An integrate-and-fire model for pulsatility in the neuroendocrine system
Abstract
A model for pulsatility in neuroendocrine regulation is proposed which combines Goodwin-type feedback control with impulsive input from neurons located in the hypothalamus. The impulsive neural input is modeled using an integrate-and-fire mechanism; namely, inputs are generated only when the membrane potential crosses a threshold, after which it is reset to baseline. The resultant model takes the form of a functional-differential equation with continuous and impulsive components. Despite the impulsive nature of the inputs, realistic hormone profiles are generated, including ultradian and circadian rhythms, pulsatile secretory patterns, and even chaotic dynamics.
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A generalized integrate and fire model has been postulated as a simple mechanism to generate a range of rhythmic neuroendocrine signals.
“More recently, a generalized integrate and fire model has been postulated as a simple mechanism to generate a range of rhythmic neuroendocrine signals (Churilov et al., 2020).”
From Dynamic Hormone Control of Stress and Fertility (2020) · cites this paper as Churilov et al., 2020
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Dynamic Hormone Control of Stress and Fertility
Zavala, E., Voliotis, M., Zerenner, T., Tabak, J., Walker, J. J., Li, X. F., Terry, J. R., Lightman, S. L., O'Byrne, K., & Tsaneva-Atanasova, K. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.598845 · Cited by 34 · see citing works
- Authors
- Churilov, A. N., Milton, J., & Salakhova, E. R.
- Affiliations
- St Petersburg University (RU)
- Corresponding author
- Churilov, Alexander N.
- Venue
- Chaos An Interdisciplinary Journal of Nonlinear Science
- Publisher
- AIP Publishing
- Published
- 2020-08-01
- Volume
- 30
- Issue
- 8
- Pages
- 083132-083132
- ISSN
- 1054-1500 (ISSN-L)
- 1089-7682
- OpenAlex
- W3049383725
- Cited by
- 10
- References
- 116
- Citations by year
- 2026: 2 · 2025: 1 · 2023: 1 · 2022: 3 · 2021: 2 · 2020: 1
- FWCI
- 1.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Chaos An Interdisciplinary Journal of Nonlinear Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- William R. Kenan Jr. Charitable Trust
- Government Council on Grants, Russian Federation (08-08)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Physical Sciences › Mathematics › Geometry and Topology › Advanced Differential Equations and Dynamical Systems
- Keywords
- pulsatile hormone secretion, neuroendocrine regulation, integrate-and-fire neuron model, functional differential equations, hypothalamic neurons, ultradian rhythms, circadian rhythm, chaotic dynamics, hormonal profile
- MeSH terms
- Circadian Rhythm, Neurons, Neurosecretory Systems
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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