Effects of melatonin on vascular reactivity, catecholamine levels, and blood pressure in healthy men
Abstract
In this study it was investigated whether the oral administration of melatonin (1 mg) in comparison to placebo was able to reduce blood pressure, vascular reactivity, and catecholamines in men, as previously reported in young women. The administration of melatonin significantly reduced blood pressure, the pulsatility index in the internal carotid artery, and catecholamines levels within 90 minutes. The effect of melatonin on the artery pulsatility index was related to baseline values, being greater in men with higher baseline values. The present data indicate that melatonin may blunt the activity of the cardiovascular system and may have both physiopathologic and clinical implications.
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In humans, 1 mg of melatonin decreases arterial pressure and plasma noradrenaline levels during standing.
“Studies in humans indicate that 1 mg of melatonin decreases arterial pressure and the plasma levels of noradrenaline during standing (Cagnacci et al. 1998; Arangino et al. 1999).”
From Melatonin attenuates the sympathetic nerve responses to orthostatic stress in humans (2003) · cites this paper as Arangino et al. 1999
Cites
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Melatonin: Nature’s most versatile biological signal?
Pandi‐Perumal, S. R., Srinivasan, V., Maestroni, G. J. M., Cardinali, D. P., Poeggeler, B., & Hardeland, R. (2006) · The FEBS Journal · doi:10.1111/j.1742-4658.2006.05322.x · Cited by 875 · see citing works
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Melatonin and stable circadian rhythms optimize maternal, placental and fetal physiology
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Dietary Sources and Bioactivities of Melatonin
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Melatonin reduces night blood pressure in patients with nocturnal hypertension
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Melatonin attenuates the sympathetic nerve responses to orthostatic stress in humans
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- Authors
- Arangino, S., Cagnacci, A., Angiolucci, M., Vacca, A. M. B., Longu, G., Volpe, A., & Melis, G. B.
- Affiliations
- University of Modena and Reggio Emilia (IT)
- University of Cagliari (IT)
- Corresponding author
- Cagnacci, Angelo
- Venue
- The American Journal of Cardiology
- Publisher
- Elsevier BV
- Published
- 1999-05
- Volume
- 83
- Issue
- 9
- Pages
- 1417-1419
- ISSN
- 0002-9149 (ISSN-L)
- OpenAlex
- W2154571212
- Cited by
- 200
- References
- 1
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 9 · 2023: 10 · 2022: 8 · 2021: 8 · 2020: 1 · 2019: 7 · 2018: 9 · 2017: 6 · 2016: 8 · 2015: 6 · 2014: 12 · 2013: 15 · 2012: 10
- FWCI
- 1.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The American Journal of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- UNICA IRIS Institutional Research Information System (University of Cagliari) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Keywords
- melatonin, vascular reactivity, catecholamines, blood pressure, circadian rhythm, nocturnal blood pressure dipping, epinephrine, norepinephrine, vasopressin, vasopressin receptor, endothelium, nitric oxide, healthy men, cardiovascular system, hypertension prevention
- MeSH terms
- Adult, Blood Pressure, Cardiovascular System, Double-Blind Method, Epinephrine, Female, Humans, Male, Melatonin, Norepinephrine, Pulsatile Flow, Regional Blood Flow, Free Radical Scavengers
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