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Acute effects of melatonin administration on cardiovascular autonomic regulation in healthy men
Abstract
Background Previous studies have suggested that melatonin, a major pineal hormone, possibly modulates the autonomic nervous system in animals. The aim of this study was to examine the effects of melatonin administration on heart rate variability (HRV) in human beings. Methods In 26 healthy men, melatonin (2 mg) or placebo was randomly administered. Power spectral analysis of HRV and blood pressure monitoring were performed in the supine position before and 60 minutes after administration and in the standing position 60 minutes after administration. Plasma catecholamine levels were also assessed. Results No differences in any baseline parameters were found between the two groups. Compared with placebo, melatonin administration within 60 minutes increased R-R interval, the square root of the mean of the squared differences between adjacent normal R-R intervals, high-frequency power, and low-frequency power of HRV and decreased the low-frequency to high-frequency ratio and blood pressure in the supine position (all P Conclusions These findings indicate that melatonin administration increased cardiac vagal tone in the supine position in awake men. Melatonin administration also may exert suppressive effects on sympathetic tone.
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“Heart rate variability studies in humans have indicated that melatonin increases cardiac vagal tone (Nishiyama et al. 2001).”
From Melatonin attenuates the sympathetic nerve responses to orthostatic stress in humans (2003) · cites this paper as Nishiyama et al. 2001
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Role of Melatonin in Regulating Gut Motility
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Melatonina: pros y contras de su empleo en atención primaria
Arboledas, G. P., & Roselló, A. L. (2011) · Anales de Pediatría Continuada · doi:10.1016/s1696-2818(11)70017-8
al Bareh, H. M., Alkidsawi, M. J. K., Hussein, H. A., Alhamaidah, M. F., Mahdi, A. H., & Kahloul, M. (2024) · Pakistan journal of life and social sciences · doi:10.57239/pjlss-2024-22.1.00151
“(10) This will positively influence heart rate variability, indicating its potential to regulate cardiovascular balance during major operations and heart rate in children undergoing major surgeries.”
BackgroundSturzrisiko, zirkadiane Rhythmen, Vagusaktivität und Melatonin
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Chang, C. C., Tzeng, N. S., Kao, Y. C., Yeh, C. B., & Chang, H. (2018) · Neuropsychiatry · doi:10.4172/neuropsychiatry.1000409
“The action of synergy between melatonergic receptors agonistic effect of agomelatine and its 5-HT2c receptor antagonistic effect was a proposed mechanism through which agomelatine increased vagal tone since both melatonergic and 5-HT2c receptors play a vital role in modulating vagal tone of the autonomic nervous syste…”
Background
Metadata
- Authors
- Nishiyama, K., Yasue, H., Moriyama, Y., Tsunoda, R., Ogawa, H., Yoshimura, M., & Kugiyama, K.
- Affiliations
- Kumamoto University (JP)
- Kumamoto University Hospital (JP)
- ORCID
- Venue
- American Heart Journal
- Publisher
- Elsevier BV
- Published
- 2001-05
- Volume
- 141
- Issue
- 5
- Pages
- 13A-17A
- ISSN
- 0002-8703 (ISSN-L)
- OpenAlex
- W2136100283
- Cited by
- 113
- References
- 0
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 5 · 2023: 8 · 2022: 7 · 2021: 7 · 2020: 5 · 2019: 4 · 2018: 3 · 2017: 2 · 2016: 5 · 2015: 3 · 2014: 7 · 2013: 2 · 2012: 3
- FWCI
- 3.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Heart Journal (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
- Keywords
- melatonin, heart rate variability, cardiovascular autonomic regulation, cardiac vagal tone, sympathetic tone, blood pressure, norepinephrine, dopamine, catecholamines, postural changes, healthy men
- MeSH terms
- Blood Pressure, Cardiovascular System, Circadian Rhythm, Dopamine, Dose-Response Relationship, Drug, Electrocardiography, Heart Rate, Humans, Male, Melatonin, Norepinephrine, Posture, Reference Values, Vagus Nerve, Free Radical Scavengers
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