Prenatal exposure to polychlorinated biphenyls and attention at school age
Abstract
Objective To examine the relation of prenatal polychlorinated biphenyl (PCB) exposure to child performance on neuropsychological tests of attention and information processing. Study design In this prospective, longitudinal study, assessment of prenatal PCB exposure was based on umbilical cord serum and maternal serum and milk concentrations. The children were tested in their homes at age 11 years. Multiple regression was used to examine the relation of this exposure to performance on 15 neuropsychological tests after controlling for a broad range of potential confounding variables. Results Adverse effects were seen primarily in children who had not been breast fed. Among these children, prenatal PCB exposure was associated with greater impulsivity, poorer concentration, and poorer verbal, pictorial, and auditory working memory. There was no evidence of visual-spatial deficit or increased hyperactivity. Conclusions These findings are consistent with earlier reports of greater vulnerability to prenatal PCB exposure in children who were not breast fed. It is not clear whether the protection offered by breast-feeding is caused by nutrients in breast milk or better quality of intellectual stimulation often provided by breast-feeding mothers.
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Reduced attention span and increased impulsivity-features reminiscent of ADHD-were reported particularly in Dutch and American cohorts.
“Reduced attention span and increased impulsivity—features reminiscent of ADHD—were reported particularly in Dutch and American cohorts (Jacobson and Jacobson, 2003).”
From Environmental endocrine disruptors at the synapse: mechanisms linking chemical exposure to cognitive and behavioral dysfunction (2026) · cites this paper as Jacobson and Jacobson, 2003
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- Authors
- Jacobson, J. L., & Jacobson, S. W.
- Affiliations
- Wayne State University (US)
- Corresponding author
- Jacobson, Joseph L
- Jacobson, Sandra W
- Venue
- The Journal of Pediatrics
- Publisher
- Elsevier BV
- Published
- 2003-12
- Volume
- 143
- Issue
- 6
- Pages
- 780-788
- ISSN
- 0022-3476 (ISSN-L)
- OpenAlex
- W2054804796
- Cited by
- 219
- References
- 31
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 4 · 2023: 4 · 2022: 5 · 2021: 11 · 2020: 7 · 2019: 7 · 2018: 6 · 2017: 9 · 2016: 9 · 2015: 16 · 2014: 12 · 2013: 13 · 2012: 17
- FWCI
- 7.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Pediatrics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01es003256-03)
- U.S. Public Health Service (80852010)
- National Institute of Environmental Health Sciences (R01-ES05843, R01-ES03256)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Pesticide Exposure and Toxicity
- Keywords
- polychlorinated biphenyls, prenatal exposure, attention, elementary school students, breastfeeding, umbilical cord serum, maternal serum, milk, impulsivity, working memory, information processing, neurodevelopmental effects
- MeSH terms
- Attention Deficit Disorder with Hyperactivity, Breast Feeding, Child, Environmental Pollutants, Female, Fetal Blood, Humans, Longitudinal Studies, Male, Memory Disorders, Milk, Human, Neuropsychological Tests, Polychlorinated Biphenyls, Pregnancy, Prenatal Exposure Delayed Effects, Prospective Studies, Serum
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