Cited by 116Toxic Organic Pollutants ImpactPesticide Exposure and ToxicityEffects and risks of endocrine disrupting chemicals

Polychlorinated biphenyls, organochlorine pesticides and neurodevelopment

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Korrick, Susan A, Sagiv, Sharon K·2008·Current Opinion in Pediatrics

Abstract

PURPOSE OF REVIEW: Although environmental levels of polychlorinated biphenyls and certain organochlorine pesticides--hexachlorobenzene, dichlorodiphenyl trichloroethane and its primary metabolite, dichlorodiphenyl dichloroethene--are generally on the decline, early-life exposures to these prevalent contaminants continue. The review will describe current understanding of the potential neurodevelopmental consequences of low-level exposures to these contaminants. RECENT FINDINGS: Animal models suggest that early-life exposures to polychlorinated biphenyls, dichlorodiphenyl trichloroethane/dichlorodiphenyl dichloroethene or hexachlorobenzene are associated with decreased cognitive or behavioral function in later development. Despite almost 30 years of research, however, results of human studies are inconsistent regarding the nature of the observed effects and their persistence over time. Overall, epidemiologic studies support modest associations of primarily prenatal polychlorinated biphenyl exposures with differences in neuromotor development, decrements in cognition and behavioral deficits, particularly regarding attention and impulse control. There are limited published human data regarding potential neurodevelopmental toxicities of early-life exposures to dichlorodiphenyl trichloroethane/dichlorodiphenyl dichloroethene and hexachlorobenzene. SUMMARY: Exposures to polychlorinated biphenyls, dichlorodiphenyl trichloroethane/dichlorodiphenyl dichloroethene and hexachlorobenzene are likely detrimental to neurodevelopment. Effective control of exposure is complicated by variable exposure sources and variable contaminant levels in food, particularly fish, for which it is important to balance the risk of contaminants with nutritional benefits.

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  • The weight of evidence from epidemiological studies supports a negative association between developmental exposure to PCBs and neuropsychological function in infancy and childhood.

    “The weight of evidence from epidemiological studies supports a negative association between developmental exposure to PCBs and neuropsychological function in infancy and childhood [ 56 , 95–99 ].”

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  1. [1]Jacobson JL, Jacobson SW. Developmental effects of PCBs in fish eater cohort studies. In: Robertson LW, Hansen LG, editors. PCBs: Recent Advances in Environmental Toxicology and Health Effects. Lexington, KY: University Press of Kentucky; 2001. pp. 127–36. [Google Scholar]
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Authors
Korrick, S. A., & Sagiv, S. K.
Affiliations
  • Brigham and Women's Hospital (US)
  • Harvard University (US)
Corresponding author
Korrick, Susan A
Venue
Current Opinion in Pediatrics
Published
2008-04
Volume
20
Issue
2
Pages
198-204
ISSN
1040-8703 (ISSN-L)
OpenAlex
W1980160389
Cited by
115
References
77
Citations by year
2026: 1 · 2025: 1 · 2024: 7 · 2023: 5 · 2022: 6 · 2021: 6 · 2020: 6 · 2019: 8 · 2018: 6 · 2017: 13 · 2016: 5 · 2015: 5 · 2014: 10 · 2013: 8 · 2012: 11
FWCI
0.58
Type
journal article
Language
en
Open access
Locations
  • Current Opinion in Pediatrics (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Institute of Mental Health (T32MH073122)
  • National Institute of Environmental Health Sciences (R01ES014864)
Topics
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Pesticide Exposure and Toxicity
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
Keywords
polychlorinated biphenyls, organochlorine pesticides, hexachlorobenzene, DDT, DDE, brain development, prenatal exposure, early life exposure, cognitive function, behavioral deficits, attention, impulse control, neuromotor development, fish consumption, environmental pollutants
MeSH terms
Child, Child Behavior Disorders, Developmental Disabilities, Environmental Exposure, Environmental Pollutants, Female, Hexachlorobenzene, Humans, Neuropsychological Tests, Pesticides, Polychlorinated Biphenyls, Pregnancy, Prenatal Exposure Delayed Effects, Prospective Studies, Cohort Studies

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