J., Lenaerts, K., Kiers, D., Pais de Barros, J.-P., Le Guern, N., Plesnik, J., Thomas, C., Bourgeois, T., Dejong, C. H. C., Kox, M., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.10.008 · Cited by 238 · see citing works
Keast, J. R., & de Groat, W. C. (1992) · The Journal of Comparative Neurology · doi:10.1002/cne.903190411 · Cited by 232 · see citing works
Ileal release of glucagon-like peptide-1 (GLP-1)
Layer, P., Holst, J. J., Grandt, D., & Goebell, H. (1995) · Digestive Diseases and Sciences · doi:10.1007/bf02064202 · Cited by 216 · see citing works
Borgmann, D., Ciglieri, E., Biglari, N., Brandt, C., Cremer, A. L., Backes, H., Tittgemeyer, M., Wunderlich, F. T., Brüning, J. C., & Fenselau, H. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.05.002 · Cited by 213 · see citing works
Glucagon-like peptide 1 and appetite
Dailey, M. J., & Moran, T. H. (2013) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2012.11.008 · Cited by 187 · see citing works
Plamboeck, A., Veedfald, S., Deacon, C. F., Hartmann, B., Wettergren, A., Svendsen, L. B., Meisner, S., Hovendal, C. P., Vilsbøll, T., Knop, F. K., et al. (2013) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00035.2013 · Cited by 183 · see citing works
Receptors, channels, and signalling in the urothelial sensory system in the bladder
Merrill, L., Gonzalez, E. J., Girard, B. M., & Vizzard, M. A. (2016) · Nature Reviews Urology · doi:10.1038/nrurol.2016.13 · Cited by 179 · see citing works
Li, X., Zhang, G., Wu, J., Zhang, Y., Zhao, Z., Lin, X., Qiao, H., Xie, H., Wang, H., Fang, L., et al. (2021) · Nature Methods · doi:10.1038/s41592-021-01225-0 · Cited by 177 · see citing works
The neural representation of taste quality at the periphery
Barretto, R. P. J., Gillis-Smith, S., Chandrashekar, J. V., Yarmolinsky, D. A., Schnitzer, M. J., Ryba, N. J. P., & Zuker, C. S. (2014) · Nature · doi:10.1038/nature13873 · Cited by 172 · see citing works
Electromyographic analysis of the ingestion and rejection of sapid stimuli in the rat.
Travers, J. B., & Norgren, R. (1986) · Behavioral Neuroscience · doi:10.1037/0735-7044.100.4.544 · Cited by 157 · see citing works
Lynn, P. A., Olsson, C., Zagorodnyuk, V. P., Costa, M., & Brookes, S. J. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)01050-3 · Cited by 153 · see citing works
Electromyographic analysis of the ingestion and rejection of sapid stimuli in the rat.
Travers, J. B., & Norgren, R. (1986) · Behavioral Neuroscience · doi:10.1037//0735-7044.100.4.544 · Cited by 152 · see citing works
The physiological role of GLP-1 in human: incretin, ileal brake or more?
Schirra, J. R. J., & Göke, B. (2004) · Regulatory Peptides · doi:10.1016/j.regpep.2004.06.018 · Cited by 146 · see citing works
Meier, J. J., Kemmeries, G., Holst, J. J., & Nauck, M. A. (2005) · Diabetes · doi:10.2337/diabetes.54.7.2212 · Cited by 146 · see citing works
Gut-Proglucagon-Derived Peptides Are Essential for Regulating Glucose Homeostasis in Mice
Song, Y., Koehler, J. A., Baggio, L. L., Powers, A. C., Sandoval, D. A., & Drucker, D. J. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.08.009 · Cited by 140 · see citing works
Burmeister, M. A., Ayala, J. E., Smouse, H., Landivar-Rocha, A., Brown, J. D., Drucker, D. J., Stoffers, D. A., Sandoval, D. A., Seeley, R. J., & Ayala, J. E. (2017) · Diabetes · doi:10.2337/db16-1102 · Cited by 136 · see citing works
A neural circuit mechanism for mechanosensory feedback control of ingestion
Kim, D.-Y., Heo, G., Kim, M., Kim, H., Jin, J. A., Kim, H. K., Jung, S., An, M., Ahn, B. H., Park, J. H., et al. (2020) · Nature · doi:10.1038/s41586-020-2167-2 · Cited by 133 · see citing works
Regulation of glucagon-like peptide-1 secretion from rat ileum by neurotransmitters and peptides
Herrmann-Rinke, C., Vöge, A., Hess, M., & Göke, B. (1995) · Journal of Endocrinology · doi:10.1677/joe.0.1470025 · Cited by 130 · see citing works
Is <scp>GLP</scp>‐1 a hormone: Whether and When?
D'Alessio, D. (2016) · Journal of Diabetes Investigation · doi:10.1111/jdi.12466 · Cited by 130 · see citing works
Prevertebral ganglia and intestinofugal afferent neurones
Szurszewski, J. H., Ermilov, L. G., & Miller, S. (2002) · Gut · doi:10.1136/gut.51.suppl_1.i6 · Cited by 109 · see citing works
Release of glucagon-like peptide-1 (GLP-1) by carbohydrates in the perfused rat ileum
Ritzel, U., Fromme, A., Ottleben, M., Leonhardt, U., & Ramadori, G. P. (1997) · Acta Diabetologica · doi:10.1007/s005920050059 · Cited by 106 · see citing works
Pivetta, C., Esposito, M. S., Sigrist, M., & Arber, S. (2014) · Cell · doi:10.1016/j.cell.2013.12.014 · Cited by 106 · see citing works
Varin, E. M., Mulvihill, E. E., Baggio, L. L., Koehler, J. A., Cao, X., Seeley, R. J., & Drucker, D. J. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.05.055 · Cited by 104 · see citing works
Milstein, J. A., Lehmann, O., Theobald, D. E. H., Dalley, J. W., & Robbins, T. W. (2007) · Psychopharmacology · doi:10.1007/s00213-006-0594-x · Cited by 94 · see citing works
Dissecting the Physiology and Pathophysiology of Glucagon-Like Peptide-1
Paternoster, S., & Falasca, M. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00584 · Cited by 91 · see citing works
Novel gut afferents: Intrinsic afferent neurons and intestinofugal neurons
Furness, J. B. (2006) · Autonomic Neuroscience · doi:10.1016/j.autneu.2006.01.007 · Cited by 90 · see citing works
Lund, M. L., Sorrentino, G., Egerod, K. L., Kroone, C., Mortensen, B., Knop, F. K., Reimann, F. M., Gribble, F. M., Drucker, D. J., de Koning, E. J. P., et al. (2020) · Diabetes · doi:10.2337/db19-0764 · Cited by 82 · see citing works
Actions of glucagon‐like peptide‐1 receptor ligands in the gut
Holst, J. J., Andersen, D. B., & Grunddal, K. V. (2021) · British Journal of Pharmacology · doi:10.1111/bph.15611 · Cited by 78 · see citing works
Glucagonlike Peptide-1 (GLP-1) Participation in Ileal Brake Induced by Intraluminal Peptones in Rat
Giralt, M., & Vergara, P. (1999) · Digestive Diseases and Sciences · doi:10.1023/a:1026654417697 · Cited by 74 · see citing works
Spinal afferent nerve endings in visceral organs: recent advances
Spencer, N. J., Zagorodnyuk, V. P., Brookes, S. J., & Hibberd, T. J. (2016) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00319.2016 · Cited by 70 · see citing works
Neural Sensing of Organ Volume
Umans, B. D., & Liberles, S. D. (2018) · Trends in Neurosciences · doi:10.1016/j.tins.2018.07.008 · Cited by 70 · see citing works
Panaro, B. L., Yusta, B., Matthews, D., Koehler, J. A., Song, Y., Sandoval, D. A., & Drucker, D. J. (2020) · Molecular Metabolism · doi:10.1016/j.molmet.2020.100990 · Cited by 67 · see citing works
Give the Receptor a Brake: Slowing Gastric Emptying by GLP-1
Tong, J., & D'Alessio, D. (2014) · Diabetes · doi:10.2337/db13-1764 · Cited by 66 · see citing works
Peripheral Glucagon-like Peptide-1 (GLP-1) and Satiation
Punjabi, M., Arnold, M., Geary, N., Langhans, W., & Pacheco‐López, G. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.02.038 · Cited by 62 · see citing works
Why is it so difficult to measure glucagon-like peptide-1 in a mouse?
Windeløv, J. A., Albrechtsen, N. J. W., Kuhre, R. E., Jepsen, S. L., Hornburg, D., Pedersen, J., Jensen, E. P., Galsgaard, K. D., Winther‐Sørensen, M., Ørgaard, A., et al. (2017) · Diabetologia · doi:10.1007/s00125-017-4347-7 · Cited by 61 · see citing works
A basal ganglia-like cortical–amygdalar–hypothalamic network mediates feeding behavior
Barbier, M., Chometton, S., Pautrat, A., Miguet‐Alfonsi, C., Datiche, F., Gascuel, J., FELLMANN, D., Peterschmitt, Y., Coizet, V., & Risold, P. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2004914117 · Cited by 60 · see citing works
A role for the gut-to-brain GLP-1-dependent axis in the control of metabolism
Burcelin, R., Sérino, M., & Cabou, C. (2009) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2009.09.003 · Cited by 47 · see citing works
Glucagon-like peptide-1 relaxes gastric antrum through nitric oxide in mice
Rotondo, A., Amato, A., Lentini, L., Baldassano, S., & Mulè, F. (2010) · Peptides · doi:10.1016/j.peptides.2010.09.028 · Cited by 44 · see citing works
The effects of GLP-1 infusion in the hepatic portal region on food intake
Kim, D.-H., D’Alessio, D. A., Woods, S. C., & Seeley, R. J. (2009) · Regulatory Peptides · doi:10.1016/j.regpep.2009.03.002 · Cited by 37 · see citing works
An intravital window to image the colon in real time
Rakhilin, N., Garrett, A., Eom, C., Chavez, K. R., Small, D. M., Daniel, A. R., Kaelberer, M. M., Mejooli, M. A., Huang, Q., Ding, S., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-13699-w · Cited by 37 · see citing works
The role of tension receptors in colonic mechanosensitivity in humans
Corsetti, M., Gevers, A.-M., Caenepeel, P., & Tack, J. F. (2004) · Gut · doi:10.1136/gut.2004.038786 · Cited by 36 · see citing works
Dual embryonic origin of the mammalian enteric nervous system.
Brokhman, I., Xu, J., Coles, B., Razavi, R., Engert, S., Lickert, H., Babona-Pilipos, R., Morshead, C., Sibley, E., Chen, C., et al. (2019) · Developmental Biology · doi:10.1016/j.ydbio.2018.11.014 · Cited by 35 · see citing works
Jessen, L., Aulinger, B. A., Hassel, J., Roy, K. J., Smith, E. P., Greer, T. M., Woods, S. C., Seeley, R. J., & D’Alessio, D. A. (2012) · Endocrinology · doi:10.1210/en.2012-1358 · Cited by 29 · see citing works
Dissection and surgical approaches to the mouse jugular-nodose ganglia
Han, W., & de Araújo, I. E. (2021) · STAR Protocols · doi:10.1016/j.xpro.2021.100474 · Cited by 29 · see citing works
Self-citationCannon, W. B., & Washburn, A. L. (1993) · Obesity Research · doi:10.1002/j.1550-8528.1993.tb00033.x · Cited by 26 · see citing works
Taste Reactivity and Fos Expression in GAD1-EGFP Transgenic Mice
Travers, J., Herman, K., Yoo, J., & Travers, S. (2006) · Chemical Senses · doi:10.1093/chemse/bjl038 · Cited by 26 · see citing works
Gastric control of food intake
Robinson, P. H., McHugh, P. R., Moran, T. H., & Stephenson, J. (1988) · Journal of Psychosomatic Research · doi:10.1016/0022-3999(88)90008-6 · Cited by 23 · see citing works
A Novel Mode of Sympathetic Reflex Activation Mediated by the Enteric Nervous System
Hibberd, T. J., Yew, W. P., Chen, B. N., Costa, M., Brookes, S. J., & Spencer, N. J. (2020) · eNeuro · doi:10.1523/eneuro.0187-20.2020 · Cited by 18 · see citing works
Flagged first, then by citations
1 of the 88 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Glucagon-like peptide-1 receptor: mechanisms and advances in therapy
Zheng, Z., Zong, Y., Ma, Y., Tian, Y., Pang, Y., Zhang, C., & Gao, J. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01931-z · Cited by 1,036 · see citing works
“176”
BackgroundSharkey, K. A., & Mawe, G. M. (2022) · Physiological Reviews · doi:10.1152/physrev.00018.2022 · Cited by 423 · see citing works
Beyond the pancreas: contrasting cardiometabolic actions of GIP and GLP1
Hammoud, R., & Drucker, D. J. (2023) · Nature Reviews Endocrinology · doi:10.1038/s41574-022-00783-3 · Cited by 244 · see citing works
Glucagon-like Peptide-1 Receptor-based Therapeutics for Metabolic Liver Disease
Yabut, J. M., & Drucker, D. J. (2022) · Endocrine Reviews · doi:10.1210/endrev/bnac018 · Cited by 180 · see citing works
Gastrointestinal effects of GLP-1 receptor agonists: mechanisms, management, and future directions
Jalleh, R. J., Rayner, C. K., Hausken, T., Jones, K. L., Camilleri, M., & Horowitz, M. (2024) · The Lancet Gastroenterology & Hepatology · doi:10.1016/s2468-1253(24)00188-2 · Cited by 144 · see citing works
Stress-sensitive neural circuits change the gut microbiome via duodenal glands
Chang, H., Perkins, M. H., Novaes, L. S., Qian, F., Zhang, T., Neckel, P. H., Scherer, S., Ley, R. E., Han, W., & de Araújo, I. E. (2024) · Cell · doi:10.1016/j.cell.2024.07.019 · Cited by 133 · see citing works
Self-citationIntestinal plasticity and metabolism as regulators of organismal energy homeostasis
Stojanović, O., Miguel‐Aliaga, I., & Trajkovski, M. (2022) · Nature Metabolism · doi:10.1038/s42255-022-00679-6 · Cited by 70 · see citing works
Ren, W., Chen, J., Wang, W., Li, Q., Yin, X., Zhuang, G., Zhou, H., & Zeng, W. (2024) · Neuron · doi:10.1016/j.neuron.2023.12.012 · Cited by 59 · see citing works
A type 2 immune circuit in the stomach controls mammalian adaptation to dietary chitin
Kim, D.-H., Wang, Y., Jung, H., Field, R. L., Zhang, X., Liu, T., Ma, C., Fraser, J. S., Brestoff, J. R., & Dyken, S. J. V. (2023) · Science · doi:10.1126/science.add5649 · Cited by 57 · see citing works
Parieto-occipital ERP indicators of gut mechanosensation in humans
Mayeli, A., Zoubi, O. A., White, E. J., Chappelle, S. D., Kuplicki, R., Morton, A., Bruce, J., Smith, R. S., Feinstein, J. S., Bodurka, J., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-39058-4 · Cited by 57 · see citing works
Dietary polyphenols regulate appetite mechanism via gut-brain axis and gut homeostasis
Liu, H., Guo, X., Jiang, K., Shi, B., Liu, L., Hou, R., Chen, G., Farag, M. A., Yan, N., & Liu, L. (2024) · Food Chemistry · doi:10.1016/j.foodchem.2024.138739 · Cited by 52 · see citing works
Liraglutide restores impaired associative learning in individuals with obesity
Hanssen, R., Rigoux, L., Kuzmanovic, B., Iglesias, S., Kretschmer, A. C., Schlamann, M., Albus, K., Edwin Thanarajah, S., Sitnikow, T., Melzer, C., et al. (2023) · Nature Metabolism · doi:10.1038/s42255-023-00859-y · Cited by 52 · see citing works
The neurobiology of overeating
Stuber, G. D., Schwitzgebel, V., & Lüscher, C. (2025) · Neuron · doi:10.1016/j.neuron.2025.03.010 · Cited by 67 · see citing works
Hedin, K. A., Zhang, H., Kruse, V., Rees, V. E., Bäckhed, F., Greiner, T. U., Vazquez-Uribe, R., & Sommer, M. O. A. (2023) · ACS Synthetic Biology · doi:10.1021/acssynbio.3c00455 · Cited by 45 · see citing works
GLP-1 and the Neurobiology of Eating Control: Recent Advances
Jones, L. A., & Brierley, D. I. (2025) · Endocrinology · doi:10.1210/endocr/bqae167 · Cited by 43 · see citing works
Zafer, M., Tavaglione, F., Romero‐Gómez, M., & Loomba, R. (2025) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.70196 · Cited by 47 · see citing works
The Coding Logic of Interoception
Wang, R. L., & Chang, R. B. (2023) · Annual Review of Physiology · doi:10.1146/annurev-physiol-042222-023455 · Cited by 41 · see citing works
A vagus nerve dominant tetra-synaptic ascending pathway for gastric pain processing
Zhang, F., Weng, R., Li, D., Li, Y., Dai, X.-X., Hu, S., Sun, Q., Li, R., & Xu, G. (2024) · Nature Communications · doi:10.1038/s41467-024-54056-w · Cited by 41 · see citing works
Physiological integration of taste and metabolism
Egan, J. M. (2024) · New England Journal of Medicine · doi:10.1056/nejmra2304578 · Cited by 40 · see citing works
Esparham, A., Mehri, A., Dalili, A., Richards, J., & Khorgami, Z. (2024) · Obesity Reviews · doi:10.1111/obr.13811 · Cited by 41 · see citing works
Nagashima, T., Tohyama, S., Mikami, K., Nagase, M., Morishima, M., Kasai, A., Hashimoto, H., & Watabe, A. M. (2022) · Nature Communications · doi:10.1038/s41467-022-35634-2 · Cited by 41 · see citing works
Weninger, S. N., Herman, C., Meyer, R. K., Beauchemin, E. T., Kangath, A., Lane, A. I., Martinez, T. M., Hasneen, T., Jaramillo, S. A., Lindsey, J., et al. (2023) · Microbiome · doi:10.1186/s40168-023-01590-2 · Cited by 37 · see citing works
Nutrients activate distinct patterns of small-intestinal enteric neurons
Fung, C., Venneman, T., Holland, A. M., Martens, T., Alata, M., Hao, M. M., Alar, C., Obata, Y., Tack, J. F., Sifrim, A., et al. (2025) · Nature · doi:10.1038/s41586-025-09228-z · Cited by 36 · see citing works
Sensory spinal interoceptive pathways and energy balance regulation
Münzberg, H., Berthoud, H., & Neuhuber, W. (2023) · Molecular Metabolism · doi:10.1016/j.molmet.2023.101817 · Cited by 35 · see citing works
Vagal sensory pathway for the gut-brain communication
Cao, Y., Li, R., & Bai, L. (2023) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2023.07.009 · Cited by 36 · see citing works
Molecular and functional diversity of the autonomic nervous system
Wang, T., Tufenkjian, A., Ajijola, O., & Oka, Y. (2025) · Nature Reviews Neuroscience · doi:10.1038/s41583-025-00941-2 · Cited by 35 · see citing works
Gut microbiome at the crossroad of genetic variants and behavior disorders
Cheng, L., Wu, H., Chen, Z., Hao, H., & Zheng, X. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2201156 · Cited by 28 · see citing works
Liu, H., Xiao, H., Lin, S., Zhou, H., Cheng, Y., Xie, B., & Xu, D. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1372399 · Cited by 34 · see citing works
Vagus Nerve and Gut-Brain Communication
Wang, Y., Duan, C., Du, X., Zhu, Y. J., Wang, L., Hu, J., & Sun, Y. (2024) · The Neuroscientist · doi:10.1177/10738584241259702 · Cited by 33 · see citing works
The gut–organ axis: Clinical aspects and immune mechanisms
Fukasawa, N., Tsunoda, J., Sunaga, S., Kiyohara, H., Nakamoto, N., Teratani, T., Mikami, Y., & Kanai∥, T. (2025) · Allergology International · doi:10.1016/j.alit.2025.01.004 · Cited by 32 · see citing works
Circadian rhythms in colonic function
Hibberd, T. J., Ramsay, S. D., Spencer-Merris, P., Dinning, P. G., Zagorodnyuk, V. P., & Spencer, N. J. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1239278 · Cited by 28 · see citing works
Vagal pathways for systemic regulation of glucose metabolism.
Borgmann, D., & Fenselau, H. (2023) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2023.07.010 · Cited by 21 · see citing works
Tissue Optical Clearing Imaging from Ex vivo toward In vivo
Zhu, D. Y., & Tuchin, V. V. (2024) · BME Frontiers · doi:10.34133/bmef.0058 · Cited by 25 · see citing works
Seeking satiety: From signals to solutions
Tschöp, M. H., & Friedman, J. M. (2023) · Science Translational Medicine · doi:10.1126/scitranslmed.adh4453 · Cited by 24 · see citing works
The emerging role of gut hormones
Cho, H., & Lim, J. (2024) · Molecules and Cells · doi:10.1016/j.mocell.2024.100126 · Cited by 25 · see citing works
Mechanisms of GLP-1 in Modulating Craving and Addiction: Neurobiological and Translational Insights
Alves, G. A. M., Teranishi, M., Ortega, A. C. T. D. C. G., James, F., & Arachchige, A. S. P. M. (2025) · Medical Sciences · doi:10.3390/medsci13030136 · Cited by 24 · see citing works
The interplay between leptin, glucocorticoids, and GLP1 regulates food intake and feeding behaviour
Perez‐Leighton, C. E., Kerr, B., Scherer, P. E., Baudrand, R. F., & Cortés, V. (2023) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.13039 · Cited by 22 · see citing works
Expanding the understanding of insulin resistance in brain and periphery
Chen, W., Kullmann, S., & Rhea, E. M. (2025) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2025.04.010 · Cited by 23 · see citing works
GLP-1 physiology and pharmacology along the gut-brain axis
Beutler, L. R. (2026) · Journal of Clinical Investigation · doi:10.1172/jci194744 · Cited by 28 · see citing works
Becetti, I., Bwenyi, E. L., de Araújo, I. E., Ard, J. D., Cryan, J. F., Farooqi, I. S., Ferrario, C. R., Gluck, M. E., Holsen, L. M., Kenny, P. J., et al. (2023) · American Journal of Clinical Nutrition · doi:10.1016/j.ajcnut.2023.05.003 · Cited by 25 · see citing works
GLP-1 receptor agonism: a transformative approach for managing type-2 diabetes and obesity
Alharbi, A. (2025) · Saudi Pharmaceutical Journal · doi:10.1007/s44446-025-00038-y · Cited by 22 · see citing works
Liu, Y., Wei, J., Luo, Z., Cui, J., Luo, Y., Mak, S. O. K., Wang, S., Zhang, F., Yang, Y. T., So, K., et al. (2023) · Science Advances · doi:10.1126/sciadv.add5330 · Cited by 22 · see citing works
Neuroimaging and neuroendocrine insights into food cravings and appetite interventions in obesity
Huang, J., Wang, C., Zhang, H.-B., Zheng, H., Huang, T., & Di, J. (2023) · Psychoradiology · doi:10.1093/psyrad/kkad023 · Cited by 22 · see citing works
Shepherd, A., Feinstein, L. H., Sabel, S. L., Rastelli, D., Mezhibovsky, E., Matthews, L., Muppirala, A. N., Robinson, A., Sharma, K. R., ElSeht, A., et al. (2022) · Gastroenterology · doi:10.1053/j.gastro.2023.11.020 · Cited by 22 · see citing works
The missing hallmark of health: psychosocial adaptation
López-Otı́n, C., & Kroemer, G. (2024) · Cell Stress · doi:10.15698/cst2024.03.294 · Cited by 24 · see citing works
Alterations in GLP-1 and PYY release with aging and body mass in the human gut
Jones, L. A., Sun, E. W. L., Lumsden, A. L., Thorpe, D. W., Peterson, R. A., de Fontgalland, D., Sposato, L., Rabbitt, P., Hollington, P., Wattchow, D. A., et al. (2023) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2023.112072 · Cited by 21 · see citing works
The vagus nerve mediates the physiological but not pharmacological effects of PYY3-36 on food intake
Alonso, A. M., Cork, S. C., Phuah, P., Hansen, B., Norton, M., Cheng, S., Xu, X., Suba, K., Ma, Y., Dowsett, G. K. C., et al. (2024) · Molecular Metabolism · doi:10.1016/j.molmet.2024.101895 · Cited by 21 · see citing works
RISING STARS: Endocrine regulation of metabolic homeostasis via the intestine and gut microbiome
Meyer, R. K., & Duca, F. A. (2023) · Journal of Endocrinology · doi:10.1530/joe-23-0019 · Cited by 20 · see citing works
Chen, B. N., Humenick, A., Yew, W. P., Peterson, R. A., Wiklendt, L., Dinning, P. G., Spencer, N. J., Wattchow, D. A., Costa, M., & Brookes, S. J. (2023) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2023.06.010 · Cited by 19 · see citing works
Interoception and gut–brain communication
Alhadeff, A. L., & Yapici, N. (2024) · Current Biology · doi:10.1016/j.cub.2024.10.035 · Cited by 18 · see citing works
New biofunctional effects of oleanane-type triterpene saponins
Matsuda, H., Morikawa, T., Nakamura, S., Muraoka, O., & Yoshikawa, M. (2023) · Journal of Natural Medicines · doi:10.1007/s11418-023-01730-w · Cited by 18 · see citing works
Raptin, a sleep-induced hypothalamic hormone, suppresses appetite and obesity
Xie, L., Hu, B., Lu, R.-B., Cheng, Y., Chen, X., Wen, J., Xiao, Y., An, Y.-Z., Peng, N., Dai, Y., et al. (2025) · Cell Research · doi:10.1038/s41422-025-01078-8 · Cited by 18 · see citing works
Cao, N., Merchant, W., & Gautron, L. (2024) · Scientific Reports · doi:10.1038/s41598-024-74000-8 · Cited by 17 · see citing works
An enteric-DRG pathway for interoception and visceral pain in mice
Wang, Z., Tang, Q., Li, K., Mou, J., Chen, Y., Kuang, W., Sun, L., Ma, Z., Wei, Y., Bao, R., et al. (2025) · Neuron · doi:10.1016/j.neuron.2025.09.035 · Cited by 15 · see citing works
Gut–brain communication: types of sensory nerves and mechanisms of activation
Spencer, N. J., Hibberd, T. J., & Hu, H. (2025) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-025-01132-1 · Cited by 15 · see citing works
Barać, M., & Roganović, J. (2025) · Biology · doi:10.3390/biology14121650 · Cited by 19 · see citing works
Poly-Agonist Pharmacotherapies for Metabolic Diseases: Hopes and New Challenges
Allard, C., Cota, D., & Quarta, C. (2023) · Drugs · doi:10.1007/s40265-023-01982-6 · Cited by 15 · see citing works
The parasubthalamic nucleus refeeding ensemble delays feeding initiation and hastens water drinking
Dunning, J. L., Lopez, C., Krull, C., Kreifeldt, M., Angelo, M., Shu, L., Ramakrishnan, C., Deisseroth, K. A., & Contet, C. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02653-y · Cited by 18 · see citing works
Sawami, K., Tanaka, A., & Node, K. (2022) · Cardiovascular Diabetology · doi:10.1186/s12933-022-01611-8 · Cited by 15 · see citing works
Ricci, A., Rubino, E., Serra, G. P., & Wallén‐Mackenzie, Å. (2024) · Neuropharmacology · doi:10.1016/j.neuropharm.2024.110003 · Cited by 15 · see citing works
Parkinson’s Disease and Diabetes Mellitus: Synergistic Effects on Pathophysiology and GI Motility
Yan, Y., Shimoga, D., & Sharma, A. (2023) · Current Gastroenterology Reports · doi:10.1007/s11894-023-00868-7 · Cited by 13 · see citing works
Xie, Y., Cai, L., Ding, M., Shan, K., Zhao, D., Zhou, G., & Li, C. (2023) · Food Research International · doi:10.1016/j.foodres.2023.113551 · Cited by 13 · see citing works
Patil, M., Casari, I., Warne, L. N., & Falasca, M. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116245 · Cited by 13 · see citing works
Ceron, E. L., Reddy, S. D., Kattamuri, L. P. V., Muvva, D. M., Chozet, L. E., & Bright, T. M. (2025) · Journal of Brown Hospital Medicine · doi:10.56305/001c.132255 · Cited by 12 · see citing works
Giez, C., Noack, C., Sakib, E., Hofacker, L.-M., Repnik, U., Bramkamp, M., & Bosch, T. C. G. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114210 · Cited by 15 · see citing works
From Mammals to Insects: Exploring the Genetic and Neural Basis of Eating Behavior
Mahishi, D., Agrawal, N., Jiang, W., & Yapici, N. (2024) · Annual Review of Genetics · doi:10.1146/annurev-genet-111523-102202 · Cited by 12 · see citing works
Zhou, P., Li, T., Zhao, J., AL‐Ansi, W., Fan, M., Qian, H., Li, Y., & Wang, L. (2025) · Food Research International · doi:10.1016/j.foodres.2025.116291 · Cited by 12 · see citing works
Zhu, Z., Wu, Y., Liu, Z., Li, Y., & Jiang, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23169358 · Cited by 11 · see citing works
Electroceuticals and Magnetoceuticals in Gastroenterology
Song, G., Sclocco, R., Sharma, A., Guerrero-López, I., & Kuo, B. (2024) · Biomolecules · doi:10.3390/biom14070760 · Cited by 11 · see citing works
Jin, F., Wang, Y., Li, M., Li, R.-J., & Guo, J. (2024) · World Journal of Diabetes · doi:10.4239/wjd.v15.i8.1764 · Cited by 11 · see citing works
Asymmetric control of food intake by left and right vagal sensory neuronsPreprint
de Araujo, A., Braga, I., Leme, G. M., Singh, A., McDougle, M. J., Smith, J. A., Vergara, M., Yang, M., Lin, M., Khoshbouei, H., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.05.08.539627 · Cited by 11 · see citing works
Stress-activated brain-gut circuits disrupt intestinal barrier integrity and social behaviourPreprint
Russo, S. J., Chan, K. L., Li, L., Parise, L. F., Cathomas, F., LeClair, K. B., Shimo, Y., Lin, H., Cuttoli, R. D.-D., Aubry, A., et al. (2023) · Research Square · doi:10.21203/rs.3.rs-3459170/v1 · Cited by 11 · see citing works
Self-citationFurness, J. B., Marklund, U., Czapla, B. J., Bornstein, J. C., & Han, M. N. (2026) · Autonomic Neuroscience · doi:10.1016/j.autneu.2026.103412 · Cited by 10 · see citing works
Breaking down a gut-to-brain circuit that prevents malabsorption
Jarvie, B. C., & Knight, Z. A. (2022) · Cell · doi:10.1016/j.cell.2022.06.012 · Cited by 10 · see citing works
Interoception and Mental Health
Khalsa, S. S., & Verdonk, C. (2024) · Springer eBooks · doi:10.1007/978-3-031-68521-7_9 · Cited by 9 · see citing works
Novel neural pathways targeted by GLP-1R agonists and bariatric surgery
Hankir, M. K., & Lutz, T. A. (2024) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-024-03047-3 · Cited by 11 · see citing works
The sympathetic neurons in the gut: Perspectives on metabolic and immune health and diseases
Wan, Y., Cao, C., & Zeng, W. (2025) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2025.103051 · Cited by 9 · see citing works
The Role of the Gut-Brain Axis in Diseases
Chen, J. W., Xu, Y., & Cao, P. (2025) · Physiology · doi:10.1152/physiol.00016.2025 · Cited by 9 · see citing works
Trapp, S., & Skoug, C. (2025) · Endocrinology · doi:10.1210/endocr/bqaf169 · Cited by 9 · see citing works
In vivo transcriptomic, functional, circuit-based, and translational analyses of enteric neurons
Millett, C. J., Shaver, J. J., Bracken, B., Jones, S. J., Lovelett, R. J., Rubinow, D. A., Singhal, R., Charlton, C., Piazza, N., Hauck, Q., et al. (2025) · Cell · doi:10.1016/j.cell.2025.11.024 · Cited by 9 · see citing works
Sun, Y., Luo, Y., Xiang, C., Xie, C. H., Huang, W., Sun, Z., Jones, K. L., Horowitz, M., Rayner, C. K., Ma, J., et al. (2024) · Diabetes Obesity and Metabolism · doi:10.1111/dom.15626 · Cited by 8 · see citing works
Jiang, Y., Zhang, S., Pan, L., Leng, J., Zhou, T., Liu, M., Li, L., & Zhao, W. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.133333 · Cited by 8 · see citing works
Spinal afferent neurons: emerging regulators of energy balance and metabolism
Jarrah, M., Tasabehji, D., Fraer, A., & Mokadem, M. (2024) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2024.1479876 · Cited by 8 · see citing works
GLP-1 and IL-6 regulates obesity in the gut and brain
Yang, K., Wu, Y., He, Y., Dai, J.-X., Luo, Y.-L., Xie, J.-H., & Ding, W. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.123339 · Cited by 8 · see citing works
Properties and functions of transcriptionally distinct enteric neurons
Shi, D., Reddy, P., Marrin, M. E., Walker, C. J., Siu, C., Muller, P. A., Yap, E.-L., & Sharma, N. (2025) · Cell · doi:10.1016/j.cell.2025.10.041 · Cited by 8 · see citing works
Chen, N., Cao, R., Zhao, Z., Zhou, S. J., & Hu, S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065544 · Cited by 8 · see citing works
Focus on Glucagon-like Peptide-1 Target: Drugs Approved or Designed to Treat Obesity
Zhang, J., Wei, J., Lai, W., Sun, J., Bai, Y., Cao, H., Guo, J., & Su, Z. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26041651 · Cited by 9 · see citing works
Adverse Food Reactions: Physiological and Ecological Perspectives
Korn, L. L., Kutyavin, V. I., Bachtel, N. D., & Medzhitov, R. M. (2024) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-061021-022909 · Cited by 7 · see citing works
Mattar, P., Jaque, C., Teske, J. A., Morselli, E., Kerr, B., Cortés, V., Baudrand, R. F., & Perez‐Leighton, C. E. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1164047 · Cited by 7 · see citing works
Page, A. J. (2023) · The Journal of Physiology · doi:10.1113/jp284075 · Cited by 7 · see citing works
The Potential Mechanism of Remission in Type 2 Diabetes Mellitus After Vertical Sleeve Gastrectomy
Wang, R., Mijiti, S., Xu, Q., Liu, Y., Deng, C., Huang, J., Yasheng, A., Tian, Y., Cao, Y., & Su, Y. (2024) · Obesity Surgery · doi:10.1007/s11695-024-07378-z · Cited by 6 · see citing works
Liu, Y., Xie, J., Yu, Z. H., Gong, M., Li, Q., Yang, G., Xu, B., & Xu, T. (2025) · Chinese Medicine · doi:10.1186/s13020-025-01099-w · Cited by 6 · see citing works
Sebhat, I. K., Murphy, M. J. M., Zheng, S., Lovelett, R. J., Engelstoft, M. S., Kosinski, D., Yang, X., Dunn, V., Whang, J., Lombardo, M., et al. (2025) · Cell Metabolism · doi:10.1016/j.cmet.2025.11.001 · Cited by 6 · see citing works
Capacitor-Less Low-Power Neuron Circuit with Multi-Gate Feedback Field Effect Transistor
Lee, J., Cha, M., & Kwon, M.-W. (2023) · Applied Sciences · doi:10.3390/app13042628 · Cited by 6 · see citing works
Chen, B. N., Humenick, A., Hibberd, T. J., Yew, W. P., Wattchow, D. A., Dinning, P. G., Costa, M., Spencer, N. J., & Brookes, S. J. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1313057 · Cited by 6 · see citing works
Neural gut-to-brain communication for postprandial control of satiation and glucose metabolism
Cabot, L., Erlenbeck-Dinkelmann, J., & Fenselau, H. (2023) · Journal of Endocrinology · doi:10.1530/joe-22-0320 · Cited by 6 · see citing works
Mo, Q., Shen, F., Ruan, S., Zhang, J., Zhao, M., Feng, F., & Liu, T. (2025) · Food Bioscience · doi:10.1016/j.fbio.2025.105879 · Cited by 5 · see citing works
Guo, D., Liu, C., Zhu, H., Cheng, Y., Huo, X., Guo, Y., & Qian, H. (2025) · Toxics · doi:10.3390/toxics13010061 · Cited by 5 · see citing works
Zhang, G., Ding, X.-Y., Romanova, E. V., Liu, C.-P., Barry, M. A., Doda, A., Chen, Q., Reaver, C. N., Jin, Q.-C., Rubakhin, S., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.116049 · Cited by 7 · see citing works
Parasubthalamic Glutamatergic Neurons Coordinate Cardiovascular Homeostasis and Locomotion in Mice
Lu, M., Huang, J., Xu, X., Sun, J., Zou, D., Zhang, J., Chi, C., Zhang, Q., & Liu, W. (2025) · Advanced Science · doi:10.1002/advs.202417353 · Cited by 5 · see citing works
- Authors
- Zhang, T., Perkins, M. H., Chang, H., Han, W., & de Araujo, I. E.
- Affiliations
- Jinan University (CN)
- Icahn School of Medicine at Mount Sinai (US)
- Corresponding author
- Han, Wenfei
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2022-07
- Volume
- 185
- Issue
- 14
- Pages
- 2478-2494.e28
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC9433108
- OpenAlex
- W4281724694
- Cited by
- 192
- References
- 88
- Citations by year
- 2026: 42 · 2025: 53 · 2024: 45 · 2023: 36 · 2022: 16
- FWCI
- 33.02
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 371 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (P20NS123220)
- National Center for Complementary and Integrative Health (R01AT011697)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- glucagon-like peptide-1, appetite suppression, myenteric neurons, enteric nervous system, gastric emptying, hypothalamic pathways, food refusal, bloating, gastric motility disorders
- MeSH terms
- Abdomen, Glucagon-Like Peptide-1 Receptor, Animals, Appetite, Cell Communication, Ileum, Male, Neurons, Nitric Oxide, Stomach, Signal Transduction, Mice, Glucagon-Like Peptide 1
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review