Polychlorinated biphenyls, organochlorine pesticides and neurodevelopment
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PURPOSE OF REVIEW: Although environmental levels of polychlorinated biphenyls and certain organochlorine pesticides--hexachlorobenzene, dichlorodiphenyl trichloroethane and its primary metabolite, dichlorodiphenyl dichloroethene--are generally on the decline, early-life exposures to these prevalent contaminants continue. The review will describe current understanding of the potential neurodevelopmental consequences of low-level exposures to these contaminants. RECENT FINDINGS: Animal models suggest that early-life exposures to polychlorinated biphenyls, dichlorodiphenyl trichloroethane/dichlorodiphenyl dichloroethene or hexachlorobenzene are associated with decreased cognitive or behavioral function in later development. Despite almost 30 years of research, however, results of human studies are inconsistent regarding the nature of the observed effects and their persistence over time. Overall, epidemiologic studies support modest associations of primarily prenatal polychlorinated biphenyl exposures with differences in neuromotor development, decrements in cognition and behavioral deficits, particularly regarding attention and impulse control. There are limited published human data regarding potential neurodevelopmental toxicities of early-life exposures to dichlorodiphenyl trichloroethane/dichlorodiphenyl dichloroethene and hexachlorobenzene. SUMMARY: Exposures to polychlorinated biphenyls, dichlorodiphenyl trichloroethane/dichlorodiphenyl dichloroethene and hexachlorobenzene are likely detrimental to neurodevelopment. Effective control of exposure is complicated by variable exposure sources and variable contaminant levels in food, particularly fish, for which it is important to balance the risk of contaminants with nutritional benefits.
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The weight of evidence from epidemiological studies supports a negative association between developmental exposure to PCBs and neuropsychological function in infancy and childhood.
“The weight of evidence from epidemiological studies supports a negative association between developmental exposure to PCBs and neuropsychological function in infancy and childhood [ 56 , 95–99 ].”
From DNA methylation: a mechanism linking environmental chemical exposures to risk of autism spectrum disorders? (2016) · cites this paper as [98]
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- Authors
- Korrick, S. A., & Sagiv, S. K.
- Affiliations
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Corresponding author
- Korrick, Susan A
- Venue
- Current Opinion in Pediatrics
- Published
- 2008-04
- Volume
- 20
- Issue
- 2
- Pages
- 198-204
- ISSN
- 1040-8703 (ISSN-L)
- PMC
- PMC3878996
- OpenAlex
- W1980160389
- Cited by
- 115
- References
- 77
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 7 · 2023: 5 · 2022: 6 · 2021: 6 · 2020: 6 · 2019: 8 · 2018: 6 · 2017: 13 · 2016: 5 · 2015: 5 · 2014: 10 · 2013: 8 · 2012: 11
- FWCI
- 0.58
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Opinion in Pediatrics (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Mental Health (T32MH073122)
- National Institute of Environmental Health Sciences (R01ES014864)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Pesticide Exposure and Toxicity
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Keywords
- polychlorinated biphenyls, organochlorine pesticides, hexachlorobenzene, DDT, DDE, brain development, prenatal exposure, early life exposure, cognitive function, behavioral deficits, attention, impulse control, neuromotor development, fish consumption, environmental pollutants
- MeSH terms
- Child, Child Behavior Disorders, Developmental Disabilities, Environmental Exposure, Environmental Pollutants, Female, Hexachlorobenzene, Humans, Neuropsychological Tests, Pesticides, Polychlorinated Biphenyls, Pregnancy, Prenatal Exposure Delayed Effects, Prospective Studies, Cohort Studies
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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