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Cited by 568

The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.

Human macrophage activation programs induced by bacterial pathogens

Nau, Gerard J., Richmond, Joan F. L., Schlesinger, Ann, Jennings, Ezra G., Lander, Eric S., Young, Richard A.·2002·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.022649799
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Abstract

Understanding the response of innate immune cells to pathogens may provide insights to host defenses and the tactics used by pathogens to circumvent these defenses. We used DNA microarrays to explore the responses of human macrophages to a variety of bacteria. Macrophages responded to a broad range of bacteria with a robust, shared pattern of gene expression. The shared response includes genes encoding receptors, signal transduction molecules, and transcription factors. This shared activation program transforms the macrophage into a cell primed to interact with its environment and to mount an immune response. Further study revealed that the activation program is induced by bacterial components that are Toll-like receptor agonists, including lipopolysaccharide, lipoteichoic acid, muramyl dipeptide, and heat shock proteins. Pathogen-specific responses were also apparent in the macrophage expression profiles. Analysis of Mycobacterium tuberculosis -specific responses revealed inhibition of interleukin-12 production, suggesting one means by which this organism survives host defenses. These results improve our understanding of macrophage defenses, provide insights into mechanisms of pathogenesis, and suggest targets for therapeutic intervention.

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Research works printed but not linked: 3

  1. 10.1379/1466-1268(2000)005<0401:IOAHPT>2.0.CO;2 · doi:10.1379/1466-1268(2000)005
  2. Goldstone S. E. Palefsky J. M. Winnett M. T. & Neefe J. R. (2002) Dis. Colon Rectum in press.
  3. S M Holland Adv Intern Med 45, 431–452 (2000).

Cited by

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Metadata

Authors
Nau, G. J., Richmond, J. F. L., Schlesinger, A., Jennings, E. G., Lander, E. S., & Young, R. A.
Affiliations
Whitehead Institute, 9 Cambridge Center, Cambridge, MA 02142; Infectious Disease Unit, Massachusetts General Hospital, Boston, MA 02114; and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139
Venue
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences
Published
2002-01-22
Volume
99
Issue
3
Pages
1503-1508
ISSN
  • 0027-8424
  • 1091-6490
DOI
10.1073/pnas.022649799
Cited by
568
References
32
Language
en

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