Motivations and Methods for Analyzing Pulsatile Hormone Secretion

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Effect of Parathyroid Hormone (1-34) on Fractures and Bone Mineral Density in Postmenopausal Women with Osteoporosis

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The Analysis of Time Series

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Intrinsic and extrinsic contributions to stochasticity in gene expression

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Somatostatin and Its Receptor Family

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Hypophysial responses to continuous and intermittent delivery of hypothalamic gonadotropin-releasing hormone

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Physiological time-series analysis: what does regularity quantify?

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Pathophysiology of the Neuroregulation of Growth Hormone Secretion in Experimental Animals and the Human*

Giustina, A., & Veldhuis, J. D. (1998) · Endocrine Reviews · doi:10.1210/edrv.19.6.0353 · Cited by 1,253 · see citing works

An amplified sensitivity arising from covalent modification in biological systems.

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Estimation of Insulin Secretion Rates from C-Peptide Levels: Comparison of Individual and Standard Kinetic Parameters for C-Peptide Clearance

Cauter, E. V., Mestrez, F., Sturis, J., & Polonsky, K. (1992) · Diabetes · doi:10.2337/diab.41.3.368 · Cited by 938 · see citing works

Cluster analysis: a simple, versatile, and robust algorithm for endocrine pulse detection

Veldhuis, J. D., & Johnson, M. L. (1986) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1986.250.4.e486 · Cited by 855 · see citing works

Episodic luteinizing hormone secretion in man. Pulse analysis, clinical interpretation, physiologic mechanisms

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The role of falling leptin levels in the neuroendocrine and metabolic adaptation to short-term starvation in healthy men

Chan, J. L., Heist, K., DePaoli, A. M., Veldhuis, J. D., & Mantzoros, C. S. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17490 · Cited by 697 · see citing works

Molecular Biology of the Pituitary Gonadotropins

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The diagnosis and medical management of advanced neuroendocrine tumors.

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The pituitary gland secretes in bursts: appraising the nature of glandular secretory impulses by simultaneous multiple-parameter deconvolution of plasma hormone concentrations.

Veldhuis, J. D., Carlson, M. L., & Johnson, M. L. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.21.7686 · Cited by 556 · see citing works

Randomness and degrees of irregularity.

Pincus, S. M., & Singer, B. H. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.5.2083 · Cited by 483 · see citing works

Dual Defects in Pulsatile Growth Hormone Secretion and Clearance Subserve the Hyposomatotropism of Obesity in Man*

Veldhuis, J. D., Iranmanesh, A., Ho, K. K. Y., Waters, M. J., Johnson, M. L., & LIZARRALDE, G. (1991) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-72-1-51 · Cited by 474 · see citing works

Gonadotropin-releasing hormone and its analogues

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Interlinked Fast and Slow Positive Feedback Loops Drive Reliable Cell Decisions

Brandman, O., Ferrell, J. E., Li, R., & Meyer, T. (2005) · Science · doi:10.1126/science.1113834 · Cited by 466 · see citing works

GONADOTROPIN-RELEASING HORMONE AND ITS ANALOGS

Conn, P. M., & Crowley, W. F. (1994) · Annual Review of Medicine · doi:10.1146/annurev.med.45.1.391 · Cited by 457 · see citing works

Multi-pulse drug delivery from a resorbable polymeric microchip device

Grayson, A. C. R., Choi, I. S., Tyler, B. M., Wang, P. P., Brem, H., Cima, M. J., & Langer, R. (2003) · Nature Materials · doi:10.1038/nmat998 · Cited by 444 · see citing works

Gonadotropin-Releasing Hormone and Its Analogues

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Role of Endocytosis in Cellular Uptake of Sex Steroids

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Differential impact of age, sex steroid hormones, and obesity on basal versus pulsatile growth hormone secretion in men as assessed in an ultrasensitive chemiluminescence assay

Veldhuis, J. D., Liem, A. Y., South, S. A., WELTMAN, A. L., Weltman, J. Y., Clemmons, D., Abbott, R. D., Mulligan, T., Johnson, M. L., & Pincus, S. M. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.11.7593428 · Cited by 385 · see citing works

Simultaneous Measurement of Luteinizing Hormone-Releasing Hormone and Luteinizing Hormone Release in Unanesthetized, Ovariectomized Sheep*

LEVINE, J. E., PAU, K.-Y. F., RAMIREZ, V. D., & JACKSON, G. L. (1982) · Endocrinology · doi:10.1210/endo-111-5-1449 · Cited by 384 · see citing works

Nongenomic Actions of Steroid Hormones in Reproductive Tissues*

Revelli, A., Massobrio, M., & Tesařík, J. (1998) · Endocrine Reviews · doi:10.1210/edrv.19.1.0322 · Cited by 378 · see citing works

Older males secrete luteinizing hormone and testosterone more irregularly, and jointly more asynchronously, than younger males

Pincus, S. M., Mulligan, T., Iranmanesh, A., Gheorghiu, S., Godschalk, M., & Veldhuis, P. P. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.24.14100 · Cited by 337 · see citing works

Hands: A Pattern Theoretic Study of Biological Shapes

Grenander, U., Chow, Y. K., & Keenan, D. M. (1990) · Medical Entomology and Zoology · Cited by 325 · see citing works

The Effects of Programmed Administration of Human Parathyroid Hormone Fragment (1–34) on Bone Histomorphometry and Serum Chemistry in Rats*

Dobnig, H., & Turner, R. T. (1997) · Endocrinology · doi:10.1210/endo.138.11.5505 · Cited by 318 · see citing works

Pathophysiology of hypercortisolism in depression

Carroll, B. J., Cassidy, F., Naftolowitz, D., Tatham, N. E., Wilson, W. H., Iranmanesh, A., Liu, P. Y., & Veldhuis, J. D. (2007) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2007.00967.x · Cited by 317 · see citing works

Insulin within islets is a physiologic glucagon release inhibitor

Maruyama, H., Hisatomi, A., Orci, L., Grodsky, G. M., & Unger, R. H. (1984) · Journal of Clinical Investigation · doi:10.1172/jci111658 · Cited by 303 · see citing works

The role of patterned burst and interburst interval on the excitation‐coupling mechanism in the isolated rat neural lobe.

Cazalis, M., Dayanithi, G., & Nordmann, J. J. (1985) · The Journal of Physiology · doi:10.1113/jphysiol.1985.sp015887 · Cited by 299 · see citing works

Contemporary Aspects of Discrete Peak-Detection Algorithms. II. The Paradigm of the Luteinizing Hormone Pulse Signal in Women*

EVANS, W. S., Sollenberger, M. J., Booth, R., Rogol, A. D., Urban, R. J., CARLSEN, E. C., Johnson, M. L., & Veldhuis, J. D. (1992) · Endocrine Reviews · doi:10.1210/edrv-13-1-81 · Cited by 286 · see citing works

Physiological regulation of circadian and pulsatile thyrotropin secretion in normal man and woman

BRABANT, G., PRANK, K., RANFT, U., SCHUERMEYER, T., WAGNER, T. O. F., HAUSER, H., KUMMER, B., FEISTNER, H., HESCH, R. D., & MÜHLEN, A. V. Z. (1990) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-70-2-403 · Cited by 282 · see citing works

Intrinsic pulsatile secretory activity of immortalized luteinizing hormone-releasing hormone-secreting neurons.

Wetsel, W. C., Valênça, M. M., Merchenthaler, I. J., Liposits, Z., LÓPEZ, F. J., Weiner, R. I., Mellon, P. L., & Negro-Vilar, A. F. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.9.4149 · Cited by 280 · see citing works

Rapid glucocorticoid effects on excitatory amino acid levels in the hippocampus: a microdialysis study in freely moving rats

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Females secrete growth hormone with more process irregularity than males in both humans and rats

Pincus, S. M., Gevers, E. F., Robinson, I. C. A. F., van den Berg, G., Roelfsema, F., Hartman, M. L., & Veldhuis, J. D. (1996) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1996.270.1.e107 · Cited by 268 · see citing works

[26] Deconvolution analysis of hormone data

Veldhuis, J. D., & Johnson, M. L. (1992) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(92)10028-c · Cited by 265 · see citing works

Central Electrophysiologic Correlates of Pulsatile Luteinizing Hormone Secretion in the Rhesus Monkey

Wilson, R. C., Kesner, J. S., Kaufman, J., Uemura, T., Akema, T., & Knobil, E. (2008) · Neuroendocrinology · doi:10.1159/000123988 · Cited by 264 · see citing works

Pulsatile Insulin Secretion Dictates Systemic Insulin Delivery by Regulating Hepatic Insulin Extraction In Humans

Meier, J. J., Veldhuis, J. D., & Butler, P. C. (2005) · Diabetes · doi:10.2337/diabetes.54.6.1649 · Cited by 261 · see citing works

Glutamate: A Major Excitatory Transmitter in Neuroendocrine Regulation

Brann, D. W. (2008) · Neuroendocrinology · doi:10.1159/000126843 · Cited by 259 · see citing works

Pulsatile Insulin Has Greater Hypoglycemic Effect Than Continuous Delivery

Matthews, D. R., Naylor, B. A., Jones, R., Ward, G. M., & Turner, R. C. (1983) · Diabetes · doi:10.2337/diab.32.7.617 · Cited by 256 · see citing works

XXXI. On the sensitivity, specificity, and discrimination of diagnostic tests

Feinstein, A. R. (1975) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt1975171104 · Cited by 253 · see citing works

Thirty-Second Sampling of Plasma Growth Hormone in Man: Correlation with Sleep Stages*

HOLL, R. W., HARTMAN, M. L., VELDHUIS, J. D., TAYLOR, W. M., & THORNER, M. O. (1991) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-72-4-854 · Cited by 239 · see citing works

Somatotropic and Gonadotropic Axes Linkages in Infancy, Childhood, and the Puberty-Adult Transition

Veldhuis, J. D., Roemmich, J. N., Richmond, E. J., & Bowers, C. Y. (2006) · Endocrine Reviews · doi:10.1210/er.2005-0006 · Cited by 235 · see citing works

Amplitude modulation of a burstlike mode of cortisol secretion subserves the circadian glucocorticoid rhythm

Veldhuis, J. D., Iranmanesh, A., Lizarralde, G., & Johnson, M. L. (1989) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1989.257.1.e6 · Cited by 224 · see citing works

Sustained Oscillations of Insulin, Glucagon, and Somatostatin from the Isolated Canine Pancreas during Exposure to a Constant Glucose Concentration

Stagner, J. I., Samols, E., & Weir, G. C. (1980) · Journal of Clinical Investigation · doi:10.1172/jci109750 · Cited by 223 · see citing works

Pulsatile Insulin Secretion: Detection, Regulation, and Role in Diabetes

Pørksen, N., Hollingdal, M., Juhl, C., Butler, P., Veldhuis, J. D., & Schmitz, O. (2002) · Diabetes · doi:10.2337/diabetes.51.2007.s245 · Cited by 223 · see citing works

Enhanced basal and disorderly growth hormone secretion distinguish acromegalic from normal pulsatile growth hormone release.

Hartman, M. L., Pincus, S. M., Johnson, M. L., Matthews, D., Faunt, L. M., Vance, M. L., Thorner, M. O., & Veldhuis, J. D. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117446 · Cited by 220 · see citing works

Contemporary Aspects of Discrete Peak-Detection Algorithms. I. The Paradigm of the Luteinizing Hormone Pulse Signal in Men*

Urban, R. J., Evans, W. S., Rogol, A. D., Kaiser, D. L., JOHNSON, M. L., & Veldhuis, J. D. (1988) · Endocrine Reviews · doi:10.1210/edrv-9-1-3 · Cited by 211 · see citing works

Oxytocin secretion and human parturition: Pulse frequency and duration increase during spontaneous labor in women

Fuchs, A., Romero, R. J., Keefe, D. L., Parra, M., Enrique Oyarzún, E., & Behnke, E. (1991) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(91)90399-c · Cited by 205 · see citing works

Operating Characteristics of the Male Hypothalamo-Pituitary-Gonadal Axis: Pulsatile Release of Testosterone and Follicle-Stimulating Hormone and Their Temporal Coupling with Luteinizing Hormone*

Veldhuis, J. D., King, J. C., Urban, R. J., Rogol, A. D., Evans, W. S., Kolp, L. A., & JOHNSON, M. L. (1987) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-65-5-929 · Cited by 205 · see citing works

Detection and characterization of peaks and estimation of instantaneous secretory rate for episodic pulsatile hormone secretion

Oerter, K. E., Guardabasso, V., & Rodbard, D. (1986) · Computers and Biomedical Research · doi:10.1016/0010-4809(86)90014-5 · Cited by 204 · see citing works

Amplitude, but not Frequency, Modulation of Adrenocorticotropin Secretory Bursts Gives Rise to the Nyctohemeral Rhythm of the Corticotropic Axis in Man*

Veldhuis, J. D., Iranmanesh, A., Johnson, M. L., & LIZARRALDE, G. (1990) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-71-2-452 · Cited by 203 · see citing works

Not all (possibly) “random” sequences are created equal

Pincus, S. M., & Kalman, R. E. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.8.3513 · Cited by 194 · see citing works

Twenty-Four-Hour Rhythms in Plasma Concentrations of Adenohypophyseal Hormones Are Generated by Distinct Amplitude and/or Frequency Modulation of Underlying Pituitary Secretory Bursts*

Veldhuis, J. D., Iranmanesh, A., Johnson, M. L., & LIZARRALDE, G. (1990) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-71-6-1616 · Cited by 193 · see citing works

Reproducibility of Serum Sex Steroid Assays in Men by RIA and Mass Spectrometry

Hsing, A. W., Stanczyk, F. Z., Bélanger, A., Schroeder, P., Chang, L., Falk, R. T., & Fears, T. R. (2007) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-06-0792 · Cited by 190 · see citing works

Spontaneous 24-h ghrelin secretion pattern in fasting subjects: maintenance of a meal-related pattern

Natalucci, G., Riedl, S., Gleiss, A., Zidek, T., & Frisch, H. (2005) · European Journal of Endocrinology · doi:10.1530/eje.1.01919 · Cited by 182 · see citing works

Cushing's disease preceded by generalized glucocorticoid resistance: clinical consequences of a novel, dominant-negative glucocorticoid receptor mutation.

Karl, M., Lamberts, S. W. J., Koper, J. W., Katz, D. A., Huizenga, N. A. T. M., Kino, T., Haddad, B. R., Hughes, M. R., & Chrousos, G. P. (1996) · PubMed · Cited by 180 · see citing works

Abdominal adiposity rather than age and sex predicts mass and regularity of GH secretion in healthy adults

Vahl, N., Jorgensen, J. O., Skjaerbaek, C., Veldhuis, J. D., Orskov, H., & Christiansen, J. S. (1997) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1997.272.6.e1108 · Cited by 178 · see citing works

Estimating false-positive and false-negative errors in analyses of hormonal pulsatility

Cauter, E. V. (1988) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1988.254.6.e786 · Cited by 177 · see citing works

Direct Measurement of Pulsatile Insulin Secretion from the Portal Vein in Human Subjects1

Song, S. H., McIntyre, S. S., Shah, H., Veldhuis, J. D., Hayes, P. C., & Butler, P. C. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.12.7043 · Cited by 173 · see citing works

Revealing the large-scale network organization of growth hormone-secreting cells

Bonnefont, X., Lacampagne, A., Sánchez‐Hormigo, A., Fino, É., Creff, A., Mathieu, M.-N., Smallwood, S. A., Carmignac, D. F., Fontanaud, P., Travo, P., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508202102 · Cited by 160 · see citing works

Gender and Sexual Maturation-Dependent Contrasts in the Neuroregulation of Growth Hormone Secretion in Prepubertal and Late Adolescent Males and Females--A General Clinical Research Center-Based Study

Veldhuis, J. D., Roemmich, J. N., & Rogol, A. D. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.7.6697 · Cited by 155 · see citing works

Mechanisms for Pulsatile Regulation of the Gonadotropin Subunit Genes by GNRH11

Ferris, H. A., & Shupnik, M. A. (2006) · Biology of Reproduction · doi:10.1095/biolreprod.105.049049 · Cited by 155 · see citing works

Mechanisms underlying episodic gonadotropin-releasing hormone secretion.

Moenter, S., DeFazio, A., Pitts, G. R., & Nunemaker, C. S. (2003) · Frontiers in neuroendocrinology (Print) · doi:10.1016/s0091-3022(03)00013-x · Cited by 152 · see citing works

A feedback-controlled ensemble model of the stress-responsive hypothalamo-pituitary-adrenal axis.

Keenan, D. M., Licinio, J., & Veldhuis, J. D. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.051624198 · Cited by 145 · see citing works

Postprandial Suppression of Glucagon Secretion Depends on Intact Pulsatile Insulin Secretion

Meier, J. J., Kjems, L. L., Veldhuis, J. D., Lefèbvre, P., & Butler, P. C. (2006) · Diabetes · doi:10.2337/diabetes.55.04.06.db05-1449 · Cited by 144 · see citing works

Temporal structure of in vivo growth hormone secretory events in humans

Hartman, M. L., FARIA, A. C. S., Vance, M. L., Johnson, M. L., Thorner, M. O., & Veldhuis, J. D. (1991) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1991.260.1.e101 · Cited by 142 · see citing works

Pulsatile secretion of thyrotropin in man

GREENSPAN, S. L., KLIBANSK, A., SCHQENFELD, D., & RIDGWAY, E. C. (1986) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-63-3-661 · Cited by 140 · see citing works

Pulsatile Secretion of Human Chorionic Gonadotropin in Normal Adults

Odell, W. D., & Griffin, J. L. (1987) · New England Journal of Medicine · doi:10.1056/nejm198712313172702 · Cited by 140 · see citing works

Aldosterone release during the sleep–wake cycle in humans

Charloux, A., Gronfier, C., Lonsdorfer-Wolf, E., Piquard, F., & Brandenberger, G. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.276.1.e43 · Cited by 138 · see citing works

Corticosteroid-binding globulin influences kinetic parameters of plasma cortisol transport and clearance.

Bright, G. M. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.3.7883829 · Cited by 137 · see citing works

Irregularity and asynchrony in biologic network signals

Pincus, S. M. (2000) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(00)21192-0 · Cited by 134 · see citing works

Ontogeny of pulsatile gonadotropin releasing hormone secretion from midchildhood, through puberty, to adulthood in the human male: a study using deconvolution analysis and an ultrasensitive immunofluorometric assay

Wu, F. C. W., Butler, G. E., Kelnar, C. J. H., Huhtaniemi, I. T., & Veldhuis, J. D. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.5.8626838 · Cited by 131 · see citing works

Metabolic clearance of biologically active luteinizing hormone in man.

Veldhuis, J. D., FRAIOLI, F., Rogol, A. D., & Dufau, M. L. (1986) · Journal of Clinical Investigation · doi:10.1172/jci112411 · Cited by 130 · see citing works

Nelson's syndrome associated with a somatic frame shift mutation in the glucocorticoid receptor gene

Karl, M., von Wichert, G., Kempter, E., Katz, D. A., Reincke, M., Mönig, H., Ali, I. U., Stratakis, C. A., Oldfield, E. H., Chrousos, G. P., et al. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.1.8550738 · Cited by 130 · see citing works

Hormone pulsatility discrimination via coarse and short time sampling

Pincus, S. M., Hartman, M. L., Roelfsema, F., Thorner, M. O., & Veldhuis, J. D. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.277.5.e948 · Cited by 130 · see citing works

A physiological view of the central and peripheral mechanisms that regulate the release of catecholamines at the adrenal medulla

de Diego, A. M. G., Gandı́a, L., & Garcı́a, A. G. (2007) · Acta Physiologica · doi:10.1111/j.1748-1716.2007.01807.x · Cited by 129 · see citing works

Measurement of Plasma Free Metanephrine and Normetanephrine by Liquid Chromatography–Tandem Mass Spectrometry for Diagnosis of Pheochromocytoma

Lagerstedt, S. A., O’Kane, D. J., & Singh, R. J. (2004) · Clinical Chemistry · doi:10.1373/clinchem.2003.024703 · Cited by 127 · see citing works

Secretory process regularity monitors neuroendocrine feedback and feedforward signaling strength in humans

Veldhuis, J. D., Straume, M., Iranmanesh, A., Mulligan, T., Jaffe, C., Barkan, A., Johnson, M. L., & Pincus, S. (2001) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2001.280.3.r721 · Cited by 127 · see citing works

Proteasome-Dependent Down-Regulation of Activated Nuclear Hippocampal Glucocorticoid Receptors Determines Dynamic Responses to Corticosterone

Conway-Campbell, B. L., McKenna, M. A., Wiles, C. C., Atkinson, H. C., de Kloet, E. R., & Lightman, S. L. (2007) · Endocrinology · doi:10.1210/en.2007-0585 · Cited by 125 · see citing works

Measurement of the Insulin Delivery Rate in Man

Turner, R. C., Grayburn, J. A., Newman, G. B., & Nabarro, J. D. N. (1971) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-33-2-279 · Cited by 121 · see citing works

Operating Characteristics of the Hypothalamo-Pituitary-Gonadal Axis in Men: Circadian, Ultradian, and Pulsatile Release of Prolactin and Its Temporal Coupling With Luteinizing Hormone*

Veldhuis, J. D., & Johnson, M. L. (1988) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-67-1-116 · Cited by 121 · see citing works

Evidence for a Hypothalamic Oxytocin-Sensitive Pattern-Generating Network Governing Oxytocin NeuronsIn Vitro

Jourdain, P., Israël, J.-M., Dupouy, B., Oliet, S. H. R., Michèle Allard, A., Vitiello, S., Theodosis, D. T., & Poulain, D. A. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-17-06641.1998 · Cited by 118 · see citing works

Modeling Advection and Diffusion of Oxygen in Complex Vascular Networks

Beard, D., & Bassingthwaighte, J. B. (2001) · Annals of Biomedical Engineering · doi:10.1114/1.1359450 · Cited by 117 · see citing works

Effects of a physiological GH pulse on interstitial glycerol in abdominal and femoral adipose tissue

Gravholt, C. H., Schmitz, O., Simonsen, L., Bülow, J., Christiansen, J. S., & Møller, N. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.277.5.e848 · Cited by 114 · see citing works

In humans at least 75% of insulin secretion arises from punctuated insulin secretory bursts

Pørksen, N. K., Nyholm, B., Veldhuis, J. D., Butler, P. C., & Schmitz, O. (1997) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1997.273.5.e908 · Cited by 114 · see citing works

Pulsatile insulin secretion accounts for 70% of total insulin secretion during fasting

Pørksen, N. K., Munn, S. R., Steers, J. L., Vore, S. J., Veldhuis, J. D., & Butler, P. C. (1995) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1995.269.3.e478 · Cited by 114 · see citing works

IGF-I assays: current assay methodologies and their limitations

Clemmons, D. R. (2007) · Pituitary · doi:10.1007/s11102-007-0032-z · Cited by 114 · see citing works

The Effects of Corticotropin-Releasing Factor on Adrenocorticotropin Secretion from Perifused Pituitariesin vitro: Rapid Inhibition by Glucocorticoids*

Widmaier, E. P., & Dallman, M. F. (1984) · Endocrinology · doi:10.1210/endo-115-6-2368 · Cited by 108 · see citing works

Perifusion of rat pituitary cells with gonadotropin-releasing hormone, activin, and inhibin reveals distinct effects on gonadotropin gene expression and secretion

Weiss, J., Crowley, W. F., Halvorson, L. M., & Jameson, J. L. (1993) · Endocrinology · doi:10.1210/endo.132.6.8504735 · Cited by 108 · see citing works

Quantification of human insulin‐like growth factor‐1 and qualitative detection of its analogues in plasma using liquid chromatography/electrospray ionisation tandem mass spectrometry

Bredehöft, M., Schänzer, W., & Thevis, M. (2008) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.3388 · Cited by 107 · see citing works

A biomathematical model of time-delayed feedback in the human male hypothalamic-pituitary-Leydig cell axis

Keenan, D. M., & Veldhuis, J. D. (1998) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1998.275.1.e157 · Cited by 107 · see citing works

Familial Corticosteroid-Binding Globulin Deficiency Due to a Novel Null Mutation: Association with Fatigue and Relative Hypotension

Torpy, D. J., Bachmann, A. W., Grice, J. E., Fitzgerald, S. P., Phillips, P. J. J., Whitworth, J. A., & Jackson, R. V. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.8.7724 · Cited by 106 · see citing works

A Paradoxical Gender Dissociation within the Growth Hormone/Insulin-Like Growth Factor I Axis during Protracted Critical Illness1

den Berghe, G. V., Baxter, R. C., Weekers, F., Wouters, P. J., Bowers, C. Y., & Veldhuis, J. D. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.1.6316 · Cited by 106 · see citing works

Pulsatile Insulin Delivery has Greater Metabolic Effects than Continuous Hormone Administration in Man: Importance of Pulse Frequency

Paolisso, G., Scheen, A. J., Giugliano, D., Sgambato, S., Albert, A., Varricchio, M., D’Onofrio, F., & Lefèbvre, P. J. (1991) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-72-3-607 · Cited by 104 · see citing works

Continuous administration of synthetic ovine corticotropin-releasing factor in man. Physiological and pathophysiological implications

Schulte, H. M., Chrousos, G. P., Gold, P. W., Booth, J. D., Oldfield, E. H., Cutler, G. B., & Loriaux, D. L. (1985) · Journal of Clinical Investigation · doi:10.1172/jci111890 · Cited by 103 · see citing works

Pulsatile Versus Continuous Intravenous Administration of Growth Hormone (GH) in GH-Deficient Patients: Effects on Circulating Insulin-Like Growth Factor-I and Metabolic Indices

Jørgensen, J. O. L., Møller, N., Lauritzen, T., & Christiansen, J. S. (1990) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-70-6-1616 · Cited by 101 · see citing works

STAT5b-deficient Mice Are Growth Hormone Pulse-resistant

Davey, H. W., Park, S.-H., Grattan, D. R., McLachlan, M. J., & Waxman, D. J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.50.35331 · Cited by 101 · see citing works

Physiological Profiles of Episodic Progesterone Release During the Midluteal Phase of the Human Menstrual Cycle: Analysis of Circadian and Ultradian Rhythms, Discrete Pulse Properties, and Correlations With Simultaneous Luteinizing Hormone Release*

Veldhuis, J. D., CHRISTIANSEN, E., Evans, W. S., Kolp, L. A., Rogol, A. D., & Johnson, M. L. (1988) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-66-2-414 · Cited by 101 · see citing works

Unequal impact of short-term testosterone repletion on the somatotropic axis of young and older men.

Gentili, A., Mulligan, T., Godschalk, M., Clore, J., Patrie, J., Iranmanesh, A., & Veldhuis, J. D. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.2.8222 · Cited by 98 · see citing works

Patients with Cushing’s Disease Secrete Adrenocorticotropin and Cortisol Jointly More Asynchronously than Healthy Subjects

Roelfsema, F., Pincus, S. M., & Veldhuis, J. D. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.2.4570 · Cited by 96 · see citing works

Physiological control of pituitary hormone secretory-burst mass, frequency, and waveform: a statistical formulation and analysis

Keenan, D. M., Roelfsema, F., Biermasz, N. R., & Veldhuis, J. D. (2003) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00195.2003 · Cited by 96 · see citing works

Direct Measurement of Pulsatile Insulin Secretion from the Portal Vein in Human Subjects

Song, S. H. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.85.12.4491 · Cited by 96 · see citing works

Disorderly and nonstationary insulin secretion in relatives of patients with NIDDM

Schmitz, O., Pørksen, N. K., Nyholm, B., Skjærbæk, C. B., Butler, P. C., Veldhuis, J. D., & Pincus, S. M. (1997) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1997.272.2.e218 · Cited by 95 · see citing works

Increased disorderliness and amplified basal and pulsatile aldosterone secretion in patients with primary aldosteronism

Siragy, H. M., Vieweg, W. V. R., Pincus, S. M., & Veldhuis, J. D. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.1.7829626 · Cited by 95 · see citing works

Dynamics of 24-Hour Endogenous Cortisol Secretion and Clearance in Primary Hypothyroidism Assessed before and after Partial Thyroid Hormone Replacement*

IRANMANESH, A., LIZARRALDE, G., JOHNSON, M. L., & VELDHUIS, J. D. (1990) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-70-1-155 · Cited by 93 · see citing works

Greater disorderliness of ACTH and cortisol release accompanies pituitary-dependent Cushing's disease

van den Berg, G., Pincus, S. M., Veldhuis, J. D., Frölich, M., & Roelfsema, F. (1997) · European Journal of Endocrinology · doi:10.1530/eje.0.1360394 · Cited by 93 · see citing works

Direct quantification of steroid glucuronides in human urine by liquid chromatography–electrospray tandem mass spectrometry

Pozo, Ó. J., Eenoo, P. V., Thuyne, W. V., Deventer, K., & Delbeke, F. T. (2008) · Journal of Chromatography A · doi:10.1016/j.chroma.2008.01.045 · Cited by 93 · see citing works

Orderliness of hormone release patterns: a complementary measure to conventional pulsatile and circadian analyses

Veldhuis, J., & Pincus, S. (1998) · European Journal of Endocrinology · doi:10.1530/eje.0.1380358 · Cited by 92 · see citing works

Mathematical Model of Paracrine Interactions between Osteoclasts and Osteoblasts Predicts Anabolic Action of Parathyroid Hormone on Bone

Komarova, S. V. (2005) · Endocrinology · doi:10.1210/en.2004-1642 · Cited by 92 · see citing works

Dose-response studies on the metabolic effects of a growth hormone pulse in humans

Møller, N., Schmitz, O., Pørksen, N. K., Møller, J., & Jørgensen, J. O. L. (1992) · Metabolism · doi:10.1016/0026-0495(92)90147-3 · Cited by 90 · see citing works

In VivoBiological Validation and Biophysical Modeling of the Sensitivity and Positive Accuracy of Endocrine Peak Detection. I. The LH Pulse Signal*

Urban, R. J., Johnson, M. L., & Veldhuis, J. D. (1989) · Endocrinology · doi:10.1210/endo-124-5-2541 · Cited by 90 · see citing works

Impact of pulsatility on the ensemble orderliness (approximate entropy) of neurohormone secretion

Veldhuis, J. D., Johnson, M. L., Veldhuis, O. L., Straume, M., & Pincus, S. M. (2001) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2001.281.6.r1975 · Cited by 88 · see citing works

Unequal impact of age, percentage body fat, and serum testosterone concentrations on the somatotrophic, IGF-I, and IGF-binding protein responses to a three-day intravenous growth hormone-releasing hormone pulsatile infusion in men

Iranmanesh, A., South, S. A., Liem, A. Y., Clemmons, D. R., Thorner, M. O., WELTMAN, A. L., & Veldhuis, J. D. (1998) · European Journal of Endocrinology · doi:10.1530/eje.0.1390059 · Cited by 88 · see citing works

Influence of the high-affinity growth hormone (GH)-binding protein on plasma profiles of free and bound GH and on the apparent half-life of GH. Modeling analysis and clinical applications.

Veldhuis, P. P., Johnson, M. L., Faunt, L. M., Mercado, M., & Baumann, G. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116243 · Cited by 87 · see citing works

Increased Disorderliness of Basal Insulin Release, Attenuated Insulin Secretory Burst Mass, and Reduced Ultradian Rhythmicity of Insulin Secretion in Older Individuals

Meneilly, G. S., Ryan, A. S., Veldhuis, J. D., & Elahi, D. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.12.4457 · Cited by 85 · see citing works

Physiological Properties of the Luteinizing Hormone Pulse Signal: Impact of Intensive and Extended Venous Sampling Paradigms on Its Characterization in Healthy Men and Women*

VELDHUIS, J. D., EVANS, W. S., JOHNSON, M. L., WILLS, M. R., & ROGOL, A. D. (1986) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-62-5-881 · Cited by 85 · see citing works

Metabolic Effects and Pharmacokinetics of a Growth Hormone Pulse in Healthy Adults: Relation to Age, Sex, and Body Composition

Vahl, N., Møller, N., Lauritzen, T., Christiansen, J. S., & Jørgensen, J. O. L. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.11.4388 · Cited by 84 · see citing works

Hysteresis in the Relationship Between Serum Ionized Calcium and Intact Parathyroid Hormone during Recovery from Induced Hyper-and Hypocalcemia in Normal Humans*

Conlin, P. R., Fajtova, V. T., Mortensen, R. M., LeBoff, M. S., & Brown, E. M. (1989) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-69-3-593 · Cited by 84 · see citing works

Pancreatic β-cells communicate via intermittent release of ATP

Hellman, B., Dansk, H., & Grapengiesser, E. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00452.2003 · Cited by 83 · see citing works

Testosterone and estradiol are co-secreted episodically by the human testis.

Winters, S. J., & Troen, P. (1986) · Journal of Clinical Investigation · doi:10.1172/jci112673 · Cited by 83 · see citing works

Control of pulsatile and tonic parathyroid hormone secretion by ionized calcium

Schmitt, C. P., Schaefer, F. S., Bruch, A., Veldhuis, J. D., Schmidt‐Gayk, H., Stein, G., Ritz, E., & Mehls, O. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.12.8954021 · Cited by 82 · see citing works

Actions of estrogen on pulsatile, nyctohemeral, and entropic modes of growth hormone secretion

Shah, N., Evans, W. S., & Veldhuis, J. D. (1999) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1999.276.5.r1351 · Cited by 82 · see citing works

In vivo pulsatility of pancreatic islet peptides

Jaspan, J. B., Lever, E. G., Polonsky, K. S., & Cauter, E. V. (1986) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1986.251.2.e215 · Cited by 82 · see citing works

Endogenous opiates modulate the pulsatile secretion of biologically active luteinizing hormone in man.

Veldhuis, J. D., Rogol, A. D., & Johnson, M. L. (1983) · Journal of Clinical Investigation · doi:10.1172/jci111168 · Cited by 80 · see citing works

Validation of methods for measurement of insulin secretion in humans in vivo.

Kjems, L., Christiansen, E., Vølund, A., Bergman, R. N., & Madsbad, S. (2000) · Diabetes · doi:10.2337/diabetes.49.4.580 · Cited by 80 · see citing works

Expression of 11 -Hydroxysteroid Dehydrogenase Isoenzymes in the Human Pituitary: Induction of the Type 2 Enzyme in Corticotropinomas and Other Pituitary Tumors

Korbonits, M., Bujalska, I. J., Shimojo, M., Nobes, J. P., Jordan, S., Grossman, A. B., & Stewart, P. M. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.6.7563 · Cited by 80 · see citing works

Effects of age on the irregularity of LH and FSH serum concentrations in women and men

Pincus, S. M., Veldhuis, J. D., Mulligan, T., Iranmanesh, A., & Evans, W. S. (1997) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1997.273.5.e989 · Cited by 78 · see citing works

Endogenous ACTH concentration-dependent drive of pulsatile cortisol secretion in the human

Keenan, D. M., Roelfsema, F., & Veldhuis, J. D. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00167.2004 · Cited by 78 · see citing works

Greater efficacy of episodic than continuous growth hormone-releasing hormone (GHRH) administration in promoting slow-wave sleep (SWS)

Marshall, L., Mölle, M., Böschen, G., Steiger, A., Fehm, H. L., & Jan Born, A. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.3.8772566 · Cited by 77 · see citing works

A novel technique for measuring hypothalamic and pituitary hormone secretion rates from collection of pituitary venous effluent in the normal horse

IRVINE, C. H. G., & Alexander, S. L. (1987) · Journal of Endocrinology · doi:10.1677/joe.0.1130183 · Cited by 76 · see citing works

A Stochastic Biomathematical Model of the Male Reproductive Hormone System

Keenan, D. M., Veldhuis, J. D., & Sun, W. (2000) · SIAM Journal on Applied Mathematics · doi:10.1137/s0036139998334718 · Cited by 75 · see citing works

A model for the identification of hormone pulses

Kushler, R. H., & Brown, M. B. (1991) · Statistics in Medicine · doi:10.1002/sim.4780100305 · Cited by 74 · see citing works

Multifactorial control of the elimination kinetics of unbound (free) growth hormone (GH) in the human: regulation by age, adiposity, renal function, and steady state concentrations of GH in plasma

Schaefer, F. S., Baumann, G., Haffner, D., Faunt, L. M., Johnson, M. L., Mercado, M., Ritz, E., Mehls, O., & Veldhuis, P. P. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.1.8550755 · Cited by 73 · see citing works

Pulsatile iv Infusion of Recombinant Human LH in Leuprolide-Suppressed Men Unmasks Impoverished Leydig-Cell Secretory Responsiveness to Midphysiological LH Drive in the Aging Male

Mulligan, T., Iranmanesh, A., & Veldhuis, J. D. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.11.8004 · Cited by 71 · see citing works

Intensive venous sampling paradigms disclose high frequency adrenocorticotropin release episodes in normal men

IRANMANESH, A., LIZARRALDE, G., SHORT, D., & VELDHUIS, J. D. (1990) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-71-5-1276 · Cited by 71 · see citing works

Development and Evaluation of a Candidate Reference Method for the Determination of Total Cortisol in Human Serum Using Isotope Dilution Liquid Chromatography/Mass Spectrometry and Liquid Chromatography/Tandem Mass Spectrometry

Tai, S. S.-C., & Welch, M. J. (2004) · Analytical Chemistry · doi:10.1021/ac034966f · Cited by 70 · see citing works

Growth, growth hormone (GH)-binding protein, and GH receptors are differentially regulated by peak and trough components of the GH secretory pattern in the rat.

Gevers, E. F., Wit, J. M., & Robinson, I. C. A. F. (1996) · Endocrinology · doi:10.1210/endo.137.3.8603568 · Cited by 70 · see citing works

Prehepaticβ-Cell Secretion During the Intravenous Glucose Tolerance Test in Humans: Application of a Combined Model of Insulin and C-Peptide Kinetics*

Watanabe, R. M., Vølund, A., Roy, S., & Bergman, R. N. (1989) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-69-4-790 · Cited by 70 · see citing works

Evidence of a corticotropin-releasing hormone pulse generator in the macaque hypothalamus

Mershon, J. L., Sehlhorst, C. S., Rebar, R. W., & Liu, J. H. (1992) · Endocrinology · doi:10.1210/endo.130.5.1572307 · Cited by 70 · see citing works

Reconstruction of <i>in vivo</i> time-evolving neuroendocrine dose–response properties unveils admixed deterministic and stochastic elements

Keenan, D. M., Alexander, S., Irvine, C. H. G., Clarke, I., Scott, C., Turner, A., Tilbrook, A. J., Canny, B. J., & Veldhuis, J. D. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0300619101 · Cited by 70 · see citing works

A comparison of six deconvolution techniques

Madden, F. N., Godfrey, K. R., Chappell, M. J., Hovorka, R., & Bates, R. A. (1996) · Journal of Pharmacokinetics and Biopharmaceutics · doi:10.1007/bf02353672 · Cited by 69 · see citing works

Reversal of fasting-induced suppression of luteinizing hormone (LH) secretion in male rhesus monkeys by intragastric nutrient infusion: evidence for rapid stimulation of LH by nutritional signals.

Schreihofer, D. A., Amico, J. A., & Cameron, J. L. (1993) · Endocrinology · doi:10.1210/endo.132.5.8477642 · Cited by 67 · see citing works

Pulsatile secretion of parathyroid hormone in normal young subjects: assessment by deconvolution analysis

Samuels, M. H., Veldhuis, J. D., Cawley, C., Urban, R. J., Luther, M., Bauer, R. L., & Mundy, G. R. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.77.2.399 · Cited by 67 · see citing works

A Minimal Mathematical Model of Calcium Homeostasis

Raposo, J. F., Sobrinho, L. G., & Ferreira, H. G. (2002) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.2002-011870 · Cited by 67 · see citing works

Disruption of the Young-Adult Synchrony between Luteinizing Hormone Release and Oscillations in Follicle-Stimulating Hormone, Prolactin, and Nocturnal Penile Tumescence (NPT) in Healthy Older Men

Veldhuis, J. D., Iranmanesh, A., Mulligan, T., & Pincus, S. M. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.10.6100 · Cited by 66 · see citing works

An Ensemble Model of the Male Gonadal Axis: Illustrative Application in Aging Men

Keenan, D. M., Takahashi, P. Y., Liu, P. Y., Roebuck, P. D., Nehra, A. X., Iranmanesh, A., & Veldhuis, J. D. (2006) · Endocrinology · doi:10.1210/en.2005-1356 · Cited by 65 · see citing works

Method for characterization of 24-h temporal variation of blood components.

Cauter, E. V. (1979) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1979.237.3.e255 · Cited by 64 · see citing works

Altered instantaneous and calcium-modulated oscillatory PTH secretion patterns in patients with secondary hyperparathyroidism.

Schmitt, C. P., Huber, D., Mehls, O., Maiwald, J., Stein, G., Veldhuis, P. P., Ritz, E., & Schaefer, F. (1998) · Journal of the American Society of Nephrology · doi:10.1681/asn.v9101832 · Cited by 64 · see citing works

Composite model of time-varying appearance and disappearance of neurohormone pulse signals in blood

Keenan, D. M., Chattopadhyay, S., & Veldhuis, J. D. (2005) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2005.03.008 · Cited by 63 · see citing works

A Sexually Dimorphic Pattern of Growth Hormone Secretion in the Elderly

Hindmarsh, P. C., Dennison, E. M., Pincus, S. M., Cooper, C. C., Fall, C. H. D., Matthews, D. R., Pringle, P. J., & Brook, C. G. D. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.8.5915 · Cited by 63 · see citing works

Gonadotropinomas

Chaidarun, S., & Klibanski, A. (2002) · Seminars in Reproductive Medicine · doi:10.1055/s-2002-36708 · Cited by 63 · see citing works

Time course and mechanism of growth hormone's negative feedback effect on its own spontaneous release.

Lanzi, R., & Tannenbaum, G. S. (1992) · Endocrinology · doi:10.1210/endo.130.2.1346379 · Cited by 62 · see citing works

Analysis of the Copulsatility of Anterior Pituitary Hormones*

Veldhuis, J. D., Johnson, M. L., & Seneta, E. B. (1991) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-73-3-569 · Cited by 61 · see citing works

Operating behavior of dual or multiple endocrine pulse generators.

Veldhuis, J. D., Lassiter, A. E., & Johnson, M. L. (1990) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1990.259.3.e351 · Cited by 61 · see citing works

Predominance of stimulatory effects of interleukin-1 beta on isolated human pancreatic islets

Eizirik, D. L., Welsh, N., & Hellerström, C. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.76.2.399 · Cited by 61 · see citing works

THE HALF‐LIFE OF EXOGENOUS GROWTH HORMONE AFTER SUPPRESSION OF ENDOGENOUS GROWTH HORMONE SECRETION WITH SOMATOSTATIN

Hindmarsh, P. C., Matthews, D. R., Brain, C. E., Pringle, P. J., Silvio, L. D., Kurtz, A. B., & Brook, C. G. D. (1989) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1989.tb00444.x · Cited by 60 · see citing works

Two weeks of daily injections and continuous infusion of recombinant human growth hormone (GH) in GH-deficient adults. II. Effects on serum lipoproteins and lipoprotein and hepatic lipase activity

Oscarsson, J., Ottosson, M., Johansson, J.-O., Wiklund, O., Mårin, P., Björntorp, P. A., & Bengtsson, B. (1996) · Metabolism · doi:10.1016/s0026-0495(96)90293-0 · Cited by 60 · see citing works

A model for the control of testosterone secretion

Cartwright, M., & Husain, M. (1986) · Journal of Theoretical Biology · doi:10.1016/s0022-5193(86)80158-8 · Cited by 59 · see citing works

Disappearance of human chorionic gonadotropin and its α- and β-subunits after term pregnancy

Korhonen, J., Alfthan, H. V., Ylöstalo, P., Veldhuis, J. D., & Stenman, U. (1997) · Clinical Chemistry · doi:10.1093/clinchem/43.11.2155 · Cited by 59 · see citing works

Muting of Androgen Negative Feedback Unveils Impoverished Gonadotropin-Releasing Hormone/Luteinizing Hormone Secretory Reactivity in Healthy Older Men1

Veldhuis, J. D., Zwart, A. D., Mulligan, T., & Iranmanesh, A. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.2.7200 · Cited by 58 · see citing works

INTRINSIC PULSATILITY OF ACTH RELEASE FROM THE HUMAN PITUITARY IN VITRO

Gambacciani, M., LIU, J. H., SWARTZ, W. H., Tueros, V. S., Rasmussen, D. D., & Yen, S. S. C. (1987) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1987.tb00810.x · Cited by 57 · see citing works

Sustained elevation of pulsatile growth hormone (GH) secretion and insulin-like growth factor I (IGF-I), IGF-binding protein-3 (IGFBP-3), and IGFBP-5 concentrations during 30-day continuous subcutaneous infusion of GH-releasing peptide-2 in older men and women.

Bowers, C. Y., Granda, R., Mohan, S., Kuipers, J., Baylink, D., & Veldhuis, J. D. (2004) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.2003-031799 · Cited by 57 · see citing works

Pulsatile Insulin Secretion by Human Pancreatic Islets

Song, S. H., Kjems, L., Ritzel, R. A., McIntyre, S., Johnson, M. L., Veldhuis, J. D., & Butler, P. C. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.1.8181 · Cited by 57 · see citing works

Corticotropin Secretory Dynamics in Humans under Low Glucocorticoid Feedback

Veldhuis, J. D., Iranmanesh, A., Naftolowitz, D. F., Tatham, N. E., Cassidy, F., & Carroll, B. J. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.11.8046 · Cited by 56 · see citing works

Joint recovery of pulsatile and basal hormone secretion by stochastic nonlinear random-effects analysis

Keenan, D. M., Veldhuis, J. D., & Yang, R. (1998) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1998.275.6.r1939 · Cited by 56 · see citing works

Two weeks of daily injections and continuous infusion of recombinant human growth hormone (GH) in GH-deficient adults: 1. effects on insulin-like growth factor-I (IGF-I), GH and IGF binding proteins, and glucose homeostasis

Johansson, J.-O., Oscarsson, J., Bjarnason, R. G., & Bengtsson, B. (1996) · Metabolism · doi:10.1016/s0026-0495(96)90292-9 · Cited by 56 · see citing works

Calcium-Sensing by Parathyroid Glands in Secondary Hyperparathyroidism1

Goodman, W. G., Veldhuis, J. D., Belin, T. R., Herle, A. J. V., Jüppner, H., & Salusky, I. B. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.8.4999 · Cited by 56 · see citing works

Disruption of the Pulsatile and Entropic Modes of Insulin Release during an Unvarying Glucose Stimulus in Elderly Individuals

Meneilly, G. S., Veldhuis, J. D., & Elahi, D. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.6.5753 · Cited by 55 · see citing works

Altered pulsatile gonadotropin signaling in nutritional deficiency in the male

Bergendahl, M., & Veldhuis, J. D. (1995) · Trends in Endocrinology and Metabolism · doi:10.1016/1043-2760(95)00081-r · Cited by 55 · see citing works

Mechanisms of Disease: the first kiss—a crucial role for kisspeptin-1 and its receptor, G-protein-coupled receptor 54, in puberty and reproduction

Seminara, S. B. (2006) · Nature Clinical Practice Endocrinology &#38 Metabolism · doi:10.1038/ncpendmet0139 · Cited by 55 · see citing works

Differential orderliness of the GH release process in castrate male and female rats

Gevers, E. F., Pincus, S. M., Robinson, I. C. A. F., & Veldhuis, J. D. (1998) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1998.274.2.r437 · Cited by 55 · see citing works

Effects of pulsatile delivery of basal growth hormone on lipolysis in humans

Cersósimo, E., Danou, F. N., Persson, M., & Miles, J. M. (1996) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1996.271.1.e123 · Cited by 55 · see citing works

Pulsatile Intravenous Gonadotropin-Releasing Hormone Administration Averts Fasting-Induced Hypogonadotropism and Hypoandrogenemia in Healthy, Normal Weight Men1

Aloi, J., Bergendahl, M., Iranmanesh, A., & Veldhuis, J. D. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.5.3947 · Cited by 55 · see citing works

Putative GH pulse renewal: periventricular somatostatinergic control of an arcuate-nuclear somatostatin and GH-releasing hormone oscillator

Farhy, L. S., & Veldhuis, J. D. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00473.2003 · Cited by 55 · see citing works

Further Evidence for the Role of Glucose as a Metabolic Regulator of Hypothalamic Gonadotropin-Releasing Hormone Pulse Generator Activity in Goats

Ohkura, S., Ichimaru, T., Itoh, F., Matsuyama, S., & Okamura, H. (2004) · Endocrinology · doi:10.1210/en.2003-1516 · Cited by 54 · see citing works

Complicating effects of highly correlated model variables on nonlinear least-squares estimates of unique parameter values and their statistical confidence intervals: estimating basal secretion and neurohormone half-life by deconvolution analysis.

Veldhuis, J. D., Evans, W. S., & Johnson, M. L. (1995) · Methods in Neurosciences · doi:10.1016/s1043-9471(06)80031-5 · Cited by 54 · see citing works

Constitutive Growth Hormone Secretion in Sheep after Hypothalamopituitary Disconnection and the Direct in vivo Pituitary Effect of Growth Hormone Releasing Peptide 6

Fletchers, T. P., Thomas, G. B., Willoughby, J. O., & Clarke, I. J. (2008) · Neuroendocrinology · doi:10.1159/000126722 · Cited by 54 · see citing works

Pilot Study for the Standardization of Insulin Immunoassays with Isotope Dilution–Liquid Chromatography/Tandem Mass Spectrometry

Cabaleiro, D. R., Uytfanghe, K. V., Stove, V. V., Fiers, T., & Thienpont, L. M. (2007) · Clinical Chemistry · doi:10.1373/clinchem.2007.088393 · Cited by 53 · see citing works

Specific Linkages Among Luteinizing Hormone, Follicle-Stimulating Hormone, and Testosterone Release in the Peripheral Blood and Human Spermatic Vein: Evidence for Both Positive (Feed-Forward) and Negative (Feedback) Within-Axis Regulation1

Foresta, C., Bordon, P., Rossato, M., Mioni, R., & Veldhuis, J. D. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.9.4198 · Cited by 53 · see citing works

Genesis of the ultradian rhythm of GH secretion: a new model unifying experimental observations in rats

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Deconvolution Analysis of Neuroendocrine Data: Waveform-Specific and Waveform-Independent Methods and Applications

Veldhuis, J. D., Moorman, J., & Johnson, M. L. (1994) · Methods in neurosciences · doi:10.1016/b978-0-12-185289-4.50021-8 · Cited by 52 · see citing works

Pulsatile signaling in intercellular communication. Periodic stimuli are more efficient than random or chaotic signals in a model based on receptor desensitization

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Diurnal variation in the elimination rate of human growth hormone (GH): the half-life of serum GH is prolonged in the evening, and affected by the source of the hormone, as well as by body size and serum estradiol

Holl, R. W., Schwarz, U., Schauwecker, P., Benz, R., Veldhuis, J. D., & Heinze, E. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.77.1.216 · Cited by 52 · see citing works

Stochastic model of admixed basal and pulsatile hormone secretion as modulated by a deterministic oscillator

Keenan, D. M., & Veldhuis, J. D. (1997) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1997.273.3.r1182 · Cited by 51 · see citing works

A Model for the Pulsatile Secretion of Gonadotropin-Releasing Hormone from Synchronized Hypothalamic Neurons

Khadra, A., & Li, Y. (2006) · Biophysical Journal · doi:10.1529/biophysj.105.080630 · Cited by 51 · see citing works

Increased episodic release and disorderliness of prolactin secretion in both micro- and macroprolactinomas

Veldman, R. G., van den Berg, G., Pincus, S., Frölich, M. A., Veldhuis, J. D., & Roelfsema, F. (1999) · European Journal of Endocrinology · doi:10.1530/eje.0.1400192 · Cited by 51 · see citing works

Partial Pharmacodynamic Model for the Circadian-Episodic Secretion of Cortisol in Man

Jusko, W. J., Slaunwhite, W. R., & Aceto, T. (1975) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-40-2-278 · Cited by 50 · see citing works

Tripartite Neuroendocrine Activation of the Human Growth Hormone (GH) Axis in Women by Continuous 24-Hour GH-Releasing Peptide Infusion: Pulsatile, Entropic, and Nyctohemeral Mechanisms1

Shah, N., Evans, W. S., Bowers, C. Y., & Veldhuis, J. D. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.6.5687 · Cited by 50 · see citing works

Interference with Feedback Inhibition of Adrenocorticotropin Release by Protein Binding of Corticosterone

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Deconvolution of Episodic Hormone Data: An analysis of the Role of Season on the Onset of Puberty in Cows

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Liquid chromatography–tandem mass spectrometry assay for human serum testosterone and trideuterated testosterone

Starcevic, B., Distefano, E. W., Wang, C., & Catlin, D. H. (2003) · Journal of Chromatography B · doi:10.1016/s1570-0232(03)00261-7 · Cited by 50 · see citing works

Diabetes: Models, Signals, and Control

Cobelli, C., Dalla Man, C., Sparacino, G., Magni, L., De Nicolao, G., & Kovatchev, B. P. (2009) · IEEE Reviews in Biomedical Engineering · doi:10.1109/rbme.2009.2036073 · Cited by 511 · see citing works

Dynamic regulation of transcriptional states by chromatin and transcription factors

Voss, T. C., & Hager, G. L. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3623 · Cited by 504 · see citing works

Growth hormone — past, present and future

Ranke, M. B., & Wit, J. M. (2018) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2018.22 · Cited by 352 · see citing works

Pulsatile insulin secretion, impaired glucose tolerance and type 2 diabetes

Satin, L. S., Butler, P. C., Ha, J., & Sherman, A. (2015) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2015.01.003 · Cited by 234 · see citing works

Perspectives on concordant and discordant relations between insulin-like growth factor 1 (IGF1) and growth in fishes

Beckman, B. R. (2010) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2010.08.009 · Cited by 233 · see citing works

Neurokinin 3 receptor antagonism as a novel treatment for menopausal hot flushes: a phase 2, randomised, double-blind, placebo-controlled trial

Prague, J., Roberts, R. E., Comninos, A. N., Clarke, S. A., Jayasena, C. N., Nash, Z., Doyle, C., Papadopoulou, D., Bloom, S. R., Mohideen, P., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(17)30823-1 · Cited by 209 · see citing works

Kisspeptin-10 is a potent stimulator of LH and increases pulse frequency in men

George, J. T., Veldhuis, J. D., Roseweir, A. K., Newton, C. L., Faccenda, E., Millar, R. P., & Anderson, R. A. (2011) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.2011-0089 · Cited by 186 · see citing works

Adrenal function and dysfunction in critically ill patients

Téblick, A., Peeters, B., Langouche, L., & den Berghe, G. V. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0185-7 · Cited by 156 · see citing works

Sleep and circadian regulation of cortisol: A short review

O'Byrne, N. A., Yuen, F., Butt, W. Z., & Liu, P. Y. (2021) · Current Opinion in Endocrine and Metabolic Research · doi:10.1016/j.coemr.2021.03.011 · Cited by 145 · see citing works

Neurokinin B Receptor Antagonism in Women With Polycystic Ovary Syndrome: A Randomized, Placebo-Controlled Trial

George, J. T., Kakkar, R. K., Marshall, J., Scott, M. L., Finkelman, R. D., Ho, T. W., Veldhuis, J. D., Skorupskaite, K., Anderson, R. A., McIntosh, S., et al. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-1202 · Cited by 131 · see citing works

Increased Hypothalamic-Pituitary-Adrenal Axis Activity in Huntington’s Disease

Aziz, N. A., Pijl, H., Frölich, M., van der Graaf, A. W. M., Roelfsema, F., & Roos, R. A. C. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-2543 · Cited by 131 · see citing works

Exploring the pathophysiology of hypogonadism in men with type 2 diabetes: Kisspeptin‐10 stimulates serum testosterone and LH secretion in men with type 2 diabetes and mild biochemical hypogonadism

George, J. T., Veldhuis, J. D., Tena‐Sempere, M., Millar, R. P., & Anderson, R. A. (2012) · Clinical Endocrinology · doi:10.1111/cen.12103 · Cited by 123 · see citing works

Thyrotropin secretion patterns in health and disease

Roelfsema, F., & Veldhuis, J. D. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1076 · Cited by 113 · see citing works

Prolactin Secretion in Healthy Adults Is Determined by Gender, Age and Body Mass Index

Roelfsema, F., Pijl, H., Keenan, D. M., & Veldhuis, J. D. (2012) · PLoS ONE · doi:10.1371/journal.pone.0031305 · Cited by 117 · see citing works

Changes in pituitary function with ageing and implications for patient care

Veldhuis, J. D. (2013) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2013.38 · Cited by 116 · see citing works

Kisspeptin resets the hypothalamic GnRH clock in men

Chan, Y.-M., Butler, J. P., Pinnell, N. E., Pralong, F. P., Crowley, W. F., Ren, C., Chan, K. K., & Seminara, S. B. (2011) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.2010-3046 · Cited by 114 · see citing works

On the Neuroendocrinopathy of Critical Illness. Perspectives for Feeding and Novel Treatments

den Berghe, G. V. (2016) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201607-1516ci · Cited by 106 · see citing works

Impact of age, sex and body mass index on cortisol secretion in 143 healthy adults

Roelfsema, F., van Heemst, D., Iranmanesh, A., Takahashi, P., Yang, R., & Veldhuis, J. D. (2017) · Endocrine Connections · doi:10.1530/ec-17-0160 · Cited by 100 · see citing works

High-resolution daily profiles of tissue adrenal steroids by portable automated collection

Upton, T. J., Zavala, E., Methlie, P., Kämpe, O., Tsagarakis, S., Øksnes, M., Bensing, S., Vassiliadi, D. A., Grytaas, M. A., Botusan, I. R., et al. (2023) · Science Translational Medicine · doi:10.1126/scitranslmed.adg8464 · Cited by 94 · see citing works

Sensitivity and specificity of pulse detection using a new deconvolution method

Liu, P. Y., Keenan, D. M., Kok, P., Padmanabhan, V., O'Byrne, K. T., & Veldhuis, J. D. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00071.2009 · Cited by 90 · see citing works

Sleep, testosterone and cortisol balance, and ageing men

Liu, P. Y., & Reddy, R. T. (2022) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-022-09755-4 · Cited by 80 · see citing works

Human longevity is characterised by high thyroid stimulating hormone secretion without altered energy metabolism

Jansen, S. W., Akintola, A. A., Roelfsema, F., van der Spoel, E., Cobbaert, C. M., Ballieux, B. E., Egri, P., Kvarta-Papp, Z., Gereben, B., Fekete, C., et al. (2015) · Scientific Reports · doi:10.1038/srep11525 · Cited by 82 · see citing works

The biology of gonadotroph regulation

Ciccone, N. A., & Kaiser, U. B. (2009) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e32832d88fb · Cited by 81 · see citing works

Cellular in vivo imaging reveals coordinated regulation of pituitary microcirculation and GH cell network function

Lafont, C., Desarménien, M. G., Cassou, M., Molino, F., Lecoq, J. A., Hodson, D. J., Lacampagne, A., Mennessier, G., Yandouzi, T. E., Carmignac, D. F., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0902599107 · Cited by 80 · see citing works

60 YEARS OF NEUROENDOCRINOLOGY: The hypothalamo-GH axis: the past 60 years

Murray, P. G., Higham, C., & Clayton, P. (2015) · Journal of Endocrinology · doi:10.1530/joe-15-0120 · Cited by 79 · see citing works

New insights into the controversy of adrenal function during critical illness

Boonen, E., Bornstein, S. R., & Van den Berghe, G. (2015) · The Lancet Diabetes &amp; Endocrinology · doi:10.1016/s2213-8587(15)00224-7 · Cited by 77 · see citing works

Reduced nocturnal ACTH-driven cortisol secretion during critical illness

Boonen, E., Meersseman, P., Vervenne, H., Meyfroidt, G., Guïza, F., Wouters, P. J., Veldhuis, J. D., & Van den Berghe, G. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00009.2014 · Cited by 75 · see citing works

Encoding and decoding mechanisms of pulsatile hormone secretion

Walker, J. J., Terry, J. R., Tsaneva‐Atanasova, K., Armstrong, S. P., McArdle, C. A., & Lightman, S. L. (2010) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2010.02087.x · Cited by 78 · see citing works

Parathyroid hormone pulsatility: physiological and clinical aspects

Chiavistelli, S., Giustina, A., & Mazziotti, G. (2015) · Bone Research · doi:10.1038/boneres.2014.49 · Cited by 64 · see citing works

Short and Long-Term Effects of Growth Hormone in Children and Adolescents With GH Deficiency

Ranke, M. B. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.720419 · Cited by 65 · see citing works

Pituitary Physiology and Diagnostic Evaluation

Melmed, S. K., Kleinberg, D. L., & Ho, K. K. Y. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4377-0324-5.00008-0 · Cited by 58 · see citing works

Kisspeptin and neurokinin B interactions in modulating gonadotropin secretion in women with polycystic ovary syndrome

Skorupskaite, K., George, J. T., Veldhuis, J. D., Millar, R. P., & Anderson, R. A. (2020) · Human Reproduction · doi:10.1093/humrep/deaa104 · Cited by 59 · see citing works

Integrating GHS into the Ghrelin System

Veldhuis, J. D., & Bowers, C. Y. (2010) · International Journal of Peptides · doi:10.1155/2010/879503 · Cited by 57 · see citing works

Sex diversity in the 21st century: Concepts, frameworks, and approaches for the future of neuroendocrinology

Smiley, K. O., Munley, K. M., Aghi, K., Lipshutz, S. E., Patton, T. M., Pradhan, D. S., Solomon‐Lane, T. K., & Sun, S. D. (2023) · Hormones and Behavior · doi:10.1016/j.yhbeh.2023.105445 · Cited by 57 · see citing works

Predictive modeling of the hypothalamic-pituitary-adrenal (HPA) axis response to acute and chronic stress

Markovic, V. M., Cupic, Z., Vukojevic, V., & Kolar-Anic, L. (2011) · Endocrine Journal · doi:10.1507/endocrj.ej11-0037 · Cited by 54 · see citing works

Deconvolution of Serum Cortisol Levels by Using Compressed Sensing

Faghih, R. T., Dahleh, M. A., Adler, G. K., Klerman, E. B., & Brown, E. N. (2014) · PLoS ONE · doi:10.1371/journal.pone.0085204 · Cited by 54 · see citing works

Pathophysiology of hypercortisolism in depression: pituitary and adrenal responses to low glucocorticoid feedback

Carroll, B. J., Iranmanesh, A., Keenan, D. M., Cassidy, F., Wilson, W. H., & Veldhuis, J. D. (2011) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2011.01821.x · Cited by 54 · see citing works

Gender, age, body mass index, and IGF-I individually and jointly determine distinct GH dynamics: analyses in one hundred healthy adults

Veldhuis, J. D., Roelfsema, F., Keenan, D. M., & Pincus, S. (2011) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.2010-1669 · Cited by 53 · see citing works

The effects of repeat traumatic brain injury on the pituitary in adolescent rats

Greco, T., Hovda, D., & Prins, M. (2013) · Journal of Neurotrauma · doi:10.1089/neu.2013.2990 · Cited by 51 · see citing works

Basal, Pulsatile, Entropic (Patterned), and Spiky (Staccato-like) Properties of ACTH Secretion: Impact of Age, Gender, and Body Mass Index

Veldhuis, J. D., Roelfsema, F., Iranmanesh, A., Carroll, B. J., Keenan, D. M., & Pincus, S. M. (2009) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.2009-1143 · Cited by 51 · see citing works

Somatostatin Is Essential for the Sexual Dimorphism of GH Secretion, Corticosteroid-Binding Globulin Production, and Corticosterone Levels in Mice

Adams, J. M., Otero-Corchón, V., Hammond, G. L., Veldhuis, J. D., Qi, N., & Low, M. J. (2014) · Endocrinology · doi:10.1210/en.2014-1429 · Cited by 50 · see citing works

Interactions Between Neurokinin B and Kisspeptin in Mediating Estrogen Feedback in Healthy Women

Skorupskaite, K., George, J. T., Veldhuis, J. D., Millar, R. P., & Anderson, R. A. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-2132 · Cited by 50 · see citing works

Neurokinin B Regulates Gonadotropin Secretion, Ovarian Follicle Growth, and the Timing of Ovulation in Healthy Women

Skorupskaite, K., George, J. T., Veldhuis, J. D., & Anderson, R. A. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2017-01306 · Cited by 49 · see citing works

Thyrotropin secretion in mild and severe primary hypothyroidism is distinguished by amplified burst mass and basal secretion with increased spikiness and approximate entropy

Roelfsema, F., Pereira, A. M., Adriaanse, R., Endert, E., Fliers, E., Romijn, J. A., & Veldhuis, J. D. (2010) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.2009-1959 · Cited by 45 · see citing works

Biological Rhythms, Drug Delivery, and Chronotherapeutics

Smolensky, M. H., Siegel, R. A., Haus, E. L., Hermida, R. C., & Portaluppi, F. (2011) · Springer eBooks · doi:10.1007/978-1-4614-0881-9_13 · Cited by 45 · see citing works

Continuous positive airway pressure increases pulsatile growth hormone secretion and circulating insulin-like growth factor-1 in a time-dependent manner in men with obstructive sleep apnea: a randomized sham-controlled study.

Hoyos, C., Killick, R., Keenan, D. M., Baxter, R. C., Veldhuis, J., & Liu, P. Y. (2014) · Sleep · doi:10.5665/sleep.3580

The HPA axis response to critical illness: New study results with diagnostic and therapeutic implications

Peeters, B., Boonen, E., Langouche, L., & den Berghe, G. V. (2014) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2014.11.012 · Cited by 44 · see citing works

Regulatory aspects of the human hypothalamus-pituitary-thyroid axis

Roelfsema, F., Boelen, A., Kalsbeek, A., & Fliers, E. (2017) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2017.09.004 · Cited by 44 · see citing works

Familial longevity is associated with higher tsh secretion and strong TSH-fT3 relationship

Jansen, S. W., Roelfsema, F., van der Spoel, E., Akintola, A. A., Postmus, I., Ballieux, B. E., Slagboom, P. E., Cobbaert, C. M., van der Grond, J., Westendorp, R. G., et al. (2015) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.2015-2624 · Cited by 41 · see citing works

Approximate entropy used to assess sitting postural sway of infants with developmental delay

Deffeyes, J. E., Harbourne, R. T., Stuberg, W. A., & Stergiou, N. (2010) · Infant Behavior and Development · doi:10.1016/j.infbeh.2010.10.001 · Cited by 40 · see citing works

Investigating the KNDy Hypothesis in Humans by Coadministration of Kisspeptin, Neurokinin B, and Naltrexone in Men

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Thyrotropin Secretion in Healthy Subjects Is Robust and Independent of Age and Gender, and Only Weakly Dependent on Body Mass Index

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Estradiol, but not testosterone, heightens cortisol-mediated negative feedback on pulsatile ACTH secretion and ACTH approximate entropy in unstressed older men and women

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Pituitary Physiology and Diagnostic Evaluation

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IGSF1 Deficiency Results in Human and Murine Somatotrope Neurosecretory Hyperfunction

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Glucose ingestion acutely lowers pulsatile LH and basal testosterone secretion in men

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Pulsatility of Hypothalamo-Pituitary Hormones: A Challenge in Quantification

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The Processes of Anterior Pituitary Hormone Pulse Generation

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Growth hormone and ghrelin secretion are associated with clinical severity in Huntington’s disease

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Altered thyrotropic and lactotropic axes regulation in Huntington’s disease

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Follicle-Stimulating Hormone Receptor: Advances and Remaining Challenges

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Acute Effects of Testosterone Infusion on the Serum Luteinizing Hormone Profile in Eumenorrheic and Polycystic Ovary Syndrome Adolescents

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Pituitary Hormone Secretion Profiles in IGSF1 Deficiency Syndrome

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Tripartite Control of Dynamic ACTH-Cortisol Dose Responsiveness by Age, Body Mass Index, and Gender in 111 Healthy Adults

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Transcriptomics and machine learning predict diagnosis and severity of growth hormone deficiency

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A 24-Hour Study of the Hypothalamo-Pituitary Axes in Huntington’s Disease

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Predicting response to leuprolide of women with premenstrual dysphoric disorder by daily mood rating dynamics

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Ultradian rhythmicity and induced changes in salivary testosterone

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Clamping Cortisol and Testosterone Mitigates the Development of Insulin Resistance during Sleep Restriction in Men

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Neurokinin 3 receptor antagonism decreases gonadotropin and testosterone secretion in healthy men

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Microevolution of neuroendocrine mechanisms regulating reproductive timing in Peromyscus leucopus

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Cortisol Production Rate Is Similarly Elevated in Obese Women with or without the Polycystic Ovary Syndrome

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Pulsatile cortisol feedback on ACTH secretion is mediated by the glucocorticoid receptor and modulated by gender

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Regulation and adaptation of endocrine axes at high altitude

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Interactions among impulsiveness, testosterone, sex hormone binding globulin and androgen receptor gene CAG repeat length

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Age and time-of-day differences in the hypothalamo–pituitary–testicular, and adrenal, response to total overnight sleep deprivation

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Entropy change of biological dynamics in COPD

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Invisible Designers: Brain Evolution Through the Lens of Parasite Manipulation

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Insulin Infusion During Normoglycemia Modulates Insulin Secretion According to Whole-Body Insulin Sensitivity

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Measurement of Pulsatile Insulin Secretion: Rationale and Methodology

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Pulsatile Interleukin-6 Leads CRH Secretion and Is Associated With Myometrial Contractility During the Active Phase of Term Human Labor

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Dynamic testosterone responses to near-physiological LH pulses are determined by the time pattern of prior intravenous LH infusion

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Hypothalamo-pituitary-adrenal axis after a single epidural triamcinolone injection

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Compound Poisson Noise Sources in Diffusion-Based Molecular Communication

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Dose-response downregulation within the span of single interpulse intervals

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Glucose ingestion selectively amplifies ACTH and cortisol secretory-burst mass and enhances their joint synchrony in healthy men.

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Sex Steroids, GHRH, Somatostatin, IGF-I, and IGFBP-1 Modulate Ghrelin's Dose-Dependent Drive of Pulsatile GH Secretion in Healthy Older Men

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Foliation-Based Parameter Tuning in a Model of the GnRH Pulse and Surge Generator

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Noninvasive Analytical Estimation of Endogenous GnRH Drive: Analysis Using Graded Competitive GnRH-Receptor Antagonism and a Calibrating Pulse of Exogenous GnRH

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Analytical construct of reversible desensitization of pituitary-testicular signaling: illustrative application in aging

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Testosterone pulses at the nest site modify ultrasonic vocalization types in a monogamous and territorial mouse

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Gonadotropin Hormones

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Pulsatile Hormone Secretion: Mechanisms, Significance and Evaluation

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Regulation of Complex Pulsatile and Rhythmic Neuroendocrine Systems: the Male Gonadal Axis as a Prototype

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